JP2019533705A5 - - Google Patents
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- Publication number
- JP2019533705A5 JP2019533705A5 JP2019524144A JP2019524144A JP2019533705A5 JP 2019533705 A5 JP2019533705 A5 JP 2019533705A5 JP 2019524144 A JP2019524144 A JP 2019524144A JP 2019524144 A JP2019524144 A JP 2019524144A JP 2019533705 A5 JP2019533705 A5 JP 2019533705A5
- Authority
- JP
- Japan
- Prior art keywords
- rhdl
- preparation according
- apolipoprotein
- rhdl preparation
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 claims 20
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 12
- 102000007592 Apolipoproteins Human genes 0.000 claims 8
- 108010071619 Apolipoproteins Proteins 0.000 claims 8
- 238000009472 formulation Methods 0.000 claims 8
- 150000002632 lipids Chemical class 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 6
- 235000012000 cholesterol Nutrition 0.000 claims 6
- 208000010125 myocardial infarction Diseases 0.000 claims 6
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 230000003907 kidney function Effects 0.000 claims 5
- 239000003381 stabilizer Substances 0.000 claims 5
- 239000004094 surface-active agent Substances 0.000 claims 5
- 101710180553 Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 4
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 4
- 230000001154 acute effect Effects 0.000 claims 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 4
- 230000003908 liver function Effects 0.000 claims 4
- 230000001906 cholesterol absorption Effects 0.000 claims 3
- 229940125753 fibrate Drugs 0.000 claims 3
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 3
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 3
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 2
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 2
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 2
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 2
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 2
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 2
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 238000008050 Total Bilirubin Reagent Methods 0.000 claims 2
- 206010000891 acute myocardial infarction Diseases 0.000 claims 2
- 229960005370 atorvastatin Drugs 0.000 claims 2
- 239000003613 bile acid Substances 0.000 claims 2
- 229940109239 creatinine Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 229960002797 pitavastatin Drugs 0.000 claims 2
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 2
- 229960000672 rosuvastatin Drugs 0.000 claims 2
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229960002855 simvastatin Drugs 0.000 claims 2
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
- 101150092476 ABCA1 gene Proteins 0.000 claims 1
- 102000055510 ATP Binding Cassette Transporter 1 Human genes 0.000 claims 1
- 108700005241 ATP Binding Cassette Transporter 1 Proteins 0.000 claims 1
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 claims 1
- 108010082126 Alanine transaminase Proteins 0.000 claims 1
- 229940123583 Factor Xa inhibitor Drugs 0.000 claims 1
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
- 235000009421 Myristica fragrans Nutrition 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- 101100379247 Salmo trutta apoa1 gene Proteins 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229940122388 Thrombin inhibitor Drugs 0.000 claims 1
- 238000002583 angiography Methods 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 229940030600 antihypertensive agent Drugs 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 239000003833 bile salt Substances 0.000 claims 1
- 229940093761 bile salts Drugs 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims 1
- 229960000815 ezetimibe Drugs 0.000 claims 1
- 229960003627 gemfibrozil Drugs 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 229960004844 lovastatin Drugs 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- 239000001115 mace Substances 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000008085 renal dysfunction Effects 0.000 claims 1
- 238000012959 renal replacement therapy Methods 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 239000003868 thrombin inhibitor Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 229940019333 vitamin k antagonists Drugs 0.000 claims 1
- 229960005080 warfarin Drugs 0.000 claims 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022089334A JP7464654B2 (ja) | 2016-11-10 | 2022-06-01 | 心筋梗塞の再構成された高密度リポタンパク質治療 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662420050P | 2016-11-10 | 2016-11-10 | |
| US62/420,050 | 2016-11-10 | ||
| US201762472240P | 2017-03-16 | 2017-03-16 | |
| US62/472,240 | 2017-03-16 | ||
| PCT/AU2017/051232 WO2018085890A1 (en) | 2016-11-10 | 2017-11-10 | Reconstituted high density lipoprotein treatment of myocardial infarction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022089334A Division JP7464654B2 (ja) | 2016-11-10 | 2022-06-01 | 心筋梗塞の再構成された高密度リポタンパク質治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019533705A JP2019533705A (ja) | 2019-11-21 |
| JP2019533705A5 true JP2019533705A5 (enExample) | 2020-11-12 |
Family
ID=62109053
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019524144A Pending JP2019533705A (ja) | 2016-11-10 | 2017-11-10 | 心筋梗塞の再構成された高密度リポタンパク質治療 |
| JP2022089334A Active JP7464654B2 (ja) | 2016-11-10 | 2022-06-01 | 心筋梗塞の再構成された高密度リポタンパク質治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022089334A Active JP7464654B2 (ja) | 2016-11-10 | 2022-06-01 | 心筋梗塞の再構成された高密度リポタンパク質治療 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20200038481A1 (enExample) |
| EP (1) | EP3538105A4 (enExample) |
| JP (2) | JP2019533705A (enExample) |
| KR (2) | KR20240044543A (enExample) |
| CN (2) | CN116196395A (enExample) |
| AU (2) | AU2017358402B2 (enExample) |
| BR (1) | BR112019007709A2 (enExample) |
| CA (1) | CA3043110A1 (enExample) |
| IL (1) | IL266428B2 (enExample) |
| MX (1) | MX2019005459A (enExample) |
| SG (2) | SG11201903945XA (enExample) |
| WO (1) | WO2018085890A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3373828B1 (en) | 2015-11-09 | 2025-12-10 | Revamp Medical Ltd. | Blood flow reducer for cardiovascular treatment |
| KR20210102284A (ko) * | 2018-12-11 | 2021-08-19 | 리벰프 메디컬 리미티드 | 체강의 혈류를 조절하기 위한 시스템, 장치 및 방법 |
| RS66416B1 (sr) | 2019-01-18 | 2025-02-28 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene |
| WO2025210584A1 (en) * | 2024-04-04 | 2025-10-09 | CSL Innovation Pty Ltd | Reconstituted high density lipoprotein treatment of myocardial infarction |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006507223A (ja) | 2002-05-17 | 2006-03-02 | エスペリオン セラピューティクス，インコーポレイテッド | 脂質代謝異常疾患の治療方法 |
| US8999920B2 (en) | 2010-06-30 | 2015-04-07 | Csl Limited | Reconstituted high density lipoprotein formulation and production method thereof |
| KR102766038B1 (ko) | 2011-12-21 | 2025-02-12 | 시에스엘 리미티드 | 아포지질단백질 제형을 위한 용량 용법 |
| US9125943B2 (en) * | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
| EP2853259A1 (en) | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Reconstituted high density lipoproteins composition and uses thereof |
| US20160074473A1 (en) | 2014-07-31 | 2016-03-17 | Kinemed, Inc. | Effect of phospholipid composition of reconstituted hdl on its cholesterol efflux and anti-inflammatory properties |
-
2017
- 2017-11-10 CN CN202310189946.6A patent/CN116196395A/zh active Pending
- 2017-11-10 CA CA3043110A patent/CA3043110A1/en active Pending
- 2017-11-10 EP EP17868674.7A patent/EP3538105A4/en active Pending
- 2017-11-10 US US16/348,106 patent/US20200038481A1/en not_active Abandoned
- 2017-11-10 WO PCT/AU2017/051232 patent/WO2018085890A1/en not_active Ceased
- 2017-11-10 JP JP2019524144A patent/JP2019533705A/ja active Pending
- 2017-11-10 AU AU2017358402A patent/AU2017358402B2/en active Active
- 2017-11-10 IL IL266428A patent/IL266428B2/en unknown
- 2017-11-10 KR KR1020247010199A patent/KR20240044543A/ko not_active Withdrawn
- 2017-11-10 BR BR112019007709A patent/BR112019007709A2/pt not_active Application Discontinuation
- 2017-11-10 SG SG11201903945XA patent/SG11201903945XA/en unknown
- 2017-11-10 SG SG10201911714YA patent/SG10201911714YA/en unknown
- 2017-11-10 CN CN201780069271.4A patent/CN109922810A/zh active Pending
- 2017-11-10 KR KR1020197016627A patent/KR20190084095A/ko not_active Ceased
- 2017-11-10 MX MX2019005459A patent/MX2019005459A/es unknown
-
2022
- 2022-06-01 JP JP2022089334A patent/JP7464654B2/ja active Active
-
2023
- 2023-08-03 US US18/230,058 patent/US20240207357A1/en active Pending
- 2023-12-15 AU AU2023282314A patent/AU2023282314A1/en active Pending
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