JP2019513829A - 抗炎症剤、抗転移剤及び／又は抗癌剤として使用するためのアミノ安息香酸誘導体 - Google Patents

抗炎症剤、抗転移剤及び／又は抗癌剤として使用するためのアミノ安息香酸誘導体 Download PDF

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JP2019513829A
JP2019513829A JP2019503603A JP2019503603A JP2019513829A JP 2019513829 A JP2019513829 A JP 2019513829A JP 2019503603 A JP2019503603 A JP 2019503603A JP 2019503603 A JP2019503603 A JP 2019503603A JP 2019513829 A JP2019513829 A JP 2019513829A
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cancer
compound
acetyl
substituted
alkyl
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JP2019513829A5 (enExample
Inventor
ベルベ、ジェルヴェ
− モレノ、カルロス レイエ
− モレノ、カルロス レイエ
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３アール ヴァロ、エス．イー．シー．
３アール ヴァロ、エス．イー．シー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
JP2019503603A 2016-04-11 2017-04-10 抗炎症剤、抗転移剤及び／又は抗癌剤として使用するためのアミノ安息香酸誘導体 Ceased JP2019513829A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662320654P 2016-04-11 2016-04-11
US62/320,654 2016-04-11
PCT/CA2017/050432 WO2017177316A1 (en) 2016-04-11 2017-04-10 Aminobenzoic acid derivatives for use as anti-inflammatory agents, anti-metastatic agents and/or anticancer agents

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JP2019513829A true JP2019513829A (ja) 2019-05-30
JP2019513829A5 JP2019513829A5 (enExample) 2020-05-21

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JP2019503603A Ceased JP2019513829A (ja) 2016-04-11 2017-04-10 抗炎症剤、抗転移剤及び／又は抗癌剤として使用するためのアミノ安息香酸誘導体

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US (2) US10759754B2 (enExample)
EP (1) EP3442943B1 (enExample)
JP (1) JP2019513829A (enExample)
CN (1) CN109071433A (enExample)
CA (1) CA3020348A1 (enExample)
WO (1) WO2017177316A1 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
MY205943A (en) 2018-01-17 2024-11-21 Aurigene Discovery Tech Ltd Substituted alkynylene compounds as anticancer agents
CA3021417A1 (en) * 2018-10-18 2020-04-18 3R Valo, S.E.C. Aminobenzoic acid derivatives for use as anti-inflammatory agents, anti-metastatic agents and/or anticancer agents
CN114516819B (zh) * 2022-02-25 2024-02-27 顺毅宜昌化工有限公司 一种n,n’-二乙酰基肼的制备方法
CN117447353B (zh) * 2023-09-21 2025-12-30 爱斯特（成都）生物制药股份有限公司 一种氘可来昔替尼中间体的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091246A1 (en) * 2004-11-01 2006-08-31 University Of Southern California Novel compounds for treatment of cancer and disorders associated with angiogenesis function

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US3046301A (en) 1959-10-29 1962-07-24 Burroughs Wellcome Co Method of making chlorambucil
DK3310800T3 (da) * 2015-06-19 2022-02-28 Centurion Biopharma Corp Leveringssystem til styret lægemiddelfrigivelse

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091246A1 (en) * 2004-11-01 2006-08-31 University Of Southern California Novel compounds for treatment of cancer and disorders associated with angiogenesis function

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AL-AZZAWI, AM ET AL.: "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW SUCCINIMIDES BEARING DIFFERENT HETEROCYCLES", INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY, vol. 4, JPN6021012994, 2014, pages 755 - 762, XP002756060, ISSN: 0004482933 *
BEYER, U ET AL.: "Synthesis of new bifunctional maleimide compounds for the preparation of chemoimmunoconjugates", MONATSHEFTE FUER CHEMIE, vol. 128, JPN6021012997, 1997, pages 91 - 102, XP009023613, ISSN: 0004482931, DOI: 10.1007/BF00807643 *
DESAI, GT ET AL.: "Study of novel pyrrolidine compounds", JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, vol. 6, JPN6021012992, 2014, pages 2624 - 2627, XP009509567, ISSN: 0004482934 *
FAHMY, MM ET AL.: "Novel Antimicrobial Organic Thermal Stabilizer and Co-Stabilizer for Rigid PVC", MOLECULES, vol. 17, JPN6021012991, 2012, pages 7927 - 7940, XP055526069, ISSN: 0004482935, DOI: 10.3390/molecules17077927 *
HAMELIN-MORRISSETTE, J ET AL.: "Identification of an anti-inflammatory derivative with anti-cancer potential: The impact of each of", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 96, JPN6021012996, 2015, pages 259 - 268, XP029168227, ISSN: 0004482932, DOI: 10.1016/j.ejmech.2015.04.026 *
HIRAN, BL ET AL.: "Radical Copolymerization of Maleimide Derivatives with n-butyl Acrylate and Characterization of Poly", INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol. 62, JPN6021012988, 2013, pages 243 - 246, ISSN: 0004482937 *
MOSTAFAVI, SH ET AL.: "Optimization of paclitaxel-loaded poly (D,L-lactide-co-glycolide-N-p-maleimido benzoic hydrazide) na", PARHACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 20, JPN6021012989, 2015, pages 845 - 853, ISSN: 0004482936 *

Also Published As

Publication number Publication date
US10759754B2 (en) 2020-09-01
EP3442943A4 (en) 2019-03-20
EP3442943B1 (en) 2020-10-07
CA3020348A1 (en) 2017-10-19
US20190127325A1 (en) 2019-05-02
WO2017177316A1 (en) 2017-10-19
EP3442943A1 (en) 2019-02-20
US20210002222A1 (en) 2021-01-07
CN109071433A (zh) 2018-12-21

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