JP2019037609A - Anti-adhesive material - Google Patents

Abstract

To provide an anti-adhesive material in which the original characteristics of the polyanionic polysaccharide which is the raw material are maintained as well as which is less likely to move (less likely to shift) from an indwelling affected area.SOLUTION: Provided is an anti-adhesive material comprising: a membranous anti-adhesive layer formed by subjecting a raw material molded body containing a water-soluble salt of polyanionic polysaccharide to water-insolubilization treatment; a membranous adhesive layer containing a water-soluble salt of polyanionic polysaccharide, disposed by lamination on at least one surface of the anti-adhesive layer. Also provided is an anti-adhesive material comprising the anti-adhesive layer and an adhesive component containing a water-soluble salt of a polyanionic polysaccharide held in the anti-adhesive layer.SELECTED DRAWING: None

Description

  The present invention relates to an adhesion preventing material.

  Polyanionic polysaccharides such as hyaluronic acid and alginic acid are known to exhibit moderate viscosity, adhesiveness, moisture retention, and biocompatibility. For this reason, these polyanionic polysaccharides and salts thereof are widely used as raw materials for medical materials, food materials, cosmetic materials and the like.

  Of these, hyaluronic acid is used for various applications such as foods, cosmetics, and pharmaceuticals because of its excellent physical properties such as water retention and high safety and biocompatibility. For example, in the medical field, hyaluronic acid is used as a raw material for joint lubricants and anti-adhesion materials. However, since sodium hyaluronate as a raw material has high water solubility, it is necessary to perform some insolubilization treatment depending on the application.

  So far, various methods for water insolubilizing sodium hyaluronate have been studied. For example, Patent Documents 1 and 2 describe a method for water-insolubilizing polyanionic polysaccharides such as hyaluronic acid and carboxyalkyl cellulose by ionic bonding using a polyvalent cation. Patent Document 3 describes acetylation by reacting powdered hyaluronic acid and acetic anhydride in the presence of concentrated sulfuric acid.

  It is necessary that medical materials such as an adhesion prevention film remain at the treatment site and do not move easily. For example, Patent Document 4 describes a medical adhesive film having a honeycomb structure. Patent Document 5 describes a bioabsorbable medical material having a two-layer sheet structure having a porous layer.

JP-A-5-124968 JP 2008-13510 A JP-A-8-53501 JP 2008-12216 A JP 2012-95731 A

  However, Patent Documents 1 and 2 do not describe any degree of water insolubility of the obtained film or the like. Patent Document 3 does not describe any degree of water insolubility of the obtained acetylated product of hyaluronic acid. In addition, in order to manufacture the adhesive film and bioabsorbable medical material described in Patent Documents 4 and 5, there is a problem that a special technique is required and the manufacturing process becomes complicated.

  The present invention has been made in view of such problems of the prior art, and the problem is that the original characteristics of the polyanionic polysaccharide as a raw material are retained and the injured affected area is retained. The object is to provide an anti-adhesion material that is difficult to move (i.e., difficult to slip).

  That is, according to the present invention, a film-shaped adhesion preventing layer formed by subjecting a raw material molded body containing a water-soluble salt of a polyanionic polysaccharide to water insolubilization treatment, and at least one surface of the adhesion preventing layer An anti-adhesion material (hereinafter also referred to as “first anti-adhesion material”) comprising a film-like adhesive layer containing a water-soluble salt of a polyanionic polysaccharide disposed in a stacked manner is provided.

  Furthermore, according to the present invention, a film-like adhesion preventing layer formed by subjecting a raw material molded body containing a water-soluble salt of a polyanionic polysaccharide to water insolubilization treatment, and the polyanion retained in the adhesion preventing layer And an adhesive component containing a water-soluble salt of a functional polysaccharide (hereinafter, also referred to as “second adhesion preventing material”).

  ADVANTAGE OF THE INVENTION According to this invention, the original characteristic of the polyanionic polysaccharide which is a raw material is hold | maintained, and the adhesion prevention material which cannot move easily from the indwelling affected part can be provided.

  Embodiments of the present invention will be described below, but the present invention is not limited to the following embodiments.

<Adhesion prevention material>
The first adhesion preventing material of the present invention is a film-shaped adhesion preventing layer formed by subjecting a raw material molded body containing a water-soluble salt of a polyanionic polysaccharide to water insolubilization treatment, and at least one surface of the adhesion preventing layer. A film-like adhesive layer disposed on top of each other. This adhesive layer is a layer containing a water-soluble salt of a polyanionic polysaccharide. The second anti-adhesion material of the present invention comprises a film-like anti-adhesion layer formed by subjecting a raw material molded body containing a water-soluble salt of a polyanionic polysaccharide to water insolubilization treatment, and an anti-adhesion layer. An adhesive component. This adhesive component contains a water-soluble salt of a polyanionic polysaccharide. Hereinafter, the details of the adhesion preventing material of the present invention will be described.

  The polyanionic polysaccharide is a polysaccharide having one or more negatively charged anionic groups such as a carboxy group and a sulfonic acid group in its molecular structure. The water-soluble salt of the polyanionic polysaccharide is a salt in which at least a part of the anionic group in the polyanionic polysaccharide forms a salt. The anionic group in the polyanionic polysaccharide may be introduced into the polysaccharide molecule.

  Specific examples of the polyanionic polysaccharide include carboxyalkyl cellulose such as carboxymethyl cellulose and carboxyethyl cellulose, carboxymethyl starch, carboxymethyl amylose, chondroitin sulfate (including chondroitin-4-sulfate and chondroitin-6-sulfate), hyaluronic acid, Examples include heparin, heparin sulfate, heparan sulfate, alginic acid, pectin, carrageenan, dermatan sulfate, and dermatan-6-sulfate. These 1st polyanionic polysaccharides can be used individually by 1 type or in combination of 2 or more types.

  Examples of water-soluble salts of polyanionic polysaccharides include inorganic salts, ammonium salts, and organic amine salts. Specific examples of the inorganic salt include alkali metal salts such as sodium and potassium; alkaline earth metal salts such as calcium salts; metal salts such as zinc and iron.

  The raw material used to form the raw material molded body may contain a radiopaque agent such as a contrast agent such as barium sulfate. If the raw material containing a radiopaque agent is used, it can be set as the adhesion prevention material provided with the adhesion prevention layer containing a radiopaque agent.

  The raw material molded body can be obtained, for example, by forming a raw material (aqueous solution) obtained by dissolving a water-soluble salt of a polyanionic polysaccharide in water into a film and drying it. Also, a sponge-like raw material molded body can be obtained by pouring an aqueous solution of a water-soluble salt of a polyanionic polysaccharide into a suitable container and then freeze-drying it. By insolubilizing the raw material molded body with water, an anti-adhesion layer (water-insoluble molded body) can be obtained. Note that a sponge-like adhesion preventing layer can be obtained by water-insolubilizing the sponge-like raw material molded body. Furthermore, by compressing the obtained sponge-like water-insoluble molded product, a so-called felt-like adhesion preventing layer can be obtained. If necessary, the obtained anti-adhesion layer may be further molded and processed into a desired shape. By making the adhesion preventing layer into a sponge shape (including felt shape), the second adhesion preventing material is preferable because more adhesive components can be held in the adhesion preventing layer.

  The method for water insolubilizing the raw material molded body is not particularly limited, and a conventionally known method for water insolubilizing a raw material molded body made of a water-soluble salt of a polyanionic polysaccharide can be employed. Specific examples of the method of water insolubilizing the raw material molded body include a method of chemically cross-linking using a cross-linking agent to insolubilize water; a method of irradiating with an electron beam and cross-linking to insolubilize water; a polyvalent metal ion And a method of cross-linking by ionic bonding to insolubilize water; a method of insolubilizing in water by contacting with a treatment liquid containing an acid anhydride; Among these, it is preferable to bring the raw material molded body into contact with a treatment liquid containing an acid anhydride because it is simple and can sufficiently and quickly insolubilize the raw material molded body to form an adhesion preventing layer. Regarding the reaction mechanism assumed when a raw material molded body formed using a water-soluble salt of polyanionic polysaccharide is treated with a treatment liquid containing an acid anhydride such as acetic anhydride, for example, International Publication No. It is disclosed in 2015/029892, JP-A-2016-163695, and the like.

  Specific examples of the acid anhydride used in the treatment liquid include acetic anhydride, propionic anhydride, succinic anhydride, butyric anhydride, phthalic anhydride, and maleic anhydride. Of these, acetic anhydride and propionic anhydride are preferable. These acid anhydrides can be used singly or in combination of two or more.

  The treatment liquid preferably further contains at least one medium of water and a water-soluble organic solvent, and the acid anhydride is preferably dissolved or dispersed in this medium. By using a treatment liquid in which an acid anhydride is dissolved or dispersed in such a medium, it is possible to sufficiently and quickly insolubilize the raw material molded body.

  Specific examples of the water-soluble organic solvent include methanol, ethanol, propanol, dimethyl sulfoxide (DMSO), acetonitrile, and tetrahydrofuran. Of these, methanol, ethanol, and dimethyl sulfoxide are preferable. These water-soluble organic solvents can be used alone or in combination of two or more.

  The concentration of the acid anhydride in the treatment liquid is usually 0.1 to 50% by mass, and preferably 5 to 30% by mass. When the concentration of the acid anhydride is less than 0.1% by mass, the degree of water insolubilization of the resulting flexible molded article tends to be insufficient, or it takes a long time for water insolubilization. On the other hand, when the concentration of the acid anhydride exceeds 50% by mass, the effect tends to reach its peak.

  In addition, since a polyanionic polysaccharide has high hydrophilicity, it is preferable that a process liquid contains water as a medium from a viewpoint of water-insolubilizing a raw material molded object more fully and rapidly. The content of water in the treatment liquid is preferably set to such an extent that the raw material molded body does not dissolve or swell. Specifically, the content of water in the treatment liquid is preferably 0.01 to 50% by mass, and more preferably 5 to 20% by mass. If the content of water in the treatment liquid is less than 0.01% by mass, water insolubilization may be insufficient with a solvent other than methanol. Moreover, when the content of water in the treatment liquid is more than 50% by mass, it may be difficult to maintain the shape of the formed adhesion prevention layer.

  By treating the raw material molded body in contact with a treatment solution containing an acid anhydride, the adhesion preventing layer can be formed by insolubilizing water while maintaining the shape of the raw material molded body. The method of bringing the raw material molded body into contact with the treatment liquid is not particularly limited, but it is preferable that the treatment liquid is in contact with the entire raw material molded body and the treatment liquid penetrates into the raw material molded body. Specific examples of the treatment method include a method of immersing the raw material molded body in the treatment liquid and applying or spraying (spraying) the treatment liquid onto the raw material molded body.

  The temperature during the treatment is not particularly limited as long as it does not exceed the boiling point of the treatment liquid. From the viewpoint of suppressing degradation and modification of the polyanionic polysaccharide, and from the viewpoint of suppressing volatilization of the medium and by-products, the temperature during the treatment is preferably 0 to 80 ° C, and preferably 0 to 70 ° C. It is further more preferable, and it is especially preferable to set it as room temperature (25 degreeC)-60 degreeC. However, if the treatment is performed under conditions where the treatment liquid does not evaporate, for example, a heat press or a heat roller, the treatment can be carried out in a shorter time without causing degradation and modification. For example, when processing by a heat press, a heat roller, etc., it is preferable that the temperature at the time of processing shall be 50-90 degreeC, and it is preferable that processing time shall be 30 minutes or less. After water insolubilization, the adhesion preventing layer can be obtained by washing with water or a water-soluble organic solvent as necessary.

  The first antiadhesive material includes a film-like adhesive layer disposed on and stacked on at least one surface of the antiadhesion layer. This adhesive layer is a layer containing a water-soluble salt of a polyanionic polysaccharide, and is preferably substantially formed of a water-soluble salt of a polyanionic polysaccharide. That is, since the pressure-sensitive adhesive layer is formed of a water-soluble salt of polyanionic polysaccharide, it is easy to handle at the time of drying, while it becomes sticky by giving appropriate moisture at the time of use. Therefore, it is possible to obtain an effect that the adhesive layer having adhesiveness sticks to the treatment surface of the affected part where it is placed and is difficult to move (becomes difficult to shift).

  As the water-soluble salt of the polyanionic polysaccharide constituting the adhesive layer, the same water-soluble salt of the polyanionic polysaccharide constituting the raw material molded body can be used. For example, an adhesive layer having a desired shape and size can be formed by drying an aqueous solution of a water-soluble salt of a polyanionic polysaccharide. Then, after laminating the adhesion preventing layer and the adhesive layer, the first layer having a laminated structure in which the adhesion preventing layer and the adhesive layer are laminated by appropriately pressing in the thickness direction using a press or the like as necessary. Anti-adhesion material can be obtained.

  The second adhesion preventing material includes an adhesive component held in the adhesion preventing layer. This adhesive component contains a water-soluble salt of a polyanionic polysaccharide and substantially consists of a water-soluble salt of a polyanionic polysaccharide. That is, since the adhesive component is held in an impregnated state in the adhesion preventing layer, it is easy to handle at the time of drying, while the adhesion preventing layer itself becomes tacky by providing appropriate moisture at the time of use. Thereby, the effect that it becomes difficult to move (it becomes difficult to shift | deviate) sticks to the treatment surface of the affected part in which the adhesive layer with adhesiveness was detained can be acquired.

  Examples of the water-soluble salt of the polyanionic polysaccharide used as the adhesive component include the same water-soluble salts of the polyanionic polysaccharide constituting the raw material molded body described above. For example, if the adhesion prevention layer is immersed in an aqueous solution of a water-soluble salt of a polyanionic polysaccharide and the adhesion prevention layer is impregnated with a water-soluble salt of a polyanionic polysaccharide that is an adhesive component, then the adhesion prevention layer is dried. A second adhesion-preventing material having a single-layer structure in which an adhesive component is retained can be obtained.

  When the raw material molded body is insolubilized by contact with a treatment solution containing an acid anhydride, that is, when the raw material molded body is water insolubilized without using a crosslinking agent, the resulting anti-adhesion layer is derived from the crosslinking agent. Structures such as functional groups are not incorporated. For this reason, the adhesion preventing layer obtained by bringing the raw material molded body into water insolubilized by contacting with a treatment liquid containing an acid anhydride has better retention of the original characteristics of the polyanionic polysaccharide as a raw material, and more Because of its high safety, it is suitable as a component of the adhesion preventing material. In addition, the thickness of the adhesion preventing layer is not particularly limited, but is preferably 20 to 200 μm, and more preferably 60 to 120 μm. Moreover, the thickness of the adhesion layer which comprises a 1st adhesion prevention material is although it does not specifically limit, Preferably it is 10-100 micrometers, More preferably, it is 30-60 micrometers.

  As used herein, “water-insoluble” means a property that does not easily dissolve in water. More specifically, the mass of the dried body obtained by repeating the operation of drying the adhesion preventing layer after being swollen with water twice is 80% or more of the dry mass before this operation.

  When the raw material molded body is brought into contact with a treatment solution containing an acid anhydride to insolubilize the raw material molded body, the molecules of the polyanionic polysaccharide constituting the adhesion preventing layer to be obtained are not substantially crosslinked. Furthermore, a new covalent bond is not substantially formed in the polyanionic polysaccharide. However, it is presumed that physical bonds such as hydrogen bonds, hydrophobic bonds, and van der Waals forces are formed between the molecules of the polyanionic polysaccharide. The fact that such a physical bond is formed between molecules of the polyanionic polysaccharide can be confirmed by measuring an infrared absorption spectrum.

  The anti-adhesion layer that is a constituent element of the anti-adhesion material of the present invention is stably water-insoluble in a wide pH range from acidic to alkaline. However, when the adhesion preventing layer is brought into contact with or immersed in an aqueous medium having a pH of 12 or more, the physical bond between molecules is dissociated and can be easily dissolved.

  It is preferable that polyhydric alcohol is retained in the adhesion preventing layer. Specific examples of the polyhydric alcohol include ethylene glycol, diethylene glycol, polyethylene glycol, methylglycerol, polyoxyelene glycoside, maltitol, mannitol, xylitol, sorbitol, reduced starch syrup, dipropylene glycol, butylene glycol, valine, propylene glycol, Examples thereof include glycerin (glycerol), polyglycerin, and glycerin fatty acid ester. Of these, polyhydric alcohols used in the medical field and food field such as glycerin, xylitol, sorbitol, and low molecular weight polyethylene glycol are preferably used. These suitably used polyhydric alcohols can be obtained from the market and used as they are. As for glycerin, sorbitol, etc., it is desirable to use those suitable for the Japanese Pharmacopoeia. Glycerin is particularly preferable because it is a material that is safe enough to be used as an intravenous injection.

  Examples of the method for retaining the polyhydric alcohol in the adhesion preventing layer include a method of immersing the adhesion preventing layer in a polyhydric alcohol or an alcohol solution of the polyhydric alcohol (for example, an ethanol solution). That is, if the adhesion prevention layer having a predetermined shape is immersed in polyhydric alcohol or the like and the inside of the adhesion prevention layer is replaced with polyhydric alcohol or the like, the polyhydric alcohol can be held inside the adhesion prevention layer.

  EXAMPLES Hereinafter, although this invention is demonstrated concretely based on an Example, this invention is not limited to these Examples. In the examples and comparative examples, “parts” and “%” are based on mass unless otherwise specified.

<Manufacture of anti-adhesion material>
(Comparative Example 1)
1.0 g of sodium hyaluronate (molecular weight (nominal value): 800,000, manufactured by Kikkoman Biochemifa) and 99.0 g of water were mixed and stirred in a beaker to obtain a uniform aqueous solution. 100 g of the obtained aqueous solution was poured into a stainless tray having a length of 12 cm and a width of 10 cm and dried in a constant temperature bath at 20 ° C. to obtain a sodium hyaluronate film having a thickness of about 50 μm. The obtained sodium hyaluronate film was immersed in a treatment solution (acetic anhydride: 75% ethanol solution = 20: 80) and left at 50 ° C. for 1 hour for water insolubilization treatment. After washing in this order with ethanol and water, it was air-dried under room temperature conditions to obtain a water-insoluble adhesion-preventing material.

Example 1
1.0 g of sodium hyaluronate (molecular weight (nominal value): 800,000, manufactured by Kikkoman Biochemifa) and 99.0 g of water were mixed and stirred in a beaker to obtain a uniform aqueous solution. 100 g of the obtained aqueous solution was poured into a stainless tray having a length of 12 cm and a width of 10 cm and dried in a constant temperature bath at 20 ° C. to obtain a sodium hyaluronate film having a thickness of about 50 μm. The obtained sodium hyaluronate film was immersed in a treatment solution (acetic anhydride: 75% ethanol solution = 20: 80) and left at 50 ° C. for 1 hour for water insolubilization treatment. After washing in this order with ethanol and water, it was air-dried at room temperature to obtain a water-insoluble adhesion prevention layer. In addition, another sodium hyaluronate film (film thickness of about 50 μm) was produced. The adhesion preventing layer and the sodium hyaluronate film were laminated, and pressed using a hand press machine (pressure weight about 50 kg) and bonded to obtain an adhesion preventing material having a laminated structure.

(Example 2)
1.0 g of sodium hyaluronate (molecular weight (nominal value): 800,000, manufactured by Kikkoman Biochemifa) and 99.0 g of water were mixed and stirred in a beaker to obtain a uniform aqueous solution. 100 g of the obtained aqueous solution was poured into a stainless tray having a length of 12 cm and a width of 10 cm and dried in a constant temperature bath at 20 ° C. to obtain a sodium hyaluronate film having a thickness of about 50 μm. The obtained sodium hyaluronate film was immersed in a treatment solution (acetic anhydride: 75% ethanol solution = 20: 80) and left at 50 ° C. for 1 hour for water insolubilization treatment. After washing in this order with ethanol and water, it was air-dried at room temperature to obtain a water-insoluble adhesion prevention layer. The obtained adhesion preventing layer was immersed in a 0.5% sodium hyaluronate aqueous solution for 2 hours and then air-dried to obtain an adhesion preventing material having a single layer structure in which sodium hyaluronate was retained in the adhesion preventing layer.

(Example 3)
1.0 g of sodium hyaluronate (molecular weight (nominal value): 800,000, manufactured by Kikkoman Biochemifa) and 99.0 g of water were mixed and stirred in a beaker to obtain a uniform aqueous solution. 100 g of the obtained aqueous solution was poured into a stainless steel vat, frozen at −30 ° C., and then freeze-dried at a shelf heating temperature of 120 ° C. to obtain a sponge-like sodium hyaluronate film. The obtained sodium hyaluronate film was immersed in 100 mL of a processing solution (10% acetic anhydride / methanol solution) and left at room temperature for 18 hours for water insolubilization treatment. Methanol, 80% by volume methanol aqueous solution, and water were washed in order to obtain a water-insoluble, sponge-like adhesion preventing layer. Further, 1.0 g of sodium hyaluronate (molecular weight (nominal value): 800,000, manufactured by Kikkoman Biochemifa) and 99.0 g of water were mixed and stirred in a beaker to obtain a uniform aqueous solution. 100 g of the obtained aqueous solution was poured into a stainless tray having a length of 12 cm and a width of 10 cm and dried in a constant temperature bath at 20 ° C. to obtain a sodium hyaluronate film having a thickness of about 50 μm. The adhesion preventing layer and the sodium hyaluronate film were laminated, and pressed using a hand press machine (pressure weight about 50 kg) and bonded to obtain an adhesion preventing material having a laminated structure.

Example 4
1.0 g of sodium hyaluronate (molecular weight (nominal value): 800,000, manufactured by Kikkoman Biochemifa) and 99.0 g of water were mixed and stirred in a beaker to obtain a uniform aqueous solution. 100 g of the obtained aqueous solution was poured into a stainless steel vat, frozen at −30 ° C., and then freeze-dried at a shelf heating temperature of 120 ° C. to obtain a sponge-like sodium hyaluronate film. The obtained sodium hyaluronate film was immersed in 100 mL of a processing solution (10% acetic anhydride / methanol solution) and left at room temperature for 18 hours for water insolubilization treatment. Methanol, 80% by volume methanol aqueous solution, and water were washed in order to obtain a water-insoluble, sponge-like adhesion preventing layer. The obtained adhesion preventing layer was immersed in a 0.5% sodium hyaluronate aqueous solution for 2 hours and then air-dried to obtain an adhesion preventing material having a single layer structure in which sodium hyaluronate was retained in the adhesion preventing layer.

<Evaluation>
(Animal experiment 1)
The anti-adhesion material produced in Example 1 and Comparative Example 1 was sealed in a sterilization bag and irradiated with 25 kGy of radiation to sterilize the entire sterilization bag. An adult dog (beagle dog, female, 1.5 years old, weight about 10 kg) was opened after general anesthesia treatment, and an adhesion prevention material was placed on the lung and physiological saline was applied. About the adhesion prevention material manufactured in Example 1, it confirmed that the adhesion layer (sodium hyaluronate film | membrane) melt | dissolved and was closely_contact | adhered to the lung, and it did not move by respiratory exercise. On the other hand, although the adhesion preventing material manufactured in Comparative Example 1 was in close contact with the lung, it was observed that it moved so as to slide on the lung surface by breathing exercise.

(Animal experiment 2)
The anti-adhesion material produced in Example 2 was sealed in a sterilization bag and irradiated with 25 kGy of radiation to sterilize the entire sterilization bag. An adult dog (beagle dog, female, 1.5 years old, weight about 10 kg) was opened after general anesthesia treatment, and an adhesion prevention material was placed on the lung and physiological saline was applied. As a result, it was confirmed that the dissolved sodium hyaluronate oozes out from the inside of the adhesion preventing material, the adhesion preventing material adheres to the lung, and does not move even by breathing exercise.

(Animal Experiment 3)
The anti-adhesion material produced in Example 3 was sealed in a sterilization bag and irradiated with 25 kGy of radiation to sterilize the entire sterilization bag. An adult dog (beagle dog, female, 1.5 years old, weight about 10 kg) was opened after general anesthesia treatment, and an adhesion prevention material was placed on the lung and physiological saline was applied. As a result, it was confirmed that the adhesive layer (sodium hyaluronate film) was dissolved and was in close contact with the lungs, and did not move even by respiratory motion.

(Animal experiment 4)
The anti-adhesion material produced in Example 4 was sealed in a sterilization bag and irradiated with 25 kGy of radiation to sterilize the entire sterilization bag. An adult dog (beagle dog, female, 1.5 years old, weight about 10 kg) was opened after general anesthesia treatment, and an adhesion prevention material was placed on the lung and physiological saline was applied. As a result, it was confirmed that the adhesive component (sodium hyaluronate) exudes from the inside of the pores, the adhesion preventing material adheres to the lung, and does not move even by breathing exercise.

  The anti-adhesion material of the present invention is difficult to move in a state of being placed on an affected area after surgery, and is useful as a medical material.

Claims (7)

A film-like anti-adhesion layer formed by water-insolubilizing a raw material molded body containing a water-soluble salt of a polyanionic polysaccharide;
A film-like pressure-sensitive adhesive layer containing a water-soluble salt of a polyanionic polysaccharide, disposed on at least one surface of the adhesion-preventing layer;
Anti-adhesion material with. A film-like anti-adhesion layer formed by water-insolubilizing a raw material molded body containing a water-soluble salt of a polyanionic polysaccharide;
An adhesive component containing a water-soluble salt of a polyanionic polysaccharide, retained in the anti-adhesion layer;
Anti-adhesion material with.   The adhesion preventing material according to claim 1 or 2, wherein the adhesion preventing layer has a sponge shape.   The adhesion preventing material according to any one of claims 1 to 3, wherein the raw material molded body is water-insolubilized with a treatment liquid containing an acid anhydride to form the adhesion preventing layer.   The adhesion preventing material according to claim 4, wherein the acid anhydride is at least one of acetic anhydride and propionic anhydride.   The adhesion preventing material according to any one of claims 1 to 5, wherein the polyanionic polysaccharide is at least one selected from the group consisting of hyaluronic acid, carboxymethyl cellulose, and alginic acid.   The adhesion preventing material according to any one of claims 1 to 6, wherein a polyhydric alcohol is retained in the adhesion preventing layer.