JP2018522053A5 - - Google Patents
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- Publication number
- JP2018522053A5 JP2018522053A5 JP2018506137A JP2018506137A JP2018522053A5 JP 2018522053 A5 JP2018522053 A5 JP 2018522053A5 JP 2018506137 A JP2018506137 A JP 2018506137A JP 2018506137 A JP2018506137 A JP 2018506137A JP 2018522053 A5 JP2018522053 A5 JP 2018522053A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- composition
- tlr4 agonist
- pharmaceutical composition
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 16
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 16
- 239000000556 agonist Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 15
- 239000002246 antineoplastic agent Substances 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- -1 combination Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 229940041181 antineoplastic drug Drugs 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000012635 anticancer drug combination Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- REEGNIYAMZUTIO-MGSMBCBTSA-N (2s)-2-[[(3r)-3-decanoyloxytetradecanoyl]amino]-3-[(2r,3r,4r,5s,6r)-3-[[(3r)-3-decanoyloxytetradecanoyl]amino]-4-[(3r)-3-decanoyloxytetradecanoyl]oxy-6-(hydroxymethyl)-5-phosphonooxyoxan-2-yl]oxypropanoic acid Chemical compound CCCCCCCCCCC[C@@H](OC(=O)CCCCCCCCC)CC(=O)N[C@H](C(O)=O)CO[C@@H]1O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCC)[C@H]1NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCC REEGNIYAMZUTIO-MGSMBCBTSA-N 0.000 claims 1
- ICLAYQQKWJGHBV-XJZMHMBSSA-N (2s)-2-[[(3r)-3-decoxytetradecanoyl]amino]-3-[(2r,3r,4r,5s,6r)-3-[[(3r)-3-decoxytetradecanoyl]amino]-4-[(3r)-3-decoxytetradecanoyl]oxy-6-(hydroxymethyl)-5-phosphonooxyoxan-2-yl]oxypropanoic acid Chemical compound CCCCCCCCCCC[C@@H](OCCCCCCCCCC)CC(=O)N[C@H](C(O)=O)CO[C@@H]1O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OCCCCCCCCCC)[C@H]1NC(=O)C[C@@H](CCCCCCCCCCC)OCCCCCCCCCC ICLAYQQKWJGHBV-XJZMHMBSSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000008271 glucosaminides Chemical class 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562201912P | 2015-08-06 | 2015-08-06 | |
| US62/201,912 | 2015-08-06 | ||
| PCT/IB2016/053290 WO2017021792A1 (en) | 2015-08-06 | 2016-06-03 | Tlr4 agonists and compositions thereof and their use in the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018522053A JP2018522053A (ja) | 2018-08-09 |
| JP2018522053A5 true JP2018522053A5 (enExample) | 2019-07-04 |
Family
ID=56121139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506137A Pending JP2018522053A (ja) | 2015-08-06 | 2016-06-03 | Ｔｌｒ４アゴニストおよびその組成物ならびに癌の処置におけるそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10765690B2 (enExample) |
| EP (1) | EP3331565A1 (enExample) |
| JP (1) | JP2018522053A (enExample) |
| KR (1) | KR20180032642A (enExample) |
| CN (1) | CN108136024A (enExample) |
| AU (1) | AU2016303387B2 (enExample) |
| BR (1) | BR112018002520A2 (enExample) |
| CA (1) | CA2994790A1 (enExample) |
| RU (1) | RU2018107930A (enExample) |
| WO (1) | WO2017021792A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| IL276608B2 (en) | 2018-02-12 | 2024-04-01 | Inimmune Corp | Toll-like receptor ligands |
| WO2020007760A1 (en) * | 2018-07-03 | 2020-01-09 | Glaxosmithkline Intellectual Property Development Limited | Tlr4 compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions or formulations, methods of preparation, treatment or uses |
| WO2020031087A1 (en) * | 2018-08-06 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| CN116457364A (zh) * | 2020-11-11 | 2023-07-18 | 第一三共株式会社 | 新型氨基烷基氨基葡糖苷4-磷酸酯衍生物 |
| CN117018195B (zh) * | 2023-08-04 | 2024-05-21 | 中国人民解放军海军军医大学 | 小分子化合物或组合在制备启动肝脏原位再生药物中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| NZ522755A (en) | 2000-05-19 | 2004-05-28 | Corixa Corp | Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds being administered in absence of exogenous antigen |
| CA2417806C (en) | 2000-08-04 | 2011-05-10 | Corixa Corporation | New immunoeffector compounds |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US7030094B2 (en) * | 2002-02-04 | 2006-04-18 | Corixa Corporation | Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21 |
| US6525028B1 (en) | 2002-02-04 | 2003-02-25 | Corixa Corporation | Immunoeffector compounds |
| US6911434B2 (en) | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| US7288640B2 (en) | 2002-07-08 | 2007-10-30 | Corixa Corporation | Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor |
| US7960522B2 (en) * | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| AU2004284090A1 (en) | 2003-10-24 | 2005-05-06 | Avidia, Inc. | LDL receptor class A and EGF domain monomers and multimers |
| WO2010075545A1 (en) * | 2008-12-23 | 2010-07-01 | Glaxosmithkline Biologicals S.A. | Method for inducing a trif-bias |
| US8741295B2 (en) * | 2009-02-09 | 2014-06-03 | Universite De La Mediterranee | PD-1 antibodies and PD-L1 antibodies and uses thereof |
| US20110293700A1 (en) * | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| US20120321694A1 (en) | 2010-10-27 | 2012-12-20 | Daniel Larocque | Compositions and uses |
| GB201101331D0 (en) * | 2011-01-26 | 2011-03-09 | Glaxosmithkline Biolog Sa | Compositions and uses |
| KR102039520B1 (ko) * | 2013-04-18 | 2019-11-01 | 이뮨 디자인 코포레이션 | 암 치료에 이용하기 위한 gla 단일요법 |
-
2016
- 2016-06-03 AU AU2016303387A patent/AU2016303387B2/en not_active Ceased
- 2016-06-03 KR KR1020187005943A patent/KR20180032642A/ko not_active Withdrawn
- 2016-06-03 RU RU2018107930A patent/RU2018107930A/ru not_active Application Discontinuation
- 2016-06-03 WO PCT/IB2016/053290 patent/WO2017021792A1/en not_active Ceased
- 2016-06-03 BR BR112018002520A patent/BR112018002520A2/pt not_active Application Discontinuation
- 2016-06-03 EP EP16729070.9A patent/EP3331565A1/en not_active Withdrawn
- 2016-06-03 CA CA2994790A patent/CA2994790A1/en not_active Abandoned
- 2016-06-03 US US15/749,854 patent/US10765690B2/en not_active Expired - Fee Related
- 2016-06-03 JP JP2018506137A patent/JP2018522053A/ja active Pending
- 2016-06-03 CN CN201680058161.3A patent/CN108136024A/zh active Pending
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