JP2020517603A5 - - Google Patents
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- Publication number
- JP2020517603A5 JP2020517603A5 JP2019556272A JP2019556272A JP2020517603A5 JP 2020517603 A5 JP2020517603 A5 JP 2020517603A5 JP 2019556272 A JP2019556272 A JP 2019556272A JP 2019556272 A JP2019556272 A JP 2019556272A JP 2020517603 A5 JP2020517603 A5 JP 2020517603A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- iodoquinoline
- ylamino
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- LWAGKUYHPRXNQT-UHFFFAOYSA-N 2-[[[4-[(7-iodoquinolin-4-yl)amino]-2-methyloctyl]amino]methyl]phenol Chemical compound CCCCC(CC(C)CNCc1ccccc1O)Nc1ccnc2cc(I)ccc12 LWAGKUYHPRXNQT-UHFFFAOYSA-N 0.000 claims 1
- MJPJLXSBVHEZMK-UHFFFAOYSA-N 2-[[[4-[(7-iodoquinolin-4-yl)amino]-2-methylpentyl]amino]methyl]phenol Chemical compound CC(CNCc1ccccc1O)CC(C)Nc1ccnc2cc(I)ccc12 MJPJLXSBVHEZMK-UHFFFAOYSA-N 0.000 claims 1
- ITNYEKOSTPAVRT-UHFFFAOYSA-N 2-hexyl-4-[(7-iodoquinolin-4-yl)amino]-3-(methylaminomethyl)phenol Chemical compound IC1=CC=C2C(=CC=NC2=C1)NC1=C(C(=C(C=C1)O)CCCCCC)CNC ITNYEKOSTPAVRT-UHFFFAOYSA-N 0.000 claims 1
- SAXMENZINXSINL-UHFFFAOYSA-N 3-(aminomethyl)-2-ethyl-5-(2-hydroxyethyl)-4-[(7-iodoquinolin-4-yl)amino]phenol Chemical compound IC1=CC=C2C(=CC=NC2=C1)NC1=C(C(=C(C=C1CCO)O)CC)CN SAXMENZINXSINL-UHFFFAOYSA-N 0.000 claims 1
- ZSFWZHZVGZLVPC-UHFFFAOYSA-N 4-[(7-iodoquinolin-4-yl)amino]-2-(piperidin-1-ylmethyl)phenol Chemical compound IC1=CC=C2C(=CC=NC2=C1)NC1=CC(=C(C=C1)O)CN1CCCCC1 ZSFWZHZVGZLVPC-UHFFFAOYSA-N 0.000 claims 1
- DMTRXEWXPSWUTO-UHFFFAOYSA-N 4-[(7-iodoquinolin-4-yl)amino]-2-[(2-methylbutylamino)methyl]phenol Chemical compound IC1=CC=C2C(=CC=NC2=C1)NC1=CC(=C(C=C1)O)CNCC(C)CC DMTRXEWXPSWUTO-UHFFFAOYSA-N 0.000 claims 1
- MWNXOHUYTFXBAW-UHFFFAOYSA-N 4-[(7-iodoquinolin-4-yl)amino]-2-[(2-methylpropylamino)methyl]phenol Chemical compound IC1=CC=C2C(=CC=NC2=C1)NC1=CC(=C(C=C1)O)CNCC(C)C MWNXOHUYTFXBAW-UHFFFAOYSA-N 0.000 claims 1
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims 1
- 241001115402 Ebolavirus Species 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762485273P | 2017-04-13 | 2017-04-13 | |
| US62/485,273 | 2017-04-13 | ||
| PCT/US2018/027528 WO2018191642A1 (en) | 2017-04-13 | 2018-04-13 | Novel amodiaquine analogs and methods of uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517603A JP2020517603A (ja) | 2020-06-18 |
| JP2020517603A5 true JP2020517603A5 (https=) | 2021-05-27 |
| JP7176767B2 JP7176767B2 (ja) | 2022-11-22 |
Family
ID=63792882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019556272A Active JP7176767B2 (ja) | 2017-04-13 | 2018-04-13 | 新規なアモジアキン類似体およびその使用方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US11571416B2 (https=) |
| JP (1) | JP7176767B2 (https=) |
| WO (1) | WO2018191642A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110214011A (zh) | 2017-01-19 | 2019-09-06 | 国立大学法人鹿儿岛大学 | 抗严重发热伴血小板减少综合征病毒的药物 |
| WO2021235390A1 (ja) * | 2020-05-18 | 2021-11-25 | 国立大学法人鹿児島大学 | 抗ＳＡＲＳ－ＣｏＶ－２薬 |
| EP3960176A1 (en) * | 2020-08-26 | 2022-03-02 | DMG Deutsche Malaria GmbH | Piperaquine and related drug combinations for use in the treatment of covid-19 |
| JPWO2023085392A1 (https=) | 2021-11-12 | 2023-05-19 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060142259A1 (en) * | 2004-06-25 | 2006-06-29 | Limin Li | Compounds, pharmaceutical compositions and methods for inhibiting HIV infectivity |
| WO2007098047A2 (en) * | 2006-02-16 | 2007-08-30 | The Mclean Hospital Corporation | Methods and compositions for the treatment of parkinson's disease |
| WO2013138200A1 (en) * | 2012-03-13 | 2013-09-19 | Howard University | Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof |
| CN104703601A (zh) * | 2012-07-03 | 2015-06-10 | 格雷斯兰生物科技股份有限公司 | 用于治疗和抑制病毒感染的组合物和方法 |
| US20140011837A1 (en) * | 2012-07-03 | 2014-01-09 | Justice E. OBI | Compositions and methods for treating warts associated with viral infections |
| AU2015214176A1 (en) * | 2014-02-06 | 2016-09-15 | Georgetown University | Treating Flavivirus infections with amodiaquine and derivatives thereof |
| CN110214011A (zh) * | 2017-01-19 | 2019-09-06 | 国立大学法人鹿儿岛大学 | 抗严重发热伴血小板减少综合征病毒的药物 |
-
2018
- 2018-04-13 JP JP2019556272A patent/JP7176767B2/ja active Active
- 2018-04-13 US US16/603,907 patent/US11571416B2/en active Active
- 2018-04-13 WO PCT/US2018/027528 patent/WO2018191642A1/en not_active Ceased
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