JP2019208691A - Skin patch - Google Patents
Skin patch Download PDFInfo
- Publication number
- JP2019208691A JP2019208691A JP2018105550A JP2018105550A JP2019208691A JP 2019208691 A JP2019208691 A JP 2019208691A JP 2018105550 A JP2018105550 A JP 2018105550A JP 2018105550 A JP2018105550 A JP 2018105550A JP 2019208691 A JP2019208691 A JP 2019208691A
- Authority
- JP
- Japan
- Prior art keywords
- aqueous gel
- patch
- release film
- base material
- support base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000000463 material Substances 0.000 claims abstract description 45
- 230000007423 decrease Effects 0.000 claims abstract description 3
- 239000000758 substrate Substances 0.000 claims description 41
- 230000002093 peripheral effect Effects 0.000 claims description 31
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- 206010061218 Inflammation Diseases 0.000 description 2
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- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 1
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
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- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
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- 239000008272 agar Substances 0.000 description 1
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- 238000012423 maintenance Methods 0.000 description 1
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- 229920000728 polyester Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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- 238000009834 vaporization Methods 0.000 description 1
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- 238000003466 welding Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
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- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
本発明は、人の皮膚に貼り付けて使用される貼付剤に関する。 The present invention relates to a patch used by being affixed to human skin.
この種の貼付剤として、例えば、発熱・頭痛や歯痛、炎症時の患部の冷却や、顔等の火照りの冷却、またスポーツ後の筋肉のクールダウン等のために、パップ剤や冷却剤等が従来から使用されており、図4に示すように、支持基材101上に水性ゲル102が積層されるとともに水性ゲル102を剥離フィルム103で覆った構造のものが一般に知られている Examples of this type of patch include poultices and coolants for fever, headache, toothache, cooling of affected areas during inflammation, cooling of hot flashes on the face, etc., and cooling of muscles after sports. Conventionally, as shown in FIG. 4, a structure in which an aqueous gel 102 is laminated on a support base 101 and the aqueous gel 102 is covered with a release film 103 is generally known.
この従来の貼付剤100は、例えば特許文献1に示されるように、長尺の支持基材上に水性ゲルを塗布した後にその表面に長尺の剥離フィルムを重ね合わせた帯状の貼付剤シートを、切断刃により所定のサイズに切断することで製造される。特許文献1では、貼付剤シートを切断刃により個々の所定サイズの貼付剤に切断する前に、貼付剤シートの切断位置をプレス加工することにより当該切断位置の水性ゲルを押し出して排除する筋付けを行っている。これにより、切断後の貼付剤の端面(切断面)に水性ゲルが露出することを防止している。 For example, as shown in Patent Document 1, this conventional patch 100 is a band-shaped patch sheet in which an aqueous gel is applied onto a long support substrate and then a long release film is superimposed on the surface thereof. It is manufactured by cutting into a predetermined size with a cutting blade. In Patent Document 1, before cutting the patch sheet into individual patches of a predetermined size with a cutting blade, the cutting position of the patch sheet is pressed to extrude and eliminate the aqueous gel at the cutting position. It is carried out. This prevents the aqueous gel from being exposed on the end face (cut face) of the cut patch.
従来の貼付剤100は、上述した筋付けにより外周縁付近に水性ゲル102が存在しない。そのため、図5に示すように、貼付剤100は、水性ゲル102が有する粘着性により支持基材101が使用者の皮膚Sに貼り付けられるが、外周縁付近に水性ゲル102が存在しないと、支持基材101の外周縁が捲れ上がり、貼付剤100が皮膚Sから容易に剥がれ易くなる。 In the conventional patch 100, the aqueous gel 102 does not exist in the vicinity of the outer peripheral edge due to the above-described creasing. Therefore, as shown in FIG. 5, the patch 100 is attached to the user's skin S due to the adhesiveness of the aqueous gel 102, but when the aqueous gel 102 does not exist in the vicinity of the outer periphery, The outer peripheral edge of the support base material 101 is rolled up, and the patch 100 is easily peeled off from the skin S.
本発明は、上記課題を解決するためになされたものであり、皮膚から剥がれ難い貼付剤を提供することを目的とする。 The present invention has been made to solve the above problems, and an object of the present invention is to provide a patch that does not easily peel off from the skin.
本発明の貼付剤は、支持基材と、前記支持基材の一方面に積層された水性ゲルと、前記水性ゲルを覆う剥離フィルムと、を備え、前記支持基材及び前記剥離フィルムの一方の外周縁の少なくとも一部分が前記支持基材及び前記剥離フィルムの他方に接合されており、前記水性ゲルは、少なくとも前記支持基材及び前記剥離フィルムの接合部側の一部分において前記水性ゲルの厚みが前記接合部に向かうに連れて徐々に小さくなっていることを特徴とする。 The patch of the present invention comprises a support substrate, an aqueous gel laminated on one surface of the support substrate, and a release film covering the aqueous gel, and one of the support substrate and the release film. At least a part of the outer peripheral edge is joined to the other of the support substrate and the release film, and the aqueous gel has a thickness of the aqueous gel at least at a part of the support base and the release film on the joining part side. It is characterized by becoming gradually smaller toward the joint.
本発明の貼付剤においては、前記支持基材及び前記剥離フィルムは、平面視矩形状を呈しており、対向する一対の辺同士が接合されていることが好ましい。 In the patch of the present invention, it is preferable that the support base material and the release film have a rectangular shape in plan view and a pair of opposing sides are joined to each other.
また、本発明の貼付剤においては、前記水性ゲルの水分含有量が65重量%以上90重量%以下であることが好ましい。 In the patch of the present invention, the water content of the aqueous gel is preferably 65% by weight or more and 90% by weight or less.
また、本発明の貼付剤においては、前記支持基材は、不織布であることが好ましい。 Moreover, in the patch of this invention, it is preferable that the said support base material is a nonwoven fabric.
また、本発明の貼付剤においては、前記不織布がポリエチレンテレフタレート樹脂繊維からなり、前記剥離フィルムがポリオレフィン系樹脂からなることが好ましい。 Moreover, in the patch of this invention, it is preferable that the said nonwoven fabric consists of a polyethylene terephthalate resin fiber, and the said peeling film consists of polyolefin resin.
なお、本発明の貼付剤においては、前記支持基材及び前記剥離フィルムの外周縁同士が全周にわたって接合されていることが好ましい。 In the patch of the present invention, it is preferable that the outer peripheral edges of the support base and the release film are joined over the entire circumference.
本発明の貼付剤によれば、支持基材及び剥離フィルムの一方の外周縁の少なくとも一部分が他方に接合されており、水性ゲルは、この接合部近傍の部分においては、水性ゲルの厚みが接合部に向かうに連れて徐々に小さくなっている。そのため、剥離フィルムを剥がし露出した水性ゲルを使用者の皮膚に当てて貼付剤を貼り付けた際に、貼付剤の当該外周縁では支持基材が水性ゲルを包むような形となって、支持基材の外周縁が使用者の皮膚から浮かずにくっついた状態で水性ゲルの粘着性により皮膚に接着する。よって、支持基材の外周縁が捲れ上がることを抑制することができるので、貼付剤を皮膚から剥がれ難くすることができる。 According to the patch of the present invention, at least a part of one outer peripheral edge of the support substrate and the release film is bonded to the other, and the aqueous gel has a thickness of the aqueous gel bonded in the vicinity of the bonded part. It gradually gets smaller as you head to the club. Therefore, when the adhesive film is applied by applying the exposed aqueous gel to the user's skin after peeling off the release film, the support base material is wrapped around the aqueous gel at the outer peripheral edge of the adhesive, and is supported. The base material adheres to the skin due to the adhesiveness of the aqueous gel in a state where the outer peripheral edge of the base material does not float from the user's skin. Therefore, since it can suppress that the outer periphery of a support base material rolls up, a patch can be made hard to peel from skin.
以下、本発明の貼付剤の実施形態について添付図面を参照して説明する。本発明の貼付剤は、人の皮膚に貼り付けて使用されるものであり、例えば発熱・頭痛や歯痛、炎症時の患部の冷却や、顔等の火照りの冷却、またスポーツ後の筋肉のクールダウン等のために用いられるシート状の冷却剤を例示することができる。 Hereinafter, embodiments of the patch of the present invention will be described with reference to the accompanying drawings. The patch of the present invention is used by being affixed to human skin, for example, fever, headache, toothache, cooling of the affected area during inflammation, cooling of hot flashes on the face, etc., and cooling of muscles after sports. The sheet-like coolant used for down etc. can be illustrated.
図1及び図2は、本実施形態の貼付剤1を示す。貼付剤1は、支持基材2と、水性ゲル3と、剥離フィルム4とを少なくとも備え、これらが積層された層構造を有している。貼付剤1は、使用前は、複数重ねられた状態で包装袋(図示せず)内に収納されている。また、使用時には、貼付剤1は、包装袋から取り出され、剥離フィルム4を支持基材2から剥がした後、露出した水性ゲル3を皮膚の冷却対象部位に直接あてることで、水性ゲル3が有する粘着性により使用者の皮膚に貼り付けられる。これにより、水性ゲル3に含まれた水分が時間の経過に伴い蒸発し、その際に奪われる気化熱で水性ゲル3の温度が低下するため、水性ゲル3に接する皮膚が冷却される。 FIG.1 and FIG.2 shows the patch 1 of this embodiment. The patch 1 has at least a support substrate 2, an aqueous gel 3, and a release film 4, and has a layer structure in which these are laminated. Prior to use, the patch 1 is stored in a packaging bag (not shown) in a stacked state. In use, the patch 1 is taken out from the packaging bag, the release film 4 is peeled off from the support base 2, and then the exposed aqueous gel 3 is directly applied to the site to be cooled of the skin. It is affixed to the user's skin due to its adhesiveness. As a result, the moisture contained in the aqueous gel 3 evaporates with time, and the temperature of the aqueous gel 3 is reduced by the heat of vaporization taken away at that time, so that the skin in contact with the aqueous gel 3 is cooled.
貼付剤1の厚み及び大きさは、特に限定されるものではなく、目的や冷却対象部位に応じて厚み及び大きさを適宜設定することができる。また、貼付剤1の外形も、特に限定されるものではなく、本実施形態では平面視長方形状であるが、正方形状、円形状、楕円形状などの他の種々の形状とすることができる。 The thickness and size of the patch 1 are not particularly limited, and the thickness and size can be appropriately set according to the purpose and the site to be cooled. Further, the external shape of the patch 1 is not particularly limited, and is rectangular in plan view in the present embodiment, but may be various other shapes such as a square shape, a circular shape, and an elliptical shape.
支持基材2は、水性ゲル3をその一方面上で支持する。支持基材2は、透湿性や通気性を有していて、水性ゲル3を担持できるものであれば、その素材は特に限定されるものではなく、種々の織布、不織布及びフィルム等で形成することができる。支持基材2の素材として織布や不織布を使用する場合には、綿、麻、羊毛等の天然繊維;レーヨン、アセテート等のセルロース系繊維;ナイロン、ビニロン、スチロール、ポリプロピレン、ポリエチレン、ポリエチレンテレフタレート、アクリル等の合成樹脂繊維等を例示することができる。また、支持基材2の素材としてフィルムを使用する場合には、ポリスチレン(スチロール)、ポリプロピレン、ポリエチレンテレフタレート、ポリエチレン等を例示することができる。 The support substrate 2 supports the aqueous gel 3 on one surface thereof. The support base material 2 is not particularly limited as long as the support base material 2 has moisture permeability and air permeability and can carry the aqueous gel 3, and is formed of various woven fabrics, nonwoven fabrics, films, and the like. can do. When woven fabric or non-woven fabric is used as the material for the supporting substrate 2, natural fibers such as cotton, hemp, wool, etc .; cellulosic fibers such as rayon and acetate; nylon, vinylon, styrene, polypropylene, polyethylene, polyethylene terephthalate, Examples thereof include synthetic resin fibers such as acrylic. Moreover, when using a film as a raw material of the support base material 2, a polystyrene (styrene), a polypropylene, a polyethylene terephthalate, polyethylene etc. can be illustrated.
支持基材2の厚みは、特に限定されるものではないが、使用感、貼付部位への馴染み易さ等の観点から、0.1mm以上3.0mm以下であることが好ましく、0.5mm以上2.0mm以下であることがより好ましい。 The thickness of the support substrate 2 is not particularly limited, but is preferably 0.1 mm or more and 3.0 mm or less, and preferably 0.5 mm or more from the viewpoints of feeling of use, ease of fitting to the pasting site, and the like. More preferably, it is 2.0 mm or less.
支持基材2は、貼り付けられる身体の様々な貼付部位にフィットして馴染むように適度な伸縮性を有することが好ましい。伸縮性の程度は、特に限定されるものではなく、また、伸縮方向も、支持基材2の一方向(長手方向)のみを伸縮可能、前記一方向に直交する他方甲(幅方向)のみを伸縮可能、又は、前記一方向(長手方向)及び前記他方向(幅方向)ともに伸縮可能としてもよいが、両方向に伸縮可能であることが好ましい。 It is preferable that the support base material 2 has an appropriate stretchability so as to fit and adapt to various application sites of the body to be applied. The degree of stretchability is not particularly limited, and the stretch direction can be stretched and contracted only in one direction (longitudinal direction) of the support base 2, and only the other upper (width direction) orthogonal to the one direction. It is possible to expand and contract, or it is possible to expand and contract both in one direction (longitudinal direction) and the other direction (width direction), but it is preferable that it can expand and contract in both directions.
水性ゲル3は、支持基材2の一方面に積層して形成される。水性ゲル3としては、皮膚への適合性のある種々のものを用いることができる。 The aqueous gel 3 is formed by laminating on one surface of the support substrate 2. As the aqueous gel 3, various materials that are compatible with the skin can be used.
水性ゲル3の厚みは、特に限定されるものではないが、冷却力、皮膚に貼り付けた時の感触、皮膚に対する貼り付け状態の維持等の観点から、適度に大きいことが好ましい。例えば、支持基材2の中心位置における厚みDCが0.1mm以上20mm以下であることが好ましく、1.0mm以上10mm以下であることがより好ましい。なお、水性ゲル3の厚みは、JIS L1913:2010の「6.1 厚さ(ISO法)」に記載されている方法を用いて計測することができる。 The thickness of the aqueous gel 3 is not particularly limited, but is preferably appropriately large from the viewpoints of cooling power, feel when affixed to the skin, maintenance of the affixed state to the skin, and the like. For example, it is preferable that the thickness D C is 0.1mm or more 20mm or less at the center position of the support substrate 2, and more preferably less than 1.0mm 10mm or less. The thickness of the aqueous gel 3 can be measured using the method described in “6.1 Thickness (ISO Method)” of JIS L1913: 2010.
また、水性ゲル3の厚みは、少なくとも支持基材2の外周縁に近い部分(後述する支持基材2に剥離フィルム4が接合された接合部5側の一部分)において、支持基材2の外周縁(接合部5)に向かうに連れて徐々に小さくなっている。すなわち、水性ゲル3は、その縦断面視において、少なくとも接合部5近傍の外周縁部分が先細りとなっている。なお、水性ゲル3は、少なくとも接合部5側の一部分において接合部5に向かうに連れて厚みが徐々に小さくなっていれば、その縦断面視で、図2に示すように、剥離フィルム4側に向けてドーム状に隆起する形状を呈していてもよいし、図示は省略するが、剥離フィルム4側に向けて中央部分が平坦又は略平坦な略台形状に隆起する形状を呈していてもよく、また、支持基材側2に向けてドーム状又は略台形状に隆起する形状を呈していてもよいし、さらに、支持基材側2及び剥離フィルム4側に向けてドーム状又は略台形状に隆起する形状を呈していてもよい。 The thickness of the aqueous gel 3 is at least a portion close to the outer peripheral edge of the support base 2 (a part on the side of the joint 5 where the release film 4 is joined to the support base 2 described later). It gradually becomes smaller toward the periphery (joint part 5). That is, the aqueous gel 3 has a tapered outer peripheral edge portion in the vicinity of the joint portion 5 in the longitudinal sectional view. If the thickness of the aqueous gel 3 is gradually reduced toward the joint part 5 at least at a part on the joint part 5 side, as shown in FIG. It may have a shape that protrudes in a dome shape toward the surface, and although it is not illustrated, it may have a shape in which the central portion protrudes toward the release film 4 in a substantially trapezoidal shape that is flat or substantially flat. Further, it may have a dome shape or a substantially trapezoidal shape rising toward the support base material side 2, and further, a dome shape or a substantially base shape toward the support base material side 2 and the release film 4 side. The shape which protrudes in the shape may be exhibited.
水性ゲル3は、抱水性、放湿性、自己保形性又は粘着性を有する。「抱水性」とは、内部に水を安定的に含む性質を意味するが、より好ましくはさらに圧縮しても含有水分を滲出しない性質を意味する。また「自己保形性」とは、流動性や崩壊性を顕著には生じず形状を保持している性質を意味する。 The aqueous gel 3 has water repellency, moisture release, self-holding property or adhesiveness. “Hydrophilic” means the property of stably containing water inside, but more preferably means the property of not exuding the contained water even when further compressed. “Self shape retention” means the property of maintaining the shape without causing significant fluidity or disintegration.
水を含んでかかる性質を奏し得る成分としては、一般にゲル化剤として用いられる天然高分子多糖類を例示することができる。具体的には、カラギーナン、アルギン酸、アルギン酸プロピレングリコールエステル、タラガム、ローカストビーンガム、グルコマンナン、キサンタンガム、ジェランガム、ペクチン、プルラン、グァーガム、サイリウムシードガム、アルギン酸ナトリウム、マンナン、ゼラチン、寒天等の天然ガム類を例示することができる。これらは単独若しくは2種以上の組み合わせて用いることができる。好ましくはグルコマンナン、ローカストビーンガムを例示することができる。 Examples of components that can exhibit such properties including water include natural polymer polysaccharides that are generally used as gelling agents. Specifically, natural gums such as carrageenan, alginic acid, propylene glycol alginate, tara gum, locust bean gum, glucomannan, xanthan gum, gellan gum, pectin, pullulan, guar gum, psyllium gum, sodium alginate, mannan, gelatin, agar Can be illustrated. These can be used alone or in combination of two or more. Preferably, glucomannan and locust bean gum can be exemplified.
ゲル化剤としては、上述した天然高分子多糖類以外に、ポリアクリル酸、ポリメタアクリル酸、ポリアクリル酸の塩、ポリメタアクリル酸の塩等を例示することができる。これらは単独若しくは2種以上の組み合わせて用いることができる。 Examples of the gelling agent include polyacrylic acid, polymethacrylic acid, a salt of polyacrylic acid, a salt of polymethacrylic acid, and the like in addition to the natural polymer polysaccharide described above. These can be used alone or in combination of two or more.
水性ゲル3は、その他の成分として、多価アルコール、界面活性剤、防腐剤、保存剤、安定剤、香料、着色料、pH調整剤、リモネン、カンフル、ハッカ油又はl−メントール等の清涼化剤、保湿剤、刺激剤、除菌剤、抗菌剤、粘着付与剤、保型剤、増粘剤等、公知の添加剤を含有していてもよい。 Aqueous gel 3 is a cooling agent such as polyhydric alcohol, surfactant, preservative, preservative, stabilizer, flavor, colorant, pH adjuster, limonene, camphor, peppermint oil or l-menthol as other components. It may contain known additives such as agents, moisturizers, stimulants, disinfectants, antibacterial agents, tackifiers, shape retainers, thickeners and the like.
水性ゲル3は、所望の冷却力を持続的に発揮するために、十分な量の水分を含んでいることが好ましく、水性ゲル3の水分含有量としては、水性ゲル3を構成する組成物中、60重量%以上であることが好ましく、70重量%以上であることがより好ましい。また、水性ゲル3の水分含有量の上限は、自己保形性の観点から、95重量%以下であることが好ましく、90重量%以下であることがより好ましい。 The aqueous gel 3 preferably contains a sufficient amount of moisture in order to continuously exhibit a desired cooling power, and the water content of the aqueous gel 3 is in the composition constituting the aqueous gel 3. 60% by weight or more, more preferably 70% by weight or more. In addition, the upper limit of the water content of the aqueous gel 3 is preferably 95% by weight or less, and more preferably 90% by weight or less, from the viewpoint of self-shape retention.
剥離フィルム4は、貼付剤1の使用前に水性ゲル3を覆っており、剥離フィルム4により、貼付剤1の取り扱い性や衛生面の向上を図ることができる。剥離フィルム4は、水性ゲル3を被覆できるものであれば、その素材は特に限定されるものではなく、ポリプロピレン、ポリエチレン、ポリエステル、ナイロン、塩化ビニル、ポリエチレンテレフタレート等の合成樹脂を例示することができる。 The release film 4 covers the aqueous gel 3 before using the patch 1, and the release film 4 can improve the handleability and hygiene of the patch 1. The material of the release film 4 is not particularly limited as long as the aqueous gel 3 can be coated. Examples of the release film 4 include synthetic resins such as polypropylene, polyethylene, polyester, nylon, vinyl chloride, and polyethylene terephthalate. .
上述した構成の貼付剤1において、支持基材2及び剥離フィルム4は、その一方の外周縁の一部分が他方に接合されている。具体的に、支持基材2及び剥離フィルム4が同じ形状及び大きさであると、外周縁の一部分同士が接合される。剥離フィルム4の方が支持基材2よりも形が大きい場合は、支持基材2の外周縁の一部分が剥離フィルム4に接合され、支持基材2の方が剥離フィルム4よりも形が大きい場合は、剥離フィルム4の外周縁の一部分が支持基材2に接合されることになる。 In the patch 1 having the above-described configuration, the support base 2 and the release film 4 have a part of one outer peripheral edge thereof joined to the other. Specifically, when the support substrate 2 and the release film 4 have the same shape and size, a part of the outer peripheral edge is joined. When the release film 4 is larger in shape than the support substrate 2, a part of the outer peripheral edge of the support substrate 2 is joined to the release film 4, and the support substrate 2 is larger in shape than the release film 4. In this case, a part of the outer peripheral edge of the release film 4 is bonded to the support base material 2.
なお、本実施形態では、支持基材2及び剥離フィルム4の外周縁同士が全周にわたって接合されおり、そのため、水性ゲル3は、支持基材2及び剥離フィルム4の内部に封入され、水性ゲル3の端面は露出していない。ここで、「外周縁が全周にわたって接合される」とは、支持基材(又は剥離フィルム)の外周縁が実質的に全周にわたって剥離フィルム(又は支持基材)に接合されていることを指し、支持基材(又は剥離フィルム)の外周縁の全てが剥離フィルム(又は支持基材)に接合されている状態に加えて、支持基材(又は剥離フィルム)の外周縁の大部分は剥離フィルム(又は支持基材)に接合されているものの一部分が剥離フィルム(又は支持基材)に接合されていない状態も含む。つまりは、貼付剤の製造時には支持基材(又は剥離フィルム)の外周縁が全周にわたって剥離フィルム(又は支持基材)に接合されていたものの、製造後の貼付剤1の輸送時や保管時等の使用前において、支持基材(又は剥離フィルム)の外周縁の一部分の接合が外れてしまった場合も含む。 In addition, in this embodiment, the outer periphery of the support base material 2 and the peeling film 4 is joined over the perimeter, Therefore, the aqueous gel 3 is enclosed with the inside of the support base material 2 and the peeling film 4, and an aqueous gel The end face of 3 is not exposed. Here, “the outer peripheral edge is bonded over the entire circumference” means that the outer peripheral edge of the support substrate (or the release film) is bonded to the release film (or the support base material) over the entire circumference. In addition to the state in which the entire outer periphery of the support substrate (or release film) is bonded to the release film (or support substrate), most of the outer periphery of the support substrate (or release film) is peeled off. A state in which a part of what is bonded to the film (or the supporting substrate) is not bonded to the release film (or the supporting substrate) is also included. That is, the outer periphery of the support substrate (or release film) was joined to the release film (or support substrate) over the entire circumference at the time of manufacture of the patch, but the patch 1 after manufacture was transported or stored. It also includes the case where a part of the outer peripheral edge of the support substrate (or release film) has been disconnected before use.
支持基材2及び剥離フィルム4の接合の方法は、水性ゲル3の粘着性を介した接着でなければ特に限定されるものではなく、例えば、(1)支持基材2及び剥離フィルム4を公知の接着剤を用いて接合する方法、(2)支持基材2及び剥離フィルム4を熱圧着(ヒートシール)により接合する方法、又は、(3)支持基材2及び剥離フィルム4を重ね合わせた状態で剥離フィルム4側から外周縁に超音波振動を作用させることで剥離フィルム4を支持基材2に溶着させて接合する方法等、公知の種々の方法を用いることができる。 The method of joining the support substrate 2 and the release film 4 is not particularly limited as long as it is not bonded via the adhesiveness of the aqueous gel 3. For example, (1) the support substrate 2 and the release film 4 are publicly known. (2) Method of joining support substrate 2 and release film 4 by thermocompression bonding (heat seal), or (3) Overlay of support substrate 2 and release film 4 Various known methods such as a method of welding the release film 4 to the support substrate 2 by applying ultrasonic vibration from the release film 4 side to the outer peripheral edge in the state can be used.
上述した構成の貼付剤1は、図示は省略するが、少なくとも一方向に貼付剤1が複数連続する貼付剤シートを、個々の貼付剤1に分断する切断ラインに沿って切断することで、効率よく製造することができる。ここで、貼付剤シートの切断時に、例えば超音波振動装置及び切断装置の間で貼付剤シートを挟持し、貼付剤シートの前記切断ラインにおいて超音波振動装置のホーンを剥離フィルム4に当接させて超音波振動を作用させながら切断装置のカット刃により貼付剤シートを切断することで、支持基材2及び剥離フィルム4の接合を切断とともに行うことができる。これにより、貼付剤の製造効率をさらに向上させることができる。さらに、水性ゲル3が支持基材2の外周縁の直近まで広範囲に積層されていても、水性ゲル3がカット刃に付着等することなく貼付剤シートを高精度に切断して切断面の綺麗な貼付剤1を製造することができるうえ、切断後の貼付剤1のライン搬送時に水性ゲルが貼付剤1の外周縁から漏れ出すことを防止することができる。そのため、支持基材2及び剥離フィルム4を接合する方法としては上記(3)の方法を用いることが好ましく、支持基材2及び剥離フィルム4の切断及び接合を良好に行うためには、支持基材2がポリエチレンテレフタレート樹脂繊維を素材とする不織布からなり、剥離フィルム4がポリプロピレンやポリエチレン等のポリオレフィン系樹脂からなることが好ましい。 Although not shown, the patch 1 having the above-described configuration is efficiently cut by cutting a patch sheet in which a plurality of the patch 1 is continuous in at least one direction along a cutting line that divides the patch 1 into individual patches 1. Can be manufactured well. Here, when cutting the patch sheet, for example, the patch sheet is sandwiched between the ultrasonic vibration device and the cutting device, and the horn of the ultrasonic vibration device is brought into contact with the release film 4 in the cutting line of the patch sheet. By cutting the patch sheet with the cutting blade of the cutting device while applying ultrasonic vibration, the support substrate 2 and the release film 4 can be joined together with the cutting. Thereby, the manufacturing efficiency of the patch can be further improved. Furthermore, even if the aqueous gel 3 is laminated in a wide range up to the immediate vicinity of the outer peripheral edge of the support base 2, the aqueous gel 3 can be cut with high precision without causing the aqueous gel 3 to adhere to the cutting blade and the cut surface is clean. In addition, the adhesive patch 1 can be produced, and the aqueous gel can be prevented from leaking out from the outer peripheral edge of the adhesive patch 1 during the line conveyance of the adhesive patch 1 after cutting. Therefore, it is preferable to use the method (3) as a method for bonding the support substrate 2 and the release film 4. In order to cut and bond the support substrate 2 and the release film 4 satisfactorily, a support group is used. It is preferable that the material 2 is made of a nonwoven fabric made of polyethylene terephthalate resin fibers, and the release film 4 is made of a polyolefin resin such as polypropylene or polyethylene.
貼付剤1における支持基材2及び剥離フィルム4の接合部5は、幅Wの小さい筋状であってもよいし、幅Wの多少大きな帯状であってもよいが、接合部5の幅Wは小さければ小さいほど、水性ゲル3を支持基材2の外周縁の直近まで広範囲に積層することができるので好ましい。水性ゲル3が支持基材2のほぼ全域に十分な厚みで積層されていることで、貼付剤1により所望の冷却力を及ぼすことができる皮膚の範囲を増大させることができるうえ、支持基材2の外周縁が水性ゲル3の粘着性により皮膚に良好に接着するので支持基材2の外周縁が捲れ上がり難くなることから、貼付剤1が皮膚から容易に剥がれるのを抑制することができる。 The joint portion 5 of the support substrate 2 and the release film 4 in the patch 1 may have a stripe shape with a small width W or a belt shape with a slightly larger width W, but the width W of the joint portion 5 may be. The smaller the is, the more preferable it is because the aqueous gel 3 can be laminated over a wide range up to the vicinity of the outer peripheral edge of the support substrate 2. By laminating the aqueous gel 3 with a sufficient thickness over almost the entire area of the support base material 2, it is possible to increase the range of the skin where the patch 1 can exert a desired cooling force, and to support the support base material. Since the outer peripheral edge of 2 adheres well to the skin due to the adhesiveness of the aqueous gel 3, the outer peripheral edge of the support base 2 becomes difficult to roll up, so that the patch 1 can be prevented from being easily peeled off from the skin. .
接合部5の幅Wは、上述した観点から、2.0mm以下であることが好ましく、1.0mm以下であることがより好ましく、0.5mm以下であることがさらに好ましい。また、接合部5の幅Wの下限は、支持基材2及び剥離フィルム4の接合強度の観点から、0.05mm以上であることが好ましく、0.1mm以上であることがより好ましく、0.2mm以上であることがさらに好ましい。 From the viewpoint described above, the width W of the joint portion 5 is preferably 2.0 mm or less, more preferably 1.0 mm or less, and further preferably 0.5 mm or less. In addition, the lower limit of the width W of the bonding portion 5 is preferably 0.05 mm or more, more preferably 0.1 mm or more, from the viewpoint of bonding strength between the support base 2 and the release film 4. More preferably, it is 2 mm or more.
上述した本実施形態の貼付剤1によると、支持基材2及び剥離フィルム4の外周縁の少なくとも一部分同士が接合されているため、水性ゲル3は、この接合部5近傍の部分においては、水性ゲル3の厚みが接合部5に向かうに連れて徐々に小さくなっている。そのため、図3(A)に示すように、剥離フィルム4を剥がして露出した水性ゲル3を使用者の皮膚Sに当てた後、図3(B)に示すように、支持基材2を水性ゲル3の粘着性により皮膚Sに貼り付けると、貼付剤1の当該外周縁では支持基材2が水性ゲル3を包むような形となって、支持基材2の外周縁が使用者の皮膚から浮かずにくっついた状態で水性ゲル3の粘着性により皮膚Sに接着する。よって、支持基材2の外周縁が捲れ上がることを抑制することができるので、貼付剤1を皮膚から剥がれ難くすることができる。なお、支持基材2及び剥離フィルム4の外周縁が全周にわたって接合されていると、支持基材2の外周縁の全周が捲れ上がり難くなるので、貼付剤1を皮膚からさらに剥がれ難くすることができる。 According to the patch 1 of the present embodiment described above, since at least a part of the outer peripheral edges of the support base 2 and the release film 4 are bonded to each other, the aqueous gel 3 is aqueous in the vicinity of the bonded portion 5. The thickness of the gel 3 gradually decreases as it goes toward the joint 5. Therefore, as shown in FIG. 3 (A), the aqueous gel 3 exposed by peeling off the release film 4 is applied to the skin S of the user, and then the support substrate 2 is aqueous as shown in FIG. 3 (B). When pasted on the skin S due to the adhesiveness of the gel 3, the support base 2 is wrapped around the aqueous gel 3 at the outer peripheral edge of the patch 1, and the outer peripheral edge of the support base 2 is the user's skin. It adheres to the skin S due to the stickiness of the aqueous gel 3 while sticking without floating. Therefore, since it can suppress that the outer periphery of the support base material 2 rolls up, the patch 1 can be made hard to peel from skin. In addition, when the outer periphery of the support base material 2 and the peeling film 4 is joined over the perimeter, since the perimeter of the outer periphery of the support base material 2 becomes difficult to roll up, it makes it difficult to peel the patch 1 from the skin further. be able to.
また、本実施形態の貼付剤1は、支持基材2及び剥離フィルム4の外周縁の少なくとも一部分同士が接合されているので、剥離フィルム4の外周縁が捲れ上がって支持基材2から容易に剥がれるのを抑制することができる。 Moreover, since the patch 1 of this embodiment has joined at least one part of the outer periphery of the support base material 2 and the peeling film 4, the outer periphery of the peeling film 4 rolls up easily from the support base material 2. It can suppress peeling.
なお、支持基材2及び剥離フィルム4の外周縁が全周にわたって接合されていると、水性ゲル3は支持基材2及び剥離フィルム4の内部に持続的に封入されるため、水性ゲル3の乾燥等を防止することができる。 In addition, when the outer periphery of the support base material 2 and the peeling film 4 is joined over the perimeter, since the aqueous gel 3 is continuously enclosed inside the support base material 2 and the release film 4, the aqueous gel 3 Drying and the like can be prevented.
さらに、支持基材2及び剥離フィルム4の外周縁が全周にわたって接合されていると、輸送時や保管時等に貼付剤1の表面及び/又は裏面が押圧される等して水性ゲル3が圧迫されても、水性ゲル3が押し出されて貼付剤1の外周縁からはみ出すことを防止することができる。これにより、使用者が貼付剤1を使用する際に、使用者の手に水性ゲル3が付着すること等を防止することができる。 Further, when the outer peripheral edges of the support substrate 2 and the release film 4 are joined over the entire circumference, the surface and / or the back surface of the patch 1 is pressed at the time of transportation or storage, etc. Even if it is pressed, it is possible to prevent the aqueous gel 3 from being pushed out and protruding from the outer peripheral edge of the patch 1. Thereby, when a user uses the patch 1, it can prevent that the aqueous gel 3 adheres to a user's hand.
加えて、貼付剤1は、輸送時や保管時等においては包装箱(図示せず)内に複数重ねられた状態で収納されるため、貼付剤1は、他の複数の貼付剤1の重みを受けることで、水性ゲル3が圧迫される。従来では、水性ゲル3が圧迫されることで貼付剤1の外周縁からはみ出すおそれがあるため、包装箱内に中仕切りをセットし、中仕切りにて貼付剤1の重みを受けて水性ゲル3が圧迫されるのを防止していた。ただし、本実施形態の貼付剤1は、包装箱内で他の複数の貼付剤1の重みにより水性ゲル3が圧迫されても、水性ゲル3が貼付剤1の外周縁からはみ出ないため、中仕切りが不要となり、その分、コスト低減を図ることができる。 In addition, since the patch 1 is stored in a state where a plurality of patches 1 are stacked in a packaging box (not shown) at the time of transportation, storage, etc., the patches 1 are weights of other patches 1. By receiving, the aqueous gel 3 is compressed. Conventionally, since the aqueous gel 3 may be pressed out from the outer peripheral edge of the patch 1, a partition is set in the packaging box, and the aqueous gel 3 receives the weight of the patch 1 in the partition. Was prevented from being pressed. However, the patch 1 of the present embodiment has a medium inside because the aqueous gel 3 does not protrude from the outer peripheral edge of the patch 1 even if the aqueous gel 3 is compressed by the weight of the other patches 1 in the packaging box. No partition is required, and the cost can be reduced accordingly.
加えて、水性ゲル3の水分含有量が多くて流動性が高くても、水性ゲル3が貼付剤1の外周縁から漏れ出さない。そのため、従来であれば、貼付剤の製造時において、貼付剤シートを個々の貼付剤へ切断した後に水性ゲル3を固めるための処理が必要であったが、本実施形態の貼付剤1によれば、この処理工程を不要とする又は処理時間を短縮することができるので、工程時間の短縮によって貼付剤の製造効率を向上させることができる。 In addition, even if the water content of the aqueous gel 3 is large and the fluidity is high, the aqueous gel 3 does not leak from the outer peripheral edge of the patch 1. Therefore, conventionally, at the time of manufacturing the patch, a treatment for solidifying the aqueous gel 3 after cutting the patch sheet into individual patches was necessary. However, according to the patch 1 of this embodiment, For example, since this processing step is unnecessary or the processing time can be shortened, the manufacturing efficiency of the patch can be improved by shortening the processing time.
以上、本発明の実施形態について説明したが、本発明は上記実施形態に限定されるものではなく、本発明の趣旨を逸脱しない限りにおいて種々の変更が可能である。 While the embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments, and various modifications can be made without departing from the spirit of the present invention.
例えば、上記実施形態において、支持基材2及び剥離フィルム4は、一方の外周縁が全周にわたって他方に接合されているが、一方の外周縁の一部分だけが剥離フィルム4に接合されていてもよい。例えば、支持基材2及び剥離フィルム4が平面視矩形状(正方形状及び長方形状を含む)を呈しているときには、支持基材2及び剥離フィルム4の対向する一対の辺同士が少なくとも接合されていればよい。 For example, in the said embodiment, although the support base material 2 and the peeling film 4 have one outer periphery joined to the other over the perimeter, even if only a part of one outer periphery is joined to the peeling film 4 Good. For example, when the support base material 2 and the release film 4 have a rectangular shape in plan view (including a square shape and a rectangular shape), a pair of opposing sides of the support base material 2 and the release film 4 are joined at least. Just do it.
また、上記実施形態において、支持基材2及び剥離フィルム4は同じ形状であるが、支持基材2及び剥離フィルム4の一方の外周縁の少なくとも一部分が他方に接合されていれば、支持基材2と剥離フィルム4とで形状が異なっていてもよい。 Moreover, in the said embodiment, although the support base material 2 and the peeling film 4 are the same shapes, if at least one part of one outer periphery of the support base material 2 and the peeling film 4 is joined to the other, a support base material 2 and the release film 4 may have different shapes.
また、上記実施形態において、貼付剤1は、支持基材2、水性ゲル3及び剥離フィルム4の三層構造であるが、その他の層を有していてもよい。 Moreover, in the said embodiment, although the patch 1 is a three-layer structure of the support base material 2, the aqueous gel 3, and the peeling film 4, you may have another layer.
1 貼付剤
2 支持基材
3 水性ゲル
4 剥離フィルム
DESCRIPTION OF SYMBOLS 1 Patch 2 Support base material 3 Aqueous gel 4 Release film
Claims (5)
前記支持基材及び前記剥離フィルムの一方の外周縁の少なくとも一部分が前記支持基材及び前記剥離フィルムの他方に接合されており、前記水性ゲルは、少なくとも前記支持基材及び前記剥離フィルムの接合部側の一部分において前記水性ゲルの厚みが前記接合部に向かうに連れて徐々に小さくなっている、貼付剤。 A support substrate, an aqueous gel laminated on one surface of the support substrate, and a release film covering the aqueous gel,
At least a part of one outer peripheral edge of the support base material and the release film is joined to the other of the support base material and the release film, and the aqueous gel is at least a joint portion of the support base material and the release film. The patch, wherein the thickness of the aqueous gel gradually decreases toward the joint in a part of the side.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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JP2018105550A JP2019208691A (en) | 2018-05-31 | 2018-05-31 | Skin patch |
TW108115403A TWI787506B (en) | 2018-05-31 | 2019-05-03 | Adhesive |
PCT/JP2019/019001 WO2019230362A1 (en) | 2018-05-31 | 2019-05-13 | Adhesive skin patch |
Applications Claiming Priority (1)
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JP2018105550A JP2019208691A (en) | 2018-05-31 | 2018-05-31 | Skin patch |
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JP2019208691A true JP2019208691A (en) | 2019-12-12 |
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JP2018105550A Pending JP2019208691A (en) | 2018-05-31 | 2018-05-31 | Skin patch |
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JP (1) | JP2019208691A (en) |
TW (1) | TWI787506B (en) |
WO (1) | WO2019230362A1 (en) |
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WO2021106210A1 (en) * | 2019-11-29 | 2021-06-03 | 小林製薬株式会社 | Poultice |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000139986A (en) * | 1998-11-06 | 2000-05-23 | Pigeon Corp | Cooling gel sheet |
JP2003019157A (en) * | 2001-07-06 | 2003-01-21 | Advance Co Ltd | Hot feeling material and cold feeling material |
JP2003102760A (en) * | 2001-09-28 | 2003-04-08 | Toko Yakuhin Kogyo Kk | Sticking material and method of manufacturing the same |
JP2003199781A (en) * | 2001-10-24 | 2003-07-15 | Daiya Seiyaku Kk | Pad material and portable pad material |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US4692462A (en) * | 1985-03-18 | 1987-09-08 | Menley & James Laboratories, Ltd. | Compositions and method of controlling transdermal penetration of topical and systemic agents |
CA2078960A1 (en) * | 1992-04-21 | 1993-10-22 | John Wick | Hydrogel applicator and methods of making same |
JP5226948B2 (en) * | 2006-12-14 | 2013-07-03 | 花王株式会社 | Laminated sheet and body sticking sheet |
-
2018
- 2018-05-31 JP JP2018105550A patent/JP2019208691A/en active Pending
-
2019
- 2019-05-03 TW TW108115403A patent/TWI787506B/en not_active IP Right Cessation
- 2019-05-13 WO PCT/JP2019/019001 patent/WO2019230362A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000139986A (en) * | 1998-11-06 | 2000-05-23 | Pigeon Corp | Cooling gel sheet |
JP2003019157A (en) * | 2001-07-06 | 2003-01-21 | Advance Co Ltd | Hot feeling material and cold feeling material |
JP2003102760A (en) * | 2001-09-28 | 2003-04-08 | Toko Yakuhin Kogyo Kk | Sticking material and method of manufacturing the same |
JP2003199781A (en) * | 2001-10-24 | 2003-07-15 | Daiya Seiyaku Kk | Pad material and portable pad material |
Also Published As
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TWI787506B (en) | 2022-12-21 |
TW202011913A (en) | 2020-04-01 |
WO2019230362A1 (en) | 2019-12-05 |
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