JP2020517704A - α線放射免疫療法薬とともにＢＣＬ−２インヒビターを使用してがんを処置するための方法 - Google Patents

α線放射免疫療法薬とともにＢＣＬ−２インヒビターを使用してがんを処置するための方法 Download PDF

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JP2020517704A
JP2020517704A JP2019558417A JP2019558417A JP2020517704A JP 2020517704 A JP2020517704 A JP 2020517704A JP 2019558417 A JP2019558417 A JP 2019558417A JP 2019558417 A JP2019558417 A JP 2019558417A JP 2020517704 A JP2020517704 A JP 2020517704A
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hum195
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ドラガン シシック，
ドラガン シシック，
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アクティニウム ファーマシューティカルズ インコーポレイテッド
アクティニウム ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
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    • A61K51/04—Organic compounds
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    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1069—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Oncology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2019558417A 2017-04-28 2018-04-26 α線放射免疫療法薬とともにＢＣＬ−２インヒビターを使用してがんを処置するための方法 Withdrawn JP2020517704A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762491803P 2017-04-28 2017-04-28
US62/491,803 2017-04-28
PCT/US2018/029607 WO2018200841A1 (en) 2017-04-28 2018-04-26 Method for treating cancer using a bcl-2 inhibitor in conjunction with an alpha-emitting radioimmunotherapeutic

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JP2020115411A Division JP2020158544A (ja) 2017-04-28 2020-07-03 α線放射免疫療法薬とともにＢＣＬ−２インヒビターを使用してがんを処置するための方法

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JP2020517704A true JP2020517704A (ja) 2020-06-18
JP2020517704A5 JP2020517704A5 (enExample) 2022-06-06

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JP2019558417A Withdrawn JP2020517704A (ja) 2017-04-28 2018-04-26 α線放射免疫療法薬とともにＢＣＬ−２インヒビターを使用してがんを処置するための方法
JP2020115411A Withdrawn JP2020158544A (ja) 2017-04-28 2020-07-03 α線放射免疫療法薬とともにＢＣＬ−２インヒビターを使用してがんを処置するための方法
JP2023168404A Withdrawn JP2023165952A (ja) 2017-04-28 2023-09-28 α線放射免疫療法薬とともにＢＣＬ－２インヒビターを使用してがんを処置するための方法
JP2025202062A Pending JP2026026133A (ja) 2017-04-28 2025-11-21 α線放射免疫療法薬とともにＢＣＬ－２インヒビターを使用してがんを処置するための方法

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JP2020115411A Withdrawn JP2020158544A (ja) 2017-04-28 2020-07-03 α線放射免疫療法薬とともにＢＣＬ−２インヒビターを使用してがんを処置するための方法
JP2023168404A Withdrawn JP2023165952A (ja) 2017-04-28 2023-09-28 α線放射免疫療法薬とともにＢＣＬ－２インヒビターを使用してがんを処置するための方法
JP2025202062A Pending JP2026026133A (ja) 2017-04-28 2025-11-21 α線放射免疫療法薬とともにＢＣＬ－２インヒビターを使用してがんを処置するための方法

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US (4) US11364235B2 (enExample)
EP (2) EP4772537A2 (enExample)
JP (4) JP2020517704A (enExample)
CN (1) CN110612109A (enExample)
BR (1) BR112019022308A2 (enExample)
CA (1) CA3059752A1 (enExample)
MX (1) MX2019012660A (enExample)
WO (1) WO2018200841A1 (enExample)

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EP4772537A2 (en) * 2017-04-28 2026-07-08 Actinium Pharmaceuticals, Inc. Method for treating cancer using a bcl-2 inhibitor in conjunction with an alpha-emitting radioimmunotherapeutic
WO2019094931A1 (en) * 2017-11-10 2019-05-16 Actinium Pharmaceuticals, Inc. Combination therapy for treatment of a hematological disease
CA3125197A1 (en) * 2019-01-04 2020-07-09 Actinium Pharmaceuticals, Inc. Methods for treating cancer using combinations of parp inhibitors and antibody radioconjugates
TW202131946A (zh) * 2020-01-10 2021-09-01 加拿大商融合製藥公司 持續性免疫療法
US20240299600A1 (en) * 2020-09-08 2024-09-12 Actinium Pharmaceuticals, Inc. Method for treating acute myeloid leukemia using venetoclax in conjunction with lintuzumab-ac225

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CA2422291C (en) 2000-09-15 2011-03-08 Sloan-Kettering Institute For Cancer Research Targeted alpha particle therapy using actinium-225 conjugates
US8487131B2 (en) * 2009-04-15 2013-07-16 Sanford-Burnham Medical Research Institute Optically pure apogossypol derivative as pan-active inhibitor of anti-apoptotic B-cell lymphoma/leukemia-2 (BCL-2)
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Publication number Publication date
CA3059752A1 (en) 2018-11-01
CN110612109A (zh) 2019-12-24
US12133849B2 (en) 2024-11-05
EP3615047A4 (en) 2021-01-13
WO2018200841A1 (en) 2018-11-01
US20220273648A1 (en) 2022-09-01
JP2020158544A (ja) 2020-10-01
US20250017919A1 (en) 2025-01-16
US20240131025A1 (en) 2024-04-25
US11844799B2 (en) 2023-12-19
US11364235B2 (en) 2022-06-21
JP2026026133A (ja) 2026-02-16
EP3615047A1 (en) 2020-03-04
US20200383974A1 (en) 2020-12-10
EP4772537A2 (en) 2026-07-08
JP2023165952A (ja) 2023-11-17
BR112019022308A2 (pt) 2020-05-26
MX2019012660A (es) 2020-07-27
US20240226095A9 (en) 2024-07-11

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