JP2019080975A - Coelomic fluid treatment device - Google Patents

Abstract

To provide a coelomic fluid treatment device having a structure capable of obtaining coelomic fluid such as an expected amount of concentrated ascites.SOLUTION: A coelomic fluid treatment device 1 comprises: a filter 11 for selectively removing a specific material in coelomic fluid; a concentrator 110 for concentrating the coelomic fluid filtered by the filter; a concentrated coelomic fluid bag 111 for collecting and storing the concentrated coelomic fluid concentrated by the concentrator; a recirculation device 62 for recirculating the concentrated coelomic fluid stored in the concentrated coelomic fluid bag to the concentrator; a liquid volume measuring device 150 for measuring a liquid volume of the concentrated coelomic fluid stored in the concentrated coelomic fluid bag; and a control device 50 for stopping filtering operation and recirculating the concentrated coelomic fluid stored in the concentrated coelomic fluid bag to the concentrator by the recirculation device when the liquid volume of the concentrated coelomic fluid stored in the concentrated coelomic fluid bag reaches a first predetermined volume, and restarting the filtering operation when concentration is performed until the liquid volume of the concentrated coelomic fluid reaches a second predetermined volume.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a body cavity fluid treatment apparatus.

  As a treatment for intractable ascites, ascites fluid is removed from the patient, pathogens such as bacteria and cancer cells are removed from the ascites fluid, and water is removed in a state where useful components such as albumin remain, and the concentrate is collected in the body. Ascites fluid filtration concentration re-injection (Cell-free and Concentrated Ascites Reinfusion Therapy).

  An ascites treatment device is generally used for such treatment. As the ascites fluid treatment apparatus, an ascites fluid bag, a filter, a concentrator, and a concentrated ascites fluid bag are connected in series in this order, and ascites fluid is made to flow by a head or a pump to filter and concentrate ascites fluid. ing. A filtration membrane such as a hollow fiber membrane is used for the filter.

  Further, as such an ascites treatment apparatus, one equipped with a system for automatically shifting from filtration to recirculation has been disclosed (see, for example, Patent Document 1).

JP, 2013-188427, A

  However, in a system that automatically shifts from filtration to recirculation, there is a problem that an expected amount of concentrated ascites may not be obtained due to an error or the like of each pump.

  In addition, the maximum volume of the concentrated ascites bag is smaller than that of the filtration bag, and if it is filtered and then recirculated, it may not enter the concentrated ascites bag and it may burst depending on the condition of water removal.

  Therefore, an object of the present invention is to provide a body cavity fluid treatment apparatus configured to obtain an expected amount of body cavity fluid such as concentrated ascites fluid.

A body cavity fluid processing apparatus according to one aspect of the present invention filters a body cavity fluid stored in a patient's body cavity or a body cavity fluid bag, removes water from the filtered body cavity fluid, and generates a concentrate cavity fluid. A liquid processing apparatus,
A filter comprising a filtering member that selectively removes a specific substance in a body cavity fluid;
A concentrator that concentrates the body cavity fluid filtered by the filter;
A concentrate cavity fluid bag for collecting and storing the concentrate cavity fluid concentrated by the concentrator;
A recirculator for recirculating concentrate cavity fluid stored in the concentrate cavity fluid bag to the concentrator;
A liquid quantity measuring device for measuring the liquid quantity of the concentrate body cavity fluid stored in the concentrate body cavity fluid bag,
When the volume of the concentrate cavity fluid stored in the concentrate cavity fluid bag reaches the first predetermined amount, the filtration operation is stopped, and the concentrate cavity fluid stored in the concentrate cavity fluid bag is recirculated to the concentrator by the recirculation device. A control device for resuming the filtration operation when the concentration of the concentrate cavity fluid reaches a second predetermined amount.
A body cavity fluid treatment apparatus.

  Usually, the volume of the concentrate cavity fluid bag itself is not controlled, and while the concentrate cavity fluid bag having a predetermined size is used, the volume of the concentrate cavity fluid actually obtained is the pump delivery volume. There are a variety of factors depending on multiple factors such as the difference in the amount of fluid flow, the patient's physical size, the amount of raw ascites fluid, the ascites fluid characteristics, the performance of the concentrator, the treatment status, and the treatment time. However, in order to reach the target body cavity fluid treatment amount (in the case of treating ascites contained in the raw ascites water bag, the total amount of the raw ascites water bag (ie, the target raw ascites water treatment amount)) Regardless of various factors, it is ideal to obtain as much concentrate cavity fluid as possible depending on the volume of the concentrate cavity fluid bag. In this respect, according to the body cavity fluid treating apparatus of the above aspect, while monitoring the stored measurement amount of the concentrate cavity fluid bag, it is possible to further remove water from the concentrate cavity fluid so that the expected volume can be obtained.

  In the cavity fluid treatment apparatus according to the above aspect, the fluid volume measuring device may calculate the fluid volume of the concentrate cavity fluid bag from the pump flow rate × time of the pump that causes the concentrate cavity fluid to flow through the concentrate cavity fluid bag. .

  In the cavity fluid treatment apparatus of the above aspect, the fluid volume measuring device may include a weight scale that weighs the concentrate cavity fluid bag.

  The body cavity fluid treating apparatus according to claim 3, wherein the fluid volume of the concentrate cavity fluid bag is defined based on the measurement value of a weighing scale.

The cavity fluid treatment apparatus according to the above aspect further includes a concentration pump, which is disposed downstream of the concentrator, and delivers the concentrate cavity fluid to the concentrate cavity fluid bag.
The liquid volume of the concentrate cavity fluid bag may be calculated from the pump flow rate × time based on the flow rate of the concentration pump controlled based on the measurement value of the weight scale.

  According to the present invention, it is possible to provide a body cavity fluid processing apparatus configured to obtain an expected amount of body cavity fluid such as concentrated ascites fluid.

It is an explanatory view showing an outline of composition of an ascites processing device in a 1st embodiment. It is explanatory drawing which shows the mode of the ascites processing apparatus of a reconcentration process. It is explanatory drawing which shows the mode of the ascites processing apparatus of a collection | recovery process. It is explanatory drawing which shows the mode of the ascites processing apparatus of a washing | cleaning process. It is a flowchart which shows an example of the processing process of ascites concentration in an ascites fluid processing apparatus. It is a graph which shows the transition example of the storage amount of the concentrated ascites fluid in the process process of ascites concentration in an ascites fluid processing apparatus. It is explanatory drawing which shows the outline of a structure of the ascites processing apparatus in 2nd Embodiment.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. In addition, the same code | symbol is attached | subjected to the same element and the overlapping description is abbreviate | omitted. Further, the positional relationship such as top, bottom, left, and right is not limited unless otherwise specified. Furthermore, the dimensional ratios in the drawings are not limited to the illustrated ratios. Also, the following embodiments are exemplifications for explaining the present invention, and the present invention is not limited to the embodiments.

  FIG. 1 is an explanatory view showing an outline of a configuration of an ascites treatment apparatus 1 as a body cavity fluid treatment apparatus according to the present embodiment. The ascites fluid treatment apparatus 1 filters the raw ascites fluid taken directly from the patient, or the raw ascites fluid collected from the patient and contained in the raw ascites fluid bag 10, removes water from the filtered ascites fluid, and produces concentrated ascites fluid. It is an apparatus.

  The ascites processing apparatus 1 comprises a filter 11, a first line 12, a second line 13, a third line 14, a first pressure measuring device 16, and a second pressure measuring device 17, The pump 18, the first opening / closing device 19, the upstream opening / closing device 21, the control device 50 and the like are provided. The ascites fluid treatment apparatus 1 is divided into a filtration system (filtering unit) 2 for performing a filtration process and a concentration system (concentrating unit) 3 for performing a concentration process (see FIG. 1 etc.).

  The filter 11 has, for example, a cylindrical shape, has flow openings 11a and 11b at both ends in the longitudinal direction, and has two flow openings 11c and 11d on the side surface. In addition, the filter 11 selectively removes a specific substance in ascites fluid, for example, to remove a predetermined etiologic substance such as bacteria and cancer cells, and to allow a predetermined useful component such as albumin to pass through. A filtration membrane 70 such as a hollow fiber membrane capable of The inner region of the filtration membrane 70 is in communication with the flow openings 11a and 11b, and the outer region of the filtration membrane 70 is in communication with the flow openings 11c and 11d.

  The first line 12 connects the raw ascites water bag 10 and the filter 11. The downstream end of the first line 12 is connected to the liquid passage port 11 a of the filter 11.

  The second line 13 connects the filter 11 and the later-described concentrator 110 of the concentration system 3. The upstream end of the second line 13 is connected to the liquid passage 11 c of the filter 11.

  One end of the third line 14 is connected to the liquid passage port 11 b of the filter 11. The other end of the third line 14 is connected to, for example, a drain (not shown).

  The connection of the filters may be reversed. That is, the downstream end of the first line 12 is connected to the liquid passage 11 c of the filter 11, the second line 13 is connected to the liquid passage 11 a of the filter 11, and the third line 14 is It may be connected to the liquid passage 11 d. Usually, a filter used for blood purification flows blood to the inside of the filtration membrane from the viewpoint of priming volume and reduces the priming volume of blood by filtering outside, but in the case of body cavity fluid treatment, body cavity fluid The treatment method may be appropriately selected according to the amount and composition of For example, in the case where the filtration is performed from the inside to the outside of the filtration membrane 70 of the filter 11, the cleaning effect in membrane cleaning performed when the membrane is clogged (flowing the cleaning solution from the outside to the inside of the filtration membrane 70) is expected When the filtration is performed from the outside to the inside of the filtration membrane 70 of the filter 11, the surface area of the filtration membrane 70 becomes larger than when flowing from the inside to the outside, which contributes to the improvement of the membrane life of the filtration 11 Be expected. In addition, the flexible tube is used for the 1st-3rd lines 12-14.

  The first pressure measuring device 16 is provided to measure the pressure in the first line 12, and measures the pressure on the primary side (inlet side) of the filtration membrane 70 of the filter 11. Here, the first pressure measuring device 16 can be omitted if the pressure difference can be grasped without measuring the pressure value using the pressure difference between the raw ascites water bag 10 and the filter 11. The second pressure measuring device 17 is provided to measure the pressure in the fourth line 15, and measures the pressure on the secondary side (outlet side) of the filtration membrane 70 of the filter 11. The pressure measurement results of the first pressure measuring device 16 and the second pressure measuring device 17 are output to the control device 50. Here, the second pressure measuring device 17 may be disposed on the second line 13, and the arrangement is limited as long as the secondary side (outlet side) of the filtration membrane 70 of the filter 11 can be measured. It is not a thing.

  The pump 18 is provided in the second line 13. The pump 18 is, for example, a tube pump capable of rotating in the forward and reverse directions which handles the tube and pumps the ascites fluid in the tube. The pump 18 also closes the second line 13 at the time of stopping, and also functions as a switching device (flow rate adjustment device).

  The first opening and closing device 19 is, for example, an opening and closing valve, and is provided in the third line 14. Alternatively, the first opening / closing device 19 may be a closed portion that is always closed.

  The upstream opening / closing device 21 is, for example, an opening / closing valve, and is provided in the first line 12.

  The control device 50 is a microcomputer having, for example, a CPU, a memory, and the like. The control device 50 operates the respective devices such as the pump 18, the first opening / closing device 19, the upstream opening / closing device 21, the first pressure measuring device 16, the second pressure measuring device 17, the concentration system 3, etc. Ascites treatment can be performed by controlling the operation of the concentration pump 115 and the like. Further, the control device 50 receives a measurement result and the like by the liquid volume measuring device 150 described later. The control device 50 can execute ascites treatment, for example, by executing a program stored in advance in a memory.

  The concentration system 3 includes a concentrator 110, a concentrated ascites bag 111 as a concentrated ascites reservoir, a concentration line 112, a drainage line 113, a circulation line 114, a concentration pump 115, and a third pressure measuring device 117. , And the fourth pressure measuring device 118 and the like, and further includes a liquid amount measuring device 150.

  The concentrator 110 has, for example, a cylindrical shape. The concentrator 110 has flow openings 110a and 110b at both ends in the longitudinal direction, and two flow openings 110c and 110d on the side surface. For example, the second line 13 is connected to the liquid passage 110 a of the concentrator 110.

  The concentrator 110 includes, for example, a concentration membrane 120 such as a hollow fiber membrane that removes water from the filtered ascites supplied from the second line 13 to concentrate the filtered ascites. The inner region of the concentration film 120 is in communication with the flow openings 110a and 110b, and the outer region of the concentration film 120 is in communication with the flow openings 110c and 110d. In the present embodiment, the liquid passage port 110d is closed.

  The concentrated ascites fluid bag 111 is a type of container that can collect and store the concentrated ascites fluid concentrated by the concentrator 110. The concentration line 112 connects the liquid passage 110 b of the concentrator 110 and the concentrated ascites fluid bag 111. One end of the drainage line 113 is connected to the liquid passage 110 c of the concentrator 110, and the other end is connected to a drainage portion (not shown).

  The circulation line 114 connects, for example, the concentrated ascites fluid bag 111 and the second line 13. The circulation line 114 is connected to the upstream side (filter 11 side) of the pump 18 of the second line 13. The circulation line 114 is provided with an opening / closing device 119 including, for example, an opening / closing valve. For the concentration line 112, the drainage line 113 and the circulation line 114, for example, flexible tubes are used.

  The concentration pump 115 is disposed, for example, on the downstream side of the concentrator 110 of the concentration line 112, and pumps the concentrated ascites into the concentration ascites bag 111. For the concentration pump 115, for example, a tube pump is used. The concentration pump 115 may be disposed in the drainage line 113.

  The third pressure measuring device 117 is provided to measure, for example, the pressure in the second line 13, and measures the pressure on the primary side (inlet side) of the concentration film 120 of the concentrator 110. The fourth pressure measurement device 118 is provided in the drainage line 113, and measures the pressure on the secondary side (outlet side) of the concentration film 120 of the concentrator 110. The fourth pressure measuring device 118 can be omitted if it can be grasped without measuring the pressure value using the pressure drop between the concentrator 110 and the end of the drainage line 113. The pressure measurement results of the third pressure measuring device 117 and the fourth pressure measuring device 118 are output to the control device 50. The control device 50 can execute ascites treatment by controlling the operation of the concentration pump 115 of the concentration system 3, the pump 18, the third pressure measurement device 117, the fourth pressure measurement device 118, and the like.

  In the concentration system 3, a device (recirculation device) is configured to recirculate the concentrated ascites fluid stored in the concentration ascites fluid bag 111 to the concentrator 110. For example, in the ascites fluid treatment apparatus 1 of the present embodiment, a system for recirculation by the circulation line 114, the concentration pump 115, the pump 18 and the like described above (herein referred to as a recirculation apparatus and indicated by reference numeral 62 in the figure) Is configured.

  The fluid volume measuring device 150 is a device for measuring the fluid volume of the concentrated ascites fluid stored in the concentrated ascites fluid bag 111. Although the specific configuration of the fluid volume measuring device 150 is not particularly limited, for example, it is provided with a weight scale capable of measuring the weight of the concentrated ascites bag 111 in which the concentrated ascites fluid is stored, and controlled based on the measurement value of the weight scale. Based on the flow rate of the concentration pump 115, it may be calculated from pump flow rate × time.

  When the fluid volume measuring device 150 is a device provided with a weight scale as described above, the fluid volume of the concentrated ascites bag 111 can also be controlled based on the measurement value of the weight device. In such a case, the liquid amount control of the concentrated ascites bag 111 is performed based on the increase / decrease amount of the volume.

  The liquid volume measuring device may be anything as long as the weight or volume in the concentrated ascites bag can be determined, and the height of a predetermined liquid level is measured by an ultrasonic sensor or a capacitance sensor to measure the volume in the concentrated ascites bag It may be possible. Alternatively, the liquid volume of the concentrated ascites fluid stored in the concentrated ascites fluid bag 111 can also be calculated from the known weight of the ascites fluid bag 111 and the weight per volume of the concentrated ascites fluid using a weight scale as described above. For example, it is possible to measure the volume by measuring the volume of the concentrated ascites bag 111 (for example, using an ultrasonic sensor or a capacitance sensor not shown), and convert it to a weight. As described above, in addition to calculating the liquid volume of concentrated ascites fluid based on the weight, the volume may be calculated using the result of the volume measurement, and control may be performed based on the calculated volume. In such a case, the liquid amount control of the concentrated ascites bag 111 is performed based on the increase / decrease amount of the volume.

  Next, an outline of ascites treatment performed using the above-described ascites treatment apparatus 1 will be described.

<Filtration, concentration process>
First, a primary ascites fluid taken directly from a patient, or a primary ascites fluid bag 10 containing ascites fluid collected from the patient is connected to the first line 12. Next, filtration and concentration steps of ascites fluid are started. With the first opening / closing device 19 closed and the second opening / closing device 20 and the upstream opening / closing device 21 opened, the pump 18 rotates forward and the concentration pump 115 operates (see FIG. 1).

  Thereby, the ascites fluid of the raw ascites fluid bag 10 is sent to the filter 11 through the first line 12. Ascites fluid flows into the inlet side (inner region) of the filtration membrane 70 from the liquid flow port 11a of the filter 11, passes through the filtration membrane 70, and flows out to the outlet side (outer region) of the filtration membrane 70. At this time, a predetermined etiologic substance is removed from the ascites fluid. The filtered ascites fluid that has flowed out to the outlet side of the filtration membrane 70 flows from the filter 11 to the second line 13 and is sent to the concentrator 110 through the second line 13 and the inlet of the concentration membrane 120 of the concentrator 110 Flow into the side. Here, due to a pressure difference (flow rate difference) between the pump 18 and the concentration pump 115, for example, a part of water of the filtered ascites passes through the concentration film 120 and flows out to the outlet side of the concentration film 120. Thereby, water is removed from the filtered ascites fluid, and the filtered ascites fluid is concentrated. The concentrated ascites fluid concentrated by the concentrator 110 is stored in the concentrated ascites fluid bag 111 through the concentration line 112.

<Reconcentration step>
With the first opening / closing device 19 and the upstream opening / closing device 21 closed, and the opening / closing device 119 opened, the pump 18 and the concentration pump 115 operate (see FIG. 2). Thereby, the concentrated ascites fluid of the concentration ascites bag 111 is sent to the concentrator 110 through the circulation line 114 and the second line 13, and is returned from the concentrator 110 to the concentration ascites bag 111 through the concentration line 112 and circulated. Thus, the concentrated ascites fluid is reconcentrated.

  In the filtration and concentration steps of ascites fluid, the first pressure measuring device 16 and the second pressure measuring device 17 are activated, and the pressure on the inlet side of the filtration membrane 70 of the filter 11 and the pressure on the outlet side are monitored. For example, when the pressure difference (P1-P2) (inter-membrane pressure difference) between the pressure P1 on the inlet side and the pressure P2 on the outlet side of the filtration membrane 70 in the filter 11 exceeds the predetermined threshold D, the filtration membrane 70 May be clogged, and the upstream switchgear 21 may be closed to stop the ascites filtration and concentration process. The threshold value D is determined and set in advance by experiment or calculation.

<Cleaning process of filtration membrane>
When processing the raw ascites water remaining in the raw ascites water bag 10, the processing capacity of the filter 11 can be restored by using a washing apparatus or the like. The cleaning apparatus is not particularly limited as long as it can remove the clogged substance, but it includes, for example, the cleaning solution storage unit 30, the cleaning line 31, the cleaning switch 32 (or the cleaning pump 32 '), etc. Accordingly, the switching device, the pump, etc. are operated appropriately. By circulating the washing solution (for example, physiological saline) from the outlet side to the inlet side of the filtration membrane 70 by the washing apparatus, it is possible to remove the substance clogged by reverse filtration and restart the filtration / concentration process again. . Alternatively, it is possible to remove a substance clogged by shearing by circulating the cleaning liquid from the liquid passage 11a to the liquid passage 11b (or the reverse).

  When the cleaning process of the filtration membrane 70 is completed, the first opening and closing device 19 and the cleaning device are stopped, and the pump 18 rotates forward while the upstream opening and closing device 21 is opened, the concentration pump 115 operates, and ascites fluid is collected. The filtration and concentration process is resumed.

  Every time the pressure difference (P1-P2) between the pressure P1 on the inlet side and the pressure P2 on the outlet side of the filtration membrane 70 in the filter 11 exceeds a predetermined threshold D, the filtration and concentration processing steps of ascites fluid are stopped Ascites fluid recovery process and filtration membrane 70 cleaning process can be performed.

  In the filtration and concentration steps of ascites fluid, the third pressure measuring device 117 and the fourth pressure measuring device 118 operate to monitor the pressure on the inlet side of the concentration film 120 of the concentrator 110 and the pressure on the outlet side. . Then, for example, when the pressure difference (P3-P4) between the pressure P3 on the inlet side of the concentration membrane 120 and the pressure P4 on the outlet side in the concentrator 110 exceeds a predetermined threshold F, the concentration membrane 120 clogs. It is considered to be awakening, and ascites fluid filtration and concentration steps are stopped. Alternatively, the throughput of the concentration step can be extended by accelerating / decelerating the concentration pump 115.

<Treatment process of ascites treatment>
Then, the process process of ascites concentration performed in the concentration system 3 of the ascites treatment apparatus 1 of this embodiment is demonstrated with a flowchart (refer FIG. 5, FIG. 6).

  The first predetermined amount (hereinafter, also referred to as “target raw ascites water treatment amount”) in phase 1 (filtration concentration phase) described below, and the second predetermined amount in phase 2 (reconcentration phase) are preset. (See Figure 5 and Figure 6). The first predetermined amount and the second predetermined amount are not particularly limited, and can be set arbitrarily. For example, the target storage amount of the concentrated ascites bag 111 is 300 cc, which is an example of an ideal value. In this case, the first predetermined amount (upper limit) can be set to +100 cc (= 400 cc), and the second predetermined amount (lower limit) can be set to -100 cc (= 200 cc) or the like.

(Phase 1 (filtration concentration phase))
At a predetermined flow rate, the process of filtration by the filtration system 2 and the process of recirculation (filtration / concentration process) by the concentration system 3 are performed (step SP1). In this step SP1, the raw ascites water is filtered by the filtration membrane 70, and subsequently the water is removed by the concentrator 110 of the concentration system 3 in the latter stage, and then it is fed into the concentration ascites bag 111 by the concentration pump 115. A portion of the concentrated ascites sent to the concentrated ascites bag 111 is recirculated to the concentrator 110 through the circulation line 114 and is further dewatered and fed to the concentrated ascites bag 111. When the filter 11 is clogged and the SP1 can not be continued in step SP1, the filtration membrane cleaning step may be performed to resume the step SP1 after the clogging is eliminated.

  If the target raw ascites fluid treatment amount has not been reached (No in the judgment 1 of step SP2), it is judged whether the liquid volume of the stored concentrated ascites has reached the first predetermined amount (judgement 2 in the step SP3). When the liquid amount of the storage concentrated ascites reaches the first predetermined amount (Yes in judgment 2), the filtration process by the filtration system 2 is stopped (step SP4).

(Phase 2 (Reconcentration Phase))
After stopping the filtration process by the filtration system 2, the re-concentration process is performed to remove the concentrated ascites water (Step SP5). In this step SP5, since only the re-concentration process is performed without the filtration process, the removed water is concentrated to reduce the liquid volume of the concentrated ascites.

  By the re-concentration process in the above-mentioned phase 2, it concentrated until the liquid volume of the said concentration condensate became the 2nd predetermined amount (in other words, the liquid volume of the said concentrated ascites becomes below the 2nd predetermined volume) If it is judged (Yes in the judgment 3 of step SP6), the re-concentration process is stopped (step SP7), it returns to the phase 1, the process of filtration by the filtration system 2 and the process of recirculation by the concentration system 3 are performed again To do (step SP1). Thereafter, phase 1 and phase 2 are repeated (see FIGS. 5 and 6).

  Further, in the filtration and concentration phase of the phase 1, when the target raw ascites processed amount (the total amount of the raw ascites water bag 10 in the case of treating ascites contained in the raw ascites water bag 10) is reached (step SP2 Yes in judgment 1), it is judged that the target raw ascites water treatment amount has been processed or clogging by the washing process can not be eliminated, and the filtration process can not be continued any more due to clogging due to filtration, etc., step SP8 Go to That is, although it is ideal to treat the target raw ascites water treatment amount, it is determined that the filtration can not be continued if there is no washing step or if the clogging of the filtration membrane by the washing can not be eliminated. In step SP8, it is judged whether or not the concentrated ascites fluid has reached the target concentrated amount (determination 4), and when it has reached (Yes in the determination 4 of step SP8), the treatment ends.

  On the other hand, when the concentrated ascites fluid has not reached the target concentrated amount (No in the judgment 4 of step SP8), the re-concentration process is performed (step SP9). Thereafter, for P4-P3 representing the differential pressure between the fourth pressure measuring device 118 and the third pressure measuring device 117, it is determined whether P4-P3 ≧ fourth predetermined amount is satisfied (step SP10), If P4-P3 第 the fourth predetermined amount (Yes in step SP10), it is determined that the concentrated ascites has reached the target concentrated amount, or that the treatment can not be continued due to clogging of the concentration film 120 or the like. Will end. On the other hand, if P4-P3.gtoreq.the fourth predetermined amount in step SP10 (No in step SP10), the process returns to step SP.

  As described above, in the ascites processing apparatus 1 of the present embodiment, predetermined ranges with the first predetermined amount and the second predetermined amount set as the upper limit and the lower limit, respectively, are set. By executing the process of repeating the phase 1 in which the storage amount of concentrated ascites fluid increases and the phase 2 in which the storage amount of concentrated ascites decreases, it is possible to avoid the situation where the storage amount greatly exceeds the expected amount. In other words, since the storage amount is increased or decreased within the range not exceeding the upper limit with the first predetermined amount as the upper limit (target value), the burden on the operator can be significantly reduced. According to this, the influence of various factors such as the difference in the discharge amount of the pump and the difference in the amount of liquid transfer, the physical size of the patient, the amount of raw ascites fluid, the properties of ascites fluid, the performance of the concentrator, the treatment status, the treatment time It is possible to obtain as much concentrated ascites as possible in the concentrated ascites bag 111 without receiving the Therefore, it is possible to avoid a situation in which the expected amount of concentrated ascites fluid can not be obtained due to an error or the like of each pump. In addition, since the contents of processing are completely different from the conventional procedure in which all the raw ascites fluid is filtered and then recirculated, there is no fear that the concentrated ascites fluid does not enter the concentrated ascites bag and it ruptures.

  Next, an outline of a configuration of an ascites treatment apparatus 1 as a body cavity fluid treatment apparatus according to another embodiment of the present embodiment is shown in FIG.

  In the ascites fluid treatment apparatus 1 according to another embodiment, the pump 180 is installed on the primary side (inlet side) of the filtration membrane 70 of the filter 11, and the ascites is pressurized by the pump 180 and directed to the filter 11. It is a method of pushing out. Furthermore, in this embodiment, when the concentrated ascites fluid stored in the concentrated ascites fluid bag 111 is recirculated to the concentrator 110, it is pressurized using the pump 23 disposed in the circulation line 114 and recirculated.

  It is needless to say that what has been described as the second embodiment here is merely another suitable example different from the first embodiment. The important point is that the specific configuration of the ascites fluid treatment apparatus 1 is particularly as long as the amount of recovered fluid is made a predetermined amount to recover the remaining filtered ascites regardless of the connection of each line and the position of the pump. It is not limited.

  In the above embodiment, the ascites treatment apparatus 1 filters and concentrates the ascites fluid stored in the raw ascites fluid bag 10 and stores it in the concentrated ascites fluid bag 111, but the first line 12 directly from the patient is used. Ascites fluid may be removed, filtered and concentrated.

  The above embodiment is a preferred example in which the present invention is applied to the ascites treatment apparatus 1 for treating ascites, but the present invention is also applied to a body cavity fluid treatment apparatus for treating other body cavity fluid such as pleural fluid. it can.

  Moreover, although the form which collect | recovers filtered and concentrated ascites fluid in the concentration ascites fluid bag 111 was illustrated in said embodiment, this is also only a suitable example. The concentrated ascites bag 111 is a type of container for collecting and containing the concentrated ascites concentrated by the concentrator 110, and a container other than such a bag may be used for collection.

  The present invention is applied to a body cavity fluid processing apparatus that filters body cavity fluid such as present ascites fluid stored in a patient body cavity or body cavity fluid bag, removes water from the filtered body cavity fluid, and generates concentrate cavity fluid. Preferred.

DESCRIPTION OF SYMBOLS 1 ... ascites water treatment apparatus (body cavity liquid treatment apparatus), 10 ... raw ascites water bag (raw body cavity fluid bag), 11 ... filter, 18 ... pump, 50 ... control device, 62 ... recirculation apparatus, 70 ... filtration membrane (filtration Parts), 110: concentrator, 111: concentrated ascites bag (concentrated body fluid bag), 115: concentrated pump (pump), 150: liquid volume measuring device

Claims (5)

A body cavity fluid treatment apparatus for filtering bulk cavity fluid stored in a patient's body cavity or bulk cavity fluid bag and removing water from the filtered body cavity fluid to generate concentrate cavity fluid,
A filter comprising a filter member that selectively removes a specific substance in the body cavity fluid;
A concentrator that concentrates the body cavity fluid filtered by the filter;
A concentrate cavity fluid bag for collecting and storing the concentrate cavity fluid concentrated by the concentrator;
A recirculating device for recirculating the concentrate cavity fluid stored in the concentrate cavity fluid bag to the concentrator;
A liquid quantity measuring device for measuring the liquid quantity of the concentrate body cavity fluid stored in the concentrate body cavity fluid bag;
When the liquid volume of the concentrate cavity fluid stored in the concentrate cavity fluid bag reaches a first predetermined amount, the filtration operation is stopped, and the concentrate cavity fluid stored in the concentrate cavity fluid bag is concentrated by the recirculation device. A controller for resuming the filtration operation when the liquid is recirculated to the vessel and concentrated until the volume of the concentrate cavity fluid reaches a second predetermined volume;
A body cavity fluid treatment apparatus comprising:   The liquid volume measuring device is characterized in that the liquid volume of the concentrate body cavity fluid bag is calculated from a pump flow rate of a pump that distributes the concentrate cavity fluid to the concentrate body cavity fluid bag × time. Body cavity fluid treatment apparatus according to claim 1.   The body cavity fluid treatment apparatus according to claim 1, wherein the fluid volume measuring device includes a scale that measures the weight of the concentrate cavity fluid bag.   The body cavity fluid treatment apparatus according to claim 3, wherein the fluid volume of the concentrate cavity fluid bag is defined based on the measurement value of the weighing scale. The system further comprises a concentration pump disposed downstream of the concentrator for delivering the concentrate cavity fluid to the concentrate cavity fluid bag,
The liquid volume of the concentrate body cavity fluid bag is calculated from the pump flow rate × time based on the flow rate of the concentration pump controlled based on the measurement value of the weight scale. Body cavity fluid treatment device.

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