RU2019105574A - Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор - Google Patents
Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор Download PDFInfo
- Publication number
- RU2019105574A RU2019105574A RU2019105574A RU2019105574A RU2019105574A RU 2019105574 A RU2019105574 A RU 2019105574A RU 2019105574 A RU2019105574 A RU 2019105574A RU 2019105574 A RU2019105574 A RU 2019105574A RU 2019105574 A RU2019105574 A RU 2019105574A
- Authority
- RU
- Russia
- Prior art keywords
- paclitaxel
- tumor
- amount
- day
- arabinofuranosyl
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (7)
1. Противоопухолевый агент, содержащий паклитаксел в количестве 1~1000 мг/м2/день; и 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина метансульфонат в количестве 1~2000 мг/м2/день.
2. Противоопухолевый агент по п. 1, где применяемое количество 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина метансульфоната равно 0,01-100-кратному молярному количеству паклитаксела.
3. Противоопухолевый агент по п. 1 или 2, где противоопухолевый агент предназначен для рака поджелудочной железы.
4. Противоопухолевый агент по любому из пп. 1-3, где паклитакселом является наночастица, содержащая паклитаксел и альбумин.
5. Противоопухолевый агент по любому из пп. 1-4, где паклитакселом является наб-паклитаксел.
6. Усилитель противоопухолевого действия, содержащий 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина метансульфонат в количестве 1~2000 мг/м2/день.
7. Противоопухолевый набор, содержащий препарат, содержащий паклитаксел в количестве 1~1000мг/м2/день; ипрепарат, содержащий 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина метансульфонат в количестве 1~2000 мг/м2/день.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016-169167 | 2016-08-31 | ||
JP2016169167 | 2016-08-31 | ||
PCT/JP2017/031074 WO2018043530A1 (ja) | 2016-08-31 | 2017-08-30 | 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2019105574A true RU2019105574A (ru) | 2020-10-01 |
RU2019105574A3 RU2019105574A3 (ru) | 2020-10-01 |
RU2752172C2 RU2752172C2 (ru) | 2021-07-23 |
Family
ID=61301073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2019105574A RU2752172C2 (ru) | 2016-08-31 | 2017-08-30 | Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор |
Country Status (14)
Country | Link |
---|---|
US (1) | US11369625B2 (ru) |
EP (1) | EP3508205B1 (ru) |
JP (2) | JP7008025B2 (ru) |
KR (1) | KR102198656B1 (ru) |
CN (1) | CN109641009B (ru) |
AU (1) | AU2017319260B2 (ru) |
BR (1) | BR112019003946A2 (ru) |
CA (1) | CA3035334C (ru) |
MX (1) | MX2019002430A (ru) |
RU (1) | RU2752172C2 (ru) |
SG (1) | SG11201901815WA (ru) |
TW (1) | TWI787201B (ru) |
WO (1) | WO2018043530A1 (ru) |
ZA (1) | ZA201901563B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3089728C (en) | 2018-01-29 | 2023-01-10 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
TW202002989A (zh) * | 2018-03-13 | 2020-01-16 | 日商富士軟片股份有限公司 | 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用試劑盒 |
WO2019176985A1 (ja) * | 2018-03-13 | 2019-09-19 | 富士フイルム株式会社 | 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット |
CN117794548A (zh) | 2021-07-29 | 2024-03-29 | 富士胶片株式会社 | 针对bap1及pbrm1中的至少一个的功能下降的肿瘤的药物组合物及抗肿瘤剂 |
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CA3089728C (en) | 2018-01-29 | 2023-01-10 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
TW202002989A (zh) | 2018-03-13 | 2020-01-16 | 日商富士軟片股份有限公司 | 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用試劑盒 |
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2017
- 2017-08-30 MX MX2019002430A patent/MX2019002430A/es unknown
- 2017-08-30 CA CA3035334A patent/CA3035334C/en active Active
- 2017-08-30 EP EP17846534.0A patent/EP3508205B1/en active Active
- 2017-08-30 CN CN201780053185.4A patent/CN109641009B/zh active Active
- 2017-08-30 RU RU2019105574A patent/RU2752172C2/ru active
- 2017-08-30 KR KR1020197006023A patent/KR102198656B1/ko active IP Right Grant
- 2017-08-30 SG SG11201901815WA patent/SG11201901815WA/en unknown
- 2017-08-30 TW TW106129543A patent/TWI787201B/zh active
- 2017-08-30 JP JP2018537328A patent/JP7008025B2/ja active Active
- 2017-08-30 AU AU2017319260A patent/AU2017319260B2/en active Active
- 2017-08-30 BR BR112019003946-5A patent/BR112019003946A2/pt not_active Application Discontinuation
- 2017-08-30 WO PCT/JP2017/031074 patent/WO2018043530A1/ja unknown
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2019
- 2019-02-27 US US16/286,930 patent/US11369625B2/en active Active
- 2019-03-13 ZA ZA2019/01563A patent/ZA201901563B/en unknown
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2020
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RU2752172C2 (ru) | 2021-07-23 |
JPWO2018043530A1 (ja) | 2019-07-04 |
EP3508205A1 (en) | 2019-07-10 |
AU2017319260A1 (en) | 2019-03-21 |
CA3035334A1 (en) | 2018-03-08 |
AU2017319260B2 (en) | 2020-01-30 |
RU2019105574A3 (ru) | 2020-10-01 |
KR20190034310A (ko) | 2019-04-01 |
EP3508205A4 (en) | 2019-09-04 |
US20190192546A1 (en) | 2019-06-27 |
CN109641009B (zh) | 2021-12-31 |
US11369625B2 (en) | 2022-06-28 |
MX2019002430A (es) | 2019-07-04 |
SG11201901815WA (en) | 2019-04-29 |
TW201811323A (zh) | 2018-04-01 |
JP7008025B2 (ja) | 2022-01-25 |
TWI787201B (zh) | 2022-12-21 |
KR102198656B1 (ko) | 2021-01-05 |
JP2021014474A (ja) | 2021-02-12 |
EP3508205B1 (en) | 2022-05-18 |
ZA201901563B (en) | 2020-09-30 |
CA3035334C (en) | 2022-05-10 |
BR112019003946A2 (pt) | 2019-05-21 |
WO2018043530A1 (ja) | 2018-03-08 |
NZ751051A (en) | 2021-09-24 |
CN109641009A (zh) | 2019-04-16 |
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