JP2018537408A5 - - Google Patents
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- Publication number
- JP2018537408A5 JP2018537408A5 JP2018516713A JP2018516713A JP2018537408A5 JP 2018537408 A5 JP2018537408 A5 JP 2018537408A5 JP 2018516713 A JP2018516713 A JP 2018516713A JP 2018516713 A JP2018516713 A JP 2018516713A JP 2018537408 A5 JP2018537408 A5 JP 2018537408A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- amine
- amino
- methyl
- dimethylpentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3170/DEL/2015 | 2015-10-01 | ||
| IN3170DE2015 | 2015-10-01 | ||
| PCT/US2016/054471 WO2017059085A1 (en) | 2015-10-01 | 2016-09-29 | Biaryl kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537408A JP2018537408A (ja) | 2018-12-20 |
| JP2018537408A5 true JP2018537408A5 (cg-RX-API-DMAC10.html) | 2019-11-07 |
| JP6785302B2 JP6785302B2 (ja) | 2020-11-18 |
Family
ID=57190217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516713A Active JP6785302B2 (ja) | 2015-10-01 | 2016-09-29 | ビアリールキナーゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10544120B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3356340B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6785302B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR102704295B1 (cg-RX-API-DMAC10.html) |
| CN (2) | CN112142655A (cg-RX-API-DMAC10.html) |
| ES (1) | ES2765730T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2017059085A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2944466C (en) | 2014-04-02 | 2020-06-09 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| CN112142655A (zh) | 2015-10-01 | 2020-12-29 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| ES2767776T3 (es) | 2015-10-01 | 2020-06-18 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
| CA3044366A1 (en) | 2016-12-19 | 2018-06-28 | Novartis Ag | New picolinic acid derivatives and their use as intermediates |
| JP2023522688A (ja) * | 2020-04-21 | 2023-05-31 | レクシコン ファーマシューティカルズ インコーポレイテッド | ウイルス感染症の治療に使用されるａａｋ１阻害剤 |
| CN111995583A (zh) * | 2020-08-18 | 2020-11-27 | 上海毕得医药科技有限公司 | 一种1,5-二甲基嘧啶-2(1h)-酮的合成方法 |
| TW202317532A (zh) | 2021-07-15 | 2023-05-01 | 大陸商四川海思科製藥有限公司 | Aak1抑制劑及其用途 |
| CA3244394A1 (en) | 2022-03-01 | 2023-09-07 | Lexicon Pharmaceuticals, Inc. | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF AN AAK1 INHIBITOR |
| US12344596B2 (en) | 2022-03-01 | 2025-07-01 | Lexicon Pharmaceuticals, Inc. | Solid forms of (S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine and salts thereof |
| TW202423433A (zh) * | 2022-11-10 | 2024-06-16 | 大陸商西藏海思科製藥有限公司 | 含aak1抑制劑的藥物组合物 |
| CN120641406A (zh) * | 2023-01-16 | 2025-09-12 | 上海海雁医药科技有限公司 | 杂环取代的含氮杂环衍生物、其药物组合物及应用与制备方法 |
| CN118772152B (zh) * | 2023-04-07 | 2026-01-02 | 艾立康药业股份有限公司 | 作为aak1抑制剂的氮杂环类化合物 |
| EP4692089A1 (en) | 2023-04-07 | 2026-02-11 | Alicorn Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compound as aak1 inhibitor |
| CN122161818A (zh) | 2023-11-02 | 2026-06-05 | 西藏海思科制药有限公司 | 一种可抑制连接蛋白相关激酶1的化合物、制备及其用途 |
| WO2025230262A1 (ko) | 2024-04-29 | 2025-11-06 | 심플렉스 주식회사 | 신규한 헤테로아릴 유도체 및 이의 aak1 억제 용도 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7348335B2 (en) | 2002-11-05 | 2008-03-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of JAK and other protein kinases |
| MX357131B (es) * | 2012-02-29 | 2018-06-27 | Meiji Seika Pharma Co Ltd | Composicion para el control de plagas que incluye un derivado de iminopiridina novedoso. |
| HK1199814A1 (en) | 2012-03-09 | 2015-07-24 | Lexicon Pharmaceuticals, Inc. | Inhibition of adaptor associated kinase 1 for the treatment of pain |
| US8703953B2 (en) * | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| US8901305B2 (en) * | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| EP2958924B1 (en) | 2013-02-22 | 2016-12-28 | Bristol-Myers Squibb Company | 5h-chromeno[3,4-c]pyridines as inhibitors of adaptor associated kinase 1 (aak1) |
| WO2015006100A1 (en) | 2013-07-08 | 2015-01-15 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| MX2016002924A (es) | 2013-09-11 | 2016-06-06 | Squibb Bristol Myers Co | Inhibidores de cinasa a base de eter arilico. |
| US10206397B2 (en) * | 2013-09-19 | 2019-02-19 | Basf Se | N-acylimino heterocyclic compounds |
| EA028587B1 (ru) | 2014-01-29 | 2017-12-29 | Бристол-Майерс Сквибб Компани | Ариллактамные ингибиторы киназы |
| ES2701903T3 (es) | 2014-01-31 | 2019-02-26 | Bristol Myers Squibb Co | Inhibidores de cinasa a base de quinolina |
| CA2944466C (en) * | 2014-04-02 | 2020-06-09 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| WO2016053794A1 (en) | 2014-09-30 | 2016-04-07 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| EP3292124B1 (en) | 2015-04-10 | 2019-05-22 | Bristol-Myers Squibb Company | 6h-isochromeno[3,4-c]pyridines and benzo[c][1,7]naphthyridin-6-(5h)-ones as adaptor associated kinase 1 (aak1) inhibitors |
| CN112142655A (zh) | 2015-10-01 | 2020-12-29 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| ES2767776T3 (es) | 2015-10-01 | 2020-06-18 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
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2016
- 2016-09-29 CN CN202010986635.9A patent/CN112142655A/zh active Pending
- 2016-09-29 CN CN201680070440.1A patent/CN108368084B/zh active Active
- 2016-09-29 KR KR1020187011874A patent/KR102704295B1/ko active Active
- 2016-09-29 ES ES16785279T patent/ES2765730T3/es active Active
- 2016-09-29 EP EP16785279.7A patent/EP3356340B1/en active Active
- 2016-09-29 WO PCT/US2016/054471 patent/WO2017059085A1/en not_active Ceased
- 2016-09-29 US US15/763,280 patent/US10544120B2/en active Active
- 2016-09-29 JP JP2018516713A patent/JP6785302B2/ja active Active