JP2020158413A - Composition for improving hair appearance - Google Patents

Abstract

To provide a novel material capable of improving hair appearance and a composition comprising the same.SOLUTION: There is provided a composition for improving hair appearance which comprises a peptide having an amino acid sequence of WY or a pharmaceutically acceptable salt thereof or a solvate as an active ingredient. The composition can be used to improve the deterioration of the appearance of hair and the deterioration of the appearance of hair can be considered to be caused by aging. The deterioration of the appearance of hair occurs, for example, in hair amount and hair quality.SELECTED DRAWING: None

Description

The present invention relates to a composition for improving the appearance of hair.

It is known that aging causes functional deterioration in many body tissues. Hair and scalp are no exception, and hair gradually develops from birth to puberty, reaching about 100,000 in a healthy state, but after that, although there are gender and individual differences, the hair becomes thinner and the amount of hair becomes thinner. There are age-related changes such as a decrease in hair, a decrease in hair gloss, and an increase in gray hair. It is known that the dwarfing of hair follicles and the decrease of hair follicle stem cells in the scalp are the causes of changes in hair with aging (Patent Document 1).

It has been pointed out that there are middle-aged and elderly people who lose confidence and energy due to deterioration of appearance such as thinning hair, hair loss, and gray hair, in addition to deterioration of scalp and hair function due to aging, and decrease opportunities for interpersonal interaction. There is. Among middle-aged and elderly people, especially elderly people, a vicious cycle in terms of physical, mental and social life has become a problem as a factor leading to the need for long-term care.

JP-A-2009-161509

An object of the present invention is to provide a novel material capable of improving the appearance of hair and a composition containing the same.

The present inventors have now experienced deterioration in hair volume and hair quality such as hair gloss and coat color in aged mice as compared with young mice, but in aged mice fed with WY peptide, hair volume and hair quality It was found that the deterioration of hair quality was improved. The present invention is based on these findings.

According to the present invention, the following inventions are provided.
[1] A composition for improving the appearance of hair and an agent for improving the appearance of hair, which comprises a peptide having an amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof as an active ingredient.
[2] The composition and agent according to the above [1], which is used for suppressing and / or improving the deterioration of hair appearance.
[3] The composition and agent according to the above [1] or [2], wherein the deterioration of the appearance of hair is caused by aging.
[4] The composition and agent according to any one of the above [1] to [3], wherein the deterioration of the appearance of the hair is related to the amount and / or the quality of the hair.
[5] The composition and agent according to the above [4], wherein the deterioration of the appearance regarding the amount of hair is at least one selected from the group consisting of hair loss, thinning hair and reduction in hair thickness.
[6] The deterioration of the appearance of hair quality is at least one selected from the group consisting of decolorization of hair color, lightening of hair color, reduction of hair gloss and reduction of hair hardness. The compositions and agents according to.
[7] The composition and preparation according to any one of the above [1] to [6] for ingestion by middle-aged and elderly people.
[8] The composition and agent according to any one of the above [1] to [7], which are in the form of food.
[9] Treatment, prevention or improvement of hair loss, thinning hair, bleaching and / or lightening, which comprises a peptide having the amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof as an active ingredient. Compositions and therapeutic, prophylactic or ameliorating agents for hair loss, thinning, bleaching and / or lightening.
[10] A hair growth promoting and / or hair loss suppressing composition and a hair growth promoting agent or a hair loss suppressing agent containing a peptide having an amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof as an active ingredient. ..

The compositions of the above [1], [9] and [10] are referred to as "the composition of the present invention" in the present specification, and the preparations of the above [1], [9] and [10] are referred to in the present specification as "the composition of the present invention". It may be referred to as "the agent of the present invention".

The dipeptide contained in the composition and preparation of the present invention: WY can be used as a functional material that exerts a function of improving the appearance of hair (particularly hair volume and hair quality), and is safe for mammals including humans. It is advantageous in that it can be used as a functional material.

FIG. 1 is a diagram showing the effect of WY peptide intake on the hair volume and hair quality (hair gloss, hair color) of aged mice. Notated as mean ± standard error. * Indicates p <0.05.

Specific description of the invention

The composition and preparation of the present invention contain a peptide having an amino acid sequence of WY (hereinafter, may be referred to as "peptide of the present invention") as an active ingredient. Here, the "peptide having an amino acid sequence" means a peptide whose sequence is specified by the amino acid sequence.

The peptide of the present invention may be obtained by chemical synthesis, and is chemically or enzymatically decomposed from a protein derived from milk, soybean, wheat, egg, livestock meat, fish meat, seafood, etc., a polypeptide raw material, or the like. You may use the obtained product. Specifically, for example, the sequences of the peptides of the invention include at least milk whey and casein, bovine serum albumin (BSA), soybean glycinin, wheat glutenin, egg yolk riboviterin, egg white ovalbumin, ovotransferase, Since it is contained in lysodium, collagen of chicken protein, etc., these foods or food materials can be subjected to acid hydrolysis, enzymatic treatment with protease, microbial fermentation, or the like to produce the above peptides. As the composition and the preparation of the present invention, the above-mentioned food or food material preparation may be used as it is, or may be used as a concentrate, or as a dry powder by spray-drying or freeze-drying. Further, if necessary, it may be used after being purified to any degree such as removal of impurities, salts, enzymes and the like.

The amino acids constituting the peptide of the present invention may be composed of only L-type amino acids, may be composed of only D-type amino acids, or may be a peptide in which both are mixed. Good. Further, it may be composed of only naturally occurring amino acids, may be composed of only modified amino acids in which arbitrary functional groups such as phosphorylation and glycosylation are bonded to amino acids, or both may be mixed. It may be any of the peptides. When the peptide contains two or more asymmetric carbons, it may be an enantiomer, a diastereomer, or a peptide in which both are mixed.

Furthermore, the peptides of the invention may be in the form of free salts or in the form of pharmaceutically acceptable salts or solvates thereof, and the compositions and solvates of the invention are any of these. Alternatively, it may contain a mixture of all or a part of these. Pharmaceutically acceptable salts include acid addition salts, metal salts, ammonium salts and organic amine addition salts. Pharmaceutically acceptable acid addition salts include inorganic acid salts such as hydrochlorides, sulfates and phosphates, and organic acid salts such as acetates, maleates, fumarates, citrates and methanesulfonates. And so on. Examples of pharmaceutically acceptable metal salts include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as magnesium salt and calcium salt, aluminum salts and zinc salts. Examples of the pharmaceutically acceptable ammonium salt include salts of ammonium, tetramethylammonium and the like. Examples of the pharmaceutically acceptable organic amine addition salt include addition salts such as morpholine and piperidine.

The composition and preparation of the present invention can be provided alone or as a material containing the peptide of the present invention (for example, a food raw material). The compositions and preparations of the present invention are also provided by mixing the peptide of the present invention or a material containing the peptide of the present invention with other components (for example, food raw materials, food additives, preparation additives). You can also. The content of the peptide of the present invention in the composition and the preparation of the present invention can be arbitrarily determined according to the purpose, use, form, dosage form, symptom, body weight, etc., and the present invention is not limited thereto. As the content thereof, it can be contained at a ratio of 0.00001 to 50% by mass (solid content equivalent) with respect to the total amount, and more preferably 0.0001 to 10% by mass (solid content equivalent). It can be contained in proportion. In the present invention, the preparation of the present invention may consist of the peptide of the present invention, and the composition of the present invention may contain the peptide of the present invention and other components.

The peptide content of the present invention can be measured by liquid chromatography tandem mass spectrometry (LC / MS / MS). Those skilled in the art can easily set the conditions, and it goes without saying that a standard peptide having a purity for LC / MS / MS measurement is used for the measurement. For example, SIGMA ALDRICH AQUA peptide manufactured by AQUA Peptide can be used.

Examples of the food material containing the peptide of the present invention include an enzymatic decomposition product of a protein, and an enzymatic decomposition product of a whey protein (hereinafter, may be referred to as a “whey decomposition product”). A method for producing a whey decomposition product containing the peptide of the present invention is known, and can be produced, for example, according to the description of International Publication No. 2017/086303. Alternatively, a commercially available whey enzymatic decomposition product containing the peptide of the present invention may be used, and for example, LE80GF-US (manufactured by DMV) or HW-3 (manufactured by Snow Brand Megmilk) may be used as the peptide of the present invention. Good.

When the peptide of the present invention is contained as a whey proteolytic product in the composition and preparation of the present invention, the ratio of the peptide of the present invention to the whey proteolytic product is 0.001 to 10% by mass (in terms of solid content). It can be contained in a proportion of 0.01 to 5% by mass (in terms of solid content), more preferably 0.01 to 5% by mass. Further, the whey proteolytic product can be contained in a proportion of 0.001 to 95% by mass (in terms of solid content) with respect to the composition and the preparation of the present invention, preferably 0.01 to 50% by mass. It can be contained in a ratio (in terms of solid content).

As shown in Examples below, the peptides of the present invention have an effect of improving the appearance of hair in old model animals. Improvement of body hair appearance (hair volume and hair quality) in rodents serves as a model for improvement in hair appearance (hair volume and hair quality) in humans (for reference, Drug Derivery System 24-2, 2009, 109- 116 and Cosmetology Research Report Vol.21, 2013, 19-23). Therefore, the peptide of the present invention can be used as an active ingredient of a composition for improving the appearance of hair and an agent for improving the appearance of hair. In the present invention, "hair" and "hair" are synonymous.

In the present invention, "improving the appearance of hair" means, in addition to improving (improving) the appearance of hair, suppressing the deterioration of the appearance of hair and recovering the deterioration of the appearance of hair. Including. That is, "improvement of hair appearance" is used to include "suppression and improvement of deterioration of hair appearance".

In the present invention, "deterioration of hair appearance" is preferably caused by aging (particularly aging). In general, the appearance of hair is often deteriorated in middle-aged and elderly people, and in particular, the degree of deterioration of hair appearance is remarkable in elderly people. Therefore, the compositions and preparations of the present invention can be ingested by middle-aged and elderly people (for example, persons aged 50 and over, persons aged 56 and over), and particularly elderly people (for example, persons aged 65 and over). It can be intended to be ingested by the person). That is, the composition and the preparation of the present invention can be ingested by middle-aged and elderly people or elderly people.

In the present invention, "hair appearance" preferably relates to either or both of hair mass and hair quality. Deterioration of the appearance of hair with respect to the amount of hair includes hair loss (without hair), thinning hair, and reduction in hair thickness, and particularly includes hair loss and thinning hair. Deterioration of appearance related to hair quality includes decolorization of hair color, lightening of hair color, reduction of hair gloss, reduction of hardness of hair, especially decolorization of hair color, lightening of hair color, and reduction of hair gloss. There is a decrease.

According to another aspect of the invention, a composition for treating, preventing or ameliorating hair loss, thinning, bleaching and / or bleaching, and hair loss, thinning, which comprises the peptides of the invention. A therapeutic, prophylactic or ameliorating agent for decolorization and / or lightening is provided. Hair loss, thinning, bleaching and lightening of hair can be attributed to aging (particularly aging).

According to another aspect of the present invention, there are also provided a composition for promoting hair growth and / or suppressing hair loss, which comprises the peptide of the present invention, and a hair growth promoting agent and a hair loss suppressing agent. In the present invention, hair growth promotion and hair loss suppression are used in the sense of including "hair growth".

The compositions and preparations of the present invention can be provided in the form of pharmaceuticals (for example, pharmaceutical compositions), quasi-drugs, foods (for example, food compositions), feeds (including pet food), etc. It can be carried out according to the description of.

The peptides of the invention can be orally administered to humans and non-human animals. Examples of oral preparations include granules, powders, tablets (including sugar-coated tablets), pills, capsules, syrups, emulsions, and suspensions. These formulations can be formulated using pharmaceutically acceptable carriers by methods commonly practiced in the art. Pharmaceutically acceptable carriers include excipients, binders, diluents, additives, fragrances, buffers, thickeners, colorants, stabilizers, emulsifiers, dispersants, suspending agents, preservatives, etc. Can be mentioned.

The peptide of the present invention can be orally ingested by humans and non-human animals, and a typical ingestion form is food. When the peptide of the present invention is provided as a food, it can be provided as it is as a food, or it can be provided by being contained in the food. For example, when the peptide of the present invention is provided as a food, an enzymatically decomposed product of a protein such as a whey decomposition product containing the peptide of the present invention can be provided as it is as a food, or it can be provided as a food. It can be contained and provided. The food provided in this manner is a food containing an effective amount of the peptide of the present invention. In the present specification, "containing an effective amount" of the peptide of the present invention means that the peptide of the present invention is ingested in the range described later when the amount normally eaten in each food is ingested. The amount. "Foods" are health foods, functional foods, nutritional supplements, health functional foods (for example, foods for specified health use, nutritional functional foods, foods with functional claims), special purpose foods (for example, infant foods, pregnant women). It is used to include foods for food, foods for the sick) and supplements. Needless to say, when the peptide of the present invention is ingested by an animal other than human, the food of the present invention is used as feed.

Since the peptide of the present invention has the above-mentioned effect of improving the deterioration of appearance, it can be contained in daily foods or provided as a supplement. That is, the composition and preparation of the present invention can be provided in the form of food. In this case, the composition and the preparation of the present invention can be provided in a unit packaging form in which the amount to be ingested per meal is predetermined. Examples of the unit packaging form per meal include a form in which a fixed amount is specified for packs, packages, cans, bottles, and the like. In order to better exert various actions of the composition and the preparation of the present invention, the intake amount per meal can be determined according to the intake amount of the peptide of the present invention described later. The food product of the present invention may be provided with an explanation regarding the amount of intake displayed on the package or together with a document or the like containing the explanation.

The predetermined intake per meal in the unit packaging form is the effective intake per day divided into two or more times (preferably two or three times). It may be the amount of intake. Therefore, the unit packaging form of the composition and the preparation of the present invention can contain the peptide of the present invention at the daily intake of humans described below, or 2 minutes of the daily intake of humans described below. The peptide of the present invention can be contained in an amount of 1 to 1/6 of that of the above. For convenience of ingestion, the compositions and preparations of the present invention are preferably provided in a "unit packaging form per meal" in which the intake per meal is the effective intake per day.

The form of the "food" is not particularly limited, and may be, for example, a beverage form, a semi-liquid or gel form, or a solid form or a powder form. In addition, examples of the "supplement" include tablets produced by adding excipients, binders and the like to the peptides of the present invention, kneading them, and then tableting them, and capsules encapsulated in capsules and the like.

The food provided in the present invention is not particularly limited as long as it contains the peptide of the present invention, and is, for example, a soft drink, a carbonated drink, a beverage containing fruit juice, a beverage containing vegetable juice, a beverage containing fruit juice and vegetable juice. Beverages, milk and other livestock milk, soy milk, milk beverages, drink-type yogurt, drink-type and stick-type jelly, coffee, cocoa, tea beverages, nutritional drinks, energy beverages, sports drinks, mineral water, near water, non- Non-alcoholic beverages such as alcoholic beer-taste beverages; carbohydrate-containing foods and drinks such as rice, noodles, breads and pasta; cheeses, hard or soft yogurt, fresh cream from livestock milk and other fats and oils, ice cream Dairy products such as cookie, cake, Western confectionery such as chocolate, Japanese confectionery such as bun and sheep, tablet confectionery such as ramune (cool confectionery), candy, gum, cold confectionery such as jelly and pudding, ice confectionery, snack confectionery, etc. Various confectionery; whiskey, bourbon, spirits, liqueur, wine, fruit liquor, Japanese liquor, Chinese liquor, shochu, beer, non-alcoholic beer with alcohol content of 1% or less, sparkling liquor, other miscellaneous liquor, alcoholic beverages such as liquor high Processed products using eggs, processed products of seafood and livestock meat (including guts such as liver) (including delicacies), processed foods such as soups such as miso soup, miso, soy sauce, sprinkles, other seasoning seasonings, etc. Examples of liquid foods such as seasonings and concentrated liquid foods can be used. The mineral water includes both effervescent and non-effervescent mineral water. In addition, the food provided in the present invention includes both food manufacturing raw materials and food additives.

The tea beverages include fermented tea, semi-fermented tea and non-fermented tea, for example, tea, green tea, barley tea, brown rice tea, roasted tea, tamaro tea, roasted tea, oolong tea, corn tea, puer tea, and louis bostee , Rose tea, Kiku tea, Ginkgo biloba tea, Herb tea (eg, mint tea, jasmine tea).

Fruits used in beverages containing fruit juice and beverages containing fruit juice and vegetable juice include, for example, apples, oranges, grapes, bananas, pears, peaches, mangoes, acai, blueberries and ume. Examples of vegetables used in beverages containing vegetable juice and beverages containing fruit juice and vegetable juice include tomatoes, carrots, celery, pumpkins, cucumbers and watermelons.

The intake of the peptide of the present invention can be determined depending on the sex, age and weight of the recipient, symptoms, intake time, dosage form, intake route, drugs to be combined, and the like. Adult daily intake of the peptide of the present invention for the purpose of improving the appearance of hair (including improvement of hair loss, thinning hair, bleaching, thinning, etc.), promoting hair growth and suppressing hair loss (dry mass conversion). ) Is, for example, 0.001 to 1000 mg (preferably 0.01 to 100 mg). The above-mentioned intake amount of the peptide of the present invention and the following intake timing and intake period are applicable when the peptide of the present invention is used for both non-therapeutic and therapeutic purposes, and in the case of therapeutic purposes, the intake is administered. Can be read as. The peptide of the present invention should also be ingested by mammals other than humans (preferably animals covered with hair, such as mice, rats, rabbits, dogs, cats, cows, horses, pigs, monkeys, etc.). The amount, timing and duration of intake can be determined with reference to the description of humans.

The ingestion period of the peptide of the present invention can be at least 3 days (preferably 5 days, 10 days, or 13 days) in the above daily dose. The ingestion interval of the peptide of the present invention can be such that the daily intake is once every three days, once every two days, or once a day.

The composition, preparation and food of the present invention may be labeled to have an effect of improving the appearance of hair. In this case, the compositions, preparations and foods of the present invention may be labeled in part or in whole as follows in order to make the labeling easy for consumers to understand. Needless to say, in the present invention, "improvement of hair appearance" is used to include the following indications.
・ For those who are concerned about aging of hair ・ For anti-aging of hair ・ For those who are concerned about hair loss, hair loss, thinning hair, and gray hair

According to another aspect of the invention, an effective amount of the peptide of the invention or a pharmaceutically acceptable salt or solvate thereof or a composition containing the same is ingested or administered to a subject in need thereof. A method for improving the appearance of hair is provided, which comprises doing so. According to the present invention, an effective amount of the peptide of the present invention or a pharmaceutically acceptable salt or solvate thereof or a composition containing the same may be ingested or administered to a subject in need thereof. A method of treating, preventing or ameliorating hair loss, thinning or bleaching, which comprises, is provided. According to the present invention, an effective amount of the peptide of the present invention or a pharmaceutically acceptable salt or solvate thereof or a composition containing the same may be ingested or administered to a subject in need thereof. A method for promoting hair growth and a method for suppressing hair loss are provided. The method of the present invention can be carried out according to the description regarding the composition and the preparation of the present invention.

According to yet another aspect of the present invention, the peptide of the present invention or a pharmaceutically acceptable product thereof, as a hair appearance improving agent for producing a hair appearance improving agent, or in the hair appearance improving method of the present invention. The use of salts or solvates to be made is provided. According to the present invention, also as a therapeutic agent, preventive agent or improving agent for hair loss, thinning or bleaching, or as a therapeutic agent, preventive agent or improving agent for hair loss, thinning or bleaching. The use of the peptides of the invention or pharmaceutically acceptable salts or solvates thereof in the methods of treating, preventing or ameliorating hair loss, thinning or bleaching of the invention is provided. According to the present invention, the peptide of the present invention is also used as a hair growth promoter or hair loss inhibitor for the production of a hair growth promoter or hair loss inhibitor, or in the hair growth promoting method or hair loss suppressing method of the present invention. Alternatively, the use of a pharmaceutically acceptable salt or solvate thereof is provided. The use of the present invention can be carried out in accordance with the description regarding the compositions and agents of the present invention.

According to yet another aspect of the present invention, there is provided a peptide having the amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof for use in improving the appearance of hair. The present invention also provides a peptide having an amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof for use in the treatment, prevention or amelioration of hair loss, thinning or bleaching. The present invention also provides a peptide having the amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof for use in promoting hair growth or suppressing hair loss. The peptides having the amino acid sequence of WY and the pharmaceutically acceptable salts and solvates thereof can be carried out according to the description regarding the compositions and solvates of the present invention.

The methods of the invention and the use of the invention may be in mammals, including humans, and are intended for both therapeutic and non-therapeutic use. As used herein, "non-therapeutic" means does not include the act of operating, treating or diagnosing a human (ie, medical practice for a human), specifically under the direction of a physician or physician. It means that a person does not include a method of performing surgery, treatment or diagnosis on a human.

The present invention will be described in more detail based on the following examples, but the present invention is not limited to these examples.

Example 1: Improvement effect of WY peptide on deterioration of appearance due to aging (1) Outline of test The appearance of the test food intake group and the non-intake group was compared and examined for aged mice. In addition, we compared it with the test food non-ingestion group of young mice. WY peptide was used as a test food.

(2) Mouse A C57BL / 6J male mouse (Charles River Japan, Inc., sometimes referred to simply as "this mouse" in the present specification) was used. According to the materials of Charles River Japan (https://www.crj.co.jp/cms/cmsrs/img/usr/top/B6-Aged.pdf), this mouse was developed by Jackson Laboratory. It is widely used in aging studies, and as a result of observing 32 of these mice, it has been disclosed that some individuals died at 100 weeks of age and all of them died by 170 weeks of age (1). Mouse phenome database (see https://www.phenome.jax.org/). The lifelong correspondence between this mouse and human is that humans 20 to 30 years old are 3 to 6 months old (mature individuals), humans 38 to 47 years old are 10 to 14 months old (middle-aged individuals), and humans 56. ~ 69 years old corresponds to 18-24 months old (aged individuals) of this mouse, respectively. In addition, it is said that the coat may become thin, gray or brown with aging, and partial hair loss may be observed. In this study, 78-week-old individuals of the present mouse as old mice and 6-month-old individuals of the present mouse as young mice were used after 1 month of acclimatization. The aged mice were grouped so that there was no bias in body weight between the "old-age WY intake group" (9 mice) that received the test food (WY peptide) and the "old-age non-ingestion group" (8 mice) that did not receive the test food. Divided. In addition, the young mice were set as the "young non-ingestion group" (5 mice) not fed with the test food, and were bred under the same conditions as the old non-ingestion group. The weight of each individual at the time of allocation and evaluation was measured.

(3) Administration of test food (WY peptide) To the old WY intake group, WY peptide was forcibly administered intragastrically with a sonde so as to have an amount of 10 mg / kg. The WY peptide was dissolved in distilled water so that the intake amount was 10 mL / kg (mouse body weight) before use. In the old-age non-ingestion group, 10 mL / kg (mouse body weight) of distilled water containing no WY peptide was forcibly administered intragastrically with a sonde. The intake period was 13 days.

(4) Evaluation After the end of the ingestion period, each individual mouse was observed from the back and evaluated. The evaluation items were three items: hair volume (appearance of volume) and hair quality, such as hair gloss and hair color. Since there was almost no variation in hair volume and hair quality in each individual in the young non-ingestion group, the old WY intake group and the old non-intake group were based on the hair volume and hair quality in the young non-ingestion group. Each individual was evaluated on a 5-point scale based on the evaluation criteria shown in Table 1. According to the observations in this test, it was confirmed that the coat color of this mouse decolorized (whitened) in the order of black, brown, light brown, and white with aging. Therefore, the evaluation of the coat color was not performed at a young age. It was not a comparison with the intake group, but an absolute evaluation that evaluated the ratio of white hair (white hair) to the entire hair in each individual. In addition, it was also confirmed by observation in this test that hair loss progressed in this mouse and the amount of hair (appearance of volume) decreased. The evaluation was conducted by discussions between two researchers.

(5) Statistical processing The measured values of each group are expressed as mean ± standard deviation. The test was performed by t-test, and when the risk rate P <0.05%, there was a significant difference between the two groups compared.

(6) Results The results were as shown in FIGS. 1, 2 and 3.

From the results of FIGS. 1, 2 and 3, the scores of hair volume and hair quality (hair gloss, hair color) in the old non-ingestion group were extremely lower than those in the young non-ingestion group. On the other hand, in the old-age WY intake group, the scores of hair volume and hair quality (hair gloss, hair color) were significantly increased as compared with the old-age non-intake group, and it was confirmed that the scores were similar to those in the young non-intake group. It was. The improvement in hair quality in the aged WY intake group was considered to be due to the improvement in hair quality (hair gloss, coat color) of newly grown hair due to turnover (hair loss and hair growth). From this, further, regarding the improvement of the amount of hair (hair loss) in the old WY intake group, it is considered that the number of newly grown hairs may have increased due to the turnover. From these results, it was shown that the intake of WY peptide improved the deterioration of hair volume and hair quality (hair gloss, hair color), and improved the aging and deterioration of hair appearance. Further, as described above, it was confirmed that in this mouse, hair loss progressed and the hair volume decreased with aging, and the hair volume increased significantly in the old WY intake group as compared with the old non-intake group. Therefore, it can be said that ingestion of WY peptide is effective in promoting hair growth and suppressing hair loss.

Claims (10)

A composition for improving the appearance of hair, which comprises a peptide having the amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof as an active ingredient. The composition according to claim 1, which is used for suppressing and / or improving the deterioration of the appearance of hair. The composition according to claim 1 or 2, wherein the deterioration of the appearance of hair is due to aging. The composition according to any one of claims 1 to 3, wherein the deterioration of the appearance of the hair is related to the amount and / or the quality of the hair. The composition according to claim 4, wherein the deterioration in appearance with respect to the amount of hair is at least one selected from the group consisting of hair loss, thinning hair and reduction in hair thickness. The composition according to claim 4, wherein the deterioration of the appearance regarding the hair quality is at least one selected from the group consisting of decolorization of hair color, lightening of hair color, reduction of hair gloss and reduction of hair hardness. object. The composition according to any one of claims 1 to 6, for ingestion by middle-aged and elderly people. The composition according to any one of claims 1 to 7, which is in the form of food. A composition for treating, preventing or ameliorating hair loss, thinning, bleaching and / or lightening, comprising as an active ingredient a peptide having the amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof. .. A composition for promoting hair growth and / or suppressing hair loss, which comprises a peptide having an amino acid sequence of WY or a pharmaceutically acceptable salt or solvate thereof as an active ingredient.

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