JP2018531231A5 - - Google Patents

Info

Publication number

JP2018531231A5

JP2018531231A5 JP2018515121A JP2018515121A JP2018531231A5 JP 2018531231 A5 JP2018531231 A5 JP 2018531231A5 JP 2018515121 A JP2018515121 A JP 2018515121A JP 2018515121 A JP2018515121 A JP 2018515121A JP 2018531231 A5 JP2018531231 A5 JP 2018531231A5

Authority

JP

Japan

Prior art keywords

composition

nanoparticles

taxane

weight

composition according

Prior art date

2016-09-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 55
• 239000002105 nanoparticle Substances 0.000 claims 37
• 229940123237 Taxane Drugs 0.000 claims 14
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 14
• XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 10
• 229930012538 Paclitaxel Natural products 0.000 claims 10
• 229960001592 paclitaxel Drugs 0.000 claims 10
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 10
• 229940079593 drug Drugs 0.000 claims 9
• 239000003814 drug Substances 0.000 claims 9
• 239000012051 hydrophobic carrier Substances 0.000 claims 8
• 235000019271 petrolatum Nutrition 0.000 claims 8
• 239000002674 ointment Substances 0.000 claims 6
• 229920002545 silicone oil Polymers 0.000 claims 6
• 239000004215 Carbon black (E152) Substances 0.000 claims 4
• 229940086555 cyclomethicone Drugs 0.000 claims 4
• 229930195733 hydrocarbon Natural products 0.000 claims 4
• 150000002430 hydrocarbons Chemical class 0.000 claims 4
• 239000012188 paraffin wax Substances 0.000 claims 4
• 235000019809 paraffin wax Nutrition 0.000 claims 4
• 239000007787 solid Substances 0.000 claims 4
• 239000008247 solid mixture Substances 0.000 claims 4
• 102000009027 Albumins Human genes 0.000 claims 2
• 108010088751 Albumins Proteins 0.000 claims 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
• 239000004264 Petrolatum Substances 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 229940088710 antibiotic agent Drugs 0.000 claims 2
• BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 claims 2
• 229960001573 cabazitaxel Drugs 0.000 claims 2
• 229960003668 docetaxel Drugs 0.000 claims 2
• 229940097789 heavy mineral oil Drugs 0.000 claims 2
• 230000002209 hydrophobic effect Effects 0.000 claims 2
• 235000010446 mineral oil Nutrition 0.000 claims 2
• 239000002480 mineral oil Substances 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 239000003961 penetration enhancing agent Substances 0.000 claims 2
• 229940066842 petrolatum Drugs 0.000 claims 2
• 239000003380 propellant Substances 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 239000002904 solvent Substances 0.000 claims 2
• 239000004094 surface-active agent Substances 0.000 claims 2
• 230000002708 enhancing effect Effects 0.000 claims 1
• 230000035515 penetration Effects 0.000 claims 1