JP2021101180A - Dispensing chip with flange - Google Patents
Dispensing chip with flange Download PDFInfo
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- JP2021101180A JP2021101180A JP2019233186A JP2019233186A JP2021101180A JP 2021101180 A JP2021101180 A JP 2021101180A JP 2019233186 A JP2019233186 A JP 2019233186A JP 2019233186 A JP2019233186 A JP 2019233186A JP 2021101180 A JP2021101180 A JP 2021101180A
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- container
- flange portion
- dispensing tip
- contact
- collar
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- 239000012530 fluid Substances 0.000 claims abstract description 12
- 239000004033 plastic Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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Abstract
Description
本発明は、鍔を設けた分注チップに関する。 The present invention relates to a dispensing tip provided with a collar.
血液や体液等の液体試料を所定量取り出し、所定の容器内に吐き出す道具としてピペットが用いられている。
一般に、このようなピペットは試料液体の持ち越しを防ぐために、取り替え可能な使い捨て分注チップを使用している。また、血液や体液中の微量成分の生化学自動分析装置に搭載されている液体試料や希釈液等を移送する装置においても使い捨て分注チップが用いられている（例えば、特許文献１参照）。
分注チップは、ノズルにはめ込まれ、試料の流入・流出を行うが、滑りネジなどで調整されている高さ位置について誤差が生じていると、試料容器内でチップの先端が閉塞したり、攪拌の効率が悪くなったりするといった問題が生じる。このような問題を回避するためには、機械部品の公差、分注チップの公差、容器の公差、容器の固定位置などを加味した細かい調整を装置の組み立て時に行うしかなかった。
A pipette is used as a tool for taking out a predetermined amount of a liquid sample such as blood or body fluid and discharging it into a predetermined container.
Generally, such pipettes use replaceable disposable dispensing tips to prevent carry-over of sample liquid. In addition, disposable dispensing chips are also used in devices for transferring liquid samples, diluents, etc. mounted on biochemical automatic analyzers for trace components in blood and body fluids (see, for example, Patent Document 1).
The dispensing tip is fitted into the nozzle to allow the sample to flow in and out. However, if there is an error in the height position adjusted by the sliding screw, the tip of the tip may become blocked in the sample container. Problems such as poor stirring efficiency occur. In order to avoid such a problem, there was no choice but to make fine adjustments at the time of assembling the device, taking into consideration the tolerance of machine parts, the tolerance of dispensing tips, the tolerance of the container, the fixing position of the container, and the like.
装置の組み立て時に細かい調整を行わなくとも、ノズルにはめ込まれた分注チップの先端と試料容器内底との距離を一定に保つことを可能とする分注チップを提供する。 Provided is a dispensing tip that enables the distance between the tip of the dispensing tip fitted in the nozzle and the inner bottom of the sample container to be kept constant without making fine adjustments when assembling the device.
上記課題を解決するために、本発明者らは鋭意検討を重ねた結果、本発明に到達した。 In order to solve the above problems, the present inventors have reached the present invention as a result of repeated diligent studies.
すなわち、本発明は、内部に流体を収容する空間を有し、先端開口部から前記流体を流入又は流出する分注チップであって、さらに鍔部を、その外周に備えており、前記鍔部は、流入又は流出される前記流体を収容する容器縁部の一部又は全部と接触できる大きさを有しており、前記鍔部と前記容器縁部の一部又は全部と接触しているときに、前記鍔部が前記容器内の空気を通過させられる構造であることを特徴とする。 That is, the present invention is a dispensing tip having a space for accommodating a fluid inside, and the fluid flows in or out from the tip opening, and further includes a collar portion on the outer periphery thereof, and the collar portion is provided. Has a size that allows contact with a part or all of the container edge portion that houses the fluid that flows in or out, and when the collar portion is in contact with a part or all of the container edge portion. In addition, the collar portion has a structure that allows air in the container to pass through.
以下、本発明を詳細に説明する。なお、分注チップが扱う流体を「試料」ということがある。 Hereinafter, the present invention will be described in detail. The fluid handled by the dispensing tip is sometimes called a "sample".
分注チップは、内部に流体を収容する空間を有し、先端開口部から前記流体を流入又は流出する構造であるならば、大きさ、形状、材質等に関して特に制限はなく、一般的な、上方が大径であり、下方が縮径したテーパー形状を有する管状体であり、内部の空間が流路となっているような構造で問題ない。 As long as the dispensing tip has a space for accommodating the fluid inside and has a structure in which the fluid flows in or out from the tip opening, there are no particular restrictions on the size, shape, material, etc. There is no problem in a structure in which the upper part has a large diameter and the lower part has a tapered shape with a reduced diameter, and the internal space serves as a flow path.
鍔部は、分注チップの外周に備わっていればよく、市販の分注チップに後から鍔部をつければよい。鍔部は、金属、プラスチック、ガラスなど加工容易な材質であれば、特に制限はないが、プラスチックは軽量で安価なため好ましく、分注チップもプラスチック製の場合、分注チップと鍔部が一体成型可能となるため特に好ましい。 The flange portion may be provided on the outer circumference of the dispensing tip, and the flange portion may be attached to a commercially available dispensing tip later. The collar is not particularly limited as long as it is a material that is easy to process, such as metal, plastic, and glass, but plastic is preferable because it is lightweight and inexpensive. If the dispensing tip is also made of plastic, the dispensing tip and collar are integrated. It is particularly preferable because it can be molded.
また、分注チップの上方（ノズル装着側）に鍔部を備えていることが好ましいが、試料の流入・流出の障害とならない位置であれば鍔部を備える位置に関して特に制限はない。 Further, it is preferable that the flange portion is provided above the dispensing tip (nozzle mounting side), but there is no particular limitation on the position where the flange portion is provided as long as it does not hinder the inflow and outflow of the sample.
鍔部は、流入又は流出される試料を収容する容器縁部の一部又は全部と接触できる大きさを有している。鍔部が容器縁部の一部又は全部と接触することで、分注チップの開口先端部と容器内底部の距離を一定に保つことが可能となる。また、装置上で容器がセッティングされるべき位置から浮き上がってしまっている場合、鍔部を容器縁部と接触させて押し込むことで、正常な高さ位置に戻すことも可能となる。 The collar has a size that allows it to come into contact with a part or all of the edge of the container that houses the inflowing or outflowing sample. When the flange portion comes into contact with a part or all of the container edge portion, the distance between the opening tip portion of the dispensing tip and the inner bottom portion of the container can be kept constant. Further, when the container is lifted from the position where it should be set on the device, it is possible to return it to the normal height position by bringing the collar portion into contact with the container edge portion and pushing it in.
しかしながら、鍔部が容器縁部と接触する際に、容器を完全に塞いでしまうと、試料の正確な流入・流出が困難となってしまう。そこで、鍔部と容器縁部が接触しているときに、鍔部は容器内の空気を通過させられる構造としておく。 However, if the container is completely closed when the flange portion comes into contact with the edge portion of the container, it becomes difficult to accurately inflow and outflow the sample. Therefore, when the collar portion and the edge portion of the container are in contact with each other, the collar portion has a structure that allows air in the container to pass through.
具体的な態様としては、図１（ａ）、（ｂ）、（ｃ）のように、試料容器の縁部の一部と鍔部が接触し、両者が接触していない部分が空気通路となる態様、図１（ｄ）のように試料容器の縁部の全部と鍔部が接触し、鍔部に孔が設けられている態様、図１（ｅ）のように試料容器の縁部の全部と鍔部が接触し、鍔部がメッシュ構造となっている態様などが例示される。 As a specific embodiment, as shown in FIGS. 1A, 1B, and 1C, a part of the edge portion of the sample container and the collar portion are in contact with each other, and the portion where the two are not in contact with each other is the air passage. A mode in which the entire edge of the sample container is in contact with the collar as shown in FIG. 1 (d) and a hole is provided in the collar, and the edge of the sample container is provided as shown in FIG. 1 (e). An example is an embodiment in which the collar portion is in contact with the entire flange portion and the collar portion has a mesh structure.
上述したいずれの態様であっても、また、容器縁部の一部又は全部と接触できる大きさを有し、接触時に容器内の空気を通過させられる構造であれば、上述した以外の態様であっても問題は無いが、加工のしやすさ等を加味すると、鍔部の形状は図１（ｃ）のような切り欠き部を有する円状であることが好ましい。なお、切り欠き部の大きさや数については適宜変更可能な設計事項であり、容器内の空気を通過させられるのであれば、円柱状の鍔部において容器に接する底面にのみ切り欠き部を有するという構造であっても問題ない。 In any of the above-described embodiments, if the structure has a size capable of contacting a part or all of the container edge and allows air in the container to pass through at the time of contact, the embodiment other than the above-described embodiment can be used. There is no problem even if there is, but considering the ease of processing and the like, the shape of the collar portion is preferably a circular shape having a notch portion as shown in FIG. 1 (c). The size and number of notches are design items that can be changed as appropriate, and if the air inside the container can be passed through, the notches are provided only on the bottom surface of the columnar brim that is in contact with the container. There is no problem even if it is a structure.
機械的な調整を行わずにチップ先端高さを精密に位置合わせすることができる。また、容器の高さずれを簡便に直すことができる。 The tip height can be precisely aligned without mechanical adjustment. In addition, the height deviation of the container can be easily corrected.
以下、具体的な実施形態を説明するが、本発明は当該例に限定されるものではなく、特許請求の範囲に記載された発明の範囲にて様々な変更が可能であることは当業者に容易に理解可能である。 Hereinafter, specific embodiments will be described, but those skilled in the art will appreciate that the present invention is not limited to this example and that various modifications can be made within the scope of the invention described in the claims. It is easy to understand.
分注チップは高さ３０ｍｍの円錐状であり、先端部に液を流入又は流出させる直径０．２ｍｍの開口部を有し、逆の一端にノズルを圧入する直径５ｍｍの開口部を有する。さらに円錐に対して同心円上かつノズル圧入側に直径９ｍｍ、厚さ２．５ｍｍの鍔部を有する。この鍔部の先端側には１ｍｍ四方の切り欠きを２つ有し、それらは同心円上で対極に位置する。斜視図を図２に示す。
この分注チップの鍔部を、試料を収容する開口部が直径７ｍｍ、深さ２８ｍｍの容器縁部に接触させることで、分注チップ先端と容器底は０．５ｍｍの距離に保たれる。さらに２つの切り欠きからは容器内の空気を通過させられるため、試料の流入又は流出が可能であった。
The dispensing tip is conical with a height of 30 mm, has an opening with a diameter of 0.2 mm at the tip for inflowing or outflowing liquid, and has an opening with a diameter of 5 mm at the opposite end for press-fitting the nozzle. Further, it has a flange portion having a diameter of 9 mm and a thickness of 2.5 mm on the concentric circle with respect to the cone and on the nozzle press-fitting side. There are two 1 mm square notches on the tip side of this collar, which are concentrically located at opposite poles. A perspective view is shown in FIG.
By bringing the collar of the dispensing tip into contact with the edge of the container having an opening having a diameter of 7 mm and a depth of 28 mm for accommodating the sample, the tip of the dispensing tip and the bottom of the container are kept at a distance of 0.5 mm. Furthermore, since the air in the container can be passed through the two notches, the sample can flow in or out.
１ 鍔部
２ 容器縁部
３ 空気通路
４ ノズル装着部
５ 孔
1
Claims (5)
さらに鍔部を、その外周に備えており、
前記鍔部は、流入又は流出される前記流体を収容する容器縁部の一部又は全部と接触できる大きさを有しており、
前記鍔部と前記容器縁部の一部又は全部と接触しているときに、前記鍔部が前記容器内の空気を通過させられる構造であることを特徴とする分注チップ。 A dispensing tip that has a space for accommodating a fluid inside and allows the fluid to flow in or out through the tip opening.
In addition, a brim is provided on the outer circumference.
The collar portion has a size that allows it to come into contact with a part or all of the container edge portion that houses the fluid that flows in or out.
A dispensing tip having a structure in which the collar portion allows air in the container to pass through when the collar portion is in contact with a part or all of the container edge portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019233186A JP7388179B2 (en) | 2019-12-24 | 2019-12-24 | Dispensing tip with flange |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019233186A JP7388179B2 (en) | 2019-12-24 | 2019-12-24 | Dispensing tip with flange |
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| Publication Number | Publication Date |
|---|---|
| JP2021101180A true JP2021101180A (en) | 2021-07-08 |
| JP7388179B2 JP7388179B2 (en) | 2023-11-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2019233186A Active JP7388179B2 (en) | 2019-12-24 | 2019-12-24 | Dispensing tip with flange |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5745350A (en) * | 1980-08-29 | 1982-03-15 | Union Giken:Kk | Automatic self-aligning mechanism of liquid sucker |
| JPH08266913A (en) * | 1995-03-24 | 1996-10-15 | Becton Dickinson & Co | Pipette chip |
| JP2006208373A (en) * | 2005-01-28 | 2006-08-10 | Molecular Bioproducts Inc | Liquid sampling utilizing ribbed pipette tip for barrier penetration |
| JP2011214842A (en) * | 2010-03-31 | 2011-10-27 | Tosoh Corp | Dispenser nozzle |
| JP2012147751A (en) * | 2011-01-21 | 2012-08-09 | Hitachi High-Technologies Corp | Dispensing chip and nucleic acid analyzer |
| JP2015068669A (en) * | 2013-09-27 | 2015-04-13 | シスメックス株式会社 | Liquid suction device, specimen analyzer, and chip container |
| JP2015175837A (en) * | 2014-03-18 | 2015-10-05 | ソニー株式会社 | Plate-like member for pipette tips, pipette tip, liquid agitation kit and liquid agitation apparatus |
| JP2017067481A (en) * | 2015-09-28 | 2017-04-06 | 富士フイルム株式会社 | Pipette tip and liquid injection method |
-
2019
- 2019-12-24 JP JP2019233186A patent/JP7388179B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5745350A (en) * | 1980-08-29 | 1982-03-15 | Union Giken:Kk | Automatic self-aligning mechanism of liquid sucker |
| JPH08266913A (en) * | 1995-03-24 | 1996-10-15 | Becton Dickinson & Co | Pipette chip |
| JP2006208373A (en) * | 2005-01-28 | 2006-08-10 | Molecular Bioproducts Inc | Liquid sampling utilizing ribbed pipette tip for barrier penetration |
| JP2011214842A (en) * | 2010-03-31 | 2011-10-27 | Tosoh Corp | Dispenser nozzle |
| JP2012147751A (en) * | 2011-01-21 | 2012-08-09 | Hitachi High-Technologies Corp | Dispensing chip and nucleic acid analyzer |
| JP2015068669A (en) * | 2013-09-27 | 2015-04-13 | シスメックス株式会社 | Liquid suction device, specimen analyzer, and chip container |
| JP2015175837A (en) * | 2014-03-18 | 2015-10-05 | ソニー株式会社 | Plate-like member for pipette tips, pipette tip, liquid agitation kit and liquid agitation apparatus |
| JP2017067481A (en) * | 2015-09-28 | 2017-04-06 | 富士フイルム株式会社 | Pipette tip and liquid injection method |
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| JP7388179B2 (en) | 2023-11-29 |
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