JP2020500071A - 造影剤を用いた合成磁気共鳴イメージングおよび磁気共鳴指紋法、ならびに造影剤注入プロトコルの決定 - Google Patents
造影剤を用いた合成磁気共鳴イメージングおよび磁気共鳴指紋法、ならびに造影剤注入プロトコルの決定 Download PDFInfo
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Abstract
Description
本出願は、その全開示が全体として参照により本明細書に組み入れられる、2016年11月22日に出願された米国仮特許出願第62/425303号の利益を主張するものである。本出願は、その全開示が参照により本明細書に組み入れられる、2016年11月22日に出願された米国仮特許出願第62/425312号の利益を主張する、2017年11月21日に本出願と同時に出願された国際出願第PCT/US2017/62728号に関連したものである。
ができる。異なる信号成分の一意性、および辞書またはライブラリがシミュレートされる正確さは、組織パラメータを正しく推定するための2つの重要な要素である。
y(t)=A*t+B (1)
式中、y(t)は、経時的な患者の血液プール中の造影剤の濃度であり、tは、時間であり、AおよびBは、造影関連パラメータを推定またはシミュレートするために使用されるモデルまたはアルゴリズムに基づいて決定される定数である。例えば、AおよびBは、例えば、図4と、その開示が参照により組み入れられる、本開示の譲受人に譲渡された、米国特許第5840026号、米国特許第6385483号、および米国特許第8295914号とに関連して本明細書により詳細に記載されているような、造影剤を含む造影液のパラメータ、患者のパラメータ、および/または撮像されている組織のパラメータと関連付けられた定数である。
y’(t)=A’*t+B’ (2)
式中、y’(t)は、患者の細胞外体積中の造影剤の濃度であり、tは、時間であり、A’およびB’は、造影関連パラメータを推定またはシミュレートするために使用されるモデルまたはアルゴリズムに基づいて決定される定数である。例えば、A’およびB’は、例えば、図4と、その開示が参照により組み入れられる、本開示の譲受人に譲渡された、米国特許第5840026号、米国特許第6385483号、および米国特許第8295914号とに関連して本明細書により詳細に記載されているような、造影剤を含む造影液のパラメータ、患者のパラメータ、および/または撮像されている組織のパラメータと関連付けられた定数である。
y(t)=M*(t−To) (3)
式中、Mは、定数Aと定数Bにと基づくものであり、tは、時間であり、Toは、時間的オフセットである。これは同じ線を表す別の方法である。
101 撮像装置
102 エネルギー源
103 エネルギーセンサ
104 コンピュータ
107 補助センサ
110 イメージングシステム
120 制御システム
121 コンピュータ
122 処理装置
123 コンピュータ可読記憶媒体
124 システムバス
125 システムメモリ
126 取り外し不能メモリ
129 外部インターフェース
130 ユーザインターフェース
131 GUIディスプレイ
132 キーボード、マウス、または他の装置
133 プリンタ
134 スピーカ
140 注入器
141 造影液
142 生理食塩水または他の流体
150 1個または複数の外部データシステム、コンピュータシステム
160 患者支持体、患者ポジショナ
200 プロセス
300 プロセス
500 プロセス
Claims (21)
前記コンピュータシステムで、前記一連のシーケンスブロックにおける経時的な前記対象物内の前記体積の前記複数のパラメータに基づいて信号展開を生成するステップであって、前記信号展開が前記一連のシーケンスブロックにおける経時的な前記少なくとも1つの造影関連パラメータを定義する、ステップと
を含む、方法。
をさらに含む、請求項1に記載の方法。
をさらに含む、請求項3に記載の方法。
をさらに含む、請求項4に記載の方法。
前記コンピュータシステムで、前記少なくとも1つの造影関連パラメータと関連付けられた所望の時間拡張出力を決定するステップと、
前記コンピュータシステムで、前記体積の前記入力関数を使用して、前記一連のシーケンスブロックにおける経時的な前記少なくとも1つの造影関連パラメータを定義する前記信号展開を決定するステップと
をさらに含む、請求項1に記載の方法。
をさらに含む、請求項1に記載の方法。
前記コンピュータシステムで、前記別の信号展開を前記データベースに格納された前記信号展開と比較するステップと、
前記比較に基づいて、前記別の信号展開と関連付けられた1つまたは複数の共鳴種を決定するステップと
をさらに含む、請求項13に記載の方法。
前記コンピュータシステムで、前記別の一連のシーケンスブロック内の各シーケンスブロックにおける前記同時生成された個々の信号を取得するよう前記NMR装置を制御するステップと、
前記コンピュータシステムで、各シーケンスブロックから取得した前記同時生成された個々の信号に基づいて前記別の信号展開を決定するステップと
をさらに含む、請求項14に記載の方法。
前記コンピュータシステムで、前記少なくとも1つの造影関連パラメータに基づいて所望の時間拡張出力を決定するステップと、
前記コンピュータシステムで、前記患者の前記入力関数を使用して、注入プロトコル入力を決定するステップであって、前記注入プロトコル入力が、前記所望の時間拡張出力を達成する時間に基づいて導出される、ステップと、
前記コンピュータシステムで、前記決定された注入プロトコル入力に基づいて前記造影剤を送達するよう注入器を制御するステップと
をさらに含む、請求項13に記載の方法。
前記一連のシーケンスブロックにおける経時的な前記対象物内の前記体積の前記複数のパラメータに基づいて信号展開を生成し、前記信号展開が前記一連のシーケンスブロックにおける経時的な前記少なくとも1つの造影関連パラメータを定義する
ようにプログラムまたは構成された1つまたは複数のプロセッサ
を含む、コンピューティングシステム。
前記対象物と関連付けられたデータに基づいて前記対象物内の前記体積の入力関数を求め、前記体積の前記入力関数が、所与の入力についての時間拡張出力を提供し、
前記少なくとも1つの造影関連パラメータと関連付けられた所望の時間拡張出力を決定し、
前記体積の前記入力関数を使用して、前記一連のシーケンスブロックにおける経時的な前記少なくとも1つの造影関連パラメータを定義する前記信号展開を決定する
ようにさらにプログラムまたは構成される、請求項19に記載のコンピューティングシステム。
患者と関連付けられたデータに基づいて前記患者の入力関数を求め、前記患者の前記入力関数が、所与の入力についての時間拡張出力を提供し、
前記少なくとも1つの造影関連パラメータに基づいて所望の時間拡張出力を決定し、
前記患者の前記入力関数を使用して注入プロトコル入力を決定し、前記注入プロトコル入力が、前記所望の時間拡張出力を達成する時間に基づいて導出され、
前記決定された注入プロトコル入力に基づいて前記造影剤を送達するよう注入器を制御する
ようにさらにプログラムまたは構成される、請求項20に記載のコンピューティングシステム。
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