JP2019527037A5 - - Google Patents
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- JP2019527037A5 JP2019527037A5 JP2018564409A JP2018564409A JP2019527037A5 JP 2019527037 A5 JP2019527037 A5 JP 2019527037A5 JP 2018564409 A JP2018564409 A JP 2018564409A JP 2018564409 A JP2018564409 A JP 2018564409A JP 2019527037 A5 JP2019527037 A5 JP 2019527037A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- patient
- smarca2
- level
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 63
- 101000702559 Homo sapiens Probable global transcription activator SNF2L2 Proteins 0.000 claims 45
- 102100031021 Probable global transcription activator SNF2L2 Human genes 0.000 claims 45
- 230000014509 gene expression Effects 0.000 claims 39
- 239000003112 inhibitor Substances 0.000 claims 39
- 206010028980 Neoplasm Diseases 0.000 claims 36
- 239000003814 drug Substances 0.000 claims 35
- 201000011510 cancer Diseases 0.000 claims 34
- 230000011987 methylation Effects 0.000 claims 29
- 238000007069 methylation reaction Methods 0.000 claims 29
- 108090000623 proteins and genes Proteins 0.000 claims 27
- 102000004169 proteins and genes Human genes 0.000 claims 19
- 208000008938 Rhabdoid tumor Diseases 0.000 claims 12
- 102100025746 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Human genes 0.000 claims 12
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 claims 8
- 206010033128 Ovarian cancer Diseases 0.000 claims 8
- 108700028341 SMARCB1 Proteins 0.000 claims 8
- 101150008214 SMARCB1 gene Proteins 0.000 claims 8
- 102100031027 Transcription activator BRG1 Human genes 0.000 claims 8
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 7
- 206010017758 gastric cancer Diseases 0.000 claims 7
- 201000011549 stomach cancer Diseases 0.000 claims 7
- 102100034580 AT-rich interactive domain-containing protein 1A Human genes 0.000 claims 6
- 206010005003 Bladder cancer Diseases 0.000 claims 6
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 claims 6
- 101000924266 Homo sapiens AT-rich interactive domain-containing protein 1A Proteins 0.000 claims 6
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 claims 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 6
- 102100037516 Protein polybromo-1 Human genes 0.000 claims 6
- 206010073334 Rhabdoid tumour Diseases 0.000 claims 6
- 102100024793 SWI/SNF complex subunit SMARCC1 Human genes 0.000 claims 6
- 102100024790 SWI/SNF complex subunit SMARCC2 Human genes 0.000 claims 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 201000005292 ovarian small cell carcinoma Diseases 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 201000005112 urinary bladder cancer Diseases 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 102100023157 AT-rich interactive domain-containing protein 2 Human genes 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 101000685261 Homo sapiens AT-rich interactive domain-containing protein 2 Proteins 0.000 claims 4
- 101000601770 Homo sapiens Protein polybromo-1 Proteins 0.000 claims 4
- 101000687718 Homo sapiens SWI/SNF complex subunit SMARCC1 Proteins 0.000 claims 4
- 101000687720 Homo sapiens SWI/SNF complex subunit SMARCC2 Proteins 0.000 claims 4
- 101000835860 Homo sapiens SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Proteins 0.000 claims 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 108010047956 Nucleosomes Proteins 0.000 claims 4
- 208000036822 Small cell carcinoma of the ovary Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 210000001623 nucleosome Anatomy 0.000 claims 4
- 238000007634 remodeling Methods 0.000 claims 4
- 230000004043 responsiveness Effects 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 238000003364 immunohistochemistry Methods 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- FKSFKBQGSFSOSM-QFIPXVFZSA-N 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-[6-(1-piperazinyl)-3-pyridinyl]-4-indolecarboxamide Chemical compound C1=C2N([C@@H](C)CC)C=C(C)C2=C(C(=O)NCC=2C(NC(C)=CC=2C)=O)C=C1C(C=N1)=CC=C1N1CCNCC1 FKSFKBQGSFSOSM-QFIPXVFZSA-N 0.000 claims 2
- LHGUZCKPFXXVPV-UHFFFAOYSA-N 1-[1-(1-ethylsulfonyl-4-piperidinyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-3-indolecarboxamide Chemical compound C1CN(S(=O)(=O)CC)CCC1C(C)N1C2=CC=CC=C2C(C(=O)NCC=2C(NC(C)=CC=2OC)=O)=C1C LHGUZCKPFXXVPV-UHFFFAOYSA-N 0.000 claims 2
- ZOIBZSZLMJDVDQ-UHFFFAOYSA-N 1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-4-indazolecarboxamide Chemical compound O=C1NC(C)=CC(C)=C1CNC(=O)C1=CC(C=2C=CC(CN3CCOCC3)=CC=2)=CC2=C1C=NN2C1CCCC1 ZOIBZSZLMJDVDQ-UHFFFAOYSA-N 0.000 claims 2
- 206010061424 Anal cancer Diseases 0.000 claims 2
- 208000007860 Anus Neoplasms Diseases 0.000 claims 2
- 102100037151 Barrier-to-autointegration factor Human genes 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 238000001353 Chip-sequencing Methods 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- ULNXAWLQFZMIHX-UHFFFAOYSA-N GSK343 Chemical compound C1=C(C)NC(=O)C(CNC(=O)C=2C=3C=NN(C=3C=C(C=2)C=2C=C(N=CC=2)N2CCN(C)CC2)C(C)C)=C1CCC ULNXAWLQFZMIHX-UHFFFAOYSA-N 0.000 claims 2
- 101000740067 Homo sapiens Barrier-to-autointegration factor Proteins 0.000 claims 2
- 101000584499 Homo sapiens Polycomb protein SUZ12 Proteins 0.000 claims 2
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000002471 Penile Neoplasms Diseases 0.000 claims 2
- 206010034299 Penile cancer Diseases 0.000 claims 2
- 102100030702 Polycomb protein SUZ12 Human genes 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 101710136946 Protein polybromo-1 Proteins 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 101710169053 SWI/SNF complex subunit SMARCC1 Proteins 0.000 claims 2
- 101710169052 SWI/SNF complex subunit SMARCC2 Proteins 0.000 claims 2
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 2
- 206010061934 Salivary gland cancer Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 206010047741 Vulval cancer Diseases 0.000 claims 2
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 2
- 201000011165 anus cancer Diseases 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 208000009060 clear cell adenocarcinoma Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 230000000121 hypercalcemic effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 210000002751 lymph Anatomy 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- NSQSAUGJQHDYNO-UHFFFAOYSA-N n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide Chemical group C=1C(C=2C=CC(CN3CCOCC3)=CC=2)=CC(C(=O)NCC=2C(NC(C)=CC=2C)=O)=C(C)C=1N(CC)C1CCOCC1 NSQSAUGJQHDYNO-UHFFFAOYSA-N 0.000 claims 2
- HRDQQHUKUIKFHT-UHFFFAOYSA-N n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-3-methyl-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindole-4-carboxamide Chemical compound C1=C2N(C(C)C)C=C(C)C2=C(C(=O)NCC=2C(NC(C)=CC=2C)=O)C=C1C(C=N1)=CC=C1N1CCN(C)CC1 HRDQQHUKUIKFHT-UHFFFAOYSA-N 0.000 claims 2
- HPODOLXTMDHLLC-QGZVFWFLSA-N n-[(4-methoxy-6-methyl-2-oxo-1h-pyridin-3-yl)methyl]-2-methyl-1-[(1r)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide Chemical compound C1=C(C)NC(=O)C(CNC(=O)C=2C3=CC=CC=C3N([C@H](C)C3CCN(CC(F)(F)F)CC3)C=2C)=C1OC HPODOLXTMDHLLC-QGZVFWFLSA-N 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000002628 peritoneum cancer Diseases 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 150000003384 small molecules Chemical group 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 201000005102 vulva cancer Diseases 0.000 claims 2
- 108010033040 Histones Proteins 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 238000003559 RNA-seq method Methods 0.000 claims 1
- 238000011529 RT qPCR Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 238000011223 gene expression profiling Methods 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 238000002483 medication Methods 0.000 claims 1
- 238000010208 microarray analysis Methods 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 238000003196 serial analysis of gene expression Methods 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662347436P | 2016-06-08 | 2016-06-08 | |
| US62/347,436 | 2016-06-08 | ||
| PCT/US2017/036515 WO2017214373A1 (en) | 2016-06-08 | 2017-06-08 | Diagnostic and therapeutic methods for cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019527037A JP2019527037A (ja) | 2019-09-26 |
| JP2019527037A5 true JP2019527037A5 (enExample) | 2020-07-27 |
Family
ID=59325632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564409A Pending JP2019527037A (ja) | 2016-06-08 | 2017-06-08 | がんのための診断及び治療方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20200129519A1 (enExample) |
| EP (1) | EP3469099A1 (enExample) |
| JP (1) | JP2019527037A (enExample) |
| CN (1) | CN109312407A (enExample) |
| WO (1) | WO2017214373A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102021642B1 (ko) | 2012-10-15 | 2019-09-16 | 에피자임, 인코포레이티드 | 암을 치료하는 방법 |
| CN108025191A (zh) | 2015-08-24 | 2018-05-11 | Epizyme股份有限公司 | 治疗癌症的方法 |
| AU2018217139A1 (en) * | 2017-02-02 | 2019-08-22 | Epizyme, Inc. | Cancer treatment modalities |
| JP2020508995A (ja) * | 2017-02-28 | 2020-03-26 | エピザイム，インコーポレイティド | 癌の処置のためのｓｍａｒｃａ２の阻害 |
| US20220154295A1 (en) * | 2019-03-27 | 2022-05-19 | The Johns Hopkins University | Methods and materials for assessing and treating cancer |
| CN111849866B (zh) * | 2020-07-15 | 2022-06-24 | 华南农业大学 | H3K27me3调控FoxO1基因表达在猪卵巢颗粒细胞中的应用 |
| CN112904006B (zh) * | 2021-01-28 | 2022-12-27 | 中山大学 | 一种乳腺癌预后预测分子标志物及其应用 |
| US20240401145A1 (en) * | 2021-09-28 | 2024-12-05 | Paul Scherrer Institut | Method for predicting the response of a patient diagnosed with cancer to treatment and/or imaging with a compound targeting cck2-r, and compound for use in methods of selectively treating and/or imaging cancer |
| JP2023082308A (ja) * | 2021-12-02 | 2023-06-14 | 国立大学法人 長崎大学 | スクリーニング方法、環状ペプチドおよびこれを含む癌細胞増殖抑制剤 |
| DE102022112378B4 (de) * | 2022-05-17 | 2024-02-15 | Abberior Instruments Gmbh | Verfahren, lichtmikroskop und computerprogramm zur bestimmung eines referenzzeitpunktes |
| KR102930473B1 (ko) * | 2022-11-22 | 2026-02-26 | 주식회사 네오나 | Gas5 억제제 및 smarca4 억제제를 유효성분으로 포함하는 간암 예방 또는 치료용 약학 조성물 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| CA2066428C (en) | 1989-09-08 | 2000-11-28 | Bert Vogelstein | Structural alterations of the egf receptor gene in human gliomas |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| DK0659439T3 (da) | 1993-12-24 | 2002-01-14 | Merck Patent Gmbh | Immunkonjugater |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| HU216142B (hu) | 1994-07-21 | 1999-04-28 | Akzo Nobel N.V. | Ciklusos keton-peroxidokat tartalmazó kompozíciók, és azok alkalmazása (ko)polimerek módosítására |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| JPH11507535A (ja) | 1995-06-07 | 1999-07-06 | イムクローン システムズ インコーポレイテッド | 腫瘍の成長を抑制する抗体および抗体フラグメント類 |
| EP0836605B1 (en) | 1995-07-06 | 2002-02-06 | Novartis AG | Pyrrolopyrimidines and processes for the preparation thereof |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| JP3370340B2 (ja) | 1996-04-12 | 2003-01-27 | ワーナー―ランバート・コンパニー | チロシンキナーゼの不可逆的阻害剤 |
| DE69716916T2 (de) | 1996-07-13 | 2003-07-03 | Glaxo Group Ltd., Greenford | Kondensierte heterozyklische verbindungen als protein kinase inhibitoren |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| ES2201484T3 (es) | 1997-05-06 | 2004-03-16 | Wyeth Holdings Corporation | Utilizacion de compuestos de quinazolina para el tratamiento de la enfermedad de la poliquistosis renal. |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| NZ503991A (en) | 1997-11-06 | 2001-11-30 | American Cyanamid Co | Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps |
| ES2188254T3 (es) | 1998-11-19 | 2003-06-16 | Warner Lambert Co | N-(4-(3-chloro-4-fluoro-fenilamino)-7-(3-morfolin-4-il-propoxi)-quin azolin-6-il)-acrilamada, un inhibidor irreversible de tirosina quinasas. |
| US20140296248A1 (en) * | 2011-04-04 | 2014-10-02 | Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
| KR102021642B1 (ko) * | 2012-10-15 | 2019-09-16 | 에피자임, 인코포레이티드 | 암을 치료하는 방법 |
| US20160091485A1 (en) * | 2013-04-25 | 2016-03-31 | The Broad Institute, Inc. | Markers for ezh2 inhibitors |
| TW201718598A (zh) * | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| MX2018003663A (es) * | 2015-09-25 | 2018-08-14 | Epizyme Inc | Metodo de tratamiento de tumor rabdoide maligno del ovario (mrto) /cancer microcitico del ovario del tipo hipercalcemico (sccoht) con un inhibidor de ezh2. |
| WO2017139404A1 (en) * | 2016-02-08 | 2017-08-17 | Epizyme, Inc. | Methods of treating cancer |
-
2017
- 2017-06-08 WO PCT/US2017/036515 patent/WO2017214373A1/en not_active Ceased
- 2017-06-08 US US16/305,708 patent/US20200129519A1/en not_active Abandoned
- 2017-06-08 EP EP17739384.0A patent/EP3469099A1/en not_active Withdrawn
- 2017-06-08 CN CN201780035692.5A patent/CN109312407A/zh active Pending
- 2017-06-08 JP JP2018564409A patent/JP2019527037A/ja active Pending
-
2021
- 2021-07-08 US US17/370,721 patent/US20210338684A1/en not_active Abandoned
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| Losada | Low Cohesive Gastric Cancer of the Antrum and Duodenum. Multi-omics analysis Can it Im-prove Treatment |