JP2020506246A - シロシビン誘導体を含む組成物及び方法 - Google Patents
シロシビン誘導体を含む組成物及び方法 Download PDFInfo
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- JP2020506246A JP2020506246A JP2019564369A JP2019564369A JP2020506246A JP 2020506246 A JP2020506246 A JP 2020506246A JP 2019564369 A JP2019564369 A JP 2019564369A JP 2019564369 A JP2019564369 A JP 2019564369A JP 2020506246 A JP2020506246 A JP 2020506246A
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- psilocybin derivative
- derivative
- receptor
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract
Description
(目的化合物の質量(グラム))/(組成物の全質量(グラム))x100%
シロシビン誘導体2.0g÷組成物25.0gx100%=8.0%
第1の精製されたシロシビン誘導体であって、第1の精製されたシロシビン誘導体は、リン酸二水素[3−(2−ジメチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N,N−ジメチルトリプタミン、リン酸二水素[3−(2−メチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N−メチルトリプタミン、リン酸二水素[3−(アミノエチル)−1H−インドール−4−イル]、4−ヒドロキシトリプタミン、リン酸二水素[3−(2−トリメチルアミノエチル)−1H−インドール−4−イル]、及び4−ヒドロキシ−N,N,N−トリメチルトリプタミンから選択される、第1の精製されたシロシビン誘導体と、
第2の精製されたシロシビン誘導体であって、第2の精製されたシロシビン誘導体は、リン酸二水素[3−(2−ジメチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N,N−ジメチルトリプタミン、リン酸二水素[3−(2−メチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N−メチルトリプタミン、リン酸二水素[3−(アミノエチル)−1H−インドール−4−イル]、4−ヒドロキシトリプタミン、リン酸二水素[3−(2−トリメチルアミノエチル)−1H−インドール−4−イル]、及び4−ヒドロキシ−N,N,N−トリメチルトリプタミンから選択される、第2の精製されたシロシビン誘導体と、
を含む新たな組成物が開示される。
式中、R1、R2、R3、R4、R5、R6、R7、R8、R9、及びR10はそれぞれ、電子対、水素、アルキル、アルケニル、アルキニル、フェニル、ハロゲン化物、ヒドロキシル、カルボニル、アルデヒド、ハロホルミル、炭酸エステル、カルボキシレート、カルボキシル、エステル、ヒドロペルオキシ、ペルオキシ、エーテル、ヘミアセタール、ヘミケタール、アセタール、ケタール、オルトエステル、メチレンジオキシ、オルト炭酸エステル(orthocarbonate ester)、カルボキサミド、アミン、イミン、アミド、アジド、アゾ、シアネート、ナイトレート、ニトリル、イソニトリル、ニトロソオキシ、ニトロ、ピリジル、チオール、スルフィド、スルフィニル、スルホニル、チオシアネート、カルボノチオイル、またはホスフェートから選択される。
治療を必要とする人に対して、
神経伝達物質活性調節因子を投与すること、及び
第1の精製されたシロシビン誘導体を含む第1の用量製剤を投与すること、
を含み、第1の用量製剤は、神経伝達物質受容体に対する活性を調節する。
治療を必要とする人を特定すること、及び
第1の精製されたシロシビン誘導体を、治療を必要とする人に投与すること、
を含み、第1の精製されたシロシビン誘導体は、神経伝達物質受容体に対する活性を調節する。
Claims (128)
- 第1の精製されたシロシビン誘導体であって、前記第1の精製されたシロシビン誘導体は、リン酸二水素[3−(2−ジメチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N,N−ジメチルトリプタミン、リン酸二水素[3−(2−メチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N−メチルトリプタミン、リン酸二水素[3−(アミノエチル)−1H−インドール−4−イル]、4−ヒドロキシトリプタミン、リン酸二水素[3−(2−トリメチルアミノエチル)−1H−インドール−4−イル]、及び4−ヒドロキシ−N,N,N−トリメチルトリプタミンから選択される、前記第1の精製されたシロシビン誘導体と、
第2の精製されたシロシビン誘導体であって、前記第2の精製されたシロシビン誘導体は、リン酸二水素[3−(2−ジメチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N,N−ジメチルトリプタミン、リン酸二水素[3−(2−メチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N−メチルトリプタミン、リン酸二水素[3−(アミノエチル)−1H−インドール−4−イル]、4−ヒドロキシトリプタミン、リン酸二水素[3−(2−トリメチルアミノエチル)−1H−インドール−4−イル]、及び4−ヒドロキシ−N,N,N−トリメチルトリプタミンから選択される、前記第2の精製されたシロシビン誘導体と、
を含む、組成物。 - 前記第1の精製されたシロシビン誘導体と前記第2の精製されたシロシビン誘導体とを約10:1〜約1:10のモル比で含む、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第2の精製されたシロシビン誘導体とを約100:1〜約1:100のモル比で含む、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第2の精製されたシロシビン誘導体とを約1,000:1〜約1:1,000のモル比で含む、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第2の精製されたシロシビン誘導体とを約10,000:1〜約1:10,000のモル比で含む、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、リン酸二水素[3−(2−ジメチルアミノエチル)−1H−インドール−4−イル]である、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、4−ヒドロキシ−N,N−ジメチルトリプタミンである、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、リン酸二水素[3−(2−メチルアミノエチル)−1H−インドール−4−イル]である、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、4−ヒドロキシ−N−メチルトリプタミンである、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、リン酸二水素[3−(アミノエチル)−1H−インドール−4−イル]である、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、4−ヒドロキシトリプタミンである、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、リン酸二水素[3−(2−トリメチルアミノエチル)−1H−インドール−4−イル]である、請求項1に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、4−ヒドロキシ−N,N,N−トリメチルトリプタミンである、請求項1に記載の組成物。
- 第1の精製されたカンナビノイドを含む、請求項1に記載の組成物。
- 前記第1の精製されたカンナビノイドが、THC、THCA、THCV、THCVA、CBC、CBCA、CBCV、CBCVA、CBD、CBDA、CBDV、CBDVA、CBG、CBGA、CBGV、またはCBGVAから選択される、請求項14に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとを約100:1〜約1:100のモル比で含む、請求項15に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとを約75:1〜約1:75のモル比で含む、請求項16に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとを約50:1〜約1:50のモル比で含む、請求項17に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとを約25:1〜約1:25のモル比で含む、請求項18に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとを約10:1〜約1:10のモル比で含む、請求項19に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとを約5:1〜約1:5のモル比で含む、請求項20に記載の組成物。
- 前記第1の精製されたシロシビン誘導体及び前記第1の精製されたカンナビノイドが、均一混合物として存在する、請求項21に記載の組成物。
- 第1の精製されたテルペンを含む、請求項1に記載の組成物。
- 前記第1の精製されたテルペンが、酢酸ボルニル、アルファ−ビサボロール、ボルネオール、カンフェン、カンファー、カレン、ベータ−カリオフィレン、セドレン、シメン、エレメン、ユーカリプトール、オイデスモール、ファルネセン、フェンコール、ゲラニオール、グアヤコール、フムレン、イソボルネオール、リモネン、リナロール、メントール、ベータ−ミルセン、ネロリドール、オシメン、フェランドレン、フィトール、ピネン、プレゴン、サビネン、テルピネオール、テルピノレン、またはバレンセンから選択される、請求項23に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとを約100:1〜約1:100のモル比で含む、請求項24に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとを約75:1〜約1:75のモル比で含む、請求項25に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとを約50:1〜約1:50のモル比で含む、請求項26に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとを約25:1〜約1:25のモル比で含む、請求項27に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとを約10:1〜約1:10のモル比で含む、請求項28に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとを約5:1〜約1:5のモル比で含む、請求項29に記載の組成物。
- 前記第1の精製されたシロシビン誘導体及び前記第1の精製されたテルペンが、均一混合物として存在する、請求項23に記載の組成物。
- 第1の精製されたカンナビノイド及び第1の精製されたテルペンを含む、請求項1に記載の組成物。
- 前記第1の精製されたカンナビノイドが、THC、THCA、THCV、THCVA、CBC、CBCA、CBCV、CBCVA、CBD、CBDA、CBDV、CBDVA、CBG、CBGA、CBGV、またはCBGVAから選択される、請求項32に記載の組成物。
- 前記第1の精製されたテルペンが、酢酸ボルニル、アルファ−ビサボロール、ボルネオール、カンフェン、カンファー、カレン、ベータ−カリオフィレン、セドレン、シメン、エレメン、ユーカリプトール、オイデスモール、ファルネセン、フェンコール、ゲラニオール、グアヤコール、フムレン、イソボルネオール、リモネン、リナロール、メントール、ベータ−ミルセン、ネロリドール、オシメン、フェランドレン、フィトール、ピネン、プレゴン、サビネン、テルピネオール、テルピノレン、またはバレンセンから選択される、請求項33に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとの含有モル比が約100:1〜約1:100であり、前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとの含有モル比が100:1〜約1:100である、請求項34に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとの含有モル比が約75:1〜約1:75であり、前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとの含有モル比が約75:1〜約1:75である、請求項35に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとの含有モル比が約50:1〜約1:50であり、前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとの含有モル比が約50:1〜約1:50である、請求項36に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとの含有モル比が25:1〜約1:25であり、前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとの含有モル比が25:1〜約1:25である、請求項37に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとの含有モル比が約10:1〜約1:10であり、前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとの含有モル比が約10:1〜約1:10である、請求項38に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と前記第1の精製されたカンナビノイドとの含有モル比が5:1〜約1:5であり、前記第1の精製されたシロシビン誘導体と前記第1の精製されたテルペンとの含有モル比が約5:1〜約1:5である、請求項39に記載の組成物。
- 前記第1の精製されたシロシビン誘導体、前記第1の精製されたカンナビノイド、及び前記第1の精製されたテルペンが、均一混合物として存在する、請求項32に記載の組成物。
- 第2の精製されたカンナビノイドを含む、請求項14に記載の組成物。
- 前記第1の精製されたカンナビノイドが、THC、THCA、THCV、THCVA、CBC、CBCA、CBCV、CBCVA、CBD、CBDA、CBDV、CBDVA、CBG、CBGA、CBGV、またはCBGVAから選択される、請求項42に記載の組成物。
- 前記第2の精製されたカンナビノイドが、THC、THCA、THCV、THCVA、CBC、CBCA、CBCV、CBCVA、CBD、CBDA、CBDV、CBDVA、CBG、CBGA、CBGV、またはCBGVAから選択される、請求項43に記載の組成物。
- 前記第1の精製されたシロシビン誘導体と、前記第1の精製されたカンナビノイド及び前記第2の精製されたカンナビノイドの総和と、を約100:1〜約1:100のモル比で含む、請求項44に記載の組成物。
- 前記モル比が、約75:1〜約1:75である、請求項45に記載の組成物。
- 前記モル比が、約50:1〜約1:50である、請求項46に記載の組成物。
- 前記モル比が、約25:1〜約1:25である、請求項47に記載の組成物。
- 前記モル比が、約10:1〜約1:10である、請求項48に記載の組成物。
- 前記モル比が、約5:1〜約1:5である、請求項49に記載の組成物。
- 前記第1の精製されたシロシビン誘導体、前記第1の精製されたカンナビノイド、及び前記第2の精製されたカンナビノイドが、均一混合物として存在する、請求項42に記載の組成物。
- 第1の精製されたシロシビン誘導体及び安定剤を含む、組成物。
- 前記第1の精製されたシロシビン誘導体が、リン酸二水素[3−(2−ジメチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N,N−ジメチルトリプタミン、リン酸二水素3−(2−メチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N−メチルトリプタミン、リン酸二水素[3−(アミノエチル)−1H−インドール−4−イル]、4−ヒドロキシトリプタミン、リン酸二水素[3−(2−トリメチルアミノエチル)−1H−インドール−4−イル]、または4−ヒドロキシ−N,N,N−トリメチルトリプタミンから選択される、請求項52に記載の組成物。
- 前記安定剤が、抗酸化剤である、請求項52に記載の組成物。
- 前記抗酸化剤が、アスコルビン酸、リコピン、トコフェロール、メラトニン、レチノール、アスタキサンチン、ルテイン、アピゲニン、カルノシン、セレン、亜鉛、またはククルミン(cucurmin)から選択される化合物を含む、請求項54に記載の組成物。
- 前記安定剤が、pH緩衝剤である、請求項52に記載の組成物。
- 前記pH緩衝剤が、クエン酸、酢酸、リン酸一ナトリウム、N−シクロヘキシル−2−アミノエタンスルホン酸、ホウ酸、塩酸、水酸化ナトリウム、またはその塩から選択される化合物を含む、請求項56に記載の組成物。
- 脱リン酸化剤を含む、請求項52に記載の組成物。
- 第1の精製されたカンナビノイドを含む、請求項52に記載の組成物。
- 前記第1の精製されたカンナビノイドが、THC、THCA、THCV、THCVA、CBC、CBCA、CBCV、CBCVA、CBD、CBDA、CBDV、CBDVA、CBG、CBGA、CBGV、またはCBGVAから選択される、請求項59に記載の組成物。
- 第1の精製されたテルペンを含む、請求項60に記載の組成物。
- 前記第1の精製されたテルペンが、酢酸ボルニル、アルファ−ビサボロール、ボルネオール、カンフェン、カンファー、カレン、ベータ−カリオフィレン、セドレン、シメン、エレメン、ユーカリプトール、オイデスモール、ファルネセン、フェンコール、ゲラニオール、グアヤコール、フムレン、イソボルネオール、リモネン、リナロール、メントール、ベータ−ミルセン、ネロリドール、オシメン、フェランドレン、フィトール、ピネン、プレゴン、サビネン、テルピネオール、テルピノレン、またはバレンセンから選択される、請求項61に記載の組成物。
- 前記組成物の含水率が、0〜5%質量パーセントである、請求項52に記載の組成物。
- 前記組成物が、水溶性である、請求項52に記載の組成物。
- 賦形剤を含む、請求項52に記載の組成物。
- 前記賦形剤が、ビタミンE TPGS、ラウリル硫酸ナトリウム、スクロース、アルコール、ゼラチン、ポリビニルピロリドン、メチオニン、ジメチルスルホキシド、タートラジン、ポリエチレングリコール、ステアリン酸マグネシウム、ステアリン酸、フュームドシリカ、タルク、炭酸マグネシウム、または塩化ベンザルコニウムから選択される化合物を含む、請求項65に記載の組成物。
- 前記賦形剤が、ビタミンE TPGSである、請求項66に記載の組成物。
- 前記第1の精製されたシロシビン誘導体が、乾燥粉末である、請求項52に記載の組成物。
- 溶媒及び賦形剤を含む、請求項52に記載の組成物。
- 前記安定剤が、抗酸化剤である、請求項69に記載の組成物。
- 前記抗酸化剤が、アスコルビン酸、リコピン、トコフェロール、メラトニン、レチノール、アスタキサンチン、ルテイン、アピゲニン、カルノシン、セレン、亜鉛、またはククルミン(cucurmin)から選択される化合物を含む、請求項70に記載の組成物。
- 前記安定剤が、pH緩衝剤である、請求項69に記載の組成物。
- 前記pH緩衝剤が、クエン酸、酢酸、リン酸一ナトリウム、N−シクロヘキシル−2−アミノエタンスルホン酸、ホウ酸、塩酸、または水酸化ナトリウムから選択される化合物を含む、請求項72に記載の組成物。
- 第1の精製されたカンナビノイドを含む、請求項69に記載の組成物。
- 前記第1の精製されたカンナビノイドが、THC、THCA、THCV、THCVA、CBC、CBCA、CBCV、CBCVA、CBD、CBDA、CBDV、CBDVA、CBG、CBGA、CBGV、またはCBGVAから選択される、請求項74に記載の組成物。
- 第1の精製されたテルペンを含む、請求項69に記載の組成物。
- 前記第1の精製されたテルペンが、酢酸ボルニル、アルファ−ビサボロール、ボルネオール、カンフェン、カンファー、カレン、ベータ−カリオフィレン、セドレン、シメン、エレメン、ユーカリプトール、オイデスモール、ファルネセン、フェンコール、ゲラニオール、グアヤコール、フムレン、イソボルネオール、リモネン、リナロール、メントール、ベータ−ミルセン、ネロリドール、オシメン、フェランドレン、フィトール、ピネン、プレゴン、サビネン、テルピネオール、テルピノレン、またはバレンセンから選択される、請求項76に記載の組成物。
- 前記賦形剤が、ビタミンE TPGS、ラウリル硫酸ナトリウム、スクロース、アルコール、ゼラチン、ポリビニルピロリドン、メチオニン、ジメチルスルホキシド、タートラジン、ポリエチレングリコール、ステアリン酸マグネシウム、ステアリン酸、フュームドシリカ、タルク、炭酸マグネシウム、または塩化ベンザルコニウムから選択される化合物を含む、請求項69に記載の組成物。
- 前記賦形剤が、ビタミンE TPGSである、請求項78に記載の組成物。
- 前記溶媒が、水である、請求項69に記載の組成物。
- 脱リン酸化剤を含む、請求項69に記載の組成物。
- 神経伝達物質受容体に対する活性の調節方法であって、前記方法が、治療を必要とする人に対して、神経伝達物質活性調節因子を投与すること、及び第1の精製されたシロシビン誘導体を含む第1の用量製剤を投与すること、を含み、前記第1の用量製剤が、神経伝達物質受容体に対する活性を調節する、前記方法。
- 前記第1の精製されたシロシビン誘導体が、リン酸二水素[3−(2−ジメチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N,N−ジメチルトリプタミン、リン酸二水素[3−(2−メチルアミノエチル)−1H−インドール−4−イル]、4−ヒドロキシ−N−メチルトリプタミン、リン酸二水素[3−(アミノエチル)−1H−インドール−4−イル]、4−ヒドロキシトリプタミン、リン酸二水素[3−(2−トリメチルアミノエチル)−1H−インドール−4−イル]、または4−ヒドロキシ−N,N,N−トリメチルトリプタミンから選択される、請求項82に記載の方法。
- 前記第1の精製されたシロシビン誘導体の脱リン酸化を含む、請求項83に記載の方法。
- モノアミン酸化酵素の阻害剤を投与することを含む、請求項82に記載の方法。
- 前記神経伝達物質受容体が、セロトニン受容体、カンナビノイド受容体、アドレナリン受容体、ドーパミン受容体、GABA受容体、グルタミン受容体、ヒスタミン受容体、コリン受容体、オピオイド受容体、またはグリシン受容体から選択される、請求項82に記載の方法。
- 前記神経伝達物質受容体が、セロトニン受容体である、請求項86に記載の方法。
- 前記神経伝達物質活性調節因子が、セロトニン系薬物である、請求項87に記載の方法。
- 前記セロトニン系薬物が、アルプラゾラム、アンフェタミン、アリピプラゾール、アザピロン、バルビツレート、ブロマゼパム、ブプロピオン、ブスピロン、カンナビノイド、クロルジアゼポキシド、シタロプラム、クロナゼパム、クロラゼパート、デキストロメトルファン、ジアゼパム、デュロキセチン、エスシタロプラム、フルオキセチン、フルラゼパム、フルボキサミン、ロラゼパム、リゼルグ酸ジエチルアミド、リセルガミド(lysergamide)、3,4−メチレンジオキシメタンフェタミン、ミルナシプラン、ミルタザピン、ナラトリプタン、パロキセチン、ペチジン、フェネチルアミン、プシカイン(psicaine)、オキサゼパム、レボキセチン、セレニック(serenic)、セロトニン、セルトラリン、テマゼパム、トラマドール、トリアゾラム、トリプタミン、ベンラファキシン、またはボルチオキセチンから選択される、請求項88に記載の方法。
- 前記神経伝達物質受容体が、アドレナリン受容体である、請求項86に記載の方法。
- 前記神経伝達物質活性調節因子が、アドレナリン系薬物である、請求項90に記載の方法。
- 前記アドレナリン系薬物が、アドレナリン、アグマチン、アモキサピン、アプタザピン、アトモキセチン、ブプロピオン、クロニジン、ドキセピン、デュロキセチン、エスミルタザピン、ミアンセリン、ミラベグロン、ミルタザピン、ノルエピネフリン、フェントラミン、フェニレフリン、ピペロキサン、レセルピン、リトドリン、セチプチリン、テソフェンシン、チモロール、トラゾドン、トリミプラミン、またはキシラジンから選択される、請求項91に記載の方法。
- 前記神経伝達物質受容体が、ドーパミン受容体である、請求項86に記載の方法。
- 前記神経伝達物質活性調節因子が、ドーパミン系薬物である、請求項93に記載の方法。
- 前記ドーパミン系薬物が、アミネプチン、アポモルヒネ、ベンジルピペラジン、ブロモクリプチン、カベルゴリン、クロルプロマジン、クロザピン、ジヒドレキシジン、ドンペリドン、ドーパミン、フルフェナジン、ハロペリドール、ケタミン、ロキサピン、メタンフェタミン、オランザピン、ペモリン、ペルフェナジン、ペルゴリド、フェンシクリジン、フェネチルアミン、フェンメトラジン、ピモジド、ピリベジル、精神刺激剤、レセルピン、リスペリドン、ロピニロール、テトラベナジン、またはチオリダジンから選択される、請求項94に記載の方法。
- 第1の精製されたカンナビノイドを含む第1の用量製剤を投与することを含む、請求項82に記載の方法。
- 前記第1の精製されたカンナビノイドが、THC、THCA、THCV、THCVA、CBC、CBCA、CBCV、CBCVA、CBD、CBDA、CBDV、CBDVA、CBG、CBGA、CBGV、またはCBGVAから選択される、請求項96に記載の方法。
- 第1の精製されたテルペンを含む第1の用量製剤を投与することを含む、請求項96に記載の方法。
- 前記第1の精製されたテルペンが、酢酸ボルニル、アルファ−ビサボロール、ボルネオール、カンフェン、カンファー、カレン、ベータ−カリオフィレン、セドレン、シメン、エレメン、ユーカリプトール、オイデスモール、ファルネセン、フェンコール、ゲラニオール、グアヤコール、フムレン、イソボルネオール、リモネン、リナロール、メントール、ベータ−ミルセン、ネロリドール、オシメン、フェランドレン、フィトール、ピネン、プレゴン、サビネン、テルピネオール、テルピノレン、またはバレンセンから選択される、請求項98に記載の方法。
- 賦形剤を投与することを含む、請求項82に記載の方法。
- 前記賦形剤が、ラウリル硫酸ナトリウム、スクロース、アルコール、ゼラチン、ポリビニルピロリドン、メチオニン、ビタミンE TPGS、ジメチルスルホキシド、タートラジン、ポリエチレングリコール、ステアリン酸マグネシウム、ステアリン酸、フュームドシリカ、タルク、炭酸マグネシウム、または塩化ベンザルコニウムから選択される化合物を含む、請求項100に記載の方法。
- 心理的障害の治療方法であって、前記方法が、治療を必要とする人を特定すること、及び第1の精製されたシロシビン誘導体を、前記治療を必要とする人に投与すること、を含み、前記第1の精製されたシロシビン誘導体が、神経伝達物質受容体に対する活性を調節する、前記方法。
- 前記神経伝達物質受容体が、セロトニン受容体、アドレナリン受容体、ドーパミン受容体、GABA受容体、グルタミン受容体、ヒスタミン受容体、コリン受容体、オピオイド受容体、またはグリシン受容体から選択される、請求項102に記載の方法。
- 前記第1の精製されたシロシビン誘導体の脱リン酸化を含む、請求項102に記載の方法。
- モノアミン酸化酵素の阻害剤を投与することを含む、請求項102に記載の方法。
- 第1の精製されたカンナビノイドを投与することを含む、請求項102に記載の方法。
- 前記第1の精製されたカンナビノイドが、THC、THCA、THCV、THCVA、CBC、CBCA、CBCV、CBCVA、CBD、CBDA、CBDV、CBDVA、CBG、CBGA、CBGV、またはCBGVAから選択される、請求項106に記載の方法。
- 第1の精製されたテルペンを投与することを含む、請求項107に記載の方法。
- 前記第1の精製されたテルペンが、酢酸ボルニル、アルファ−ビサボロール、ボルネオール、カンフェン、カンファー、カレン、ベータ−カリオフィレン、セドレン、シメン、エレメン、ユーカリプトール、オイデスモール、ファルネセン、フェンコール、ゲラニオール、グアヤコール、フムレン、イソボルネオール、リモネン、リナロール、メントール、ベータ−ミルセン、ネロリドール、オシメン、フェランドレン、フィトール、ピネン、プレゴン、サビネン、テルピネオール、テルピノレン、またはバレンセンから選択される、請求項108に記載の方法。
- 賦形剤を投与することを含む、請求項102に記載の方法。
- 第1の精製されたシロシビン誘導体を含む第2の用量製剤を投与することを含む、請求項102に記載の方法。
- 前記第1の用量製剤及び前記第2の用量製剤が、均一混合物である、請求項111に記載の方法。
- 前記均一混合物が、約10%のずれをほとんど〜全く有さない、請求項112に記載の方法。
- 前記均一混合物が、約5%のずれをほとんど〜全く有さない、請求項113に記載の方法。
- 前記第1の用量製剤が、第1の精製されたシロシビン誘導体、第2の精製されたシロシビン誘導体、及び第1の精製されたカンナビノイドを単一の組成物に含む、請求項102に記載の方法。
- 前記第1の用量製剤が、第1の精製されたシロシビン誘導体、第2の精製されたシロシビン誘導体、及び第1の精製されたカンナビノイドを2つ以上の組成物に含む、請求項103に記載の方法。
- 前記心理的障害が、不安障害である、請求項102に記載の方法。
- 前記不安障害が、急性ストレス障害、病状に起因する不安、全般性不安障害、パニック障害、パニック発作、恐怖症、心的外傷後ストレス障害、分離不安障害、社会不安障害、物質誘発性不安障害、または場面緘黙症から選択される、請求項117に記載の方法。
- 抗不安薬を投与することを含む、請求項117に記載の方法。
- 前記抗不安薬が、アルプラゾラム、アルファ遮断剤、抗ヒスタミン剤、バルビツレート、ベータ遮断剤、ブロマゼパム、カルバメート、クロルジアゼポキシド、クロナゼパム、クロラゼパート、ジアゼパム、フルラゼパム、ロラゼパム、オピオイド、オキサゼパム、テマゼパム、またはトリアゾラムから選択される、請求項119に記載の方法。
- 前記心理的障害が、抑鬱障害である、請求項102に記載の方法。
- 前記抑鬱障害が、非定型鬱病、双極性障害、緊張病性鬱病、病状に起因する抑鬱障害、大抑鬱障害、産後鬱病、月経前不快気分障害、または季節性情動障害から選択される、請求項121に記載の方法。
- 抗鬱剤を投与することを含む、請求項121に記載の方法。
- 前記抗鬱剤が、ブプロプリオン、シタロプラム、デュロキセチン、エスシタロプラム、フルオキセチン、フルボキサミン、ミルナシプラン、ミルタザピン、パロキセチン、レボキセチン、セルトラリン、及びベンラファキシンから選択される、請求項123に記載の方法。
- 前記心理的障害が、強迫性障害である、請求項102に記載の方法。
- 前記強迫性障害が、嗜癖、身体醜形障害、皮膚むしり症、ためこみ症、強迫性障害、及び抜毛癖から選択される、請求項125に記載の方法。
- 神経伝達物質活性調節因子を投与することを含む、請求項125に記載の方法。
- 前記神経伝達物質活性調節因子が、アリピプラゾール、ブプロプリオン、シタロプラム、クロミプラミン、デキストロアンフェタミン、デュロキセチン、エスシタロプラム、フルオキセチン、フルボキサミン、ミルナシプラン、ミルタザピン、パロキセチン、クエチアピン、レボキセチン、リスペリドン、セルトラリン、及びベンラファキシンから選択される、請求項127に記載の方法。
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US20180221396A1 (en) | 2018-08-09 |
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