JP2020078363A5 - - Google Patents

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Publication number
JP2020078363A5
JP2020078363A5 JP2018211857A JP2018211857A JP2020078363A5 JP 2020078363 A5 JP2020078363 A5 JP 2020078363A5 JP 2018211857 A JP2018211857 A JP 2018211857A JP 2018211857 A JP2018211857 A JP 2018211857A JP 2020078363 A5 JP2020078363 A5 JP 2020078363A5
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Japan
Prior art keywords
mold
manufacturing
production method
water
irradiating
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Pending
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JP2018211857A
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Japanese (ja)
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JP2020078363A (en
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Priority to JP2018211857A priority Critical patent/JP2020078363A/en
Priority claimed from JP2018211857A external-priority patent/JP2020078363A/en
Publication of JP2020078363A publication Critical patent/JP2020078363A/en
Publication of JP2020078363A5 publication Critical patent/JP2020078363A5/ja
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Claims (9)

レーザー鋳型の材料に照射して削孔し、鋳型を成型する工程、及び
前記成型した鋳型の上に水溶性高分子又は水膨潤性樹脂含有する基材水溶液を流延し、乾燥させる工程を含むマイクロニードルアレイの製造方法。
The process of irradiating the material of the mold with laser light to make holes and molding the mold, and spreading a base material aqueous solution containing a water-soluble polymer or a water-swellable resin on the molded mold. A method for manufacturing a microneedle array, which comprises a step of drying and drying.
前記鋳型の材料がプラスチックシートである、請求項1に記載の製造方法。The manufacturing method according to claim 1, wherein the material of the mold is a plastic sheet. 前記プラスチックがポリ塩化ビニル、ポリスチレン、ポリメチルメタクリレート、ポリエチレンテレフタレート、及びナイロンからなる群より選ばれる、請求項2に記載の製造方法。The production method according to claim 2, wherein the plastic is selected from the group consisting of polyvinyl chloride, polystyrene, polymethylmethacrylate, polyethylene terephthalate, and nylon. 前記レーザー光を鋳型の材料に照射して開けられた孔の大きさが、最深部において直径10〜80μmであり、最深部までの深さ100〜1600μmであり、孔の表面直径120〜400μmである、請求項1〜3のいずれか1項に記載の製造方法。The size of the hole formed by irradiating the material of the mold with the laser beam is 10 to 80 μm in diameter at the deepest part, 100 to 1600 μm in depth to the deepest part, and the surface diameter of the hole is 120 to 400 μm. The manufacturing method according to any one of claims 1 to 3. 前記削孔のピッチが100〜1800μmである、請求項1〜4のいずれか1項に記載の製造方法。The manufacturing method according to any one of claims 1 to 4, wherein the drilling pitch is 100 to 1800 μm. 前記レーザー光を鋳型の材料に照射して開けられた孔の形状が円錐形、円錐台形、又はコニーデ形である、請求項1〜5のいずれか1項に記載の製造方法。The manufacturing method according to any one of claims 1 to 5, wherein the shape of the hole formed by irradiating the material of the mold with the laser beam is a conical shape, a conical trapezoidal shape, or a conide shape. 前記水溶性高分子又は水膨潤性樹脂がThe water-soluble polymer or water-swellable resin
グリコーゲン、デキストリン、デキストラン、デキストラン硫酸、コンドロイチン硫酸ナトリウム、ヒドロキシプロピルセルロース、アルギン酸、アガロース、キチン、キトサン、プルラン、アミロペクチン、澱粉、ヒアルロン酸、カルボキシメチルセルロース、;Glycogen, dextrin, dextran, dextran sulfate, sodium chondroitin sulfate, hydroxypropyl cellulose, alginic acid, agarose, chitin, chitosan, pullulan, amylopectin, starch, hyaluronic acid, carboxymethyl cellulose ,;
コラーゲン、ゼラチン、アルブミン、及びこれらの加水分解物;ならびに、Collagen, gelatin, albumin, and their hydrolysates; and
ポリビニルアルコール、カルボキシビニルポリマー、ポリアクリル酸ナトリウム、ポリビニルピロリドン、ポリエチレングリコールPolyvinyl alcohol, carboxyvinyl polymer, sodium polyacrylate, polyvinylpyrrolidone, polyethylene glycol
からなる群より選ばれる1種又は2種以上である、請求項1〜6のいずれか1項に記載の製造方法。The production method according to any one of claims 1 to 6, wherein the production method is one or more selected from the group consisting of two or more.
前記基剤水溶液が、さらに、香粧的又は薬学的に利用可能な薬効成分を含有していることを特徴とする、請求項1〜7のいずれか1項に記載の製造方法。The production method according to any one of claims 1 to 7, wherein the base aqueous solution further contains a medicinal ingredient that can be used cosmetically or pharmaceutically. 前記乾燥工程後に、香粧的又は薬学的に利用可能な薬効成分をマイクロニードルアレイに塗布する工程を含む、請求項1〜7のいずれか1項に記載の製造方法。The production method according to any one of claims 1 to 7, further comprising a step of applying a cosmetically or pharmaceutically usable medicinal ingredient to the microneedle array after the drying step.
JP2018211857A 2018-11-10 2018-11-10 Method of manufacturing microneedle arrays Pending JP2020078363A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018211857A JP2020078363A (en) 2018-11-10 2018-11-10 Method of manufacturing microneedle arrays

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2018211857A JP2020078363A (en) 2018-11-10 2018-11-10 Method of manufacturing microneedle arrays

Publications (2)

Publication Number Publication Date
JP2020078363A JP2020078363A (en) 2020-05-28
JP2020078363A5 true JP2020078363A5 (en) 2021-12-09

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ID=70801346

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018211857A Pending JP2020078363A (en) 2018-11-10 2018-11-10 Method of manufacturing microneedle arrays

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JP (1) JP2020078363A (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
JP4427691B2 (en) * 2008-04-14 2010-03-10 コスメディ製薬株式会社 Microneedle array
JP6186806B2 (en) * 2013-03-29 2017-08-30 凸版印刷株式会社 Acicular body manufacturing method and acicular body

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