JP2020070257A5 - - Google Patents
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- JP2020070257A5 JP2020070257A5 JP2018205705A JP2018205705A JP2020070257A5 JP 2020070257 A5 JP2020070257 A5 JP 2020070257A5 JP 2018205705 A JP2018205705 A JP 2018205705A JP 2018205705 A JP2018205705 A JP 2018205705A JP 2020070257 A5 JP2020070257 A5 JP 2020070257A5
- Authority
- JP
- Japan
- Prior art keywords
- atrophy
- lys
- amino acid
- acid sequence
- found
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 206010003694 Atrophy Diseases 0.000 description 2
- CZVQSYNVUHAILZ-UWVGGRQHSA-N His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CN=CN1 CZVQSYNVUHAILZ-UWVGGRQHSA-N 0.000 description 2
- 210000003079 Salivary Glands Anatomy 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 210000004072 Lung Anatomy 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Description
本発明者らは、上記課題を解決するために鋭意研究したところ、Ｈｉｓ−Ｌｙｓ（ヒスチジン−リジン）のアミノ酸配列を含むペプチド又はその塩が、唾液腺及び肺の萎縮又は機能低下を抑制又は回復させる作用を有することを見出した。Ｈｉｓ−Ｌｙｓのアミノ酸配列を含むペプチドが、唾液腺等の臓器の萎縮又は機能低下を抑制又は回復させる作用を有することは、これまで報告されていない。本発明者らは、かかる知見に基づいて、さらに研究を行って本発明を完成させた。
As a result of diligent research to solve the above problems, the present inventors have found that a peptide containing the amino acid sequence of His-Lys (histidine-lysine ) or a salt thereof suppresses or restores atrophy or functional deterioration of salivary glands and lungs. It was found to have an effect. It has not been reported so far that a peptide containing the amino acid sequence of His-Lys has an action of suppressing or recovering atrophy or functional deterioration of organs such as salivary glands. Based on such findings, the present inventors further conducted research to complete the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018205705A JP7097023B2 (en) | 2018-10-31 | 2018-10-31 | Peptides, compositions for suppressing or recovering salivary gland atrophy or dysfunction, and compositions for suppressing or recovering lung atrophy or dysfunction. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018205705A JP7097023B2 (en) | 2018-10-31 | 2018-10-31 | Peptides, compositions for suppressing or recovering salivary gland atrophy or dysfunction, and compositions for suppressing or recovering lung atrophy or dysfunction. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020070257A JP2020070257A (en) | 2020-05-07 |
| JP2020070257A5 true JP2020070257A5 (en) | 2021-05-27 |
| JP7097023B2 JP7097023B2 (en) | 2022-07-07 |
Family
ID=70547015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018205705A Active JP7097023B2 (en) | 2018-10-31 | 2018-10-31 | Peptides, compositions for suppressing or recovering salivary gland atrophy or dysfunction, and compositions for suppressing or recovering lung atrophy or dysfunction. |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7097023B2 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011065552A1 (en) | 2009-11-30 | 2011-06-03 | 明治乳業株式会社 | Nutritional composition beneficial to small intestine |
| ITMI20132169A1 (en) | 2013-12-20 | 2015-06-21 | Thompson S R L | COMPOSITION FOR THE PREVENTION AND TREATMENT OF COPD AND RELATED SYMPTOMS |
-
2018
- 2018-10-31 JP JP2018205705A patent/JP7097023B2/en active Active
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