JP2018529345A5 - - Google Patents

Info

Publication number

JP2018529345A5

JP2018529345A5 JP2018515528A JP2018515528A JP2018529345A5 JP 2018529345 A5 JP2018529345 A5 JP 2018529345A5 JP 2018515528 A JP2018515528 A JP 2018515528A JP 2018515528 A JP2018515528 A JP 2018515528A JP 2018529345 A5 JP2018529345 A5 JP 2018529345A5

Authority

JP

Japan

Prior art keywords

cells

seq

sample

mammal

cpg

Prior art date

2016-09-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims 17
• 210000003719 b-lymphocyte Anatomy 0.000 claims 10
• 241000124008 Mammalia Species 0.000 claims 7
• 230000011987 methylation Effects 0.000 claims 7
• 238000007069 methylation reaction Methods 0.000 claims 7
• 239000000523 sample Substances 0.000 claims 7
• 108090000623 proteins and genes Proteins 0.000 claims 6
• 108091093088 Amplicon Proteins 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 4
• 238000004458 analytical method Methods 0.000 claims 4
• 238000012544 monitoring process Methods 0.000 claims 4
• 102000001770 Low Density Lipoprotein Receptor-Related Protein-5 Human genes 0.000 claims 3
• 108010015167 Low Density Lipoprotein Receptor-Related Protein-5 Proteins 0.000 claims 3
• 210000004369 blood Anatomy 0.000 claims 3
• 239000008280 blood Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 108091029523 CpG island Proteins 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
• 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108091036066 Three prime untranslated region Proteins 0.000 claims 1
• 108700009124 Transcription Initiation Site Proteins 0.000 claims 1
• 206010052779 Transplant rejections Diseases 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 230000003321 amplification Effects 0.000 claims 1
• 239000012620 biological material Substances 0.000 claims 1
• 238000001369 bisulfite sequencing Methods 0.000 claims 1
• 210000001124 body fluid Anatomy 0.000 claims 1
• 239000010839 body fluid Substances 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 239000013068 control sample Substances 0.000 claims 1
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
• 230000017858 demethylation Effects 0.000 claims 1
• 238000010520 demethylation reaction Methods 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 238000001976 enzyme digestion Methods 0.000 claims 1
• 230000003325 follicular Effects 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
• 210000003714 granulocyte Anatomy 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 210000004698 lymphocyte Anatomy 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 210000001616 monocyte Anatomy 0.000 claims 1
• 210000000822 natural killer cell Anatomy 0.000 claims 1
• 238000003199 nucleic acid amplification method Methods 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 230000035897 transcription Effects 0.000 claims 1
• 238000013518 transcription Methods 0.000 claims 1
• 238000011144 upstream manufacturing Methods 0.000 claims 1