|
JP6261500B2
(ja)
|
2011-07-22 |
2018-01-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ヌクレアーゼ切断特異性の評価および改善
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
US9068179B1
(en)
|
2013-12-12 |
2015-06-30 |
President And Fellows Of Harvard College |
Methods for correcting presenilin point mutations
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
AU2015330699B2
(en)
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
AU2015342749B2
(en)
|
2014-11-07 |
2022-01-27 |
Editas Medicine, Inc. |
Methods for improving CRISPR/Cas-mediated genome-editing
|
|
CA2986310A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
EP3307887A1
(en)
|
2015-06-09 |
2018-04-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
|
WO2017053879A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
EP3365356B1
(en)
|
2015-10-23 |
2023-06-28 |
President and Fellows of Harvard College |
Nucleobase editors and uses thereof
|
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
US11236313B2
(en)
|
2016-04-13 |
2022-02-01 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
EP3497214B1
(en)
|
2016-08-09 |
2023-06-28 |
President and Fellows of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
EP3526320A1
(en)
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
|
WO2018119010A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
JP7229923B2
(ja)
|
2017-01-06 |
2023-02-28 |
エディタス・メディシン、インコーポレイテッド |
ヌクレアーゼ切断を評価する方法
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
WO2018165631A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
KR20190127797A
(ko)
|
2017-03-10 |
2019-11-13 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
시토신에서 구아닌으로의 염기 편집제
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
WO2018201086A1
(en)
|
2017-04-28 |
2018-11-01 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
MX2019014640A
(es)
|
2017-06-09 |
2020-10-05 |
Editas Medicine Inc |
Nucleasas de repeticiones palíndromicas agrupadas y regularmente interespaciadas de proteina asociada 9 (cas9) genomanipuladas.
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
CN111757937A
(zh)
|
2017-10-16 |
2020-10-09 |
布罗德研究所股份有限公司 |
腺苷碱基编辑器的用途
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
SG11202009452WA
(en)
*
|
2018-04-03 |
2020-10-29 |
Stridebio Inc |
Antibody-evading virus vectors
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CA3104856A1
(en)
|
2018-06-29 |
2020-01-02 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
MX2021011426A
(es)
|
2019-03-19 |
2022-03-11 |
Broad Inst Inc |
Metodos y composiciones para editar secuencias de nucleótidos.
|
|
EP3956349A1
(en)
|
2019-04-17 |
2022-02-23 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN110499334A
(zh)
*
|
2019-08-08 |
2019-11-26 |
复旦大学 |
CRISPR/SlugCas9基因编辑系统及其应用
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
MX2022014008A
(es)
|
2020-05-08 |
2023-02-09 |
Broad Inst Inc |
Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo.
|
|
IL298134A
(en)
*
|
2020-05-12 |
2023-01-01 |
Lonza Houston Inc |
Methods and kits for the detection of adeno-associated viruses
|
|
CN113717960B
(zh)
*
|
2021-08-27 |
2023-07-18 |
电子科技大学 |
一种新Cas9蛋白、CRISPR-Cas9基因组定向编辑载体及基因组编辑方法
|
|
WO2024112479A1
(en)
*
|
2022-11-22 |
2024-05-30 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides, lipid nanoparticles, and methods of use thereof
|
|
WO2024211456A1
(en)
*
|
2023-04-03 |
2024-10-10 |
The Broad Institute, Inc. |
Engineered type ii cas polynucleotides with reduced immunogenicity and uses thereof
|
|
CN117448300B
(zh)
*
|
2023-05-08 |
2024-04-30 |
珠海舒桐医疗科技有限公司 |
一种Cas9蛋白、II型CRISPR/Cas9基因编辑系统及应用
|
|
US20250001010A1
(en)
|
2023-06-30 |
2025-01-02 |
Christiana Care Gene Editing Institute, Inc. |
Nras gene knockout for treatment of cancer
|
|
US20250319206A1
(en)
|
2024-04-04 |
2025-10-16 |
Christina Care Gene Editing Institute, Inc. |
Crispr/cas gene editing of neh4 and/or neh5 domains in nrf2
|
|
WO2025226816A1
(en)
|
2024-04-23 |
2025-10-30 |
Christiana Care Gene Editing Institute, Inc. |
Methods of identifying and correlating crispr-induced exon skipping to phenotypic outcomes
|