JP2020501734A5 - - Google Patents

Info

Publication number

JP2020501734A5

JP2020501734A5 JP2019532946A JP2019532946A JP2020501734A5 JP 2020501734 A5 JP2020501734 A5 JP 2020501734A5 JP 2019532946 A JP2019532946 A JP 2019532946A JP 2019532946 A JP2019532946 A JP 2019532946A JP 2020501734 A5 JP2020501734 A5 JP 2020501734A5

Authority

JP

Japan

Prior art keywords

pulses

processor

ultrasonic device

generate

item

Prior art date

2017-12-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 210000004556 brain Anatomy 0.000 claims description 15
• 238000000034 method Methods 0.000 claims description 15
• 206010012289 Dementia Diseases 0.000 claims description 12
• 230000003412 degenerative effect Effects 0.000 claims description 8
• 210000001130 astrocyte Anatomy 0.000 claims description 7
• 238000002604 ultrasonography Methods 0.000 claims description 7
• 230000004913 activation Effects 0.000 claims description 5
• 230000004044 response Effects 0.000 claims description 4
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims description 3
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims description 3
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 3
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 3
• 210000002569 neuron Anatomy 0.000 claims description 3
• 230000008569 process Effects 0.000 claims description 3
• 210000001320 hippocampus Anatomy 0.000 description 3
• 208000024827 Alzheimer disease Diseases 0.000 description 2
• 206010027175 memory impairment Diseases 0.000 description 2
• 230000037361 pathway Effects 0.000 description 2
• 208000027765 speech disease Diseases 0.000 description 2
• SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
• 208000031091 Amnestic disease Diseases 0.000 description 1
• 210000005013 brain tissue Anatomy 0.000 description 1
• 230000001149 cognitive effect Effects 0.000 description 1
• HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 description 1
• 229960004253 dexmedetomidine Drugs 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 230000006870 function Effects 0.000 description 1
• 230000030214 innervation Effects 0.000 description 1
• 230000003692 lymphatic flow Effects 0.000 description 1
• 229960002748 norepinephrine Drugs 0.000 description 1
• SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• 210000003478 temporal lobe Anatomy 0.000 description 1