JP2019007971A5 - - Google Patents

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JP2019007971A5
JP2019007971A5 JP2018153454A JP2018153454A JP2019007971A5 JP 2019007971 A5 JP2019007971 A5 JP 2019007971A5 JP 2018153454 A JP2018153454 A JP 2018153454A JP 2018153454 A JP2018153454 A JP 2018153454A JP 2019007971 A5 JP2019007971 A5 JP 2019007971A5
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peptide
seq
amino acid
acid sequence
amount
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JP2018153454A
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JP6553264B2 (en
JP2019007971A (en
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被検者より採取した卵胞液中の、配列番号２で表されるアミノ酸配列からなるペプチドおよび配列番号４で表されるアミノ酸配列からなるペプチドからなる群より選択される１以上のペプチドの量を測定することを特徴とする、該被検者における卵子の受精可能性の検査方法。 The amount of one or more peptides selected from subjects follicular fluid collected from, the amino acid sequence represented by SEQ ID NO: 2 peptide and consisting of the amino acid sequence of SEQ ID NO: 4 Ru peptide Tona group A method for examining fertility of an ovum in the subject, characterized in that 卵胞液を質量分析にかけることを含む、請求項１に記載の方法。   The method of claim 1, comprising subjecting the follicular fluid to mass spectrometry. 前記測定により得られたペプチドの量を、対照試料中のペプチドの量に基づいて設定された閾値と比較し、前記測定により得られた配列番号２で表されるアミノ酸配列からなるペプチドの量が対照試料中の配列番号２で表されるアミノ酸配列からなるペプチドの量に基づいて設定された閾値に比べて統計学的に有意に高い場合、および前記測定により得られた配列番号４で表されるアミノ酸配列からなるペプチドの量が対照試料中の配列番号４で表されるアミノ酸配列からなるペプチドの量に基づいて設定された閾値に比べて統計学的に有意に高い場合の少なくとも一方の場合に、卵子の受精可能性が高いと判定することをさらに含む、請求項１に記載の方法。 The amount of the peptide obtained by the measurement is compared with a threshold value set based on the amount of the peptide in the control sample, and the amount of the peptide consisting of the amino acid sequence represented by SEQ ID NO: 2 obtained by the measurement is When it is statistically significantly higher than the threshold set based on the amount of the peptide consisting of the amino acid sequence represented by SEQ ID NO: 2 in the control sample, and represented by SEQ ID NO: 4 obtained by the measurement At least one of cases where the amount of the peptide comprising the amino acid sequence is statistically significantly higher than the threshold value set based on the amount of the peptide comprising the amino acid sequence represented by SEQ ID NO: 4 in the control sample The method of claim 1, further comprising: determining that the egg is highly fertile. 配列番号２で表されるアミノ酸配列からなるペプチドおよび配列番号４で表されるアミノ酸配列からなるペプチドからなる群より選択されるペプチドからなる卵子の受精可能性の検査のためのバイオマーカー。 Biomarkers for testing the fertility potential of oocytes comprising a peptide selected from Ru peptide Tona group consisting of the amino acid sequence represented by peptide and SEQ ID NO: 4 comprising the amino acid sequence as shown in SEQ ID NO: 2. 卵子の受精可能性を検査する方法であって、
配列番号２で表されるアミノ酸配列からなるペプチドおよび配列番号４で表されるアミノ酸配列からなるペプチドからなる群より選択されるペプチドを特異的に認識する抗体を用いた方法。 A method for testing fertility of an egg,
Method using an antibody specifically recognizing a peptide selected from Ru peptide Tona group consisting of the amino acid sequence represented by peptide and SEQ ID NO: 4 comprising the amino acid sequence as shown in SEQ ID NO: 2. 抗体を含む卵子の受精可能性を検査するための判定キットであって、当該抗体が、配列番号２で表されるアミノ酸配列からなるペプチドおよび配列番号４で表されるアミノ酸配列からなるペプチドからなる群より選択されるペプチドを特異的に認識する抗体である、判定キット。 A determination kit for testing the fertility potential of oocytes comprising an antibody, the antibody is comprised of amino acid sequence represented by peptide and SEQ ID NO: 4 consisting of the amino acid sequence of SEQ ID NO: 2 peptide Tona A determination kit, which is an antibody that specifically recognizes a peptide selected from the group .
JP2018153454A 2013-07-29 2018-08-17 Biomarker for fertilization test of egg and determination using it Expired - Fee Related JP6553264B2 (en)

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JP2013156672 2013-07-29
JP2013156672 2013-07-29

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JP2015529492A Division JP6470178B2 (en) 2013-07-29 2014-07-10 Biomarker for fertilization test of egg and determination using it

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JP2019007971A JP2019007971A (en) 2019-01-17
JP2019007971A5 true JP2019007971A5 (en) 2019-02-28
JP6553264B2 JP6553264B2 (en) 2019-07-31

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WO (1) WO2015016036A1 (en)

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JP7300660B2 (en) * 2019-04-03 2023-06-30 京都府公立大学法人 Methods for detecting colorectal cancer
JP7032764B2 (en) * 2019-04-03 2022-03-09 京都府公立大学法人 How to detect colorectal cancer

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* Cited by examiner, † Cited by third party
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EP0214969A4 (en) * 1984-04-19 1987-12-17 Univ Queensland Contraceptive methods and delivery systems therefore.
US6011005A (en) * 1997-09-18 2000-01-04 The Picower Institute For Medical Research Prevention of pregnancy miscarriages
AU2001286726B2 (en) * 2000-08-24 2007-03-22 Sidney Lerner Non-hormonal vaginal contraceptive
JP5714285B2 (en) * 2010-09-29 2015-05-07 株式会社プロトセラ Pregnancy hypertension marker and diagnosis using it
WO2013099376A1 (en) * 2011-12-26 2013-07-04 国立大学法人福井大学 Mature ovum marker for use in in vitro fertilization, and use thereof

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