JP2019145228A - Illumination system - Google Patents

Abstract

To provide an illumination system in which the inside of a work room that can be hermetically shielded from an external environment can be easily visually recognized from any position with a simple configuration in the work room.SOLUTION: An illumination system includes illumination means having illumination of a plurality of tones, and control means for controlling the illumination means to change the color tone of the illumination, and the inside of a work room can be easily visually recognized from inside or outside the work room by lighting the color tone illumination corresponding to the situation inside the work room inside the work room.SELECTED DRAWING: Figure 1

Description

  INDUSTRIAL APPLICABILITY The present invention can be used for work performed while maintaining the interior in a sterilized state, and work for handling substances that affect the human body inside, and illuminates the interior of a work room that can be hermetically shielded from the external environment. It is about the system.

  Isolators, clean benches, RABS (access restriction barrier system), clean rooms, and the like are important to maintain sterility inside. In particular, in the decontamination of an aseptic room, which is a working room for pharmaceutical manufacturing, it is necessary to complete advanced decontamination validation in accordance with GMP (Good Manufacturing Practice).

  Therefore, the inside of these work rooms is periodically decontaminated. Decontamination gas such as hydrogen peroxide gas is used for decontamination, but when the decontamination gas is supplied indoors or the room is full of decontamination gas, it is mistaken for the aseptic room. Entering is dangerous. Further, when the door of the sterile room is opened in such a state, not only the internal decontamination work is impaired, but also the external environment is contaminated and the health of workers outside the work room is adversely affected. On the contrary, when the inside of the working chamber is in a sterile state, if the door of the sterile chamber is opened, the internal sterile state is impaired.

  Accordingly, it is possible to easily recognize that the inside of the working chamber is in a sterile state in which decontamination is completed or a dangerous state during the decontamination work. is necessary. Furthermore, it is necessary for the worker to be able to easily recognize what process or state is currently in the working room in which the decontamination work is being performed.

  On the other hand, in a containment work room that handles environmental pollutants inside the work room, it is very dangerous to accidentally enter the work room or open the work room door when there are environmental pollutants in the room. . Therefore, it is necessary to make it easy for workers outside the work room to recognize that environmental pollutants are present in the room.

  In addition, as described above, not only is the internal state of the working chamber recognized, but also the internal airtightness is destroyed during the work of checking the internal airtightness and working in the working chamber. It is important to give a warning to the worker even in the event of a failure. Furthermore, in the work through a glove such as an isolator, a dangerous state may be considered depending on the operating state of the device inside the work chamber and the position of the operator's hand through the glove. Even in such a case, it is important to promptly alert the worker.

  As a method of informing the worker about the internal state of the work room and a method of issuing a warning, for example, a warning is displayed on the door of the work room being decontaminated, or a warning such as a pilot lamp indicating that decontamination is in progress. It is done to display with a light. Further, in the following Patent Document 1, as a method for notifying an operator of the presence of a fire in the work space of a clean bench, combining a fire alarm sensor and a warning unit is proposed.

JP 2008-253203 A

  By the way, the clean bench proposed in Patent Document 1 issues a warning immediately when a dangerous state occurs, and cannot be adopted as a method for notifying the operator of the internal state of the work room. In addition, in the caution display and pilot lamp, there is a problem that the caution display and pilot lamp are not turned on due to some work mistakes, or the display or pilot lamp is only in a specific position and the operator overlooks them. .

  Accordingly, the present invention addresses the above-described problems and makes it possible to easily change the internal state of the work chamber from any position with a simple configuration in a work chamber that can be hermetically shielded from the external environment. An object is to provide a lighting system that can be visually recognized.

  In solving the above-mentioned problems, the present inventors have found that the object of the present invention can be achieved by changing the color tone of the interior lighting of the working room corresponding to the state inside the working room as a result of intensive studies. The present invention has been completed.

That is, the illumination system according to the present invention is as described in claim 1.
An illumination system (60) for illuminating the interior of a work room (10) that can be hermetically shielded from an external environment,
Illuminating means (61a, 61b, 62a, 62b) having lighting of a plurality of color tones, and control means for controlling the lighting means to change the color tone of the illumination,
By turning on the illumination of the color tone corresponding to the situation inside the work room by the control means inside the work room,
The environment inside the working chamber can be easily visually recognized from inside or outside the working chamber.

According to the description of claim 2, the present invention is the illumination system according to claim 1,
In decontamination work inside the working chamber,
In the decontamination step of performing decontamination inside the working chamber using a supply means for supplying decontamination gas,
The control means includes an operation sensor that detects an operation state of the supply means of the supply means,
When the operation sensor detects the operating state of the supply unit, the control unit controls the illumination unit to change the color tone of the illumination.

According to the description of claim 3, the present invention is the illumination system according to claim 1,
In decontamination work inside the working chamber,
A decontamination step of decontaminating the inside of the working chamber using a supply means for supplying a decontamination gas;
After the decontamination step, the air supply means for supplying dilution air for eliminating the decontamination gas filled in the working chamber, and the decontamination gas and dilution air inside the working chamber are discharged. In the aeration process of performing aeration inside the working chamber using the exhaust means,
The control means includes a concentration sensor (63) for detecting the concentration of the decontamination gas inside the working chamber,
When the concentration sensor detects the concentration of the decontamination gas inside the working chamber, the control unit controls the illumination unit to change the color tone of the illumination.

Moreover, according to the description of Claim 4, this invention is an illumination system as described in any one of Claims 1-3,
In decontamination work inside the working chamber,
A humidity sensor (66) for detecting the humidity inside the work chamber in the humidity control step of adjusting the humidity inside the work chamber using a humidity control means before the decontamination step With
When the humidity sensor detects the humidity inside the working chamber, the control means controls the illumination means to change the color tone of the illumination.

Moreover, according to the description of Claim 5, this invention is the illumination system of Claim 4, Comprising:
In decontamination work inside the working room and work in aseptic conditions,
During the humidity control process, humidity control completion, decontamination gas supply, decontamination gas supply completion, decontamination, aeration, aeration completion, and aseptic operation, according to the state of each process,
The control means controls the illumination means to change the color tone of the illumination.

Moreover, according to the description of Claim 6, this invention is an illumination system as described in any one of Claims 1-5,
In the airtightness inspection work to inspect or manage the airtightness of the inside of the working room that is in a positive pressure state compared to the external environment,
The control means includes a pressure sensor (64) for detecting the pressure inside the working chamber,
The control means calculates a pressure reduction speed inside the work chamber based on information from the pressure sensor, and determines that the airtightness of the work chamber is in a broken state when the pressure reduction speed exceeds a predetermined value. Then, the illumination means is controlled to change the color tone of the illumination.

Moreover, according to the description of Claim 7, this invention is the illumination system of Claim 1, Comprising:
The working chamber is a chamber of an isolator, and has a working device inside the chamber.
The control means includes an operation sensor that detects an operation state of the work device,
When the operation sensor detects the operation state of the working device, the control unit controls the illumination unit to change the color tone of the illumination.

Moreover, according to the description of Claim 8, this invention is the illumination system of Claim 7, Comprising:
The isolator has a glove for an outside worker to work inside the chamber,
The control means includes an area sensor (65) for detecting the position of the globe,
When the area sensor detects when the operator puts an arm on the glove or when the glove is in the vicinity of the work device, the control unit controls the illumination unit to change the color tone of the illumination. It is characterized by changing.

Moreover, this invention is an illumination system as described in any one of Claims 1-8 according to description of Claim 9, Comprising:
The working chamber is an isolator chamber,
The isolator includes, in addition to the main body chamber, one or more pass boxes for putting in and out articles inside the chamber,
The chamber and each pass box have independent illumination means,
The control means controls the illumination means to change the color tone of illumination of the chamber and each pass box simultaneously or separately.

Moreover, according to the description of Claim 10, this invention is the illumination system as described in any one of Claims 1-9,
The control means controls the illuminating means to perform a change due to blinking of the illumination in addition to a change due to the color tone of the illumination.

  According to the said structure, the illumination system which concerns on this invention is an illumination system which illuminates the inside of the working room which can be sealed airtight with an external environment. In addition, this illumination system has illumination means and control means. The illumination means has illumination of a plurality of colors. The control means controls the illumination means to change the color tone of the illumination. Then, the illumination means is controlled by the control means, and the illumination of the color tone corresponding to the situation inside the work room is turned on inside the work room.

  As a result, the environment inside the work room can be easily seen from the inside or the outside of the work room. Therefore, according to the present invention, there is provided a lighting system capable of easily recognizing the internal state of a work room from any position with a simple configuration in a work room that can be hermetically shielded from the external environment. be able to.

  Moreover, according to the said structure, in the decontamination process of the decontamination operation | work inside a working chamber, the inside of a working chamber is decontaminated using the supply means which supplies the gas for decontamination. At this time, the operation state of the supply means is detected by an operation sensor provided in the control means. Based on the detection of the operation sensor, the control unit controls the illumination unit to change the color tone of the illumination.

  This makes it easy to visually recognize that the inside of the working chamber is in a decontamination process and requires attention. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

  Further, according to the above configuration, in the decontamination process and the aeration process of the decontamination work inside the work chamber, in order to exclude the decontamination gas filled in the work chamber, the supply means for supplying the decontamination gas The interior of the work chamber is decontaminated and aerated using an air supply means for supplying the dilution air and an exhaust means for exhausting the decontamination gas and dilution air inside the work chamber. At this time, the concentration of the decontamination gas inside the working chamber is detected by a concentration sensor provided in the control means. Based on the detection of the concentration sensor, the control unit controls the illumination unit to change the color tone of the illumination in accordance with the concentration of the decontamination gas.

  This makes it easy to visually recognize whether the inside of the working chamber is in the decontamination process or in which stage of the aeration process. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

  Moreover, according to the said structure, in the humidity control process of the decontamination operation | work inside a working chamber, the humidity inside a working chamber is adjusted using a humidity control means before a decontamination process. At this time, the humidity inside the working chamber is detected by a humidity sensor provided in the control means. Based on the detection of the humidity sensor, the control unit controls the illumination unit to change the color tone of the illumination according to the humidity inside the work room.

  Thereby, it is possible to easily visually check at which stage of the humidity control process the interior of the working chamber is located or whether the humidity control is completed. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

  Further, according to the above configuration, in the decontamination work inside the work room and the work in the aseptic state, during the humidity adjustment process, humidity adjustment completion, decontamination gas supply, decontamination gas supply completion, decontamination In accordance with the state of each process during aeration, completion of aeration, and aseptic operation, the control means controls the illumination means to change the color tone of the illumination.

  Thereby, it is possible to easily visually recognize which step of the decontamination work the inside of the working chamber is in or a state in which work in a sterile state is possible. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

  Moreover, according to the said structure, the inside of a working chamber may be in a positive pressure state compared with an external environment, and the airtightness inside a working chamber may be test | inspected or managed. In this airtightness inspection work, the pressure inside the working chamber is detected by a pressure sensor provided in the control means. Further, the control means calculates the pressure reduction speed inside the work chamber based on information from the pressure sensor, and determines that the airtightness of the work chamber is in a broken state when the pressure reduction speed exceeds a predetermined value. When it is determined that the airtightness is in a broken state, the control unit controls the lighting unit to change the color tone of the lighting.

  This makes it easy to visually recognize that the airtightness inside the working chamber is in a broken state and is in a dangerous state. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

  Moreover, according to the said structure, a working chamber is a chamber of an isolator and has a working apparatus inside the chamber. At this time, the operation state of the work device is detected by an operation sensor provided in the control means. Based on the detection of the operation sensor, the control unit controls the illumination unit to change the color tone of the illumination.

  This makes it easy to visually recognize that the working device inside the chamber is in an operating state or that the working device is in an abnormal state and requires attention. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

  Moreover, according to the said structure, a working chamber is a chamber of an isolator, and the isolator has the glove for an outside worker to work inside the said chamber. At this time, the area sensor provided in the control means detects when the operator puts his arm in the glove or when the glove is in the vicinity of the work device. Based on the detection of the area sensor, the control unit controls the illumination unit to change the color tone of the illumination.

  This makes it easy to visually recognize that the worker is in the working state inside the chamber or that the worker's glove is in the vicinity of the working device and requires attention. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

  Further, according to the above configuration, the working chamber is a chamber of an isolator, and the isolator includes one or two or more pass boxes for putting articles into and out of the chamber in addition to the main body chamber. The chamber and each pass box have independent illumination means. At this time, the control means controls the illumination means to change the color tone of the illumination of the chamber and each pass box simultaneously or separately.

  Thereby, it is possible to easily visually check the state of the chamber and each pass box. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

  Further, according to the above configuration, the control unit may control the illumination unit to perform a change due to blinking of the illumination in addition to a change due to the color tone of the illumination.

  Accordingly, it is possible to easily visually recognize the state of the chamber and each pass box, or the emergency state. Therefore, according to the said structure, the above-mentioned effect can be demonstrated more concretely.

It is the schematic of the cross section which looked at the inside of the isolator apparatus with which the illumination system which concerns on this invention was mounted | worn from the side surface. It is a figure which shows the color tone change by the illumination system with respect to the flowchart of the airtightness test | inspection work in an Example. It is a figure which shows the color change by the illumination system with respect to the humidity control process of the decontamination work in an Example, and the flowchart of a decontamination process. It is a figure which shows the color tone change by the illumination system with respect to the flowchart of the aeration process of the decontamination work in an Example. It is a figure which shows the color tone change by the illumination system with respect to the operation | work in the chamber of the aseptic state in an Example.

  Hereinafter, an embodiment of an illumination system according to the present invention will be described with reference to the drawings. FIG. 1 is a schematic cross-sectional view of the inside of an isolator device equipped with the illumination system according to the present embodiment as viewed from the side. In the present embodiment, an isolator chamber will be described as an example of the “working room” in the present invention, but the present invention is not limited to this, and an external device such as a clean bench, RABS (access restriction barrier system), or a clean room is used. It includes an internal environment that is hermetically shielded from the environment.

  First, the isolator device will be described. In FIG. 1, an isolator device 1 includes a gantry 2 placed on a floor surface and an isolator body 3 placed on the gantry 2. The gantry 2 is covered with a wall material made of a stainless steel metal plate, and an electrical equipment and a machine room (not shown) are accommodated therein. The isolator main body 3 includes a chamber 10, an air supply mechanism 20, and an exhaust mechanism 30.

  The isolator device 1 of FIG. 1 includes a decontamination gas generator 40 for decontaminating the inside of the chamber 10 in order to ensure the aseptic condition of the chamber 10. In addition, a medicine filling device 50 that is operated in a sterile state is placed inside the chamber 10.

  The chamber 10 is formed of a box made of a stainless steel metal plate, and is hermetically shielded from an external environment in which an operator (not shown) works except for the limited intake and exhaust ports. A front door 11a and a back door 11b are provided on the front wall portion 10a (right side surface in the drawing) and the back wall portion 10b (left side surface in the drawing) of the chamber 10, respectively.

  Above the interior of the chamber 10, there is a circulation fan 12 that circulates the air inside the chamber 10, a HEPA filter 13 that cleans the circulated air below and a HEPA filter 13 that is below it And a rectifying plate 14 that rectifies the rectified air.

  On the other hand, a front partition wall 15a and a back partition wall 15b are disposed below the interior of the chamber 10 inside the front door 11a and the back door 11b of the chamber 10, respectively, in parallel with the doors 11a and 11b. Both the partition walls 15a and 15b are supported by the both side wall portions so that the left and right end portions (not shown) are in contact with the left and right side wall portions (front and back in the drawing direction) of the facing chamber 10, respectively.

  Moreover, both the partition walls 15a and 15b are provided with a certain space without contacting the bottom wall portions 10c of the chambers 10 facing the lower end portions. Furthermore, both the partition walls 15a and 15b are supported by the rectifying plate 14 so that the upper end portions thereof are in contact with the rectifying plate 14 provided below the upper wall portion 10d of the opposing chamber 10.

  Thus, due to both the partition walls 15a and 15b provided inside the chamber 10, the internal space of the chamber 10 is a space between the partition walls 15a and 15b (hereinafter referred to as the central space 16a), and both the partition walls 15a and 15b. And two spaces between the front and rear doors 11a and 11b (hereinafter referred to as peripheral space 16b). An upper space 16c is divided above the two peripheral spaces 16b.

  The front door 11a and the back door 11b provided on the front wall portion 10a and the back wall portion 10b of the chamber 10 are provided with transparent glass windows 17a and 17b, respectively, and the front wall portion 10a and the back wall portion 10b Transparent glass windows 17c and 17d are also provided in the front partition wall 15a and the back partition wall 15b provided in parallel. Thus, an operator standing on the front or back of the chamber 10 can visually recognize the inside of the chamber 10 through the glass windows 17a, 17b, 17c, and 17d provided in the doors 11a and 11b and the partition walls 15a and 15b. can do.

  Two working openings 18a are provided through which the outside communicates with the internal space 16a of the chamber 10 via the front door 11a and the front partition 15a. Further, two working openings 18b are provided for communicating the outside with the internal space 16a of the chamber 10 through the back door 11b and the back partition 15b. The base end portions of the resin gloves 19a and 19b are hermetically attached to the respective work openings 18a and 18b by an attachment frame (not shown), and the distal ends thereof are inserted into the central space 16a.

  The air supply mechanism 20 includes an air supply blower 21 for supplying outside air into the chamber 10, an air supply filter unit 22 for filtering the air supplied from the air supply blower 21, a damper 23, It has. On the other hand, the exhaust mechanism 30 includes an exhaust blower 31 for exhausting the air in the chamber 10 to the outside, an exhaust filter unit 32 for filtering the air exhausted from the exhaust blower 31, a damper 33, It has.

  The air supply mechanism 20 and the exhaust mechanism 30 are used for maintaining the air pressure in the chamber 10 at a positive pressure from the external environment, or for aeration after decontamination, in addition to supplying and exhausting air into the chamber 10. Is done. Inside the chamber 10 configured in this manner, the air in the upper space 16 c is circulated by the circulation fan 12, and the air blown from the circulation fan 12 is cleaned by the HEPA filter 13 and is centered via the rectifying plate 14. It flows through the space 16a as a laminar flow from above to below. Further, the air that flows below the central space 16a circulates in the upper space 16c through the peripheral space 16b.

  The decontamination gas generator 40 is used in the decontamination work for decontaminating the inside of the chamber 10 and ensuring a sterility state. The decontamination gas generator 40 includes a hydrogen peroxide solution storage tank (not shown) and a vaporizer 41 that vaporizes the hydrogen peroxide solution to generate hydrogen peroxide gas containing water vapor. In the decontamination work for decontaminating the inside of the chamber 10, hydrogen peroxide gas (decontamination gas) generated in the vaporizer 41 is supplied from the upper wall portion 10 d of the chamber 10 to the upper space 16 c through the introduction pipe 42. Then, the inside of the chamber 10 is circulated by the circulation fan 12.

  The pharmaceutical filling device 50 is given as an example of the “working device” in the present invention. In this embodiment, it is an apparatus for filling a container with a medicine, and may be automatic or manual. In the present invention, the working device is not limited to the pharmaceutical filling device, and may be a crushing device, a mixing device, a measuring device, a processing device, or the like.

  Next, the illumination system according to the present embodiment in the isolator device configured as described above will be described. The illumination system according to the present invention has illumination means and control means. The illumination means has illumination of a plurality of colors. Here, the illumination of a plurality of color tones means that it has illumination of an operation color tone and at least one illumination of a different color tone. The illuminations of different colors are illuminations for warning, alerting, or notifying some information to the worker, unlike during normal work. Hereinafter, the working color tone illumination is referred to as a work illumination lamp, and the warning or alert color tone illumination is referred to as a notification illumination lamp.

  Here, “color tone” is, according to Kojien 6th edition (Iwanami Shoten), “color strength and shade of color. Accordingly, in the present invention, the “color tone” means the tone of all the colors (including not only chromatic colors but also achromatic colors) represented by the three attributes of color (hue, lightness, and saturation). Any color including

  On the other hand, the control means controls the illumination means to change the color tone of the illumination. This control device may be a switch for switching between the work illumination lamp and the notification illumination lamp alone, or may be an automatic control device such as a microcomputer having a control circuit. The control device may include various sensors, arithmetic circuits, and the like. Although this control device is not shown in FIG. 1, it may be installed at a position away from the isolator device 1 or stored in the gantry 2 in the same manner as the electrical equipment and machine room (not shown) of the isolator device 1. It may be done.

  In this embodiment, in FIG. 1, the illumination system 60 mounted on the isolator device 1 includes work illumination lamps 61a and 61b, notification illumination lamps 62a and 62b, a hydrogen peroxide gas concentration sensor 63, a pressure sensor 64, An area sensor 65, a humidity sensor 66, and a control device (not shown) are provided. Note that the lighting system according to the present invention does not need to include all of these elements, but may include an illumination lamp and a control device and combine other elements in accordance with the purpose.

  In FIG. 1, work illumination lamps 61 a and 61 b are disposed in a space between the HEPA filter 13 and the rectifying plate 14. In addition, the arrangement | positioning position of the working illumination lamps 61a and 61b is not restricted to this, You may make it arrange | position in the other position in the chamber 10. FIG. The work illumination lamps 61a and 61b are illuminations for an operator to perform work in the chamber 10 of the isolator device 1 through the globes 19a and 19b, and are not particularly limited in kind. For example, the color tone, illuminance, and the like can be appropriately selected depending on the size of the chamber 10 and the type of work. In the present embodiment, two white fluorescent tubes are employed. The work illumination lamps 61a and 61b may be turned on and off by the control device.

  In FIG. 1, the notification illumination lamps 62a and 62b are disposed at different positions. One notification lamp 62a is disposed at the same position as the work lamps 61a and 61b in the space between the HEPA filter 13 and the rectifying plate 14. The other notification illumination lamp 62b is disposed above the back partition 15b of the central space 16a. The arrangement positions of the notification lamps 62a and 62b are not limited to these, and other positions in the chamber 10 can be used as long as the environment inside the work room can be easily visually recognized from the inside or outside of the work room. You may make it arrange | position to.

  Further, in the present embodiment, the two notification illumination lamps 62a and 62b are disposed at different positions, but two or more notification illumination lamps may be disposed at the same position. Furthermore, in the present embodiment, two notification illumination lamps are employed, but the present invention is not limited to this, and only one notification illumination lamp or three or more notification illumination lamps may be employed. When one notification illumination lamp is employed, one illumination lamp may express a single color tone or may express a plurality of color tones. Further, when two or more notification illumination lamps are employed, each expresses a single color tone, and a plurality of tone colors may be expressed by a plurality of illumination lamps.

  These notification illumination lamps 62 a and 62 b are lights for notifying the worker in the external environment of the isolator device 1 of the state in the chamber 10. Therefore, it is an illumination lamp having a color tone different from that of the white illumination used at the time of operation, and may be an illumination lamp changing to a plurality of color tones as described above. In the present embodiment, an LED lamp capable of changing color tone by RGB is employed. By adopting this LED lamp, a plurality of or many colors can be expressed by one or a small number of illumination lamps. In addition, it is not restricted to the LED lamp which can change color tone, You may make it employ | adopt multiple LED lamps or fluorescent tubes of a single light.

  The hydrogen peroxide gas concentration sensor 63 inserts the sensor main body into the central space 16a from the bottom wall portion 10c of the chamber 10, and detects the hydrogen peroxide gas concentration inside the chamber 10 during the decontamination work. This hydrogen peroxide gas concentration sensor 63 is used for the decontamination work in the chamber 10, the concentration of hydrogen peroxide gas introduced into the chamber 10 from the decontamination gas generator 40 in the decontamination process, and the chamber in the aeration process. The decreasing concentration of the hydrogen peroxide gas in 10 is sequentially detected and information is transmitted to the control device. Therefore, it is possible to notify the operator of the concentration of the hydrogen peroxide gas in the chamber 10 and to warn or call attention.

  The measurement principle of the hydrogen peroxide gas concentration sensor 63 includes various methods such as an ultraviolet excitation fluorescence method (enzyme catalyst removal method peroxidation), but the sensor model and measurement principle are not particularly limited. What is necessary is just to employ | adopt suitably what is suitable for the decontamination operation | work of an isolator apparatus.

  In the present embodiment, the hydrogen peroxide gas concentration sensor is employed, but instead of this, an operation sensor for detecting the operation state of the decontamination gas generator 40 may be employed. This operation sensor detects the operation state of the decontamination gas generator 40 and transmits information to the controller. Therefore, it is possible to notify the worker that the hydrogen peroxide gas is being supplied into the chamber 10 and warn or call attention. When the operation sensor is employed, the supply of hydrogen peroxide gas in the decontamination process can be detected, but the change in the concentration of the hydrogen peroxide gas in the chamber 10 cannot be sequentially detected.

  The pressure sensor 64 sequentially detects the pressure inside the chamber 10 via the pipe 64a led out from the bottom wall portion 10c of the chamber 10, and transmits information to the control device. This pressure sensor 64 is used in the airtightness test in the chamber 10 or when detecting that the airtightness in the chamber 10 is broken during the operation of the isolator device. The airtightness test will be described later. Therefore, the operator can be alerted or alerted that the airtightness in the chamber 10 has been destroyed.

  The measurement principle of the pressure sensor 64 includes various types such as a Bourdon tube pressure gauge, a diaphragm pressure gauge, a bellow pressure gauge, and a liquid column pressure gauge, but the sensor model and the measurement principle are not particularly limited. What is necessary is just to employ | adopt suitably what is suitable for the airtight test of an isolator apparatus.

  The area sensor 65 is disposed at the position of the globe 19a from the front partition 15a of the chamber 10 toward the central space 16a. By adjusting the position of the area sensor 65 to the arm portion of the glove 19a, it is detected when the operator puts the arm into the glove 19a, and information is transmitted to the control device. In addition, by adjusting the position of the area sensor 65 in the vicinity of the medicine filling device 50, the operator detects when the hand inserted in the glove 19a is brought close to the medicine filling device 50 operated by the operator and sends information to the control device. Send. Accordingly, it is possible to notify the operator that the pharmaceutical filling device 50 that is operating is approached and to warn or alert.

  The area sensor 65 has various measurement principles such as a photoelectric sensor. However, the sensor model and measurement principle are not particularly limited, and a sensor suitable for work in the isolator device may be appropriately adopted. Good.

  In the present embodiment, the area sensor 65 is used for detection when the operator brings the glove 19a close to the medicine filling device 50. Instead, an operation sensor for detecting the operating state of the medicine filling device 50 is used. You may make it do. This operation sensor detects the operation state of the medicine filling device 50 and transmits information to the control device. Therefore, it is possible to notify the operator that the medicine filling device 50 is operating, or that the operation of the operating device is in an abnormal state, and warn or warn the operator.

  The humidity sensor 66 inserts the sensor main body into the upper space 16c from the back wall portion 10b of the chamber 10, and the humidity in the chamber 10 during the humidity control process during the decontamination work or the work in the isolator device. Are sequentially detected and information is transmitted to the control device. Therefore, it is possible to inform the operator of how much the humidity in the chamber 10 is, and to alert or notify the operator.

  The measurement principle of the humidity sensor 66 includes various types such as a polymer sensor such as a resistance type and a capacitance type, and a ceramic sensor. However, the sensor model and the measurement principle are not particularly limited. What is necessary is just to employ | adopt suitably for the humidity measurement in the inside.

  The control device (not shown) controls the illumination means (working illumination lamps 61a and 61b and notification illumination lamps 62a and 62b) in accordance with a program set in advance by receiving information from each sensor. Change the color of the lighting. The control device may not only change the color tone of the illumination but also control the illumination means to blink the illumination. The specific correspondence with each sensor will be described later.

  As described above, when the color tone of the illumination is different from the color tone at the time of normal work, the worker can be warned, alerted or notified of some information. Note that the notification illumination lamps 62a and 62b are disposed in the chamber 10 and irradiate all the wall surfaces in the chamber 10, so that an operator outside the chamber 10 can change the state of the chamber 10 in any way. It can be easily visually recognized from the position.

  Next, various operations performed using the isolator device and the illumination system configured as described above will be described with reference to examples. In addition, this invention is not limited only to a following example.

  In the present embodiment, the illumination system 60 is effectively used in a series of operations with the isolator device. The present embodiment relates to an airtightness inspection operation for confirming the airtightness in the chamber 10, a decontamination operation for ensuring aseptic conditions in the chamber 10, and operations in the aseptic chamber 10. Hereinafter, the effectiveness of each work and the lighting system 60 will be described.

1. Airtightness inspection work FIG. 2 is a diagram showing a change in color tone by the illumination system with respect to a flow chart of the airtightness inspection work in the present embodiment. In FIG. 1, both doors 11a and 11b of the isolator device 1 are sealed, and the airtightness inspection work is started from a state in which both dampers 23 and 33 of the air supply and exhaust mechanisms 20 and 30 are closed.

  In step S1 of FIG. 2, the pressure in the chamber 10 is increased to a positive pressure rather than the external environment. Specifically, the damper 23 of the air supply mechanism 20 is opened and the blower 21 is driven to supply air into the chamber 10. At this time, the inside of the chamber 10 is illuminated with white light by the working illumination lamps 61a and 61b by the control device of the illumination system 60. Further, the pressure sensor 64 is activated to transmit information related to the internal pressure of the chamber 10 to the control device.

  Next, in step S2, when the internal pressure of the chamber 10 reaches a preset pressure in the airtightness inspection operation, information from the pressure sensor 64 is transmitted to the control device. Accordingly, the control device blinks the white light of the work illumination lamps 61a and 61b in order to notify that the internal pressure of the chamber 10 has reached a predetermined pressure. Thus, an operator outside the isolator device 1 can easily visually recognize that the internal pressure of the chamber 10 has reached a predetermined pressure through the glass windows 17a, 17b, 17c, and 17d of the isolator device 1. Can do.

  Next, in step S3, the pressurization in the chamber 10 is stopped, and the measurement of the internal pressure by the pressure sensor 64 is continued. These measured values are sequentially transmitted from the pressure sensor 64 to the control device. In the present embodiment, the illumination lamps 62a and 62b for notification are turned on by the control device and the color tone is controlled to yellow so that the inside of the chamber 10 is illuminated with yellow light. As a result, all the wall surfaces in the chamber 10 are irradiated with yellow light, so that an operator outside the chamber 10 can easily recognize that the inside of the chamber 10 is measuring a change in internal pressure. Can do.

  Next, in step S4, the pressure reduction rate of the internal pressure by the control device is calculated while measuring the internal pressure of the chamber 10 by the pressure sensor 64. The calculation of the pressure reduction speed is indicated by the pressure change (pressure reduction amount) per unit time according to a program preset in the control device. In addition, a limit value (set value) of the decompression speed is set for each isolator device that performs the airtightness inspection, and if a large decompression speed exceeding this set value is calculated, the control device Is judged as the destruction of airtightness.

  When it is determined that the airtightness is broken, the control device controls the notification lamps 62a and 62b to change the color tone to red and blinks to issue a warning. As a result, all wall surfaces in the chamber 10 are irradiated with red flashing light, so that an operator outside the chamber 10 can easily visually recognize that the airtightness of the chamber 10 is in a broken state. it can.

  On the other hand, in step S4, if the hermetic breakdown is not detected within a preset time while repeating the calculation of the decompression speed, the elapse of a predetermined time is confirmed in step S5. If no hermetic breakdown is detected until the elapse of the predetermined time in step S5, the chamber 10 is illuminated with yellow light.

  If it is confirmed in step S5 that the predetermined time has elapsed, the airtightness test is terminated in step S6. When the airtightness inspection is completed, the control device controls the notification illumination lamps 62a and 62b to change to a yellow blinking light and notifies it. As a result, all wall surfaces in the chamber 10 are irradiated with yellow flashing light, so that an operator outside the chamber 10 can easily recognize that the airtightness inspection of the chamber 10 has been completed. .

2. Decontamination Work FIG. 3 is a diagram showing a change in color tone by the illumination system with respect to a humidity control process and a flow chart of the decontamination process in the present embodiment. Moreover, FIG. 4 is a figure which shows the color tone change by an illumination system with respect to the flowchart of the aeration process of the decontamination work in a present Example. Prior to the decontamination process, the humidity inside the chamber 10 is conditioned in the humidity control process for the isolator device 1 that has not detected the hermeticity breakage in the above-described airtightness inspection work.

  In step S7 of FIG. 3, the damper 23 of the air supply mechanism 20 is adjusted to drive the blower 21 to supply air into the chamber 10, and the damper 33 of the exhaust mechanism 30 is adjusted to drive the blower 31 to drive the chamber. The air inside 10 is exhausted. Along with this air supply / exhaust, the circulation fan 12 in the chamber 10 is driven. In this state, the humidity inside the chamber 10 is adjusted to a predetermined humidity suitable for decontamination. Note that humidification into the chamber 10 may be performed via the air supply mechanism 20 or may be performed by a humidifier provided separately.

  At this time, the control device of the illumination system 60 controls the notification illumination lamps 62a and 62b to change the color tone to amber. As a result, all wall surfaces in the chamber 10 are irradiated with amber light, so that an operator outside the chamber 10 can easily recognize that the inside of the chamber 10 is in a humidity control operation. . Further, the humidity sensor 66 is activated to transmit information on the humidity in the chamber 10 to the control device.

  Next, when the humidity in the chamber 10 becomes a preset humidity, the humidity control process is terminated in step S8. At this time, the control device controls the notification illumination lamps 62a and 62b to change to the amber flashing light for notification. Thereby, since all the wall surfaces in the chamber 10 are irradiated with the amber flashing light, an operator outside the chamber 10 can easily recognize that the humidity control process of the chamber 10 has been completed. .

  In response to the notification of the end of the humidity control process, the humidity control is stopped in preparation for the subsequent decontamination process and the air supply mechanism 20 and the exhaust mechanism 30 are closed. Next, the decontamination process is started. First, in step S <b> 9, a decontamination gas is supplied into the chamber 10. In this example, hydrogen peroxide gas was used as the decontamination gas.

  Hydrogen peroxide gas was supplied by a decontamination gas generator 40. Hydrogen peroxide water is vaporized by the vaporizer 41 of the decontamination gas generator 40 to generate hydrogen peroxide gas containing water vapor, and is supplied from the upper wall portion 10d of the chamber 10 to the upper space 16c via the introduction pipe 42. . At this time, the circulation fan 12 was driven to circulate the hydrogen peroxide gas in the chamber 10.

  At this time, the control device of the illumination system 60 controls the notification illumination lamps 62a and 62b to change the color tone to purple and warn. As a result, since all the wall surfaces in the chamber 10 are irradiated with violet light, an operator outside the chamber 10 can easily recognize that the inside of the chamber 10 is being decontaminated. . Further, the concentration sensor 63 is activated to transmit information on the hydrogen peroxide gas concentration in the chamber 10 to the control device.

  Next, in step S <b> 10, the measurement of the hydrogen peroxide gas concentration by the concentration sensor 63 is continued while supplying the hydrogen peroxide gas into the chamber 10. These measured values are sequentially transmitted from the concentration sensor 63 to the control device.

  Next, when the hydrogen peroxide gas concentration in the chamber 10 reaches a preset concentration in the decontamination work in step S11, information from the concentration sensor 63 is transmitted to the control device. Thus, the control device blinks the purple light of the notification illumination lamps 62a and 62b in order to notify that the hydrogen peroxide gas concentration in the chamber 10 has reached a predetermined concentration suitable for decontamination. Thus, an operator outside the isolator device 1 can easily recognize that the hydrogen peroxide gas concentration in the chamber 10 has reached a predetermined concentration.

  When the hydrogen peroxide gas concentration in the chamber 10 reaches a predetermined concentration, the decontamination gas generator 40 is stopped and the supply of hydrogen peroxide gas is terminated. In this state, it is left for a predetermined time in order to complete decontamination. Next, the elapse of a predetermined time is confirmed in step S12. Until the passage of the predetermined time is confirmed in step S12, the inside of the chamber 10 is illuminated with purple light to notify that decontamination is in progress.

  If the elapse of the predetermined time is confirmed in step S12, the decontamination process is terminated in step S13. When the decontamination process is completed, the control device controls the notification illumination lamps 62a and 62b to change to a purple blinking light and notifies it. Thereby, since all the wall surfaces in the chamber 10 are irradiated with purple flashing light, an operator outside the chamber 10 can easily recognize that the decontamination process of the chamber 10 has been completed. .

  In response to the notification of the end of the decontamination process, the aeration process is started in step S14 of FIG. At this time, the control device of the illumination system 60 controls the notification illumination lamps 62a and 62b to change the color tone to dark green and warn. Thereby, since all the wall surfaces in the chamber 10 are irradiated with dark green light, an operator outside the chamber 10 can easily visually recognize that the inside of the chamber 10 enters the aeration process. Further, the concentration sensor 63 is activated to transmit information on the hydrogen peroxide gas concentration in the chamber 10 to the control device.

  Next, in step S15, supply / exhaust of clean air (dilution air) is started. Specifically, the air supply mechanism 20 is driven to introduce clean air (dilution air) into the chamber 10 to dilute the hydrogen peroxide gas in the chamber 10. Further, the exhaust mechanism 30 is driven to exhaust the hydrogen peroxide gas and the dilution air in the chamber 10 to the outside. By continuing these operations, all the hydrogen peroxide gas in the chamber 10 is exhausted to the outside.

  At this time, the control device controls the notification illumination lamps 62a and 62b to blink the dark green light of the notification illumination lamps 62a and 62b. As a result, since all the wall surfaces in the chamber 10 are irradiated with the flashing light of dark green, an operator outside the chamber 10 can easily visually recognize that the inside of the chamber 10 is being aerated. it can. Further, the concentration sensor 63 is activated to transmit information on the hydrogen peroxide gas concentration in the chamber 10 to the control device.

  Next, in step S <b> 16, the measurement of the hydrogen peroxide gas concentration by the concentration sensor 63 is continued while continuing the supply and exhaust of clean air (dilution air) into the chamber 10. These measured values are sequentially transmitted from the concentration sensor 63 to the control device. In the present embodiment, the color of the notification illumination lamps 62a and 62b is changed from dark green flashing light (corresponding to high concentration hydrogen peroxide gas) to light green flashing light (low) according to a program preset in the control device. Change gradation to correspond to the concentration of hydrogen peroxide gas.

  In this manner, when the hydrogen peroxide gas in the chamber 10 is diluted and the concentration reaches the detection limit of the concentration sensor 63, the aeration process is terminated in step S18. When the aeration process is finished, the control device controls the notification illumination lamps 62a and 62b to change to a blue blinking light and notifies it. This notification by the blue flashing light continues for several minutes. As a result, all wall surfaces in the chamber 10 are irradiated with blue flashing light for several minutes, so that an operator outside the chamber 10 has completed the aeration process of the chamber 10 and has ensured sterility. Can be easily recognized.

  The air supply mechanism 20 and the exhaust mechanism 30 are switched to normal operation in response to the notification of the end of the aeration process. Next, in step S19, the control device turns off the notification illumination lamps 62a and 62b and turns on the white light of the work illumination lamps 61a and 61b to ensure the sterility of the chamber 10 so that the work can be performed. Notify that there is.

3. Operation in Aseptic Chamber FIG. 5 is a diagram showing a change in color tone by the illumination system for an operation in the aseptic chamber according to this embodiment. In the isolator device 1 in which the sterility is ensured as described above, an external worker starts work through a glove.

  In step S19 of FIG. 5, the inside of the chamber 10 is in a state in which aseptic conditions are ensured, and white light of the work illumination lamps 61a and 61b is turned on by the control device of the illumination system 60.

  Next, in step S20, a work difference outside the chamber 10 starts work through the gloves 19a and 19b. At this time, the inside of the chamber 10 is illuminated with white light by the working illumination lamps 61a and 61b by the control device. Further, the pressure sensor 64 is activated to monitor the destruction of the airtightness during the work. Furthermore, a medicine filling device 50 is driven inside the chamber 10, and an operation sensor (not shown) for detecting the driving state of the medicine filling device 50 and an area sensor 65 is operated in the vicinity of the medicine filling device 50. doing. Hereinafter, the operation of each sensor and the color tone change by the illumination system will be described.

  First, in step S21, the operation of the pressure sensor 64 is the same as that in the above-described airtightness test. Here, both the air supply mechanism 20 and the exhaust mechanism 30 are in a normal operation state, and the internal pressure of the chamber 10 is kept constant. Again, the control device calculates the pressure reduction rate of the internal pressure. However, when some abnormality occurs during the work and the airtightness is destroyed, the controller calculates a large pressure reduction rate exceeding the set value based on information from the pressure sensor 64, and determines that the airtightness is broken.

  When it is determined that the airtightness is broken, the control device controls the notification lamps 62a and 62b to turn on the color tone in red and blink to issue a warning. As a result, all wall surfaces in the chamber 10 are irradiated with red flashing light, so that an operator working from outside the chamber 10 can easily recognize that the airtightness of the chamber 10 is in a broken state. can do.

  On the other hand, in step S22, if the predetermined work is completed without detecting the hermeticity breakage during the work while repeating the calculation of the decompression speed, the work is finished in step S24. When the hermetic breakdown is not detected during the operation, the inside of the chamber 10 is illuminated with white light for operation.

  Next, in step S22, when the operator's hand wearing the glove 19a approaches the vicinity of the medicine filling device 50 in operation due to the action of the area sensor 65, the lighting system 40 is activated in order to call attention. Specifically, the control device controls the illumination lamps 62a and 62b for notification to light the color tone orange and blink it to call attention. As a result, all wall surfaces in the chamber 10 are illuminated with orange flashing light, so that an operator working from outside the chamber 10 approaches the vicinity of the pharmaceutical filling device 50 in which his / her hand operates. This can be easily recognized.

  Next, in step S23, when the operation of the medicine filling device 50 is abnormal due to the action of an operation sensor (not shown), the illumination system 40 is activated in the sense of issuing a warning. Specifically, the control device controls the notification illumination lamps 62a and 62b to light up the color tone in reddish purple and blink to warn. As a result, all the wall surfaces in the chamber 10 are irradiated with the flashing light of reddish purple, so that an operator working from the outside of the chamber 10 is aware that some abnormality has occurred in the operation of the medicine filling device 50. It can be easily visually recognized.

  As described above, in the present invention, in the working room that can be hermetically shielded from the external environment, the lighting system can easily recognize the internal state of the working room from any position with a simple configuration. Can be provided.

In carrying out the present invention, not only the above-described embodiment but also the following various modifications can be mentioned.
(1) In the above embodiment, the illumination system is described by being disposed in the chamber of the isolator. However, the present invention is not limited to this, and an external environment such as a clean bench, a RABS (access restriction barrier system), a clean room, and the like. The lighting system can be applied to any working room as long as it has an airtightly shielded internal environment.
(2) In the above embodiment, each situation is changed so as to illuminate or blink in a different color according to the situation in the chamber of the isolator. However, the present invention is not limited to this, and only when a danger or the like is detected. A warning may be issued.
(3) In the above embodiment, the gradation of illumination color is changed by detecting the hydrogen peroxide gas concentration in the isolator chamber. However, the present invention is not limited to this, and the decontamination gas generator includes an operation sensor. A warning may be issued only when hydrogen peroxide gas is supplied into the chamber.
(4) In the above embodiment, when an area sensor is disposed in the vicinity of the medicine filling device disposed in the chamber of the isolator, and the operator brings the hand inserted into the glove near the operating device. Although it calls attention, it is not restricted to this, You may make it call attention when an operator inserts an arm in a glove.
(5) In the above embodiment, in the humidity adjustment process in the isolator chamber, only the start and completion of humidity adjustment are notified. However, the present invention is not limited to this, and the humidity value detected by the humidity sensor is used. In addition, the humidity state that changes during the humidity control operation may be notified sequentially.
(6) In the above embodiment, an LED lamp capable of changing the color tone by RGB is adopted in the illumination system. However, the present invention is not limited to this, and a plurality of single light LED lamps or fluorescent tubes are adopted. It may be.
(7) In the above embodiment, the illumination system is described by being disposed in the chamber of the isolator. However, the present invention is not limited to this, and in the isolator including one or more pass boxes, A notification illumination lamp may be provided in each pass box, and the color of illumination of the chamber and each pass box may be changed independently.
(8) In the above embodiment, the illumination system is arranged in a sterile isolator that operates in a sterile environment. However, the present invention is not limited to this, but a containment isolator that handles environmental pollutants inside the chamber. An illumination system may be provided to alert workers outside the isolator that environmental contaminants are present inside the chamber and are in danger.

1 ... isolator device, 2 ... mount, 3 ... isolator body,
10 ... chamber, 10a, 10b, 10c, 10d ... wall part,
11a, 11b ... door, 12 ... circulation fan, 13 ... HEPA filter, 14 ... current plate,
15a, 15b ... partition walls, 16a, 16b, 16c ... space,
17a, 17b, 17c, 17d ... glass window, 18a, 18b ... work opening,
19a, 19b ... Globe, 20 ... Air supply mechanism, 30 ... Exhaust mechanism,
21, 31 ... Blower, 22, 32 ... Filter unit, 23, 33 ... Damper,
40 ... Decontamination gas generator, 41 ... Vaporizer, 42 ... Introduction pipe, 50 ... Drug filling device,
60 ... Lighting system, 61a, 61b ... Working lamp,
62a, 62b ... notification lamp, 63 ... hydrogen peroxide gas concentration sensor,
64 ... Pressure sensor, 65 ... Area sensor, 66 ... Humidity sensor.

Claims (10)

An illumination system that illuminates the interior of a work room that can be hermetically shielded from the outside environment,
Illumination means having a plurality of color tone illumination, and control means for controlling the illumination means to change the color tone of the illumination,
By turning on the illumination of the color tone corresponding to the situation inside the work room by the control means inside the work room,
An illumination system characterized in that the environment inside the work room can be easily seen from inside or outside the work room. In decontamination work inside the working chamber,
In the decontamination step of performing decontamination inside the working chamber using a supply means for supplying decontamination gas,
The control means includes an operation sensor that detects an operation state of the supply means of the supply means,
The lighting system according to claim 1, wherein when the operation sensor detects an operation state of the supply unit, the control unit controls the illumination unit to change a color tone of the illumination. In decontamination work inside the working chamber,
A decontamination step of decontaminating the inside of the working chamber using a supply means for supplying a decontamination gas;
After the decontamination step, the air supply means for supplying dilution air for eliminating the decontamination gas filled in the working chamber, and the decontamination gas and dilution air inside the working chamber are discharged. In the aeration process of performing aeration inside the working chamber using the exhaust means,
The control means includes a concentration sensor that detects the concentration of the decontamination gas inside the working chamber,
2. The control device according to claim 1, wherein the concentration sensor detects the concentration of the decontamination gas inside the working chamber, and the control unit controls the illumination unit to change the color tone of the illumination. Lighting system. In decontamination work inside the working chamber,
In the humidity control step of adjusting the humidity inside the work chamber using a humidity control means before the decontamination step, the control means includes a humidity sensor that detects the humidity inside the work chamber,
The said humidity sensor detects the humidity inside the said working chamber, The said control means controls the said illumination means, The color tone of illumination is changed to any one of Claims 1-3 characterized by the above-mentioned. The lighting system described. In decontamination work inside the working room and work in aseptic conditions,
During the humidity control process, humidity control completion, decontamination gas supply, decontamination gas supply completion, decontamination, aeration, aeration completion, and aseptic operation, according to the state of each process,
The lighting system according to claim 4, wherein the control unit controls the lighting unit to change a color tone of the lighting. In the airtightness inspection work to inspect or manage the airtightness of the inside of the working room that is in a positive pressure state compared to the external environment,
The control means includes a pressure sensor for detecting the pressure inside the working chamber,
The control means calculates a pressure reduction speed inside the work chamber based on information from the pressure sensor, and determines that the airtightness of the work chamber is in a broken state when the pressure reduction speed exceeds a predetermined value. The lighting system according to claim 1, wherein the lighting unit is controlled to change a color tone of the lighting. The working chamber is a chamber of an isolator, and has a working device inside the chamber.
The control means includes an operation sensor that detects an operation state of the work device,
The lighting system according to claim 1, wherein when the operation sensor detects an operation state of the work device, the control unit controls the illumination unit to change a color tone of the illumination. The isolator has a glove for an outside worker to work inside the chamber,
The control means includes an area sensor for detecting the position of the globe,
When the area sensor detects when the operator puts an arm on the glove or when the glove is in the vicinity of the work device, the control unit controls the illumination unit to change the color tone of the illumination. The lighting system according to claim 7, wherein the lighting system is changed. The working chamber is an isolator chamber,
The isolator includes, in addition to the main body chamber, one or more pass boxes for putting in and out articles inside the chamber,
The chamber and each pass box have independent illumination means,
The illumination system according to claim 1, wherein the control unit controls the illumination unit to change the color tone of illumination of the chamber and each pass box simultaneously or separately.   The lighting system according to claim 1, wherein the control unit controls the lighting unit to perform a change due to blinking of the illumination in addition to a change due to a color tone of the illumination.

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