JP2018538247A5 - - Google Patents
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- JP2018538247A5 JP2018538247A5 JP2018521137A JP2018521137A JP2018538247A5 JP 2018538247 A5 JP2018538247 A5 JP 2018538247A5 JP 2018521137 A JP2018521137 A JP 2018521137A JP 2018521137 A JP2018521137 A JP 2018521137A JP 2018538247 A5 JP2018538247 A5 JP 2018538247A5
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- JP
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- Prior art keywords
- aml
- genes
- patient
- gene
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims 29
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 18
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 17
- 230000014509 gene expression Effects 0.000 claims 16
- 238000000034 method Methods 0.000 claims 13
- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 claims 10
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 claims 10
- 101000928259 Homo sapiens NADPH:adrenodoxin oxidoreductase, mitochondrial Proteins 0.000 claims 10
- 102100036777 NADPH:adrenodoxin oxidoreductase, mitochondrial Human genes 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 102100032500 40S ribosomal protein S27-like Human genes 0.000 claims 8
- 101000731896 Homo sapiens 40S ribosomal protein S27-like Proteins 0.000 claims 8
- 101000780559 Homo sapiens Apoptosis-enhancing nuclease Proteins 0.000 claims 8
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 7
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 7
- 102100034150 Apoptosis-enhancing nuclease Human genes 0.000 claims 6
- 102100022477 DNA repair protein complementing XP-C cells Human genes 0.000 claims 6
- 101000618535 Homo sapiens DNA repair protein complementing XP-C cells Proteins 0.000 claims 6
- 102100021122 DNA damage-binding protein 2 Human genes 0.000 claims 5
- 101001041466 Homo sapiens DNA damage-binding protein 2 Proteins 0.000 claims 5
- 101000836394 Homo sapiens Sestrin-1 Proteins 0.000 claims 5
- 101000795222 Homo sapiens TP53-regulated inhibitor of apoptosis 1 Proteins 0.000 claims 5
- 101000723893 Homo sapiens Zinc finger matrin-type protein 3 Proteins 0.000 claims 5
- 102100027288 Sestrin-1 Human genes 0.000 claims 5
- 101150080074 TP53 gene Proteins 0.000 claims 5
- 102100029669 TP53-regulated inhibitor of apoptosis 1 Human genes 0.000 claims 5
- 102100028482 Zinc finger matrin-type protein 3 Human genes 0.000 claims 5
- 108700025694 p53 Genes Proteins 0.000 claims 5
- 102100038252 Cyclin-G1 Human genes 0.000 claims 4
- 101000884191 Homo sapiens Cyclin-G1 Proteins 0.000 claims 4
- 101000679907 Homo sapiens Tumor necrosis factor receptor superfamily member 27 Proteins 0.000 claims 4
- 102100022202 Tumor necrosis factor receptor superfamily member 27 Human genes 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- XOYCLJDJUKHHHS-LHBOOPKSSA-N (2s,3s,4s,5r,6r)-6-[[(2s,3s,5r)-3-amino-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@H](O2)C(O)=O)O)[C@@H](N)C1 XOYCLJDJUKHHHS-LHBOOPKSSA-N 0.000 claims 3
- 102100036413 2',5'-phosphodiesterase 12 Human genes 0.000 claims 3
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 3
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims 3
- 101150060120 C1qbp gene Proteins 0.000 claims 3
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 3
- 102100037078 Complement component 1 Q subcomponent-binding protein, mitochondrial Human genes 0.000 claims 3
- 102100035481 DNA polymerase eta Human genes 0.000 claims 3
- 102100022273 Disrupted in schizophrenia 1 protein Human genes 0.000 claims 3
- 101150061947 EIF2D gene Proteins 0.000 claims 3
- 102100021309 Elongation factor Ts, mitochondrial Human genes 0.000 claims 3
- 102100038075 Eukaryotic translation initiation factor 2D Human genes 0.000 claims 3
- 102100027681 Fructose-2,6-bisphosphatase TIGAR Human genes 0.000 claims 3
- 102100033506 G-rich sequence factor 1 Human genes 0.000 claims 3
- 108050004787 GREB1 Proteins 0.000 claims 3
- 102000016251 GREB1 Human genes 0.000 claims 3
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 3
- 102100040579 Guanidinoacetate N-methyltransferase Human genes 0.000 claims 3
- 101001072024 Homo sapiens 2',5'-phosphodiesterase 12 Proteins 0.000 claims 3
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 3
- 101001094607 Homo sapiens DNA polymerase eta Proteins 0.000 claims 3
- 101000865085 Homo sapiens DNA polymerase theta Proteins 0.000 claims 3
- 101000902072 Homo sapiens Disrupted in schizophrenia 1 protein Proteins 0.000 claims 3
- 101000895350 Homo sapiens Elongation factor Ts, mitochondrial Proteins 0.000 claims 3
- 101000651314 Homo sapiens Fructose-2,6-bisphosphatase TIGAR Proteins 0.000 claims 3
- 101000870806 Homo sapiens G-rich sequence factor 1 Proteins 0.000 claims 3
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 3
- 101000893897 Homo sapiens Guanidinoacetate N-methyltransferase Proteins 0.000 claims 3
- 101001032502 Homo sapiens Iron-sulfur cluster assembly enzyme ISCU, mitochondrial Proteins 0.000 claims 3
- 101000576989 Homo sapiens Mannose-P-dolichol utilization defect 1 protein Proteins 0.000 claims 3
- 101001033754 Homo sapiens Mediator of RNA polymerase II transcription subunit 31 Proteins 0.000 claims 3
- 101000574631 Homo sapiens Meteorin Proteins 0.000 claims 3
- 101000583714 Homo sapiens Pleckstrin homology-like domain family A member 3 Proteins 0.000 claims 3
- 101001105683 Homo sapiens Pre-mRNA-processing-splicing factor 8 Proteins 0.000 claims 3
- 101000842302 Homo sapiens Protein-cysteine N-palmitoyltransferase HHAT Proteins 0.000 claims 3
- 101001061669 Homo sapiens Required for excision 1-B domain-containing protein Proteins 0.000 claims 3
- 101000701936 Homo sapiens Signal peptidase complex subunit 1 Proteins 0.000 claims 3
- 101000648224 Homo sapiens Syntaxin-8 Proteins 0.000 claims 3
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims 3
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 3
- 102100038096 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial Human genes 0.000 claims 3
- 102100025297 Mannose-P-dolichol utilization defect 1 protein Human genes 0.000 claims 3
- 102100039122 Mediator of RNA polymerase II transcription subunit 31 Human genes 0.000 claims 3
- 102100025695 Meteorin Human genes 0.000 claims 3
- 102100021769 Mitochondrial 2-oxoglutarate/malate carrier protein Human genes 0.000 claims 3
- 102100030925 Pleckstrin homology-like domain family A member 3 Human genes 0.000 claims 3
- 102100021231 Pre-mRNA-processing-splicing factor 8 Human genes 0.000 claims 3
- 102100030616 Protein-cysteine N-palmitoyltransferase HHAT Human genes 0.000 claims 3
- 102100028426 Required for excision 1-B domain-containing protein Human genes 0.000 claims 3
- 108091006417 SLC25A11 Proteins 0.000 claims 3
- 102100030313 Signal peptidase complex subunit 1 Human genes 0.000 claims 3
- 102100028808 Syntaxin-8 Human genes 0.000 claims 3
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims 3
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims 3
- 102100021573 Bcl-2-binding component 3, isoforms 3/4 Human genes 0.000 claims 2
- 101000971203 Homo sapiens Bcl-2-binding component 3, isoforms 1/2 Proteins 0.000 claims 2
- 101000971209 Homo sapiens Bcl-2-binding component 3, isoforms 3/4 Proteins 0.000 claims 2
- 101000629088 Homo sapiens Mitochondria-eating protein Proteins 0.000 claims 2
- 101001095783 Homo sapiens Ribonucleoside-diphosphate reductase subunit M2 B Proteins 0.000 claims 2
- 102100027034 Mitochondria-eating protein Human genes 0.000 claims 2
- 102100038013 Ribonucleoside-diphosphate reductase subunit M2 B Human genes 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 2
- 102100027308 Apoptosis regulator BAX Human genes 0.000 claims 1
- 108050006685 Apoptosis regulator BAX Proteins 0.000 claims 1
- 101000645266 Homo sapiens Mitochondrial import inner membrane translocase subunit Tim22 Proteins 0.000 claims 1
- 101000717450 Homo sapiens RCC1 and BTB domain-containing protein 1 Proteins 0.000 claims 1
- 101000929936 Homo sapiens Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Proteins 0.000 claims 1
- 101000618110 Homo sapiens Sperm-associated antigen 7 Proteins 0.000 claims 1
- 102100026258 Mitochondrial import inner membrane translocase subunit Tim22 Human genes 0.000 claims 1
- 102100020837 RCC1 and BTB domain-containing protein 1 Human genes 0.000 claims 1
- 102100035766 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 1
- 102100021912 Sperm-associated antigen 7 Human genes 0.000 claims 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical group O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245667P | 2015-10-23 | 2015-10-23 | |
| US62/245,667 | 2015-10-23 | ||
| PCT/JP2016/081974 WO2017069288A1 (en) | 2015-10-23 | 2016-10-21 | Pharmaceutical composition for use in treating aml and method of treating aml in a subject in need thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018538247A JP2018538247A (ja) | 2018-12-27 |
| JP2018538247A5 true JP2018538247A5 (https=) | 2019-12-19 |
Family
ID=57349100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521137A Withdrawn JP2018538247A (ja) | 2015-10-23 | 2016-10-21 | Ａｍｌを処置することに用いるための医薬組成物およびそれを必要とする対象においてａｍｌを処置する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180303812A1 (https=) |
| EP (1) | EP3364966A1 (https=) |
| JP (1) | JP2018538247A (https=) |
| KR (1) | KR20180067677A (https=) |
| CN (1) | CN108135884A (https=) |
| HK (1) | HK1253320A1 (https=) |
| TW (1) | TW201722428A (https=) |
| WO (1) | WO2017069288A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US20190240210A1 (en) * | 2016-10-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor |
| CN119280393A (zh) * | 2018-10-30 | 2025-01-10 | 宏观基因有限公司 | 用于治疗血液系统恶性肿瘤的双特异性CD123 x CD3双抗体 |
| CN111893172A (zh) * | 2020-06-24 | 2020-11-06 | 南通大学附属医院 | Grsf1在判断脓毒症患者严重程度及预后方面的应用 |
| CN115992226B (zh) * | 2021-10-19 | 2024-10-01 | 上海交通大学医学院附属新华医院 | 检测c1q表达水平的试剂在制备急性髓细胞白血病诊断或预后判断及治疗试剂中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009120561A2 (en) | 2008-03-22 | 2009-10-01 | Merck & Co., Inc. | Methods and gene expression signature for assessing growth factor signaling pathway regulation status |
| AU2012226890B2 (en) * | 2011-03-10 | 2016-10-06 | Daiichi Sankyo Company, Limited | Dispiropyrrolidine derivative |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| US20160333419A1 (en) * | 2014-01-14 | 2016-11-17 | Daiichi Sankyo Company, Limited | Gene signatures associated with sensitivity to mdm2 inhibitors |
-
2016
- 2016-10-21 TW TW105134054A patent/TW201722428A/zh unknown
- 2016-10-21 KR KR1020187014441A patent/KR20180067677A/ko not_active Withdrawn
- 2016-10-21 US US15/769,308 patent/US20180303812A1/en not_active Abandoned
- 2016-10-21 WO PCT/JP2016/081974 patent/WO2017069288A1/en not_active Ceased
- 2016-10-21 JP JP2018521137A patent/JP2018538247A/ja not_active Withdrawn
- 2016-10-21 CN CN201680061013.7A patent/CN108135884A/zh not_active Withdrawn
- 2016-10-21 HK HK18112613.2A patent/HK1253320A1/zh unknown
- 2016-10-21 EP EP16798290.9A patent/EP3364966A1/en not_active Withdrawn
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| Nourazarian | Masoud Nikanfar1, Mohammad Nouri2, Mehdi Hassanpour2, Jafar Rezaei3 & |