JP2021008532A - Gelatin-containing composition and use of the same - Google Patents
Gelatin-containing composition and use of the same Download PDFInfo
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- JP2021008532A JP2021008532A JP2019121692A JP2019121692A JP2021008532A JP 2021008532 A JP2021008532 A JP 2021008532A JP 2019121692 A JP2019121692 A JP 2019121692A JP 2019121692 A JP2019121692 A JP 2019121692A JP 2021008532 A JP2021008532 A JP 2021008532A
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- gelatin
- mass
- hexyl acetate
- containing composition
- calcium lactate
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- 229920000159 gelatin Polymers 0.000 title claims abstract description 101
- 108010010803 Gelatin Proteins 0.000 title claims abstract description 99
- 235000019322 gelatine Nutrition 0.000 title claims abstract description 99
- 235000011852 gelatine desserts Nutrition 0.000 title claims abstract description 99
- 239000008273 gelatin Substances 0.000 title claims abstract description 98
- 239000000203 mixture Substances 0.000 title claims abstract description 84
- AOGQPLXWSUTHQB-UHFFFAOYSA-N hexyl acetate Chemical compound CCCCCCOC(C)=O AOGQPLXWSUTHQB-UHFFFAOYSA-N 0.000 claims abstract description 98
- 239000001527 calcium lactate Substances 0.000 claims abstract description 41
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims abstract description 41
- 229960002401 calcium lactate Drugs 0.000 claims abstract description 41
- 235000011086 calcium lactate Nutrition 0.000 claims abstract description 41
- 238000000034 method Methods 0.000 claims description 9
- 239000006185 dispersion Substances 0.000 abstract description 5
- 239000000796 flavoring agent Substances 0.000 abstract description 3
- 235000019634 flavors Nutrition 0.000 abstract 1
- -1 fluidizers Substances 0.000 description 23
- 235000014113 dietary fatty acids Nutrition 0.000 description 21
- 229930195729 fatty acid Natural products 0.000 description 21
- 239000000194 fatty acid Substances 0.000 description 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 235000013305 food Nutrition 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 7
- 235000015110 jellies Nutrition 0.000 description 7
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000008274 jelly Substances 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- ORYOIBJWFDNIPD-UHFFFAOYSA-N diacetyl 2,3-dihydroxybutanedioate Chemical compound CC(=O)OC(=O)C(O)C(O)C(=O)OC(C)=O ORYOIBJWFDNIPD-UHFFFAOYSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 150000004686 pentahydrates Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/045—Organic compounds containing nitrogen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
- Fats And Perfumes (AREA)
Abstract
Description
本発明は、ゼラチン含有組成物及びその利用に関する。 The present invention relates to a gelatin-containing composition and its use.
ゼラチンは、人体に対して毒性がなく安価であり、ゼリー形成能、増粘性等に優れている。このため、ゼラチンは、医薬や食品等の分野において広く使用されている。 Gelatin is not toxic to the human body, is inexpensive, and has excellent jelly-forming ability, thickening, and the like. Therefore, gelatin is widely used in fields such as pharmaceuticals and foods.
通常、ゼラチンは水で膨潤させてから使用する。例えば、特許文献１には、ゼラチンを含有するソフトキャンディの製法が開示されており、予め水で膨潤したゼラチンを他の成分と混合してソフトキャンディを製造したことが開示されている。 Gelatin is usually swollen with water before use. For example, Patent Document 1 discloses a method for producing a soft candy containing gelatin, and discloses that a soft candy is produced by mixing gelatin previously swollen with water with other components.
しかし、このようにゼラチンは水で膨潤させてから使用するため、香料といった油系成分とは非常に混ざりにくい。そこで、これらの混合を容易にするために界面活性剤が用いられている。しかし、界面活性剤を使用した場合であっても、ゼラチンと油系成分とを均一に分散させることは難しく、特に、夏の自動車内等の高温下では均一に分散させておくことが一層困難になる。 However, since gelatin is used after being swollen with water in this way, it is extremely difficult to mix with oil-based components such as fragrances. Therefore, a surfactant is used to facilitate the mixing of these. However, even when a surfactant is used, it is difficult to uniformly disperse gelatin and oil-based components, and it is even more difficult to uniformly disperse gelatin, especially in a high temperature such as in a car in summer. become.
本発明は、高温下であってもゼラチンと香料の分散性が向上された組成物を提供することを目的とする。 An object of the present invention is to provide a composition in which the dispersibility of gelatin and fragrance is improved even at a high temperature.
本発明者らは、前記課題に鑑み鋭意検討を行ったところ、ゼラチンを含有する組成物において、乳酸カルシウムと、香料である酢酸ヘキシルとを特定の割合で併用することにより、高温下であるにもかかわらず、該組成物における酢酸ヘキシルの分散性を向上できることを見出した。本発明は該知見に基づき更に検討を重ねた結果完成されたものであり、次に掲げるものである。 As a result of diligent studies in view of the above problems, the present inventors have found that calcium lactate and hexyl acetate, which is a fragrance, are used in combination at a specific ratio in a composition containing gelatin to obtain a high temperature. Nevertheless, it has been found that the dispersibility of hexyl acetate in the composition can be improved. The present invention has been completed as a result of further studies based on the findings, and is as follows.
項１．酢酸ヘキシルと乳酸カルシウムとを含有し、酢酸ヘキシル１質量部に対して乳酸カルシウムが１０質量部以下である、ゼラチン含有組成物。
項２．前記組成物中、ゼラチン１００質量部に対して乳酸カルシウムが３０質量部以下である、項１に記載のゼラチン含有組成物。
項３．前記組成物中、ゼラチン１００質量部に対して酢酸ヘキシルが６質量部以下である、項１または２に記載のゼラチン含有組成物。
項４．ゼラチン含有組成物において、酢酸ヘキシルと乳酸カルシウムとを、酢酸ヘキシル１質量部に対して乳酸カルシウムを１０質量部以下で含有させることを特徴とする、ゼラチン含有組成物における、酢酸ヘキシルの分散性向上方法。
項５．５０℃以上の環境下での酢酸ヘキシルの分散性向上方法である、項４に記載の方法。
Item 1. A gelatin-containing composition containing hexyl acetate and calcium lactate, and containing 10 parts by mass or less of calcium lactate with respect to 1 part by mass of hexyl acetate.
Item 2. Item 2. The gelatin-containing composition according to Item 1, wherein the amount of calcium lactate is 30 parts by mass or less with respect to 100 parts by mass of gelatin in the composition.
Item 3. Item 2. The gelatin-containing composition according to Item 1 or 2, wherein the amount of hexyl acetate is 6 parts by mass or less with respect to 100 parts by mass of gelatin in the composition.
Item 4. In the gelatin-containing composition, hexyl acetate and calcium lactate are contained in an amount of 10 parts by mass or less based on 1 part by mass of hexyl acetate, and the dispersibility of hexyl acetate in the gelatin-containing composition is improved. Method.
Item 5. The method according to Item 4, which is a method for improving the dispersibility of hexyl acetate in an environment of 50 ° C. or higher.
本発明によれば、ゼラチンを含有する組成物において、酢酸ヘキシルの分散性を向上することができる。 According to the present invention, the dispersibility of hexyl acetate can be improved in a composition containing gelatin.
本発明は、酢酸ヘキシルと乳酸カルシウムとを含有し、酢酸ヘキシル１質量部に対して乳酸カルシウムが１０質量部以下である、ゼラチン含有組成物を提供する。 The present invention provides a gelatin-containing composition containing hexyl acetate and calcium lactate, and the amount of calcium lactate is 10 parts by mass or less with respect to 1 part by mass of hexyl acetate.
酢酸ヘキシルは、化学式Ｃ８Ｈ１６Ｏ２で表される公知の物質である。 Hexyl acetate is a known substance represented by the chemical formula C 8 H 16 O 2.
乳酸カルシウムは、公知の物質であり、本発明において乳酸カルシウムは無水物であってもよく水和物であってもよい。乳酸カルシウムにはＬ型、Ｄ型、ＤＬ型が存在するが、これらはいずれであってよい。 Calcium lactate is a known substance, and in the present invention, calcium lactate may be anhydrous or hydrated. There are L-type, D-type, and DL-type calcium lactate, and any of these may be used.
本ゼラチン含有組成物は、ゼラチンを含有する。ゼラチンは、食品、医薬品、医薬部外品等の分野において従来使用されているゼラチンであればよく、好ましくは可食性のゼラチンが例示される。この限りにおいて制限されないが、該ゼラチンとして、豚、牛、魚等の皮、骨、腱、靭帯、鱗等を原料とした、酸及び／またはアルカリ処理ゼラチン、アシル化ゼラチン等の化学修飾ゼラチン、ゼラチンの加水分解物等のゼラチンが例示される。これらのゼラチンは１種単独で使用してもよく、２種以上を組み合わせて使用してもよい。ゼラチンは商業的に入手可能であり、例えば株式会社ニッピ、新田ゼラチン株式会社、ゼライス株式会社、Ｒｏｕｓｓｅｌｏｔ社、Ｗｅｉｓｈａｒｄｔ社等から市販されている。 The present gelatin-containing composition contains gelatin. The gelatin may be any gelatin conventionally used in the fields of foods, pharmaceuticals, quasi-drugs, etc., and edible gelatin is preferably exemplified. The gelatin is not limited to this, but the gelatin is a chemically modified gelatin such as acid and / or alkali-treated gelatin, acylated gelatin, etc., which is made from the skin, bone, tendon, ligament, scale, etc. of pig, cow, fish, etc. Gelatin such as a hydrolyzate of gelatin is exemplified. These gelatins may be used alone or in combination of two or more. Gelatin is commercially available and is commercially available, for example, from Nippi Co., Ltd., Nitta Gelatin Co., Ltd., Zerais Co., Ltd., Rousselot Co., Ltd., Weishhardt Co., Ltd. and the like.
ゼラチンは、この限りにおいて制限されず、例えばゼリー強度（ブルーム値）を指標として適宜選択して使用してもよい。本発明を制限するものではないが、ゼラチンのゼリー強度としては、好ましくは５０〜３５０ｇ、より好ましくは８０〜３００ｇ程度が例示される。ゼラチンのゼリー強度はＪＩＳ Ｋ−６５０３（２００１）に準じて測定され、具体的には、６．６７質量％のゼラチン水溶液を、１０℃で１７時間冷却して調製したゼリーの表面を２分の１インチ（１２．７ｍｍ）径のプランジャーで４ｍｍ押し下げるのに必要な荷重（ｇ）をゼリー強度とする。 Gelatin is not limited as long as this is limited, and for example, jelly strength (bloom value) may be appropriately selected and used as an index. Although not limiting the present invention, the jelly strength of gelatin is preferably about 50 to 350 g, more preferably about 80 to 300 g. The jelly strength of gelatin was measured according to JIS K-6503 (2001). Specifically, the surface of the jelly prepared by cooling a 6.67 mass% gelatin aqueous solution at 10 ° C. for 17 hours was divided into two minutes. The jelly strength is the load (g) required to push down 4 mm with a 1-inch (12.7 mm) diameter plunger.
本ゼラチン含有組成物は、酢酸ヘキシルと乳酸カルシウムとを含有し、その含有量は、酢酸ヘキシル１質量部に対して乳酸カルシウムは１０質量部以下である。本発明において、乳酸カルシウムの含有量は、後述の実施例に示す通り、乳酸カルシウム（無水物）への換算値である。 The gelatin-containing composition contains hexyl acetate and calcium lactate, and the content thereof is 10 parts by mass or less of calcium lactate with respect to 1 part by mass of hexyl acetate. In the present invention, the content of calcium lactate is a value converted to calcium lactate (anhydrous) as shown in Examples described later.
この限りにおいて制限されないが、本ゼラチン含有組成物において、酢酸ヘキシル１質量部に対して乳酸カルシウムは、好ましくは０．０５〜１０質量部、より好ましくは０．５〜８質量部、更に好ましくは０．７〜７．５質量部が例示される。 Although not limited to this limitation, in the present gelatin-containing composition, calcium lactate is preferably 0.05 to 10 parts by mass, more preferably 0.5 to 8 parts by mass, still more preferably 1 part by mass with respect to 1 part by mass of hexyl acetate. 0.7 to 7.5 parts by mass is exemplified.
本ゼラチン含有組成物中、ゼラチンの含有量は制限されないが、ゼラチン１００質量部に対して乳酸カルシウムが、好ましくは３０質量部以下、より好ましくは０．２〜３０質量部、更に好ましくは０．７〜２５質量部が例示される。 The content of gelatin in the present gelatin-containing composition is not limited, but calcium lactate is preferably 30 parts by mass or less, more preferably 0.2 to 30 parts by mass, and further preferably 0. 7 to 25 parts by mass is exemplified.
また、本ゼラチン含有組成物中、ゼラチンの含有量は制限されないが、ゼラチン１００質量部に対して酢酸ヘキシルが、好ましくは６質量部以下、より好ましくは０．５〜６質量部、更に好ましくは１〜３質量部が例示される。 The content of gelatin in the present gelatin-containing composition is not limited, but hexyl acetate is preferably 6 parts by mass or less, more preferably 0.5 to 6 parts by mass, still more preferably 100 parts by mass of gelatin. 1 to 3 parts by mass are exemplified.
本ゼラチン含有組成物中、これらの成分の含有量は制限されないが、該組成物中、酢酸ヘキシル、乳酸カルシウムならびにゼラチンの含有量は、その合計量で、好ましくは５〜３５質量％、より好ましくは７〜３３質量％、更に好ましくは８〜３２質量％が例示される。 The content of these components in the gelatin-containing composition is not limited, but the content of hexyl acetate, calcium lactate and gelatin in the composition is preferably 5 to 35% by mass, more preferably in total. Is exemplified by 7 to 33% by mass, more preferably 8 to 32% by mass.
本ゼラチン含有組成物には、本発明の効果が得られる範囲において、必要に応じて、薬学的に許容される成分、香粧学的に許容される成分、可食性の成分といった任意の他の成分を更に含有してもよい。該他の成分として好ましくは可食可能な成分が挙げられる。 The gelatin-containing composition may contain any other components, such as pharmaceutically acceptable components, cosmetically acceptable components, and edible components, as required, to the extent that the effects of the present invention can be obtained. Ingredients may be further contained. The other components preferably include edible components.
該他の成分として、水、界面活性剤、着色料、アミノ酸、ビタミン類、酵素、甘味料、清涼剤、果汁、賦形剤、崩壊剤、流動化剤、矯味剤、矯臭剤、懸濁剤、湿潤剤、可溶化剤、分散剤、緩衝剤、結合剤、滑沢剤、可塑剤、浸透促進剤、安定化剤、増量剤、防腐剤、増粘剤、ｐＨ調整剤、コーティング剤、吸収促進剤、酸化防止剤、抗炎症剤、酢酸ヘキシル以外の香料、蝋、各種有用成分等が例示される。これらは１種単独で使用してもよく、２種以上を組み合わせて使用してもよく、その含有量も適宜決定すればよい。 Other ingredients include water, surfactants, colorants, amino acids, vitamins, enzymes, sweeteners, refreshing agents, fruit juices, excipients, disintegrants, fluidizers, flavoring agents, flavoring agents, suspensions. , Wetting agents, solubilizers, dispersants, buffers, binders, lubricants, plasticizers, penetration enhancers, stabilizers, bulking agents, preservatives, thickeners, pH adjusters, coating agents, absorption Examples include accelerators, antioxidants, anti-inflammatory agents, fragrances other than hexyl acetate, waxes, and various useful ingredients. These may be used alone or in combination of two or more, and the content thereof may be appropriately determined.
本発明を制限するものではないが、界面活性剤として、有機酸モノグリセリド、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ソルビタン脂肪酸エステル、ショ糖脂肪酸エステル、レシチン誘導体、ポリオキシエチレン硬化ヒマシ油等が例示される。 Although not limiting the present invention, as surfactants, organic acid monoglyceride, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, lecithin derivative, polyoxyethylene hydrogenated castor Examples include oil.
本発明を制限するものではないが、有機酸モノグリセリドとして、酢酸モノグリセリド、乳酸モノグリセリド、クエン酸モノグリセリド、コハク酸モノグリセリド、ジアセチル酒石酸モノグリセリド等；グリセリン脂肪酸エステル及びポリグリセリン脂肪酸エステルとして、グリセリンモノ脂肪酸エステル、グリセリンジ脂肪酸エステル、トリグリセリンモノ脂肪酸エステル、ポリグリセリンモノ脂肪酸エステル、ポリグリセリンジ脂肪酸エステル等；プロピレングリコール脂肪酸エステルとして、プロピレングリコールモノ脂肪酸エステル、プロピレングリコールジ脂肪酸エステル等；ソルビタン脂肪酸エステルとして、ソルビタンモノ脂肪酸エステル、ソルビタンジ脂肪酸エステル、ソルビタントリ脂肪酸エステル等；ショ糖脂肪酸エステルとして、ショ糖モノ脂肪酸エステル等が例示される。 Although not limiting the present invention, organic acid monoglycerides such as acetate monoglyceride, lactic acid monoglyceride, citric acid monoglyceride, succinic acid monoglyceride, diacetyl tartrate monoglyceride, etc .; glycerin fatty acid ester and polyglycerin fatty acid ester include glycerin monofatty acid ester and glycerin. Di fatty acid ester, triglycerin mono fatty acid ester, polyglycerin mono fatty acid ester, polyglycerin di fatty acid ester, etc .; as propylene glycol fatty acid ester, propylene glycol mono fatty acid ester, propylene glycol di fatty acid ester, etc .; sorbitan mono fatty acid as sorbitan fatty acid ester. Esters, sorbitandi fatty acid esters, sorbitantri fatty acid esters, etc .; Examples of sucrose fatty acid esters include sucrose monofatty acid esters.
該界面活性剤において、脂肪酸としては、本発明を制限するものではないが、食用可能な動物由来または植物由来の油脂を起源とする脂肪酸が好ましく例示される。本発明を制限するものではないが、炭素数６〜２４の、飽和脂肪酸または不飽和脂肪酸等が例示され、より具体的には、ステアリン酸、ラウリン酸、オレイン酸、カプリル酸、カプリン酸、ミリスチン酸、パルミチン酸、リノール酸、リノレン酸、アラキジン酸、ベヘン酸等が例示される。 In the surfactant, the fatty acid is not limited to the present invention, but a fatty acid derived from edible animal-derived or plant-derived fats and oils is preferably exemplified. Although not limiting the present invention, saturated fatty acids or unsaturated fatty acids having 6 to 24 carbon atoms are exemplified, and more specifically, stearic acid, lauric acid, oleic acid, caprylic acid, capric acid, and myristic acid. Examples thereof include acids, palmitic acid, linoleic acid, linoleic acid, arachidic acid, and behenic acid.
本ゼラチン含有組成物の形態は制限されず、液状、半固形状（ゲル状（ゼリー状）、クリーム状、ペースト状等）、固形状（粉末状、顆粒状等）等のいずれであってもよい。 The form of the gelatin-containing composition is not limited, and may be liquid, semi-solid (gel (jelly), cream, paste, etc.), solid (powder, granule, etc.), etc. Good.
本ゼラチン含有組成物は、目的とする形態に応じて、従来公知の製造手順に従い、酢酸ヘキシル、乳酸カルシウム、ゼラチン、必要に応じて前記他の成分を適宜混合等して製造することができる。 The gelatin-containing composition can be produced by appropriately mixing hexyl acetate, calcium lactate, gelatin, and if necessary, the other components according to a conventionally known production procedure, depending on the desired form.
本発明を制限するものではないが、例えば、ゼラチンと水とを混合して混合物を調製し、更に酢酸ヘキシルを混合し、更に乳酸カルシウムを混合して、また、各混合の際に必要に応じて前記他の成分を更に混合等して、本ゼラチン含有組成物を製造すればよい。また、本発明を制限するものではないが、例えば、ゼラチンと水とを混合して混合物Ａを調製し、これとは別に、酢酸ヘキシルと乳酸カルシウムとを混合して混合物Ｂを調製し、次いで、混合物ＡとＢとを混合して混合物Ｃを調製して、また、混合物Ａ〜Ｃのそれぞれの調製の際に必要に応じて前記他の成分を更に混合等して、本ゼラチン含有組成物を製造すればよい。 Although not limiting the present invention, for example, gelatin and water are mixed to prepare a mixture, hexyl acetate is further mixed, calcium lactate is further mixed, and if necessary at the time of each mixing. The gelatin-containing composition may be produced by further mixing the other components. Further, although not limiting the present invention, for example, gelatin and water are mixed to prepare a mixture A, and separately, hexyl acetate and calcium lactate are mixed to prepare a mixture B, and then the mixture B is prepared. , Mixtures A and B are mixed to prepare a mixture C, and the other components are further mixed as necessary in the preparation of the mixtures A to C to prepare the present gelatin-containing composition. Should be manufactured.
また、更に必要に応じて、このようにして得た、ゼラチンと、酢酸ヘキシルと、乳酸カルシウムとを含有する混合物を成型、乾燥等して、本ゼラチン含有組成物を製造することができる。成型は所望の形であればよく、例えばフットボール型、オブロング（長楕円）型、ラウンド（球状）型、涙型、三角形、ひし型、シート型等のいずれであってもよく、また、成型後に、必要に応じて成形物を切り分けたもの等であってもよい。 Further, if necessary, the mixture containing gelatin, hexyl acetate, and calcium lactate thus obtained can be molded, dried, or the like to produce the present gelatin-containing composition. The molding may be any desired shape, for example, football type, oblong (oval) type, round (spherical) type, tear type, triangle, diamond type, sheet type, etc., and molding. Later, the molded product may be cut into pieces as needed.
このような成形物として、グミキャンディー、ゼリー、ババロア等が例示される。また、本ゼラチン含有組成物は、更に糖衣等により被覆されてもよい。被覆も本分野において従来公知の手法に従って行えばよい。 Examples of such molded products include gummy candies, jellies, and bavarois. Further, the gelatin-containing composition may be further coated with a sugar coating or the like. The coating may also be performed according to a method conventionally known in the art.
また、成型物として、本ゼラチン含有組成物はカプセル剤（ソフトカプセル剤、ハードカプセル剤）の皮膜をとして使用されるものであってもよい。本ゼラチン含有組成物がカプセル剤の皮膜として使用される場合、該皮膜に内包される内容物は制限されず、目的に応じて適宜決定すればよい。例えば、薬学的に許容される成分、香粧学的に許容される成分、可食性の成分等を任意に選択して使用すればよく、好ましくは可食可能な成分が例示される。皮膜への内容物の内包は、本分野において従来公知の手順に従い行えばよい。 Further, as a molded product, the gelatin-containing composition may be used as a film of a capsule (soft capsule, hard capsule). When the gelatin-containing composition is used as a film of a capsule, the content contained in the film is not limited and may be appropriately determined according to the purpose. For example, a pharmaceutically acceptable ingredient, a cosmetically acceptable ingredient, an edible ingredient and the like may be arbitrarily selected and used, and edible ingredients are preferably exemplified. Encapsulation of the contents in the film may be carried out according to a procedure conventionally known in the art.
本ゼラチン含有組成物は、経口、非経口のいずれで使用してもよく、好ましくは経口で使用される。本ゼラチン含有組成物の使用態様は制限されず、目的に応じて適宜設定すればよい。該使用態様として経口で使用する場合を例示すると、食品組成物（飲料を含む、保健機能食品（特定保健用食品、栄養機能食品、機能性表示食品、サプリメント等を含む）、健康補助食品、病者用食品を含む）、医薬組成物、医薬部外品組成物、飼料組成物、また、食品組成物、医薬組成物、医薬部外品組成物、飼料等への添加剤等として使用することができる。本ゼラチン含有組成物は、例えば、速やかに飲み込むものであってもよく、口腔内に一定時間とどめておき、その後飲み込むものであってもよい。 The gelatin-containing composition may be used orally or parenterally, and is preferably used orally. The mode of use of the gelatin-containing composition is not limited, and may be appropriately set according to the intended purpose. For example, when used orally as the mode of use, food compositions (including beverages, foods with health claims (including foods for specified health use, foods with nutritional claims, foods with functional claims, supplements, etc.), health supplements, diseases, etc. (Including foods for humans), pharmaceutical compositions, non-medicinal products compositions, feed compositions, and as additives to food compositions, pharmaceutical compositions, non-pharmaceutical products compositions, feeds, etc. Can be done. The gelatin-containing composition may be, for example, one that is swallowed promptly, or one that is kept in the oral cavity for a certain period of time and then swallowed.
本ゼラチン含有組成物を適用（摂取、投与等）する対象者も制限されず、ヒト、ヒト以外の哺乳動物が例示される。ヒト以外の哺乳動物としては、モルモット、ウサギ、イヌ、ネコ、サル、チンパンジー等の動物が例示される。 The subjects to which the gelatin-containing composition is applied (ingestion, administration, etc.) are not limited, and humans and mammals other than humans are exemplified. Examples of mammals other than humans include animals such as guinea pigs, rabbits, dogs, cats, monkeys, and chimpanzees.
本ゼラチン含有組成物によれば、ゼラチンを含有する組成物において、酢酸ヘキシル１質量部に対して、乳酸カルシウムを１０質量部以下で用いることにより、該組成物における酢酸ヘキシルの分散性を向上させることができる。特に、５０℃以上の高温条件下で酢酸ヘキシルの分散性が一層悪くなるものの、本ゼラチン含有組成物によれば、５０℃以上の高温条件下あっても、ゼラチンを含有する組成物において、酢酸ヘキシルの分散性を向上できる。この観点から、本発明によれば、例えば、室温（２５℃）程度で固形状や半固形状のゼラチン含有組成物が５０℃以上の高温条件下でたとえ液状となった場合であっても、その熱安定性が高められており、該組成物における分散性の低下を抑制できる。このことから、本発明によれば、熱安定性の高いゼラチン含有組成物を提供することができる。 According to the present gelatin-containing composition, in the gelatin-containing composition, the dispersibility of hexyl acetate in the composition is improved by using 10 parts by mass or less of calcium lactate with respect to 1 part by mass of hexyl acetate. be able to. In particular, although the dispersibility of hexyl acetate becomes worse under high temperature conditions of 50 ° C. or higher, according to the present gelatin-containing composition, acetic acid is used in the gelatin-containing composition even under high temperature conditions of 50 ° C. or higher. The dispersibility of hexyl can be improved. From this point of view, according to the present invention, for example, even when a solid or semi-solid gelatin-containing composition at room temperature (25 ° C.) becomes liquid under high temperature conditions of 50 ° C. or higher. Its thermal stability is enhanced, and it is possible to suppress a decrease in dispersibility in the composition. From this, according to the present invention, it is possible to provide a gelatin-containing composition having high thermal stability.
このことから、本発明はまた、ゼラチン含有組成物において、酢酸ヘキシルと乳酸カルシウムとを、酢酸ヘキシル１質量部に対して乳酸カルシウムを１０質量部以下で含有させることを特徴とする、ゼラチン含有組成物における、酢酸ヘキシルの分散性向上方法を提供するといえる。 From this, the present invention is also characterized in that the gelatin-containing composition contains hexyl acetate and calcium lactate in an amount of 10 parts by mass or less based on 1 part by mass of hexyl acetate. It can be said that it provides a method for improving the dispersibility of hexyl acetate in a substance.
該方法において、ゼラチン、酢酸ヘキシル、乳酸カルシウム等については、前述と同様にして説明される。 In the method, gelatin, hexyl acetate, calcium lactate and the like will be described in the same manner as described above.
以下、実施例を示して本発明をより詳細に説明するが、本発明はこれらに限定されない。 Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.
試験例
ゼラチン含有組成物の調製
表１の組成に従いゼラチン（商品名ＢＬＫ２００、新田ゼラチン株式会社製）に水を添加し、５分間膨潤させ、次いで８０℃の湯浴でゼラチンを溶解することにより、ゼラチンストックを調製した。また、表１の組成に従い酢酸ヘキシルと界面活性剤（商品名ポエムＫ−３７Ｖ、理研ビタミン株式会社製（有機酸モノグリセリド（クエン酸モノグリセライド））またはポリオキシエチレン硬化ヒマシ油（商品名エマノーンＣＨ−６０（Ｋ）、花王株式会社製））とを混合して超音波処理を行うことにより、酢酸ヘキシルを完全に溶解させた。次いで、得られた溶解物に水を加えて分散させて、酢酸ヘキシルストックを調製した。完全にゼラチンが溶解したゼラチンストックと酢酸ヘキシルストックとを混合し、得られた混合物を目視にて一様になるまでスパチュラで攪拌し、ゼラチン／酢酸ヘキシルストックを調製した。別途、表１の組成に従い、乳酸カルシウム（商品名乳酸カルシウム・５水和物（Ｌ型乳酸カルシウム）、太平化学産業株式会社製）に水を添加し、撹拌して、乳酸カルシウムストックを調製した。
Test example
Preparation of Gelatin-Containing Composition According to the composition in Table 1, water is added to gelatin (trade name BLK200, manufactured by Nitta Gelatin Co., Ltd.), swelled for 5 minutes, and then gelatin is dissolved in a hot water bath at 80 ° C. to gelatin. Stock was prepared. In addition, according to the composition in Table 1, hexyl acetate and a surfactant (trade name Poem K-37V, manufactured by RIKEN Vitamin Co., Ltd. (organic acid monoglyceride (citric acid monoglyceride)) or polyoxyethylene hydrogenated castor oil (trade name Emanon CH-60). (K), manufactured by Kao Co., Ltd.)) was mixed and subjected to sonication to completely dissolve hexyl acetate. Then, water was added to the obtained lysate and dispersed to prepare a hexyl acetate stock. Gelatin stock in which gelatin was completely dissolved and hexyl acetate stock were mixed, and the obtained mixture was stirred with a spatula until it was visually uniform to prepare gelatin / hexyl acetate stock. Separately, according to the composition in Table 1, water was added to calcium lactate (trade name: calcium lactate / pentahydrate (L-type calcium lactate), manufactured by Taihei Kagaku Sangyo Co., Ltd.) and stirred to prepare a calcium lactate stock. ..
次いで、前述のようにして得たゼラチン／酢酸ヘキシルストックを、スクリュー管（３５ｍｍ×６５ｍｍ）に添加し、更に乳酸カルシウムストックを加えて、よく攪拌した。ゼラチン／酢酸ヘキシルストックと乳酸カルシウムストックの添加量は、その合計が２０ｇとなるように、表１の含有量に従いスクリュー管に添加した。すなわち、表１において、成分の含有量はいずれもｇ（グラム）で示し、実施例１では、前記ストックを表１の比率になるように混合しゼラチン含有組成物を調製し、スクリュー管に各２０ｇずつ入れた。このようにして、実施例１〜５、比較例１及び２のゼラチン含有組成物を調製した。 Next, the gelatin / hexyl acetate stock obtained as described above was added to a screw tube (35 mm × 65 mm), calcium lactate stock was further added, and the mixture was well stirred. The amount of gelatin / hexyl acetate stock and calcium lactate stock added was added to the screw tube according to the content in Table 1 so that the total amount was 20 g. That is, in Table 1, the content of each component is shown in g (grams), and in Example 1, the stocks are mixed so as to have the ratio shown in Table 1 to prepare a gelatin-containing composition, and each is placed in a screw tube. 20g each was added. In this way, gelatin-containing compositions of Examples 1 to 5 and Comparative Examples 1 and 2 were prepared.
分散性評価
得られたゼラチン含有組成物を、スクリュー管に蓋をして、室温（２５℃）で２時間静置させて保管した後、５０℃に設定した恒温内で一週間静置した。
Dispersibility Evaluation The obtained gelatin-containing composition was stored in a screw tube covered with a lid and allowed to stand at room temperature (25 ° C.) for 2 hours, and then allowed to stand at a constant temperature set at 50 ° C. for 1 week.
一週間静置後、スクリュー管内のゼラチン含有組成物を真横から観察し、図１に示す通り、組成物において分散が均一かどうか、また、組成物が透明かどうかを、専門パネラー３人が目視にて観察し、次の判定基準に従い、分散性を評価した。 After standing for one week, the gelatin-containing composition in the screw tube was observed from the side, and as shown in FIG. 1, three specialized panelists visually inspected whether the composition was uniformly dispersed and whether the composition was transparent. The dispersibility was evaluated according to the following criteria.
判定基準
○：分散が均一且つ透明
△：分散が均一且つやや透明
×：分散が均一でない
結果を表１に示す。
Judgment criteria ◯: Dispersion is uniform and transparent Δ: Dispersion is uniform and slightly transparent ×: Dispersion is not uniform The results are shown in Table 1.
表１の比較例１に示す通り、酢酸ヘキシルとゼラチンとを含むものの、乳酸カルシウムを含有しない組成物では、分散性評価が×（分散が均一でない）であった。また、表１の比較例２に示す通り、ゼラチンを含む組成物において、乳酸カルシウム１質量部に対して乳酸カルシウムを１４．１６質量部含有させた場合も、分散性評価は×であった。なお、比較例1及び２において組成物はいずれも透明ではなかった。これに対して、表１の実施例１〜６に示す通り、ゼラチンを含む組成物において、酢酸ヘキシルに対して乳酸カルシウムを特定の割合で使用することにより、比較例１や２よりも分散性を向上することができ、また、組成物は透明またはやや透明であった。このことから、酢酸ヘキシルに対して乳酸カルシウムを特定の割合で使用することにより、ゼラチン含有組成物において酢酸ヘキシルの分散性を向上できることが分かった。 As shown in Comparative Example 1 of Table 1, in the composition containing hexyl acetate and gelatin but not containing calcium lactate, the dispersibility evaluation was × (dispersion was not uniform). Further, as shown in Comparative Example 2 of Table 1, in the composition containing gelatin, when 14.16 parts by mass of calcium lactate was contained with respect to 1 part by mass of calcium lactate, the dispersibility evaluation was ×. In addition, in Comparative Examples 1 and 2, none of the compositions was transparent. On the other hand, as shown in Examples 1 to 6 of Table 1, in the composition containing gelatin, by using calcium lactate in a specific ratio with respect to hexyl acetate, the dispersibility is higher than that of Comparative Examples 1 and 2. The composition was transparent or slightly transparent. From this, it was found that the dispersibility of hexyl acetate in the gelatin-containing composition can be improved by using calcium lactate in a specific ratio with respect to hexyl acetate.
Claims (4)
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| PCT/JP2020/023105 WO2020262027A1 (en) | 2019-06-28 | 2020-06-11 | Gelatin-containing composition and use thereof |
| CN202080045403.1A CN113993394A (en) | 2019-06-28 | 2020-06-11 | Gelatin-containing composition and use thereof |
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| JP2008067638A (en) * | 2006-09-14 | 2008-03-27 | Unitec Foods Co Ltd | New palate texture gumi candy and method for producing the same |
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| JP2013153718A (en) * | 2012-01-31 | 2013-08-15 | Kabaya Shokuhin Kk | Food of double-layer structure and method for producing the same |
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| JP2017178905A (en) * | 2016-03-31 | 2017-10-05 | 小林製薬株式会社 | Perfume composition for inhibiting motion sickness |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2682148B2 (en) * | 1989-06-26 | 1997-11-26 | 日本合成ゴム株式会社 | Rubber composition |
| JP5913933B2 (en) * | 2011-11-30 | 2016-05-11 | 日澱化學株式会社 | Thickening composition with improved dispersibility and metal salt-containing starch degradation product used therefor |
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2019
- 2019-06-28 JP JP2019121692A patent/JP2021008532A/en active Pending
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2020
- 2020-06-11 WO PCT/JP2020/023105 patent/WO2020262027A1/en active Application Filing
- 2020-06-11 CN CN202080045403.1A patent/CN113993394A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH0332673A (en) * | 1989-06-30 | 1991-02-13 | Lion Corp | Gelatinous aromatic agent composition |
| JP2008067638A (en) * | 2006-09-14 | 2008-03-27 | Unitec Foods Co Ltd | New palate texture gumi candy and method for producing the same |
| JP2008081447A (en) * | 2006-09-27 | 2008-04-10 | Osaka Univ | Recalcification promoter for tooth and composition for oral cavity or oral administration containing the same |
| JP2010130935A (en) * | 2008-12-04 | 2010-06-17 | Kobata Sogo Kenkyusho:Kk | Gummy candy and method for producing the same |
| JP2013153718A (en) * | 2012-01-31 | 2013-08-15 | Kabaya Shokuhin Kk | Food of double-layer structure and method for producing the same |
| JP2016141656A (en) * | 2015-02-03 | 2016-08-08 | 日本テルペン化学株式会社 | Composition in which the volatility of allyl isothiocyanate is controlled, and solid agent including the same |
| JP2017178905A (en) * | 2016-03-31 | 2017-10-05 | 小林製薬株式会社 | Perfume composition for inhibiting motion sickness |
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| CN113993394A (en) | 2022-01-28 |
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