JP2021018240A - Liquid sample inspection tool - Google Patents

Abstract

To provide a liquid sample inspection tool capable of developing a liquid sample in a uniform manner over the whole test strip, improving efficiency of an immune response, and improving color development of a color indicating an inspection result.SOLUTION: A liquid sample inspection tool comprises: an upper case 10 in which a drop hole 13 for a liquid sample and a determination window 14 for an inspection result are juxtaposed; a lower case 40 assembled to the upper case 10; and a test strip 30 stored between the upper case 10 and the lower case 40. The upper case 10 comprises: a first protrusion part 11 protruding toward the lower case 40; and a second protrusion part 12 protruding toward the lower case 40. Shapes of the first and second protrusion parts 11, 12 are designed so that capillary force generated between the second protrusion part 12 and the liquid sample becomes greater than capillary force generated between the first protrusion part 11 and the liquid sample.SELECTED DRAWING: Figure 3

Description

The present invention relates to a liquid sample inspection tool.

In recent years, liquid sample inspection tools using an immunochromatography method have been widely used for inspection of infectious diseases that require particularly rapid diagnosis. This type of liquid sample inspection tool consists of a test strip and an upper and lower case for accommodating them. By adding a liquid sample to the test strip from the dropping holes provided in the upper case, the color indicating the inspection result can be visually recognized from the determination windows provided side by side with respect to the dropping holes.

In order to make the inspection result visible quickly, it is necessary to quickly deploy the liquid sample added from the dropping hole into the judgment window. Therefore, a liquid sample inspection tool in which a ridge is provided on the determination window side of the dropping hole of the upper case and the liquid sample is developed along the ridge on the determination window side has been considered (Patent Document 1).

Japanese Patent No. 4643415

However, in the conventional liquid sample inspection tool described above, the liquid sample is rapidly deployed toward the determination window side by the ridge. Therefore, the liquid sample flows toward the determination window side at once. That is, there is a problem that the liquid sample cannot be uniformly spread over the entire test strip. In addition, if the liquid sample cannot be uniformly developed, the dry agent held on the test strip cannot be sufficiently dissolved, so that the reaction efficiency of the immune reaction is deteriorated and the color indicating the test result is poorly developed. ..

The present invention has been made in view of the above circumstances, and an object of the present invention is to spread a liquid sample uniformly over the entire test strip, improve the efficiency of immune reaction, and show a color indicating a test result. It is an object of the present invention to provide a liquid sample inspection tool having improved color development.

In order to achieve the above-mentioned object, the liquid sample inspection tool according to the present invention is characterized by the following [1] to [9].

[1]
An upper case in which a drop hole for a liquid sample and a judgment window for inspection results are provided side by side,
The lower case to be assembled to the upper case and
In a liquid sample inspection tool provided with a test strip housed between the upper case and the lower case.
The upper case
A first protrusion protruding from the edge of the dropping hole on the determination window side toward the lower case, and
It has a second protrusion that protrudes toward the lower case from an edge portion of the dropping hole that is opposite to the determination window from the first protrusion.
The first protrusion and the liquid sample so that the capillary force generated between the second protrusion and the liquid sample is larger than the capillary force generated between the first protrusion and the liquid sample. The shape of the second protrusion is provided,
Must be a liquid sample inspection tool.
[2]
In the liquid sample inspection tool according to [1],
The first protrusion extends from the edge of the dropping hole toward the determination window side along the alignment direction of the dropping hole and the determination window.
The second protrusion extends from the edge of the dropping hole toward the side opposite to the determination window along the alignment direction.
Must be a liquid sample inspection tool.
[3]
In the liquid sample inspection tool according to [2],
The length of the second protrusion in the alignment direction is longer than the length of the first protrusion in the alignment direction.
Must be a liquid sample inspection tool.
[4]
In the liquid sample inspection tool according to [2] or [3],
The number of the second protrusions is larger than the number of the first protrusions,
Must be a liquid sample inspection tool.
[5]
In the liquid sample inspection tool according to any one of [2] to [4],
A plurality of the first protrusions and the second protrusions are provided side by side in a direction other than the arrangement direction.
The distance between the plurality of second protrusions is narrower than the distance between the plurality of first protrusions.
Must be a liquid sample inspection tool.
[6]
In the liquid sample inspection tool according to [1],
The second protrusion is provided in a pillar shape and is provided.
A second protrusion in which a plurality of the second protrusions are arranged at intervals from the edge of the drop hole toward the side opposite to the determination window along the arrangement direction of the determination window and the drop hole. With rows
The second row of protrusions is a liquid sample inspection tool provided side by side in a direction other than the line-up direction.
[7]
In the liquid sample inspection tool according to [6],
The first protrusion extends from the edge of the dropping hole toward the determination window side along the alignment direction.
A plurality of the first protrusions are provided side by side in a direction other than the arrangement direction.
The distance between the plurality of second protrusions is narrower than the distance between the plurality of first protrusions.
Must be a liquid sample inspection tool.
[8]
In the liquid sample inspection tool according to any one of [1] to [7],
The test strip includes a sample pad exposed from the dropping hole, an adjusting pad arranged with a gap on the determination window side of the sample pad, and a conju arranged so as to be connected to the determination window side of the adjusting pad. It has a gate pad and a membrane that is arranged in a row on the determination window side of the conjugate pad and is visible from the determination window.
The end of the first protrusion on the drop hole side in the alignment direction is located on the sample pad, and the end of the first protrusion in the alignment direction on the determination window side is on the adjusting pad. Located in,
Must be a liquid sample inspection tool.
[9]
In the liquid sample inspection tool according to any one of [1] to [8],
The test strip includes a sample pad exposed from the dropping hole, an adjusting pad arranged with a gap on the determination window side of the sample pad, and a conju arranged so as to be connected to the determination window side of the adjusting pad. It has a gate pad and a membrane that is arranged in a row on the determination window side of the conjugate pad and is visible from the determination window.
The first protrusion is provided so as to face the gap and is not inserted into the gap.
Must be a liquid sample inspection tool.

According to the liquid sample inspection tool having the configuration of [1] above, the capillary force generated between the second protrusion and the liquid sample is larger than the capillary force generated between the first protrusion and the liquid sample. The shapes of the first protrusion and the second protrusion are provided so as to be. As a result, the force with which the second protrusion pulls the liquid sample dropped on the test strip to the opposite side of the judgment window is stronger than the force with which the first protrusion pulls the liquid sample dropped on the test strip toward the judgment window. be able to. Therefore, the flow of the liquid sample in the test strip can be controlled so that the liquid sample dropped in the dropping hole is once advanced to the side opposite to the judgment window and then expanded to the judgment window side, and the liquid sample can be uniformly spread over the entire test strip. Can be expanded. Further, by uniformly developing the liquid sample, the dry agent held on the test strip can be sufficiently dissolved to improve the efficiency of the immune reaction and improve the color development of the color indicating the test result.

According to the liquid sample inspection tool having the configuration of the above [2], the first protrusion and the second protrusion can be easily provided.

According to the liquid sample inspection tool having the configuration of [3] above, the length of the second protrusion in the alignment direction is longer than the length of the first protrusion in the alignment direction. As a result, the force with which the second protrusion pulls the liquid sample dropped on the test strip to the opposite side of the judgment window is more easily than the force with which the first protrusion pulls the liquid sample dropped on the test strip toward the judgment window. Can also be strengthened.

According to the liquid sample inspection tool having the configuration of [4] above, the number of the second protrusions is larger than the number of the first protrusions. As a result, the force with which the second protrusion pulls the liquid sample dropped on the test strip to the opposite side of the judgment window is more easily than the force with which the first protrusion pulls the liquid sample dropped on the test strip toward the judgment window. Can also be strengthened.

According to the liquid sample inspection tool having the configuration of [5] above, the distance between the plurality of second protrusions in directions other than the arrangement direction is narrower than the distance between the plurality of first protrusions. That is, the capillary path formed between the second protrusions is narrower than the capillary path formed between the first protrusions. As a result, the capillary force generated between the second protrusion and the liquid sample can be easily made larger than the capillary force generated between the first protrusion and the liquid sample.

According to the liquid sample inspection tool having the configuration of [6] above, a plurality of rows of second protrusions in which a plurality of second protrusions are arranged in an arrangement direction are provided side by side in a direction other than the arrangement direction. As a result, the second protrusion can be provided in a pillar shape.

According to the liquid sample inspection tool having the configuration of [7] above, the distance between the plurality of second protrusions is narrower than the distance between the plurality of first protrusions. That is, the capillary path formed between the second protrusions is narrower than the capillary path formed between the first protrusions. As a result, the capillary force generated between the second protrusion and the liquid sample can be easily made larger than the capillary force generated between the first protrusion and the liquid sample.

According to the liquid sample inspection tool having the configuration of [8] above, the end of the first protrusion on the drop hole side in the alignment direction is located on the sample pad, and the end of the first protrusion in the alignment direction on the determination window side. The section is located on the adjusting pad. As a result, the liquid sample developed through the first protrusion to the end on the determination window side can be impregnated into the adjusting pad.

According to the liquid sample inspection tool having the configuration of [9] above, the first protrusion is provided so as to face the gap between the sample pad and the adjusting pad. As a result, the liquid sample can flow along the first protrusion, overcome the gap, and expand to the adjusting pad.

As described above, according to the liquid sample inspection tool of the present invention, the liquid sample can be uniformly spread over the entire test strip. Further, by uniformly developing the liquid sample, the dry agent held on the test strip can be sufficiently dissolved to improve the efficiency of the immune reaction and improve the color development of the color indicating the test result.

The present invention has been briefly described above. Further, the details of the present invention will be further clarified by reading through the embodiments for carrying out the invention described below (hereinafter, referred to as "embodiments") with reference to the accompanying drawings. ..

FIG. 1 is a perspective view of an upper case of the liquid sample inspection tool according to the first embodiment of the present invention. FIG. 2 is a perspective view of a lower case of the liquid sample inspection tool according to the first embodiment of the present invention. FIG. 3 is a cross-sectional view of the liquid sample inspection tool according to the first embodiment of the present invention. FIG. 4 is an enlarged perspective view of a main part of the upper case shown in FIG. FIG. 5 is a perspective view of the upper case of the liquid sample inspection tool according to the second embodiment of the present invention. FIG. 6 is an enlarged perspective view of a main part of the upper case shown in FIG. FIG. 7 is a perspective view of the upper case of the liquid sample inspection tool according to the third embodiment of the present invention. FIG. 8 is an enlarged top view of a main part of the upper case shown in FIG. 7.

Specific embodiments of the present invention will be described below with reference to the respective figures.

<First Embodiment>
FIG. 1 shows a perspective view of the upper case 10 of the liquid sample inspection tool according to the first embodiment of the present invention. FIG. 2 shows a perspective view of the lower case 40 of the liquid sample inspection tool according to the first embodiment of the present invention. FIG. 3 shows a cross-sectional view of the liquid sample inspection tool according to the first embodiment, particularly a cross-sectional view of the upper case 10, the lower case 40, and the test strip 30. The liquid sample inspection tool according to the first embodiment includes an upper case 10 in which a liquid sample dropping hole 13 and an inspection result determination window 14 are provided side by side, a lower case 40 assembled to the upper case 10, and an upper case. A test strip 30 housed between the 10 and the lower case 40 is provided. The liquid sample inspection tool is, for example, an instrument that uses an immunochromatography method for inspection of various infectious diseases. By adding a liquid sample to the test strip 30 from the dropping hole 13 provided in the upper case 10, the liquid sample is added to the dropping hole 13. It is configured so that the color indicating the inspection result can be visually recognized from the determination windows 14 provided side by side.

The upper case 10 includes a first protrusion 11, a second protrusion 12, a dropping hole 13, a determination window 14, and a holding pin 15. FIG. 1 shows a perspective view of the back side of the upper case 10, that is, a perspective view of the upper case 10 as viewed from the lower side of FIG. 3, and the first protrusion 11, the second protrusion 12, and the holding pin 15 are the lower case. It protrudes toward the test strip 30 mounted on the 40. On the other hand, the dropping hole 13 and the determination window 14 are provided so as to penetrate the upper case 10 so that the test strip 30 inside the liquid sample inspection tool can be visually observed. In the present embodiment, the dropping hole 13 has a circular shape and the determination window 14 has a rectangular shape, but the shape, position, and the like of each are not particularly limited.

The first protrusion 11 is provided so as to project toward the lower case 40 and extend from the edge of the dropping hole 13 on the determination window 14 side along the alignment direction X of the dropping hole 13 and the determination window 14. There is. The tip of the first protrusion 11 faces the test strip 30 in the thickness direction Z. On the other hand, the second protrusion 12 is provided so as to project toward the lower case 40 and extend along the alignment direction X from the edge portion of the dropping hole 13 opposite to the determination window 14. The tip of the second protrusion 12 faces the test strip 30 in the thickness direction Z. In FIG. 3, the first protrusion 11 and the second protrusion 12 are positioned at predetermined intervals with respect to the test strip 30, but the first protrusion 11 and the second protrusion 12 are formed on the test strip 30. You may make contact. Details of the first protrusion 11 and the second protrusion 12 will be described later.

The holding pins 15 are arranged two along the alignment direction X and two along the orthogonal direction Y orthogonal to the alignment direction X, that is, a total of four, and are members for preventing the test strip 30 from floating. In FIG. 3, the holding pins 15 are positioned with respect to the test strip 30 at predetermined intervals, but the holding pins 15 may come into contact with the test strip 30. However, the holding pin 15 is not an indispensable member, and the number, position, shape, etc. of the holding pin 15 are not particularly limited. In the present embodiment, the upper case 10 is provided with the holding pin 15, but the holding pin 15 is not an indispensable configuration and may not be provided. Further, in the present embodiment, the holding pin 15 is provided in a pin shape, but the present invention is not limited to this. A pressing member 151 as shown in FIG. 7 may be provided. The pressing member 151 may be configured to more stably overlap the pads 22, 32, 33, and the membrane 34 along the cross-sectional shape of the test strip 30.

The test strip 30 is a long member placed on the lower case 40, and as shown in FIG. 3, a sample pad 31, an adjusting pad 32, and a conju are provided in order along the arrangement direction X. It has a gate pad 33, a membrane 34, and an absorption pad 22. Note that FIG. 3 schematically depicts the test strip 30, and the thicknesses of the adjusting pad 32, the conjugate pad 33, and the absorbing pad 22 are not constant. However, in reality, the sample pad 31, the adjusting pad 32, the conjugate pad 33, the membrane 34, and the absorption pad 22 are each formed into a sheet having a uniform thickness.

The sample pad 31 is exposed from the dropping hole 13 and has a property of absorbing the liquid sample added from the dropping hole 13 and moving the liquid sample. In the present embodiment, the second protrusion 12 is provided adjacent to the dropping hole 13, and most of the liquid sample added from the dropping hole 13 is pulled by the second protrusion 12 due to the capillary phenomenon. It will diffuse to the sample pad 31. Of course, some of the liquid samples added from the dropping hole 13 do not face the second protrusion 12 side but toward the first protrusion 11 side (details will be described later).

The adjusting pad 32 is arranged with a gap G provided on the side of the determination window 14 of the sample pad 31. The adjusting pad 32 is a member arranged for the purpose of imparting a specific function in order to promote a supplementary reaction of an antigen contained in a liquid sample, and one example thereof is extraction of an antigen contained in a liquid sample. By providing the gap G between the sample pad 31 and the adjusting pad 32, deterioration of the chemical impregnated in the adjusting pad 32 can be suppressed. Since the first protrusion 11 is provided on the gap G adjacent to the dropping hole 13 as in the second protrusion 12, the liquid sample travels from the sample pad 31 to the first protrusion 11 and travels through the gap G. It is possible to move to the side of the adjusting pad 32 over the above.

The conjugate pad 33 is arranged so as to be continuous with the determination window 14 of the adjusting pad 32. The conjugate pad 33 is partially laminated with the adjusting pad 32. The conjugate pad 33 carries a specific antibody (antibody labeled with a substance such as colloidal gold or color latex; a colored label), and the liquid sample that reaches the conjugate pad 33 is a membrane 34 while dissolving the specific antibody. Penetrate into. At this time, the antigen contained in the liquid sample binds to the specific antibody.

The membrane 34 is arranged so as to be continuous with the determination window 14 of the conjugate pad 33, and is visible from the determination window 14 of the upper case 10 existing above. On the membrane 34, the supplementary antibody is applied and fixed in a line shape along the orthogonal direction Y. When an antigen (measured object) bound to a specific antibody is present in the liquid sample, this antigen and the supplementary antibody immobilized on the membrane 34 cause an antigen-antibody reaction, and a colored label appears as a signal on the membrane 34. It has become like. Further, the membrane 34 is connected to the absorption pad 22 placed on the end of the backing sheet 20, and the liquid sample is finally absorbed by the absorption pad 22.

FIG. 4 shows an enlarged perspective view of a main part of the upper case 10 shown in FIG. The first protrusion 11 projects from the side of the determination window 14 of the dropping hole 13 toward the lower case 40, that is, along the thickness direction Z, and along the alignment direction X of the dropping hole 13 and the determination window 14. It is provided. In the present embodiment, the first protrusions 11 have a strip shape extending linearly along the alignment direction X, and three are arranged along the orthogonal direction Y.

On the other hand, the second protrusion 12 projects from the side opposite to the determination window 14 of the dropping hole 13 toward the lower case 40, that is, along the thickness direction Z, and is provided along the alignment direction X. In the present embodiment, the first protrusions 11 have a strip shape extending linearly along the alignment direction X, and three are arranged along the orthogonal direction Y.

Then, in the present embodiment, the length of the alignment direction X of the second protrusion 12 is longer than the length of the alignment direction X of the first protrusion 11. That is, as shown in FIG. 4, the relationship between the length L1 of the first protrusion 11 in the alignment direction X and the length L2 of the second protrusion 12 in the alignment direction X is L1 <L2.

According to such a configuration, the capillary force generated between the second protrusion 12 and the liquid sample is larger than the capillary force generated between the first protrusion 11 and the liquid sample. As a result, the second protrusion 12 pulls the liquid sample dropped on the test strip 30 to the opposite side of the determination window 14, and the first protrusion 11 applies the liquid sample dropped on the test strip 30 to the judgment window 14. It can be stronger than the pulling force to the side. That is, most of the liquid sample is developed toward the second protrusion 12 by the second protrusion 12, as shown by the arrow A in FIG. The liquid sample developed on the second protrusion 12 side then heads toward the absorption pad 22 side due to the absorption force of the absorption pad 22. The liquid sample directed toward the absorption pad 22 passes through the first protrusion 11 and overcomes the gap G, and expands (penetrates and flows) to the absorption pad 22 through the conjugate pad 33 and the membrane 34. The shape, structure, and the like of the test strip 30 are not particularly limited, and for example, the adjusting pad 32 can be omitted. Further, the adjusting pad 32 may be arranged between the conjugate pad 33 and the membrane 34.

As described above, in the liquid sample inspection tool according to the present embodiment, the test strip 30 is such that the liquid sample dropped in the dropping hole 13 is once advanced to the side opposite to the determination window 14 and then expanded to the side of the determination window 14. The flow of the liquid sample in the inside can be controlled, and the liquid sample can be uniformly spread over the entire test strip 30. Further, by uniformly developing the liquid sample, the drying agent held on the test strip 30 can be sufficiently dissolved to improve the efficiency of the immune reaction and improve the color development of the color indicating the test result.

Further, in the present embodiment, a plurality of first protrusions 11 and 12 are provided in orthogonal directions Y orthogonal to the alignment direction X (three in this embodiment). The distance W2 in the orthogonal direction Y of the plurality of second protrusions 12 is narrower than the distance W1 in the orthogonal direction Y of the plurality of first protrusions 11. That is, as shown in FIG. 4, the relationship between the distance W1 in the orthogonal direction Y of the first protrusion 11 and the distance W2 in the orthogonal direction Y of the second protrusion 12 is W1> W2.

According to such a configuration, the capillary path formed between the second protrusions 12 is narrower than the capillary path formed between the first protrusions 11. As a result, the second protrusion 12 pulls the liquid sample dropped on the test strip 30 to the opposite side of the determination window 14, and the first protrusion 11 applies the liquid sample dropped on the test strip 30 to the judgment window 14. It can be stronger than the pulling force to the side. Therefore, similarly to the above, the liquid sample can be uniformly developed, and the pH adjuster, aggregation inhibitor, salt and the like (drying agent) held on the test strip 30 are sufficiently dissolved to improve the efficiency of the immune reaction. It is possible to improve the color development of the color indicating the inspection result. In the present embodiment, a pH adjuster, an aggregation inhibitor, a salt and the like have been described as examples of the drying agent, but the present invention is not limited to this, and the drying agent may be an agent held on the test strip 30. Just do it.

By satisfying at least one of the above-mentioned relationships of L1 <L2 and W1> W2, improvement in color development of the color indicating the inspection result is expected.

Further, the end portion 11b (see FIG. 3) on the side of the dropping hole 13 in the alignment direction X of the first protrusion 11 is located on the sample pad 31, and the determination window 14 in the alignment direction X of the first protrusion 11 The side end 11a (see FIG. 3) is located above the adjusting pad 32. According to such a configuration, the liquid sample developed through the first protrusion 11 to the end portion 11a on the side of the determination window 14 can be impregnated into the adjusting pad 32. Further, when the end portion 11a of the first protrusion 11 is extended to the conjugate pad 33, the liquid sample flows between the first protrusion 11 and the test strip 30 toward the membrane 34 side, and the adjusting pad There is a risk that the penetration into 32 will be shallow. However, in the present embodiment, as described above, since the end portion 11a of the first protrusion 11 is positioned on the adjusting pad 32, the liquid sample easily permeates into the adjusting pad 32.

Further, the first protrusion 11 is provided so as to face the gap G, is not inserted into the gap G, and is in a state of covering the gap G. According to such a configuration, the liquid sample can flow along the first protrusion 11 and extend over the gap G to the adjusting pad 32.

<Second Embodiment>
FIG. 5 shows a perspective view of the upper case 10 of the liquid sample inspection tool according to the second embodiment of the present invention. FIG. 6 shows an enlarged perspective view of a main part of the upper case 10 shown in FIG. In this embodiment, only one first protrusion 11 is provided, and three second protrusions 12 are provided as in the first embodiment. That is, the number of the second protrusions 12 is larger than that of the first protrusions 11. The number of the first protrusions 11 and the number of the second protrusions 12 are not particularly limited, but in the present embodiment, the relationship (the number of the first protrusions 11 <the number of the second protrusions 12) is established.

According to such a configuration, the force of pulling the liquid sample dropped on the test strip 30 by the second protrusion 12 to the opposite side of the determination window 14 is applied to the liquid sample dropped on the test strip 30 by the first protrusion 11. Can be made stronger than the pulling force toward the determination window 14. Therefore, as in the first embodiment, the liquid sample can be uniformly developed, the dry agent held on the test strip 30 is sufficiently dissolved to improve the efficiency of the immune reaction, and the color indicating the test result is shown. Color development can be improved.

<Third Embodiment>
FIG. 7 shows a perspective view of the upper case of the liquid sample inspection tool according to the third embodiment of the present invention. FIG. 8 shows an enlarged top view of a main part of the upper case shown in FIG. 7. In the present embodiment, the second protrusion 12 is provided in a columnar shape (pillar shape). A plurality of second protrusions 12 are provided at intervals along the direction X arranged from the edge of the dropping hole 13 toward the side opposite to the determination window 14. A plurality of second protrusions 12 arranged along the arrangement direction X form a second protrusion row 16. A plurality of second projecting rows 16 are provided side by side in the orthogonal direction Y. In the present embodiment, the second protrusion row 16 is provided side by side in 11 rows.

It should be noted that one of the second protrusions 12 and the other second protrusion 12 of the adjacent second protrusion rows 16 are not aligned in the orthogonal direction Y, and are about 45 ° to 75 ° with respect to the alignment direction X. They are lined up in the direction of forming the angle θ. That is, the other second protrusion 12 is located between the second protrusion 12 and the second protrusion 12 of the adjacent second protrusion row 16. As a result, the distance W22 between the second protrusions 12 constituting the adjacent second protrusion rows 16 can be narrowed. The distance W21 between the second protrusions 12 of the same second protrusion row 16 is the same as or narrower than the distance W22. The intervals W21 and W22 of the second protrusions 12 are narrower than the intervals W1 of the first protrusions 11.

Further, in the present embodiment, from the edge portion of the dropping hole 13 on the side away from the determination window 14, the second protrusion row 16 composed of the six second protrusions 12 and the five second protrusions 12 The second protrusion row 16 composed of the two is arranged alternately in a total of five rows. Further, from the edges on both sides of the dropping hole 13 in the orthogonal direction Y, three rows of second protrusion rows 16 composed of seven second protrusions 12 are arranged. Of course, the present invention is not limited to the examples shown in FIGS. 7 and 8 in terms of the arrangement position and the number of pillar-shaped second protrusions 12.

According to the above-described configuration, the distances W21 and W22 of the plurality of second protrusions 12 are narrower than the distances W1 of the plurality of first protrusions 11 in the orthogonal direction Y, as in the first embodiment. That is, the capillary path formed between the second protrusions 12 is narrower than the capillary path formed between the first protrusions 11. As a result, the capillary force generated between the second protrusion 12 and the liquid sample can be easily made larger than the capillary force generated between the first protrusion 11 and the liquid sample.

As described above, regardless of whether the second protrusion 12 has a shape extending in the alignment direction X as in the first embodiment or a pillar shape, the narrower the intervals W2, W21, and W22 are, the stronger the capillary force is. Can occur. However, if the intervals W2, W21, and W22 are made too narrow, the amount of liquid that holds the liquid sample between the second protrusions 12 may be insufficient. Therefore, the intervals W2, W21, and W22 are preferably 0.2 mm to 1.0 mm, more preferably 0.3 to 0.7 mm.

The present invention is not limited to the above-described embodiment, and can be appropriately modified, improved, and the like. In addition, the material, shape, size, numerical value, form, number, arrangement location, etc. of each component in the above-described embodiment are arbitrary and are not limited as long as the present invention can be achieved.

For example, in the second embodiment, the second protrusion 12 is provided in a columnar shape, but the present invention is not limited to this. The second protrusion 12 may have a brush shape or a porous shape.

Further, in the second embodiment, the second protrusion 12 is also provided at the edges of the dropping hole 13 on both sides in the orthogonal direction Y, but the present invention is not limited to this. It is not necessary to provide the second protrusions 12 on the edges of the dropping holes 13 on both sides in the orthogonal direction Y.

Further, in order to more effectively adjust the capillary force generated between the first protrusion 11 and the second protrusion 12 with the liquid sample, the surface states of the first protrusion 11 and the second protrusion 12 are adjusted. You may adjust. Specifically, the first protrusion 11 and the second protrusion 12 are formed by forming the first protrusion 11 and the second protrusion 12 with a material having appropriate surface energy, modifying the surface (coating, etc.), blasting, or the like. A method of using a fine structure such as unevenness on the surface of the surface can be mentioned, but the method is not limited to this as long as the capillary force can be adjusted. Further, the adjustment of the surface state is not limited to the surfaces of the first protrusion 11 and the second protrusion 12. In the upper case 10, go to a part other than the first protrusion 11 and the second protrusion 12 (for example, the entire surface of the upper case 10 or around the roots of the first protrusion 11 and the second protrusion 12 of the upper case 10). May be good.

10 Upper case 11 1st protrusion 12 2nd protrusion 13 Drop hole 14 Judgment window 15 Holding pin 20 Backing sheet 22 Absorption pad 30 Test strip 31 Sample pad 32 Adjusting pad 33 Conjugate pad 34 Membrane 40 Lower case

Claims (9)

An upper case in which a drop hole for a liquid sample and a judgment window for inspection results are provided side by side,
The lower case to be assembled to the upper case and
In a liquid sample inspection tool provided with a test strip housed between the upper case and the lower case.
The upper case
A first protrusion protruding from the edge of the dropping hole on the determination window side toward the lower case, and
It has a second protrusion that protrudes toward the lower case from an edge portion of the dropping hole that is opposite to the determination window from the first protrusion.
The first protrusion and the liquid sample so that the capillary force generated between the second protrusion and the liquid sample is larger than the capillary force generated between the first protrusion and the liquid sample. The shape of the second protrusion is provided,
Liquid sample inspection tool. In the liquid sample inspection tool according to claim 1,
The first protrusion extends from the edge of the dropping hole toward the determination window side along the alignment direction of the dropping hole and the determination window.
The second protrusion extends from the edge of the dropping hole toward the side opposite to the determination window along the alignment direction.
Liquid sample inspection tool. In the liquid sample inspection tool according to claim 2.
The length of the second protrusion in the alignment direction is longer than the length of the first protrusion in the alignment direction.
Liquid sample inspection tool. In the liquid sample inspection tool according to claim 2 or 3.
The number of the second protrusions is larger than the number of the first protrusions,
Liquid sample inspection tool. In the liquid sample inspection tool according to any one of claims 2 to 4.
A plurality of the first protrusions and the second protrusions are provided side by side in a direction other than the arrangement direction.
The distance between the plurality of second protrusions is narrower than the distance between the plurality of first protrusions.
Liquid sample inspection tool. In the liquid sample inspection tool according to claim 1,
The second protrusion is provided in a pillar shape and is provided.
A second protrusion in which a plurality of the second protrusions are arranged at intervals from the edge of the drop hole toward the side opposite to the determination window along the arrangement direction of the determination window and the drop hole. With rows
A liquid sample inspection tool in which the second row of protrusions is provided side by side in a direction other than the arrangement direction. In the liquid sample inspection tool according to claim 6,
The first protrusion extends from the edge of the dropping hole toward the determination window side along the alignment direction.
A plurality of the first protrusions are provided side by side in a direction other than the arrangement direction.
The distance between the plurality of second protrusions is narrower than the distance between the plurality of first protrusions.
Liquid sample inspection tool. In the liquid sample inspection tool according to any one of claims 1 to 7.
The test strip includes a sample pad exposed from the dropping hole, an adjusting pad arranged with a gap on the determination window side of the sample pad, and a conju arranged so as to be connected to the determination window side of the adjusting pad. It has a gate pad and a membrane that is arranged in a row on the determination window side of the conjugate pad and is visible from the determination window.
The end of the first protrusion on the drop hole side in the alignment direction is located on the sample pad, and the end of the first protrusion in the alignment direction on the determination window side is on the adjusting pad. Located in,
Liquid sample inspection tool. In the liquid sample inspection tool according to any one of claims 1 to 8.
The test strip includes a sample pad exposed from the dropping hole, an adjusting pad arranged with a gap on the determination window side of the sample pad, and a conju arranged so as to be connected to the determination window side of the adjusting pad. It has a gate pad and a membrane that is arranged in a row on the determination window side of the conjugate pad and is visible from the determination window.
The first protrusion is provided so as to face the gap and is not inserted into the gap.
Liquid sample inspection tool.

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