JP2020536643A5 - - Google Patents
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- JP2020536643A5 JP2020536643A5 JP2020520207A JP2020520207A JP2020536643A5 JP 2020536643 A5 JP2020536643 A5 JP 2020536643A5 JP 2020520207 A JP2020520207 A JP 2020520207A JP 2020520207 A JP2020520207 A JP 2020520207A JP 2020536643 A5 JP2020536643 A5 JP 2020536643A5
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- 230000001684 chronic Effects 0.000 claims 72
- 230000000007 visual effect Effects 0.000 claims 72
- 210000004556 Brain Anatomy 0.000 claims 35
- 210000002442 Prefrontal Cortex Anatomy 0.000 claims 34
- 210000001320 Hippocampus Anatomy 0.000 claims 32
- 210000000857 Visual Cortex Anatomy 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 230000001537 neural Effects 0.000 claims 6
- 230000001360 synchronised Effects 0.000 claims 6
- 210000004092 Somatosensory Cortex Anatomy 0.000 claims 5
- 230000005684 electric field Effects 0.000 claims 5
- 206010001897 Alzheimer's disease Diseases 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 210000002569 neurons Anatomy 0.000 claims 4
- 230000032258 transport Effects 0.000 claims 4
- 231100000277 DNA damage Toxicity 0.000 claims 3
- 210000000274 Microglia Anatomy 0.000 claims 3
- 230000006907 apoptotic process Effects 0.000 claims 3
- 210000003008 brain-resident macrophage Anatomy 0.000 claims 3
- 230000010189 intracellular transport Effects 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 230000003959 neuroinflammation Effects 0.000 claims 3
- 108091005965 phosphorylated proteins Proteins 0.000 claims 3
- 238000006366 phosphorylation reaction Methods 0.000 claims 3
- 230000000865 phosphorylative Effects 0.000 claims 3
- 230000003977 synaptic function Effects 0.000 claims 3
- 210000004940 Nucleus Anatomy 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 2
- 230000002708 enhancing Effects 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 1
- 102000008491 Dynamins Human genes 0.000 claims 1
- 108010020522 Dynamins Proteins 0.000 claims 1
- 102000037108 Glutamate transporters Human genes 0.000 claims 1
- 108091006135 Glutamate transporters Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 210000000225 Synapses Anatomy 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000002730 additional Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000000051 modifying Effects 0.000 claims 1
- 230000002314 neuroinflammatory Effects 0.000 claims 1
- 230000017854 proteolysis Effects 0.000 claims 1
- 230000002797 proteolythic Effects 0.000 claims 1
- 230000001131 transforming Effects 0.000 claims 1
- 230000002861 ventricular Effects 0.000 claims 1
Claims (82)
Ａ）約３０Ｈｚ〜約５０Ｈｚの周波数を有する慢性視覚刺激を前記対象に非侵襲的に送達し、前記対象の少なくとも前頭前野皮質（ＰＦＣ）および海馬を含む、前記対象の複数の脳領域において同期化ガンマ振動を同調させることを含む、前記方法。 A method for treating dementia or Alzheimer's disease in the subject in need.
A) A chronic visual stimulus with a frequency of about 30 Hz to about 50 Hz is delivered non-invasively to the subject and synchronized in multiple brain regions of the subject, including at least the prefrontal cortex (PFC) and hippocampus of the subject. comprising tuning the gamma vibration, said method.
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項６に記載の方法。 The method of claim 6, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項１０に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
10. The method of claim 10, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
Ａ１）前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を前記対象に非侵襲的に送達し、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域において同期化ガンマ振動を同時に同調させることを含む、請求項１に記載の方法。 A),
A1) The chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz is delivered non-invasively to the subject and synchronized in the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject. The method of claim 1, comprising tuning gamma vibrations simultaneously.
前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の複数の脳領域間で、３０Ｈｚ〜５０Ｈｚの周波数を有するガンマコヒーレンスを有意に増加させることを含む、請求項１５に記載の方法。 A1),
15. The method of claim 15, comprising significantly increasing gamma coherence having a frequency of 30 Hz to 50 Hz among the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項２２に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
22. The method of claim 22, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
Ａ２）前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域間のニューロン活動を変調させることを含む、請求項１５に記載の方法。 A1) is further
A2) Non-invasively deliver the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz to perform neuronal activity between the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject. 15. The method of claim 15, comprising modulating.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域間のニューロン活動を連動させることを含む、請求項２４に記載の方法。 A2) is further
The chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz is non-invasively delivered to link neuronal activity between the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject. 24. The method of claim 24.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項２７に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
27. The method of claim 27, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
Ａ３）前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の神経変性を低下させることを含む、請求項２４に記載の方法。 A2) is further
A3) Non-invasively deliver the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz to degenerate neurodegeneration in the subject's multiple brain regions, including at least the prefrontal cortex and hippocampus of the subject. 24. The method of claim 24, comprising reducing.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中のアミロイドプラークを低下させることを含む、請求項３３に記載の方法。 A3) is even more
The chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz is non-invasively delivered to reduce amyloid plaques in the subject's plurality of brain regions, including at least the prefrontal cortex and hippocampus of the subject. 33. The method of claim 33.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中のタウの過剰リン酸化を低下させることを含む、請求項３３に記載の方法。 A3) is even more
Excessive phosphorylation of tau in the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject, non-invasively delivering the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz. 33. The method of claim 33, comprising reducing.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中のニューロンおよびシナプスの減少を低下させることを含む、請求項３３に記載の方法。 A3) is even more
Non-invasive delivery of the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz to reduce neurons and synapses in the subject's plurality of brain regions, including at least the prefrontal cortex and hippocampus of the subject. 33. The method of claim 33, comprising reducing.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の脳委縮を低下させることを含む、請求項３３に記載の方法。 A3) is even more
The chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz is non-invasively delivered to reduce brain atrophy in the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject. 33. The method of claim 33.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の脳室拡張を低下させることを含む、請求項３３に記載の方法。 A3) is even more
Non-invasively deliver the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz to reduce ventricular dilation in the subject's plurality of brain regions, including at least the prefrontal cortex and hippocampus of the subject. 33. The method of claim 33.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項４１に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
41. The method of claim 41, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項４５に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
45. The method of claim 45, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
Ａ３）前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の神経炎症を低下させることを含む、請求項２４に記載の方法。 A2) is further
A3) Non-invasively deliver the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz to cause neuroinflammation in the subject's multiple brain regions, including at least the prefrontal cortex and hippocampus of the subject. 24. The method of claim 24, comprising reducing.
Ａ４）前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の少なくとも一部のミクログリアの免疫反応を低下させることを含む、請求項４７に記載の方法。 A3) is even more
A4) At least a portion of the subject's multiple brain regions, including at least the prefrontal cortex and hippocampus of the subject, non-invasively delivering the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz. 47. The method of claim 47, comprising reducing the immune response of microglia.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の前記少なくとも一部のミクログリアを形態変換させることを含む、請求項４８に記載の方法。 A4) is further
Non-invasively delivering the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz, said at least a portion of the subject's plurality of brain regions, including at least the prefrontal cortex and hippocampus of the subject. 48. The method of claim 48, comprising morphologically transforming microglia.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の前記少なくとも一部のミクログリアにおいてタンパク質分解を増加させることを含む、請求項４８に記載の方法。 A4) is further
Non-invasively delivering the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz, said at least a portion of the subject's plurality of brain regions, including at least the prefrontal cortex and hippocampus of the subject. 48. The method of claim 48, comprising increasing proteolysis in microglia.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項５３に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
53. The method of claim 53, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の膜輸送、細胞内輸送、シナプス機能、神経炎症、アポトーシスプロセス、およびＤＮＡ損傷のうちの少なくとも一つに関与する異常改変された遺伝子およびタンパク質を改善することを含む、請求項２４に記載の方法。 A2) is further
Non-invasively delivering the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz, membrane transport, intracellular transport within the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject. 24. The method of claim 24, comprising ameliorating aberrantly modified genes and proteins involved in at least one of transport, synaptic function, neuroinflammatory, apoptotic processes, and DNA damage.
Ａ２）前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の学習および記憶を強化することを含む、請求項１５に記載の方法。 A1) is further
A2) The method of claim 15, comprising non-invasively delivering the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz to enhance learning and memory of the subject.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項５９に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
59. The method of claim 59, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
Ａ）約３０Ｈｚ〜約５０Ｈｚの周波数を有する慢性視覚刺激を前記対象に非侵襲的に送達し、前記対象の少なくとも前頭前野皮質（ＰＦＣ）および海馬を含む、前記対象の複数の脳領域において同期化ガンマ振動を同調させることを含み、Ａ）が、前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を、前記対象に非侵襲的に送達して、
Ａ１）前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域において同期化ガンマ振動を同時に同調させること、
Ａ２）前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域間のニューロン活動を連動させること、
Ａ３）前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の神経変性を低下させること、
Ａ４）前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の神経炎症を低下させること、
Ａ５）前記対象の少なくとも前頭前野皮質および海馬を含む、前記対象の前記複数の脳領域中の膜輸送、細胞内輸送、シナプス機能、神経炎症、アポトーシスプロセス、およびＤＮＡ損傷のうちの少なくとも一つに関与する異常改変された遺伝子およびタンパク質を改善すること、および
Ａ５）前記対象の学習および記憶を強化すること、を含む、前記方法。 A method for treating dementia or Alzheimer's disease in the subject in need.
A) A chronic visual stimulus with a frequency of about 30 Hz to about 50 Hz is delivered non-invasively to the subject and synchronized in multiple brain regions of the subject, including at least the prefrontal cortex (PFC) and hippocampus of the subject. A) non-invasively delivers the chronic visual stimulus having a frequency of about 30 Hz to about 50 Hz to the subject, comprising tuning gamma vibrations.
A1) Simultaneously synchronizing synchronized gamma oscillations in the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject.
A2) Linking neuronal activity between the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject.
A3) To reduce neurodegeneration in the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject.
A4) To reduce neural inflammation in the plurality of brain regions of the subject, including at least the prefrontal cortex and hippocampus of the subject.
A5) For at least one of membrane transport, intracellular transport, synaptic function, neuroinflammation, apoptotic process, and DNA damage in the subject's multiple brain regions, including at least the prefrontal cortex and hippocampus of the subject. improving the involvement abnormally altered genes and proteins, and A5) to enhance learning and memory of the object, including the method.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項６３に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
63. The method of claim 63, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項６１に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
61. The method of claim 61, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
Ａ）約３０Ｈｚ〜約５０Ｈｚの周波数を有する慢性視覚刺激を前記対象に非侵襲的に送達し、前記対象の複数の脳領域において同期化ガンマ振動を同調させ、前記対象の複数の脳領域において変性ニューロン中の異常改変された遺伝子およびタンパク質を改善することを含み、
前記対象の前記複数の脳領域において、前記変性ニューロン中の前記異常改変された遺伝子およびタンパク質が、膜輸送、細胞内輸送、シナプス機能、神経炎症、アポトーシスプロセス、およびＤＮＡ損傷のうちの少なくとも一つに関与し、
前記異常改変された遺伝子およびタンパク質が、Ｓ／Ｔリン酸化タンパク質を含み、
Ａ）が、前記慢性視覚刺激を非侵襲的に送達して、前記Ｓ／Ｔリン酸化タンパク質を改変し、前記対象の少なくとも視覚皮質中のＳ／Ｔリン酸化を低下させることをさらに含む、
前記方法。 A method for treating dementia or Alzheimer's disease in the subject in need.
A) A chronic visual stimulus with a frequency of about 30 Hz to about 50 Hz is delivered non-invasively to the subject, synchronized gamma oscillations are tuned in the subject's multiple brain regions, and degeneration in the subject's multiple brain regions. see contains at improving abnormal altered genes and proteins in neurons,
In the plurality of brain regions of the subject, the abnormally modified gene and protein in the degenerated neuron is at least one of membrane transport, intracellular transport, synaptic function, neuroinflammation, apoptotic process, and DNA damage. Involved in
The aberrantly modified gene and protein comprises an S / T phosphorylated protein.
A) further comprises non-invasively delivering the chronic visual stimulus to modify the S / T phosphorylated protein and reduce S / T phosphorylation in at least the visual cortex of the subject.
The method.
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、請求項７５に記載の方法。 A) comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
75. The method of claim 75, wherein the square wave current signal has a 50% load cycle and the frequency of the square wave current signal is equal to or approximately 40 Hz.
Ａ）約３０Ｈｚ〜約５０Ｈｚの周波数を有する慢性視覚刺激を、少なくとも４２日間、少なくとも１日あたり１時間前記対象に非侵襲的に送達し、前記対象の複数の脳領域において同期化ガンマ振動を同時に同調させ、前記対象の前記複数の脳領域の間で、前記３０Ｈｚ〜５０Ｈｚの周波数を有するガンマコヒーレンスを有意に増加させることを含み、
Ａ）が、矩形波電流シグナルを伴う発光ダイオード（ＬＥＤ）のアレイを駆動させ、前記慢性視覚刺激を生成することをさらに含み、
前記矩形波電流シグナルが、５０％負荷サイクルを有し、および
前記矩形波電流シグナルの周波数が、４０Ｈｚと等しいか、またはおよそ４０Ｈｚである、
前記方法。 A method for treating dementia or Alzheimer's disease in the subject in need.
A) Chronic visual stimuli with frequencies of about 30 Hz to about 50 Hz are delivered non-invasively to the subject for at least 42 days, at least 1 hour per day, and simultaneous synchronized gamma oscillations in multiple brain regions of the subject. tuned, among the plurality of brain regions of the object, seen including to increase significantly the gamma coherence with the frequency of the 30Hz～50Hz,
A) further comprises driving an array of light emitting diodes (LEDs) with a square wave current signal to generate the chronic visual stimulus.
The square wave current signal has a 50% load cycle and
The frequency of the square wave current signal is equal to or approximately 40 Hz.
The method.
前記約３０Ｈｚ〜約５０Ｈｚの周波数を有する前記慢性視覚刺激を非侵襲的に送達して、前記対象の前記複数の脳領域間のニューロン活動を連動させることを含む、請求項７７に記載の方法。 A) is further
The chronic visual stimuli delivered noninvasively, causing interlocking neuronal activities between the multiple brain regions of the object, method according to claim 77 having a frequency of the about 30Hz~ about 50 Hz.
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| PCT/US2018/055258 WO2019075094A1 (en) | 2017-10-10 | 2018-10-10 | Treating dementia with visual stimulation to synch gamma oscillations in brain |
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