JP2019513359A5 - - Google Patents
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- Publication number
- JP2019513359A5 JP2019513359A5 JP2018550449A JP2018550449A JP2019513359A5 JP 2019513359 A5 JP2019513359 A5 JP 2019513359A5 JP 2018550449 A JP2018550449 A JP 2018550449A JP 2018550449 A JP2018550449 A JP 2018550449A JP 2019513359 A5 JP2019513359 A5 JP 2019513359A5
- Authority
- JP
- Japan
- Prior art keywords
- colloidal suspension
- nanocapsules
- suspension according
- eox
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002088 nanocapsule Substances 0.000 claims description 20
- 239000000725 suspension Substances 0.000 claims description 18
- 239000002563 ionic surfactant Substances 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 8
- 239000002736 nonionic surfactant Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- -1 polyoxyethylene Polymers 0.000 claims 5
- 229920001400 block copolymer Polymers 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 229920001477 hydrophilic polymer Polymers 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 125000000129 anionic group Chemical group 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 239000000341 volatile oil Substances 0.000 claims 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical group CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 claims 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 240000002234 Allium sativum Species 0.000 claims 1
- 235000017519 Artemisia princeps Nutrition 0.000 claims 1
- 244000065027 Artemisia princeps Species 0.000 claims 1
- 244000056139 Brassica cretica Species 0.000 claims 1
- 235000003351 Brassica cretica Nutrition 0.000 claims 1
- 235000003343 Brassica rupestris Nutrition 0.000 claims 1
- 240000001548 Camellia japonica Species 0.000 claims 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims 1
- 241000555825 Clupeidae Species 0.000 claims 1
- 235000007129 Cuminum cyminum Nutrition 0.000 claims 1
- 244000304337 Cuminum cyminum Species 0.000 claims 1
- 244000163122 Curcuma domestica Species 0.000 claims 1
- 235000003392 Curcuma domestica Nutrition 0.000 claims 1
- 244000133098 Echinacea angustifolia Species 0.000 claims 1
- 235000013628 Lantana involucrata Nutrition 0.000 claims 1
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 claims 1
- 240000007673 Origanum vulgare Species 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 244000178231 Rosmarinus officinalis Species 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 244000223014 Syzygium aromaticum Species 0.000 claims 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims 1
- 240000002657 Thymus vulgaris Species 0.000 claims 1
- 235000007303 Thymus vulgaris Nutrition 0.000 claims 1
- 241000219094 Vitaceae Species 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 229930003448 Vitamin K Natural products 0.000 claims 1
- 244000273928 Zingiber officinale Species 0.000 claims 1
- 235000006886 Zingiber officinale Nutrition 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
- 235000021028 berry Nutrition 0.000 claims 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 235000017803 cinnamon Nutrition 0.000 claims 1
- 235000020971 citrus fruits Nutrition 0.000 claims 1
- 235000018597 common camellia Nutrition 0.000 claims 1
- 235000003373 curcuma longa Nutrition 0.000 claims 1
- 235000014134 echinacea Nutrition 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 235000004611 garlic Nutrition 0.000 claims 1
- 235000008397 ginger Nutrition 0.000 claims 1
- 235000021021 grapes Nutrition 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 235000010460 mustard Nutrition 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 235000019512 sardine Nutrition 0.000 claims 1
- 229940083466 soybean lecithin Drugs 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 239000001585 thymus vulgaris Substances 0.000 claims 1
- 235000013976 turmeric Nutrition 0.000 claims 1
- 235000019155 vitamin A Nutrition 0.000 claims 1
- 239000011719 vitamin A Substances 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 235000019168 vitamin K Nutrition 0.000 claims 1
- 239000011712 vitamin K Substances 0.000 claims 1
- 150000003721 vitamin K derivatives Chemical class 0.000 claims 1
- 229940045997 vitamin a Drugs 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 229940046010 vitamin k Drugs 0.000 claims 1
- 239000008267 milk Substances 0.000 description 10
- 210000004080 milk Anatomy 0.000 description 7
- 235000013336 milk Nutrition 0.000 description 7
- 239000012071 phase Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR16/52592 | 2016-03-25 | ||
| FR1652592 | 2016-03-25 | ||
| PCT/FR2017/050622 WO2017162963A1 (fr) | 2016-03-25 | 2017-03-17 | Nanocapsules de principe actif liposoluble, fabrication et utilisations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019513359A JP2019513359A (ja) | 2019-05-30 |
| JP2019513359A5 true JP2019513359A5 (https=) | 2021-09-16 |
Family
ID=56263861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550449A Pending JP2019513359A (ja) | 2016-03-25 | 2017-03-17 | 脂溶性の有効成分のナノカプセル並びにその製造方法及び使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10765639B2 (https=) |
| EP (1) | EP3432729B1 (https=) |
| JP (1) | JP2019513359A (https=) |
| KR (1) | KR20180128025A (https=) |
| CN (1) | CN108882729A (https=) |
| AU (1) | AU2017236312B2 (https=) |
| BR (1) | BR112018069392B1 (https=) |
| CA (1) | CA3017931C (https=) |
| ES (1) | ES3040905T3 (https=) |
| MX (1) | MX2018011620A (https=) |
| RU (1) | RU2745844C2 (https=) |
| UA (1) | UA127243C2 (https=) |
| WO (1) | WO2017162963A1 (https=) |
| ZA (1) | ZA201806197B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102370217B1 (ko) * | 2019-11-27 | 2022-03-07 | 군산대학교 산학협력단 | 유자 오일을 포함하는 나노복합체의 제조방법 |
| RU2736051C1 (ru) * | 2020-03-04 | 2020-11-11 | Александр Александрович Кролевец | Способ получения нанокапсул сухого экстракта эхинацеи |
| RU2743010C1 (ru) * | 2020-03-23 | 2021-02-12 | Таисия Скандарбековна Гутнова | Способ получения нанокапсул витамина D3 |
| CN114847488A (zh) * | 2022-05-17 | 2022-08-05 | 江南大学 | 一种高稳定性和生物可给率的橘味维生素a-维生素d纳米复合载体制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2788007B1 (fr) | 1999-01-05 | 2001-02-09 | Oreal | Nanoemulsion a base de copolymeres blocs d'oxyde d'ethylene et d'oxyde de propylene, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| FR2803203B1 (fr) * | 1999-12-31 | 2002-05-10 | Fournier Ind & Sante | Nouvelles formulations galeniques du fenofibrate |
| FR2806005B1 (fr) * | 2000-03-10 | 2002-06-14 | Univ Claude Bernard Lyon | Procede de preparation de particules colloidales sous forme de nanocapsules |
| FR2814380B1 (fr) * | 2000-09-25 | 2002-11-08 | Serobiologiques Lab Sa | Poudre de microcapsules et procede d'obtention |
| JP2005028559A (ja) * | 2003-07-08 | 2005-02-03 | Shinobu Ito | ナノカプセル |
| FR2864900B1 (fr) * | 2004-01-09 | 2007-10-12 | Oreal | Dispersion aqueuse de nanocapsules a coeur huileux |
| WO2007046632A1 (en) * | 2005-10-18 | 2007-04-26 | Amorepacific Corporation | Cationic polymer nanoparticles encapsulating an active ingredients, and the cosmetic composition containing the same |
| ATE515260T1 (de) * | 2006-03-13 | 2011-07-15 | Advanced In Vitro Cell Technologies S L | Stabile nanokapselsysteme für die verabreichung von wirkstoffen |
| FR2924943A1 (fr) * | 2007-12-18 | 2009-06-19 | Galderma Sa | Composition dermatologique comprenant des nanocapsules polymeriques de calcitriol, son procede de preparation et son utilisation |
| BRPI0805854A2 (pt) | 2008-10-10 | 2010-08-24 | Biolab Sanus Farmaceutica Ltda | sistema nanoparticulado, processo de preparaÇço do mesmo, uso do mesmo, composiÇço fotoproterora, processo de preparaÇço da mesma, mÉtodo de prevenÇço de doenÇas e distérbios da pele |
| SG10201401705VA (en) * | 2009-04-24 | 2014-08-28 | Iceutica Pty Ltd | Production of encapsulated nanoparticles at commercial scale |
| EP2266546A1 (en) * | 2009-06-08 | 2010-12-29 | Advancell Advanced in Vitro Cell Technologies,S.A. | Process for the preparation of colloidal systems for the delivery of active compounds |
| ES2351756B1 (es) * | 2009-07-28 | 2011-10-05 | Universidad Del Pais Vasco | Nanopartículas lipídicas para terapia génica. |
| US20150231069A1 (en) * | 2014-02-20 | 2015-08-20 | Pankaj Modi | Oral formulations of chemotherapeutic agents |
| RU2557900C1 (ru) * | 2014-03-25 | 2015-07-27 | Александр Александрович Кролевец | Способ получения нанокапсул витаминов |
| WO2017021983A1 (en) * | 2015-08-06 | 2017-02-09 | Rubicon Research Private Limited | Particulate delivery systems |
-
2017
- 2017-03-17 RU RU2018135575A patent/RU2745844C2/ru active
- 2017-03-17 UA UAA201810156A patent/UA127243C2/uk unknown
- 2017-03-17 BR BR112018069392-8A patent/BR112018069392B1/pt active IP Right Grant
- 2017-03-17 KR KR1020187030631A patent/KR20180128025A/ko not_active Ceased
- 2017-03-17 EP EP17715241.0A patent/EP3432729B1/fr active Active
- 2017-03-17 ES ES17715241T patent/ES3040905T3/es active Active
- 2017-03-17 CA CA3017931A patent/CA3017931C/fr active Active
- 2017-03-17 CN CN201780019062.9A patent/CN108882729A/zh active Pending
- 2017-03-17 MX MX2018011620A patent/MX2018011620A/es unknown
- 2017-03-17 JP JP2018550449A patent/JP2019513359A/ja active Pending
- 2017-03-17 US US16/088,242 patent/US10765639B2/en active Active
- 2017-03-17 AU AU2017236312A patent/AU2017236312B2/en active Active
- 2017-03-17 WO PCT/FR2017/050622 patent/WO2017162963A1/fr not_active Ceased
-
2018
- 2018-09-14 ZA ZA2018/06197A patent/ZA201806197B/en unknown
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