JP2020529994A - 有機リン酸誘導体 - Google Patents
有機リン酸誘導体 Download PDFInfo
- Publication number
- JP2020529994A JP2020529994A JP2020505363A JP2020505363A JP2020529994A JP 2020529994 A JP2020529994 A JP 2020529994A JP 2020505363 A JP2020505363 A JP 2020505363A JP 2020505363 A JP2020505363 A JP 2020505363A JP 2020529994 A JP2020529994 A JP 2020529994A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- alkyl
- acceptable salt
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762538879P | 2017-07-31 | 2017-07-31 | |
| US62/538,879 | 2017-07-31 | ||
| US201862637960P | 2018-03-02 | 2018-03-02 | |
| US62/637,960 | 2018-03-02 | ||
| PCT/US2018/044389 WO2019027905A1 (en) | 2017-07-31 | 2018-07-30 | ORGANOPHOSPHATE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020529994A true JP2020529994A (ja) | 2020-10-15 |
| JP2020529994A5 JP2020529994A5 (enExample) | 2021-09-09 |
Family
ID=65234161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505363A Pending JP2020529994A (ja) | 2017-07-31 | 2018-07-30 | 有機リン酸誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11306111B2 (enExample) |
| EP (1) | EP3661513A4 (enExample) |
| JP (1) | JP2020529994A (enExample) |
| CN (1) | CN111491634A (enExample) |
| AU (1) | AU2018312224A1 (enExample) |
| CA (1) | CA3071612A1 (enExample) |
| WO (1) | WO2019027905A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111491634A (zh) | 2017-07-31 | 2020-08-04 | 詹纽瑞治疗公司 | 有机磷酸酯衍生物 |
| AU2019207626B2 (en) | 2018-01-10 | 2023-10-05 | Nucorion Pharmaceuticals, Inc. | Phosphor(n)amidatacetal and phosph(on)atalcetal compounds |
| US11427550B2 (en) | 2018-01-19 | 2022-08-30 | Nucorion Pharmaceuticals, Inc. | 5-fluorouracil compounds |
| AU2019227986A1 (en) * | 2018-03-02 | 2020-10-08 | January Therapeutics, Inc. | Nanoparticle compositions |
| CN112638927A (zh) * | 2018-08-20 | 2021-04-09 | 治愈生物医药公司 | 吉西他滨前药 |
| MX428883B (es) * | 2019-04-22 | 2025-11-13 | Ligand Pharm Inc | Compuestos ciclicos de fosfato |
| GR1009958B (el) * | 2019-04-24 | 2021-03-18 | ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." | Παραγωγα γεμσιταβινης και μεθοδοι δημιουργιας παραγωγων γεμσιταβινης |
| WO2021011692A1 (en) | 2019-07-17 | 2021-01-21 | Nucorion Pharmaceuticals, Inc. | Cyclic deoxyribonucleotide compounds |
| US11708637B2 (en) | 2019-08-13 | 2023-07-25 | The Regents Of The University Of California | Methods of supporting a graphene sheet disposed on a frame support |
| EP4013159B1 (en) * | 2019-09-10 | 2025-07-30 | Sony Group Corporation | Wireless communication device and method |
| EP4143199B1 (en) | 2020-04-21 | 2025-11-19 | Ligand Pharmaceuticals, Inc. | Nucleotide prodrug compounds |
| WO2021216431A1 (en) | 2020-04-21 | 2021-10-28 | Ligand Pharmaceuticals, Inc. | Benzyloxy phosph(on)ate compounds |
| JP7559223B2 (ja) | 2020-08-24 | 2024-10-01 | ギリアード サイエンシーズ， インコーポレイテッド | リン脂質化合物及びその使用 |
| TWI925033B (zh) | 2020-10-16 | 2026-05-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130131008A1 (en) * | 2011-10-25 | 2013-05-23 | Board Of Regents, The University Of Texas System | Lipophilic monophosphorylated derivatives and nanoparticles |
| JP2013540129A (ja) * | 2010-10-06 | 2013-10-31 | ニューカナー、バイオメッド、リミテッド | がん治療で使用するためのゲムシタビンのアミド亜リン酸エステル誘導体 |
| JP2016538252A (ja) * | 2013-10-11 | 2016-12-08 | アラ・ケム・エルエルシー | 置換された（ｓ）−（２ｒ，３ｒ，５ｒ）−３−ヒドロキシ−（５−ピリミジン−１−イル）テトラヒドロフラン−２−イルメチルアリールホスホロアミデート |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2874016B1 (fr) | 2004-06-30 | 2006-11-24 | Centre Nat Rech Scient Cnrse | Nanoparticules de derives de la gemcitabine |
| EP1915053A2 (en) | 2005-08-12 | 2008-04-30 | Merck & Co., Inc. | Novel 2'-c-methyl and 4'-c-methyl nucleoside derivatives |
| CA2721153C (en) | 2008-04-10 | 2018-10-02 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
| CN101732258B (zh) | 2008-11-19 | 2013-12-25 | 复旦大学附属华山医院 | 一种用于肿瘤化疗的纳米微球制剂及其制备方法 |
| AU2012209274A1 (en) | 2011-01-24 | 2013-09-12 | Anterios, Inc. | Nanoparticle compositions, formulations thereof, and uses therefor |
| KR102072041B1 (ko) | 2011-12-22 | 2020-01-31 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
| CN103239733A (zh) | 2012-02-09 | 2013-08-14 | 复旦大学附属肿瘤医院 | 一种整合素靶向型载药白蛋白纳米粒制剂及其制备方法 |
| AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
| US20140199404A1 (en) | 2013-01-11 | 2014-07-17 | Abraxis Bioscience, Llc | Method for treating cancer based on level of a nucleoside transporter |
| WO2014138278A1 (en) | 2013-03-05 | 2014-09-12 | The Regents Of The University Of California | Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents |
| CN105829333A (zh) * | 2013-10-11 | 2016-08-03 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸及其类似物 |
| KR20150047336A (ko) | 2013-10-24 | 2015-05-04 | 삼성전자주식회사 | 나노입자, 이를 제조하는 방법, 및 이의 용도 |
| CR20160400A (es) * | 2014-02-06 | 2016-11-07 | Riboscience Llc | Derivados de nucleosido sustituidos con 4´-difluorometilo como inhibidores de la replicación de arn de la influenza |
| WO2015134334A1 (en) * | 2014-03-03 | 2015-09-11 | Suo Zucai | Gemcitabine analogs |
| US9603864B2 (en) | 2014-06-24 | 2017-03-28 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TWI678373B (zh) * | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| WO2016188943A1 (en) | 2015-05-27 | 2016-12-01 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of cancer |
| CN104961786B (zh) | 2015-06-05 | 2018-09-25 | 苏州大学 | 基于吉西他滨结构的前体药物及其应用 |
| WO2017120537A1 (en) | 2016-01-08 | 2017-07-13 | The Regents Of The University Of California | Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery |
| CN111491634A (zh) | 2017-07-31 | 2020-08-04 | 詹纽瑞治疗公司 | 有机磷酸酯衍生物 |
| AU2019227986A1 (en) | 2018-03-02 | 2020-10-08 | January Therapeutics, Inc. | Nanoparticle compositions |
| WO2019169324A1 (en) | 2018-03-02 | 2019-09-06 | January Therapeutics, Inc. | Nanoparticle compositions |
| WO2020041051A1 (en) | 2018-08-20 | 2020-02-27 | Cure Biopharma Inc. | Gemcitabine prodrugs |
| CN112638927A (zh) | 2018-08-20 | 2021-04-09 | 治愈生物医药公司 | 吉西他滨前药 |
| WO2020223530A1 (en) | 2019-04-30 | 2020-11-05 | Cure Biopharma Inc. | Gemcitabine prodrugs |
| US11708637B2 (en) | 2019-08-13 | 2023-07-25 | The Regents Of The University Of California | Methods of supporting a graphene sheet disposed on a frame support |
-
2018
- 2018-07-30 CN CN201880063984.4A patent/CN111491634A/zh active Pending
- 2018-07-30 EP EP18840263.0A patent/EP3661513A4/en not_active Withdrawn
- 2018-07-30 AU AU2018312224A patent/AU2018312224A1/en not_active Abandoned
- 2018-07-30 JP JP2020505363A patent/JP2020529994A/ja active Pending
- 2018-07-30 WO PCT/US2018/044389 patent/WO2019027905A1/en not_active Ceased
- 2018-07-30 US US16/635,469 patent/US11306111B2/en not_active Expired - Fee Related
- 2018-07-30 CA CA3071612A patent/CA3071612A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013540129A (ja) * | 2010-10-06 | 2013-10-31 | ニューカナー、バイオメッド、リミテッド | がん治療で使用するためのゲムシタビンのアミド亜リン酸エステル誘導体 |
| US20130131008A1 (en) * | 2011-10-25 | 2013-05-23 | Board Of Regents, The University Of Texas System | Lipophilic monophosphorylated derivatives and nanoparticles |
| JP2016538252A (ja) * | 2013-10-11 | 2016-12-08 | アラ・ケム・エルエルシー | 置換された（ｓ）−（２ｒ，３ｒ，５ｒ）−３−ヒドロキシ−（５−ピリミジン−１−イル）テトラヒドロフラン−２−イルメチルアリールホスホロアミデート |
Non-Patent Citations (1)
| Title |
|---|
| JOURNAL OF CONTROLLED RELEASE, vol. Vol. 169, No. 1-2, JPN6022034070, 2013, pages 17 - 27, ISSN: 0004850617 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111491634A (zh) | 2020-08-04 |
| AU2018312224A1 (en) | 2020-02-27 |
| WO2019027905A1 (en) | 2019-02-07 |
| EP3661513A1 (en) | 2020-06-10 |
| US20200369695A1 (en) | 2020-11-26 |
| CA3071612A1 (en) | 2019-02-07 |
| EP3661513A4 (en) | 2021-07-14 |
| US11306111B2 (en) | 2022-04-19 |
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