JP2021003178A - Wet wiper sheet having discoloration performance of povidone iodine liquid, and chemical solution to impregnate the wet wiper sheet - Google Patents

Abstract

To provide a wet wiper sheet decolorizing povidone iodine liquid attached to the skin, and having sufficient antibacterial and antifungal effect.SOLUTION: In a wet wiper sheet, adhering povidone iodine liquid can be decolorized by impregnating a solution containing sodium sulfite, and, as the need arises, a chemical solution containing a preservative into the wet wiper sheet such as a paper towels or a wet wipe.SELECTED DRAWING: None

Description

The present invention relates to a wet wiper sheet typified by a paper towel or a wet tissue impregnated with a chemical solution having a decolorizing performance of povidone iodine solution into a sheet such as paper or non-woven fabric, and a chemical solution that can be used for impregnating the wet wiper sheet.
More specifically, the present invention relates to a wet wiper sheet impregnated with a chemical solution containing sodium sulfite as a chemical solution having decolorizing performance, and further, as another preferred embodiment, the above chemical solution contains benzalkonium chloride, benzethonium chloride, and cetyltrimethylammonium chloride. The present invention relates to a wet wiper sheet impregnated with a chemical solution containing one or more quaternary ammonium salts selected from stearyltrimethylammonium chloride and propynyl iodide butylcarbamate as a preservative.
At the same time, the present invention relates to a chemical solution having a decolorizing performance of a povidone iodine solution and which can also be used for impregnation of the wet wiper sheet.

As described in Patent Document 1, popidone iodine solution, which is one of the external disinfectants, has been used in the medical field, but this chemical solution has an excellent bactericidal action, but the color is brown, and it is used for clothing. There is a problem that the coloring is hard to be removed when it adheres.
Therefore, there is a demand for a technique for decolorizing the adhered povidone iodine solution before the povidone iodine solution used for the skin as an external disinfectant is transferred to clothing. For example, in Patent Document 2, thio is applied to a cellulose fiber-containing sheet. It has been proposed to erase the color of the iodine-based disinfectant with a sheet impregnated with sodium thiosulfate and an aqueous alcohol solution.
However, since the above-mentioned sheet for erasing the color of iodine-based disinfectants uses an alcohol component in the drug, its use is restricted for people with alcohol hypersensitivity, so improvements in these points are also possible. There is a demand for a decolorizing chemical solution for popidone iodine solution and a wet wiper sheet with higher performance.

Japanese Unexamined Patent Publication No. 2005-137702 JP-A-2010-189814

An object of the present invention is to provide a wet wiper sheet effective for decolorizing a povidone iodine solution, a chemical solution having a decolorizing ability to impregnate the wet wiper sheet, and a chemical solution having excellent storage stability.

In order to solve the above problems, the present inventors have focused on ingredients that can be blended in cosmetics from the viewpoint of ensuring safety, and discovered that sodium sulfite has a decolorizing effect of povidone iodine solution, and the present invention has been made. Was completed.

Furthermore, in order to improve the storage performance of the wet wiper sheet, when wiping the hands and fingers, select a specific ingredient from the ingredients that ensure safety to the skin and have sufficient antibacterial and antifungal effects, and povidone iodine solution. The present invention, which has both the decolorizing performance and the storage performance of the povidone iodine solution, has been completed by using it in combination with sodium sulfite, which has the decolorizing effect of.

Specifically, the wet wiper sheet is impregnated with the chemical solution containing sodium sulfite of the present invention, and the wet wiper sheet is imparted with the decolorizing performance of the popidone iodine solution. Further, the wet wiper sheet is required to have a sufficient storage effect. In some cases, the present invention is prepared by blending the above-mentioned chemical solution with one or more quaternary ammonium salts selected from benzalkonium chloride, benzethonium chloride, cetyltrimethylammonium chloride and stearyltrimethylammonium chloride and propynyl iodide butylcarbamate as a preservative. The wet wiper sheet is impregnated with the chemical solution of.

The wet wiper sheet and the povidone iodine solution decolorizing chemical solution of the present invention have a decolorizing effect of the povidone iodine solution and can be stored for a long period of time.

(Chemical solution component)
The drug solution of the present invention is a drug solution containing sodium sulfite, or one or more quaternary ammonium salts selected from benzalkonium chloride, benzethonium chloride, cetyltrimethylammonium chloride and stearyltrimethylammonium chloride in the drug solution containing sodium sulfite. And propynyl butyl carbamate iodide as a preservative.
(Wet wiper sheet material)
In the present invention, materials usually used for paper towels and wet tissues can be used, and specifically, non-woven fabrics, woven fabrics, knitted fabrics, paper and the like can be used, but the relationship between impregnation property, wiping performance and strength A non-woven fabric sheet can be preferably used.

As a method of impregnating the wet wiper sheet, about 150 to 300% of the weight of the raw fabric sheet of paper, non-woven fabric, etc. (hereinafter referred to as raw fabric) can be impregnated by a method such as spraying or dipping. .. However, the appropriate impregnation amount differs depending on the raw material to be impregnated.
The concentration and blending ratio of each component in the drug solution are 0.15 to 0.3% for sodium sulfite, 0.05 to 0.2% for quaternary ammonium salts such as benzalkonium chloride, and propynyl iodide butylcarbamate. It is preferably 0.005 to 0.01%, but it can be appropriately changed depending on the raw material and the chemical component, and is not necessarily limited to the above range.

In the present invention, in addition to the above-mentioned chemical component, it is also preferable to add water and stabilized chlorine dioxide water for the purpose of sterilizing the raw fabric sheet, or to add a component such as a fragrance for the purpose of imparting a refreshing feeling during use. This is one of the aspects.

The wet wiper sheet of the present invention can be used for decolorizing and wiping the povidone iodine solution, and the chemical solution for impregnation of the present invention not only impregnates the wet wiper sheet but also makes itself, for example, absorbent cotton. It can also be included to decolorize and wipe the povidone iodine solution. In this case, the formulation of a preservative is not particularly required.

Hereinafter, the present invention will be described in detail with reference to Examples, but the present invention is not limited to these Examples.

(Example 1)
Table 1 shows the compounding weight ratios of the quaternary ammonium salt such as sodium sulfite and benzalkonium chloride salt used in the present invention, and propynyl iodide butylcarbamate.

Drugs used A: Sodium sulfite B: Benzalkonium chloride C: Cetyltrimethylammonium chloride D: Benzethonium chloride E: Stearyltrimethylammonium chloride F: Propinyl iodide butylcarbamate G: 1,3-butylene glycol H: Purified water

(Test 1: Confirmation test of iodine decolorization effect)
After applying rare iodine tincture (Kenei Pharmaceutical Co., Ltd.) to the arm, it was lightly dried, and a wet wiper sheet impregnated with the drug was pressed for several seconds, and then the decolorization performance was visually observed.
For comparison, a wet sheet impregnated with an aqueous solution of sodium thiosulfate pentahydrate at 0.1 to 1.0% was prepared, and the same test was performed.
The evaluation method is shown according to the following criteria.
◯: The brown color of the povidone iodine solution attached to the arm has been completely decolorized.
Δ: A state in which a slight brown color of the povidone iodine solution attached to the arm remains.
X: A state in which the brown color of the povidone iodine solution attached to the arm remains.

Table 2 shows the decolorization performance.

亜硫酸ナトリウムの配合量を０．３％にした場合、きれいに脱色することが確認された。
薬液中の各成分の濃度、配合割合は、亜硫酸ナトリウム０．３％以上により、色消し効果が見られることが確認された。また、比較のチオ硫酸ナトリウム水溶液では、同様の濃度において、色消し効果を確認できなかった。

It was confirmed that when the blending amount of sodium sulfite was 0.3%, the color was completely decolorized.
It was confirmed that the achromatic effect was observed when the concentration and blending ratio of each component in the chemical solution were 0.3% or more of sodium sulfite. Moreover, in the comparative sodium thiosulfate aqueous solution, the achromatic effect could not be confirmed at the same concentration.

(Test 2: Antibacterial and antifungal test)
Test method Antibacterial test: According to JIS L-1902 Textile product antibacterial test.
Bacteria under test
A: Escherichia coli NBRC 3301 (E. coli)
B: Staphylococcus aureus NBRC 12732 (Staphylococcus aureus)
Antifungal test: JIS Z-2911 Mold resistance test Fiber test Designated fiber mold
A: Aspergillus niger FERM S-1
B: Penicillium citrinum FERM S-5
Chaetomium globosum FERM S-11
Myrothecium verrucaria FERM S-13 Mixing of the above 3 types

Judgment method Antibacterial test Bacteria: Effective (-)
No effect (+)
Antifungal test ・ ・ ・ JIS Z-2911 Mold resistance test Depending on the display method
0 ... No mold growth on the sample
The number on the right is the number of growth inhibition mm
1 ... The growth area of mold on the sample is 1/3 or less of the whole
2 ... The growth area of mold on the sample is 1/3 or more of the whole

The results of the antibacterial and antifungal test are shown in Table 3.

The wet wiper sheet of the present invention comprises sodium sulfite and, optionally, one or more quaternary ammonium salts and butylcarbamic acid selected from benzalkonium chloride, benzethonium chloride, cetyltrimethylammonium chloride and stearyltrimethylammonium chloride. It is impregnated with a chemical solution containing propynyl iodide, which exhibits excellent decolorization effect of popidone iodine solution and antibacterial / antifungal effect.

Claims (5)

A wet wiper sheet having a decolorizing performance of a povidone iodine solution, which is characterized by being impregnated with a chemical solution containing sodium sulfite. The chemical solution further contains (A) one or more quaternary ammonium salts selected from benzalkonium chloride, benzethonium chloride, cetyltrimethylammonium chloride and stearyltrimethylammonium chloride, and (B) propynyl iodide butylcarbamate. The wet wiper sheet having the decolorizing performance of the popidone iodine solution according to claim 1, which comprises. The wet wiper sheet having the decolorizing performance of the povidone iodine solution according to claim 1 or 2, wherein the wet wiper sheet is individually wrapped or stored in a container. A chemical solution having a decolorizing performance of a povidone iodine solution, which is characterized by containing sodium sulfite as an active ingredient. The decolorizing chemical solution further contains (A) one or more quaternary ammonium salts selected from benzalkonium chloride, benzethonium chloride, cetyltrimethylammonium chloride and stearyltrimethylammonium chloride, and (B) iodide butylcarbamate. The decolorizing chemical solution for a popidone iodine solution according to claim 4, which contains propynyl.