JP2020516427A - 腫瘍進行のrecist評価 - Google Patents
腫瘍進行のrecist評価 Download PDFInfo
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Abstract
Description
Claims (43)
- 医用画像における1つまたは複数の病変の体積特性を決定するための方法であって、
画像データを受け取るステップと、
前記画像データ内の1つまたは複数の病変の1つまたは複数の位置を決定するステップと、
前記画像データ内の1つまたは複数の病変の決定された1つまたは複数の位置を含む画像セグメンテーションを作成するステップと、
前記画像セグメンテーションを用いて病変の体積特性を決定するステップと、
を含む方法。 - 前記1つまたは複数の病変の1つまたは複数の位置を決定するステップは、前記1つまたは複数の病変の焦点を識別するステップを含む、請求項1に記載の方法。
- 前記1つまたは複数の病変の焦点は、前記1つまたは複数の病変の質量中心を含む、請求項2に記載の方法。
- 前記1つまたは複数の病変の1つまたは複数の位置を決定するステップは、前記1つまたは複数の解剖学的目印の焦点を識別するステップを含む、請求項1〜3のいずれかに記載の方法。
- 前記1つまたは複数の解剖学的目印の焦点は、前記1つまたは複数の病変の質量中心を含む、請求項4に記載の方法。
- 前記1つまたは複数の病変の1つまたは複数の位置を決定するステップは、1つまたは複数の解剖学的目印に関連する前記位置を決定するステップを含む、請求項1に記載の方法。
- 前記1つまたは複数の解剖学的目印は、脊椎、肋骨、肺、心臓、肝臓、腎臓のいずれか1つを含む、請求項4〜6のいずれかに記載の方法。
- 前記1つまたは複数の病変の1つまたは複数の位置を決定するステップは、前記1つまたは複数の病変の焦点を識別するステップと、前記1つまたは複数の解剖学的目印の焦点を識別するステップと、前記1つまたは複数の解剖学的目印に関連する前記1つまたは複数の病変の位置を決定するステップとを含む、請求項2〜6のいずれかに記載の方法。
- 前記画像データは、CTスキャンデータと、ダイコム画像ファイルと、解剖学的構造の連続したスライスの一連の画像と、1つまたは複数のグレースケール画像と、患者層情報と、以前の画像データと、のいずれか1つまたはいずれかの組合せを含む、請求項1〜8のいずれかに記載の方法。
- 前記画像データは、1つまたは複数の画像を含む、請求項1〜9のいずれかに記載の方法。
- 前記1つまたは複数の画像は、共通の患者の解剖学的構造の共通部分に関連する、請求項10に記載の方法。
- 前記1つまたは複数の画像は、異なる時間に保存される、請求項10または11に記載の方法。
- 前記1つまたは複数の画像は、3D表現の複数の2Dスライスを含む、請求項10〜12のいずれかに記載の方法。
- 前記1つまたは複数の病変をセグメント化して病変セグメントデータを作成するステップと、前記病変セグメントデータを前記画像セグメンテーションに格納するステップとをさらに含む、請求項1〜13のいずれかに記載の方法。
- 前記画像セグメンテーションは、マスクまたは輪郭を生成することを含む、請求項14に記載の方法。
- 前記1つまたは複数の病変を測定して病変測定データを作成するステップと、前記病変セグメントデータを画像マスクに格納するステップとをさらに含む、請求項1〜15のいずれかに記載の方法。
- 前記画像データを前処理するステップをさらに含み、前記前処理は、前記画像データを読み取るステップと、前記画像データをメモリに格納するステップとを含む、請求項1〜16のいずれかに記載の方法。
- 前記画像データは、少なくとも4次元浮動小数点テンソルとしてメモリに格納され、前記次元は、高さ、幅、バッチサイズ、およびチャネルを含む、請求項1〜17のいずれかに記載の方法。
- 前記チャネルは、1つまたは複数のコントラストウィンドウまたはコントラスト値を含む、請求項18のいずれかに記載の方法。
- 前記画像データ内の前記1つまたは複数の病変の1つまたは複数の位置を決定するステップは、完全畳み込みニューラルネットワークを使用することを含む、請求項1〜19のいずれかに記載の方法。
- 前記完全畳み込みニューラルネットワークは、バックプロパゲーションを使用して訓練され、および/または、高密度訓練のための損失関数は、個々のピクセルの前記損失関数の空間次元にわたる合計である、請求項20に記載の方法。
- 腫瘍である可能性が高い画像データのそれぞれの1つまたは複数の画像内の領域を示すために1つまたは複数のヒートマップを作成することをさらに含む、請求項21に記載の方法。
- 前記1つまたは複数のヒートマップを条件付き確率場法によって供給することにより前記1つまたは複数のヒートマップを後処理するステップをさらに含む、請求項22に記載の方法。
- 前記決定された1つまたは複数の位置を条件付き確率場法を通して供給することによって、前記画像データ内の前記1つまたは複数の病変の前記決定された1つまたは複数の位置を後処理するステップをさらに含む、請求項1〜23のいずれかに記載の方法。
- 発見された病変の1次元測定値を決定するステップをさらに含み、前記1次元測定値は、最大径または垂直径のいずれかを含む、請求項1〜24のいずれかに記載の方法。
- 発見された病変の2次元測定値を決定するステップをさらに含み、任意選択で、前記2次元測定値は病変領域を含む、請求項1〜25のいずれかに記載の方法。
- 2Dスライス間の補間を用いて、発見された病変の3次元モデルを決定するステップをさらに含む、請求項1〜26のいずれかに記載の方法。
- 3次元空間における最大直径を決定するステップをさらに含む、請求項1〜27のいずれかに記載の方法。
- 3次元空間における体積および表面を決定するステップをさらに含む、請求項1〜28のいずれかに記載の方法。
- 1Dおよび/または2Dおよび/または3D測定値で壊死の程度を決定するステップをさらに含む、請求項1〜29のいずれかに記載の方法。
- 所定の基準に従って標的病変を選択するステップをさらに含み、前記所定の基準は、悪性度、大きさ、位置、壊死、その他の分類のいずれか1つまたはいずれかの組合せを含む、請求項1〜30のいずれかに記載の方法。
- ヒトが与えた、またはコンピュータが与えた、またはコンピュータが最適化した確率しきい値に基づいて、多数の標的病変を選択するステップ、任意選択的に、潜在的に変化するクラスおよび/または変化する位置および/または変化するサイズの多数の追跡可能な標的病変を生じるステップをさらに含む、請求項1〜31のいずれかに記載の方法。
- コンピュータ/人間によって識別された目印を使用して異なる時点で取られたスキャンの間に、病変をコロケーションする(すなわち、同じ病変を位置決めし、識別する)ステップをさらに含む、請求項1〜32のいずれかに記載の方法。
- 病変の局在、コンテキスト変数、分類、測定値、数、および/またはこれらすべての要約統計のいずれか1つまたはいずれかの組合せに基づいて、病期を決定するステップをさらに包含する、請求項1〜33のいずれかに記載の方法。
- コロケーションされた病変の1次元および/または2次元および/または3次元サイズおよび壊死測定比較を行うステップをさらに含む、請求項1〜34のいずれかに記載の方法。
- 病変の分類における変化を分析するステップをさらに含む、請求項1〜35のいずれかに記載の方法。
- 任意選択的に、サイズ測定値、分類、解剖学的コンテキストおよび位置の数および重症度のいずれか1つまたはいずれかの組合せに基づいて、腫瘍組織量および病気の段階の統計分析を実施するステップをさらに包含する、請求項1〜36のいずれかに記載の方法。
- 腫瘍組織量および病期変化の統計的分析を実施するステップをさらに含み、病期変化は、進行/停滞/退縮のいずれかを含み、任意に、サイズ測定値、分類、解剖学的コンテキストおよび位置の数および重症度のいずれか1つまたはいずれかの組合せに基づいて病期変化の統計的分析を実施する、請求項1〜37のいずれかに記載の方法。
- 結果のいずれかまたはすべての可視化、前記結果のいずれかまたはすべてを用いた自動テンプレートレポート作成をさらに含む、請求項1〜38のいずれかに記載の方法。
- 上記のすべての結果の品質管理および不確実性分析を実施するステップをさらに含む請求項1〜39のいずれかに記載の方法。
- 請求項1〜40のいずれかに記載の方法を実行するように動作可能な装置。
- 請求項41に記載の装置を含むシステム。
- 請求項1〜40のいずれかに記載の方法を実行するように動作可能なコンピュータプログラム。
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