JP2019524774A - 炎症性皮膚疾患及び皮膚病変を処置するための酸素化コレステロール硫酸（ｏｃｓ）の使用 - Google Patents

炎症性皮膚疾患及び皮膚病変を処置するための酸素化コレステロール硫酸（ｏｃｓ）の使用 Download PDF

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JP2019524774A
JP2019524774A JP2019505256A JP2019505256A JP2019524774A JP 2019524774 A JP2019524774 A JP 2019524774A JP 2019505256 A JP2019505256 A JP 2019505256A JP 2019505256 A JP2019505256 A JP 2019505256A JP 2019524774 A JP2019524774 A JP 2019524774A
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composition
skin
ocs
disease
25hc3s
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JP2019524774A5 (enExample
Inventor
レン，シュンリン
リン，ウェイチー
イー． ブラウン，ジェームズ
イー． ブラウン，ジェームズ
ティーウウェス，フェリックス
ジーン キム，ミー
ジーン キム，ミー
アール． ミクスズタル，アンドリュー
アール． ミクスズタル，アンドリュー
ウー，ホンウェイ
エル． リー，ミン
エル． リー，ミン
スー，フエイ−チン
タムラズ，ウィルマ
Original Assignee
ヴァージニア コモンウェルス ユニバーシティ
ヴァージニア コモンウェルス ユニバーシティ
デュレクト コーポレーション
デュレクト コーポレーション
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Publication of JP2019524774A publication Critical patent/JP2019524774A/ja
Publication of JP2019524774A5 publication Critical patent/JP2019524774A5/ja
Priority to JP2021185644A priority Critical patent/JP2022031733A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019505256A 2016-08-02 2017-08-01 炎症性皮膚疾患及び皮膚病変を処置するための酸素化コレステロール硫酸（ｏｃｓ）の使用 Pending JP2019524774A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021185644A JP2022031733A (ja) 2016-08-02 2021-11-15 炎症性皮膚疾患及び皮膚病変を処置するための酸素化コレステロール硫酸（ｏｃｓ）の使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662370036P 2016-08-02 2016-08-02
US62/370,036 2016-08-02
US201762470576P 2017-03-13 2017-03-13
US62/470,576 2017-03-13
PCT/US2017/044821 WO2018026767A1 (en) 2016-08-02 2017-08-01 Use of oxygenated cholesterol sulfates (ocs) to treat inflammatory skin disease and skin lesions

Related Child Applications (1)

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JP2021185644A Division JP2022031733A (ja) 2016-08-02 2021-11-15 炎症性皮膚疾患及び皮膚病変を処置するための酸素化コレステロール硫酸（ｏｃｓ）の使用

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JP2019524774A true JP2019524774A (ja) 2019-09-05
JP2019524774A5 JP2019524774A5 (enExample) 2020-08-27

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JP2019505256A Pending JP2019524774A (ja) 2016-08-02 2017-08-01 炎症性皮膚疾患及び皮膚病変を処置するための酸素化コレステロール硫酸（ｏｃｓ）の使用
JP2021185644A Pending JP2022031733A (ja) 2016-08-02 2021-11-15 炎症性皮膚疾患及び皮膚病変を処置するための酸素化コレステロール硫酸（ｏｃｓ）の使用

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US (2) US20190374554A1 (enExample)
EP (1) EP3493671A4 (enExample)
JP (2) JP2019524774A (enExample)
KR (2) KR102568036B1 (enExample)
CN (1) CN109862787A (enExample)
AU (2) AU2017306140A1 (enExample)
BR (1) BR112019001193A2 (enExample)
CA (1) CA3031211A1 (enExample)
IL (1) IL264389A (enExample)
MX (1) MX2019001324A (enExample)
TW (2) TW201818944A (enExample)
WO (1) WO2018026767A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023539595A (ja) * 2020-08-26 2023-09-15 オティカラ，インコーポレーテッド 鼻、耳及び他の組織の感染症及び／又は炎症を処置するための組成物、デバイス及び方法

Families Citing this family (7)

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WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
SMT202200094T1 (it) 2013-12-24 2022-05-12 Univ Virginia Commonwealth Uso di solfati di colesterolo ossigenati (ocs) per il trattamento dell’insufficienza epatica acuta
WO2018026781A1 (en) 2016-08-02 2018-02-08 Virginia Commonwealth University Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
AU2021221109A1 (en) * 2020-02-11 2022-08-25 Durect Corporation Treatment of infectious diseases
CN113040140B (zh) * 2021-01-28 2022-06-03 菲吉乐科(南京)生物科技有限公司 一种适合噬菌体浸入藤本和木本植物用的辅助渗透剂及其制备方法和应用
CN113521094A (zh) * 2021-05-23 2021-10-22 广州奇维生物信息技术有限公司 一种治疗湿疹的乳剂软膏及其制备方法
CN114646702B (zh) * 2022-03-03 2023-01-06 四川大学华西医院 胆固醇硫酸酯检测试剂在制备脓毒症辅助诊断、治疗效果监测和预后评估试剂盒中的用途

Citations (3)

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JPS63502437A (ja) * 1986-01-27 1988-09-14 ジャビット、ノ−マン・ビィ 酸素化コレステロ−ル含有組成物および疾患の局所的処置のためのその用途
US20100273761A1 (en) * 2004-10-25 2010-10-28 Shunlin Ren Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
JP2015512937A (ja) * 2012-04-12 2015-04-30 ヴァージニア コモンウェルス ユニバーシティ 代謝障害、高脂血症、糖尿病、脂肪性肝疾患及びアテローム性動脈硬化症の治療のための新規コレステロール代謝物、５−コレステン−３β，２５−ジオール二硫酸塩（２５ＨＣＤＳ）

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US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
US20120253143A1 (en) * 2011-04-04 2012-10-04 Raphael Warren Method of measuring a skin agent transferred to skin
SMT202200094T1 (it) * 2013-12-24 2022-05-12 Univ Virginia Commonwealth Uso di solfati di colesterolo ossigenati (ocs) per il trattamento dell’insufficienza epatica acuta

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JPS63502437A (ja) * 1986-01-27 1988-09-14 ジャビット、ノ−マン・ビィ 酸素化コレステロ−ル含有組成物および疾患の局所的処置のためのその用途
US20100273761A1 (en) * 2004-10-25 2010-10-28 Shunlin Ren Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
JP2015512937A (ja) * 2012-04-12 2015-04-30 ヴァージニア コモンウェルス ユニバーシティ 代謝障害、高脂血症、糖尿病、脂肪性肝疾患及びアテローム性動脈硬化症の治療のための新規コレステロール代謝物、５−コレステン−３β，２５−ジオール二硫酸塩（２５ＨＣＤＳ）

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023539595A (ja) * 2020-08-26 2023-09-15 オティカラ，インコーポレーテッド 鼻、耳及び他の組織の感染症及び／又は炎症を処置するための組成物、デバイス及び方法

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MX2019001324A (es) 2019-07-04
KR102568036B1 (ko) 2023-08-17
AU2017306140A1 (en) 2019-02-21
AU2022205208A1 (en) 2022-08-04
CN109862787A (zh) 2019-06-07
WO2018026767A1 (en) 2018-02-08
EP3493671A1 (en) 2019-06-12
US20190374554A1 (en) 2019-12-12
CA3031211A1 (en) 2018-02-08
EP3493671A4 (en) 2020-04-08
TW201818944A (zh) 2018-06-01
JP2022031733A (ja) 2022-02-22
KR20230124756A (ko) 2023-08-25
IL264389A (en) 2019-02-28
TW202308651A (zh) 2023-03-01
KR20190032530A (ko) 2019-03-27
BR112019001193A2 (pt) 2019-04-30
US20210169902A1 (en) 2021-06-10

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