JP2018519355A - 透析後ウォッシュアウトを改善する方法およびこのような方法において使用するための栄養補助食品 - Google Patents
透析後ウォッシュアウトを改善する方法およびこのような方法において使用するための栄養補助食品 Download PDFInfo
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Abstract
Description
本発明は、透析を受けた患者において透析後ウォッシュアウト(post-dialysis washout)(透析後宿酔(post-dialysis hangover)としても知られる)を改善するまたは低減する方法に関する。また、このような改善または治療において使用するための栄養補助食品も提供される。
透析、特に血液透析後、患者は、「ウォッシュアウト」と呼ばれる症候群または期間を経験することがある。ウォッシュアウトは、透析後に現れる一連の症状を指し、したがって、患者は、透析後に、脱力感、震えおよび極度の疲労を覚える。これらの症状のうち1種以上、頻繁にはすべてが、さまざまな程度で存在し得る。患者は、会話できないほど、または本もしくは新聞でさえ持てないほど、極めて疲れているまたは脱力感があると報告している。症状はまた、全身の疼痛、関節のこわばり、ならびに頭痛、吐き気および食欲不振を含むその他のインフルエンザ様症状に至るまで、強度が異なることがある。症候群は、治療の終了の少し前、または治療後数分で始まり得る。消散していく形態で、それは、30分または12〜14時間持続し得る。患者は、疲れ果てているが、なかなか寝つかれない。軽食を食べること、休息、および静かな環境を提供することが、患者がウォッシュアウトに、それが「摩耗する」まで対処するのに役立ち得る。「血液透析の段階的説明(Step−by−step Description of Hemodialysis)」、(Wikipedia, http://en.wikipedia.org/wiki/Step−by−step_description_of_ Hemodialysis、2015年2月8日;2015年4月8日)。
A)ヒスチジン、アラニン、イソロイシン、アルギニン、ロイシン、アスパラギン、リジン、アスパラギン酸、メチオニン、システイン、フェニルアラニン、グルタミン酸、トレオニン、グルタミン、トリプトファン、グリシン、バリン、ピロリジン、プロリン、セレノシステイン、セリンおよびチロシンならびにそれらの混合物ならびに/またはそのヒドロキシもしくはケト類似体からなる群から選択されるアミノ酸の群と、
B)糖、非栄養性甘味料またはそれらの混合物からなる群から選択される少なくとも1種の甘味料と
C)少なくとも1種の非栄養性繊維、少なくとも1種のタンパク質、少なくとも1種の油、少なくとも1種のビタミン、少なくとも1種のペプチド、少なくとも1種の炭水化物、少なくとも1種の無機質、少なくとも1種の天然または人工フレーバーおよびそれらの混合物からなる群から選択される少なくとも1種の成分と
を含む有効量の栄養補助食品を投与することを含む、透析後ウォッシュアウトを改善する方法もまた提供される。
Claims (19)
- 血液透析または腹膜透析を受けた患者において透析後ウォッシュアウトを改善する方法であって、透析セッションの終了の約45分前から透析セッションの終了の約2時間後の期間内に、有効量の少なくとも1種の遊離アミノ酸および/またはそのヒドロキシルもしくはケト類似体を前記患者に経口投与することを含む、方法。
- 少なくとも2種の遊離アミノ酸および/またはそれらのヒドロキシもしくはケト類似体の群を投与することを含む、請求項1に記載の方法。
- 前記遊離アミノ酸の群が、ヒスチジン、アラニン、イソロイシン、アルギニン、ロイシン、アスパラギン、リジン、アスパラギン酸、メチオニン、システイン、フェニルアラニン、グルタミン酸、トレオニン、グルタミン、トリプトファン、グリシン、バリン、ピロリジン、プロリン、セレノシステイン、セリンおよびチロシンおよび/またはそれらのヒドロキシもしくはケト類似体のうち2種以上から選択される、請求項2に記載の方法。
- 前記遊離アミノ酸の群が、ヒスチジン、イソロイシン、ロイシン、リジン、メチオニン、フェニルアラニン、トレオニン、トリプトファンおよびバリンならびに/またはそれらのヒドロキシもしくはケト類似体のうち2種以上から選択される、請求項3に記載の方法。
- 前記遊離アミノ酸の群が、イソロイシン、ロイシンおよびバリンならびに/またはそれらのヒドロキシもしくはケト類似体のうち2種以上から選択される、請求項4に記載の方法。
- 前記透析セッションの約30分前から前記透析セッションの終了の約1時間後までの期間内に前記遊離アミノ酸を投与することを含む、請求項1に記載の方法。
- 前記透析セッションの終了の約20分前から前記透析セッションの終了の約30分後の期間内に、前記遊離アミノ酸を投与することを含む、請求項6に記載の方法。
- 前記透析セッションの終了の約10分前から前記透析セッションの終了の約10分後の期間内に、前記遊離アミノ酸を投与することを含む、請求項7に記載の方法。
- 前記遊離アミノ酸を複数回用量で投与することを含む、請求項1に記載の方法。
- 透析を受けた患者において透析後ウォッシュアウトを改善する方法であって、前記患者に、透析セッションの終了の約45分前から透析セッションの終了の約2時間後の期間内に、有効量の、遊離アミノ酸および/またはそのヒドロキシもしくはケト類似体の群を含む栄養補助食品を経口投与することを含む、方法。
- 前記遊離アミノ酸の群が、ヒスチジン、アラニン、イソロイシン、アルギニン、ロイシン、アスパラギン、リジン、アスパラギン酸、メチオニン、システイン、フェニルアラニン、グルタミン酸、トレオニン、グルタミン、トリプトファン、グリシン、バリン、ピロリジン、プロリン、セレノシステイン、セリンおよびチロシンならびにそれらの混合物ならびに/またはそれらのヒドロキシもしくはケト類似体から選択される少なくとも2種のアミノ酸を含む、請求項10に記載の方法。
- 前記遊離アミノ酸の群が、ヒスチジン、イソロイシン、ロイシン、リジン、メチオニン、フェニルアラニン、トレオニン、トリプトファンおよびバリンならびにそれらの混合物ならびに/またはそれらのヒドロキシもしくはケト類似体から選択される少なくとも2種のアミノ酸を含む、請求項11に記載の方法。
- 前記遊離アミノ酸の群が、イソロイシン、ロイシンおよびバリンならびにそれらの混合物ならびに/またはそれらのヒドロキシもしくはケト類似体から選択される少なくとも2種のアミノ酸を含む、請求項12に記載の方法。
- 前記透析セッションの終了の約10分前から前記透析セッションの終了の約2時間後の期間内に、前記栄養補助食品を投与することを含む、請求項10に記載の方法。
- 前記栄養補助食品が、甘味料をさらに含む、請求項10に記載の方法。
- 前記甘味料が、糖、非栄養性甘味料およびそれらの混合物からなる群から選択される、請求項15に記載の方法。
- 甘味料が、アスパルテーム、アセスルファム−K、シクラメート、サッカリン、スクラロース、スクロース、フルクトース、ガラクトース、マルトース、ラクトース、ブラゼイン、クルクリン、エリスリトール、グリセロール、グリチルリチン、加水分解水添デンプン、イヌリン、イソマルト、ラクチトール、マビンリン、マルチトール、マルトオリゴ糖、マンニトール、ミラクリン、羅漢果(S.grosvenorii)果実の抽出物、モナチン、モネリン、オスラジン、ペンタジン、ソルビトール、ステビアおよびその抽出物、タガトース、タウマチンおよびキシリトール、またはそれらの混合物からなる群から選択される、請求項16に記載の方法。
- 前記栄養補助食品が、少なくとも1種の非栄養性繊維、少なくとも1種のタンパク質、少なくとも1種の油、少なくとも1種のビタミン、少なくとも1種のペプチド、少なくとも1種の炭水化物、少なくとも1種の無機質、少なくとも1種の天然または人工フレーバーおよびそれらの混合物からなる群から選択される成分をさらに含む、請求項10に記載の方法。
- 透析を受けた患者において透析後ウォッシュアウトを改善する方法であって、前記患者に、透析セッションの終了の約45分前から透析セッションの終了の約2時間後の期間内に、
A)ヒスチジン、アラニン、イソロイシン、アルギニン、ロイシン、アスパラギン、リジン、アスパラギン酸、メチオニン、システイン、 フェニルアラニン、グルタミン酸、トレオニン、グルタミン、トリプトファン、グリシン、バリン、ピロリジン、プロリン、セレノシステイン、セリンおよびチロシンならびにそれらの混合物ならびに/またはそれらのヒドロキシもしくはケト類似体から選択される遊離アミノ酸の群と、
B)糖、非栄養性甘味料またはそれらの混合物からなる群から選択される少なくとも1種の甘味料と、
C)少なくとも1種の非栄養性繊維、少なくとも1種のタンパク質、少なくとも1種の油、少なくとも1種のビタミン、少なくとも1種のペプチド、少なくとも1種の炭水化物、少なくとも1種の無機質、少なくとも1種の天然または人工フレーバーおよびそれらの混合物からなる群から選択される少なくとも1種の成分と
を含む、有効量の栄養補助食品を経口投与することを含む、方法。
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US14/692,151 US20160309753A1 (en) | 2015-04-21 | 2015-04-21 | Methods of ameliorating post-dialysis washout and nutritional supplements for use in such methods |
US14/692,151 | 2015-04-21 | ||
PCT/US2016/028396 WO2016172180A2 (en) | 2015-04-21 | 2016-04-20 | Methods of ameliorating post-dialysis washout and nutritional supplements for use in such methods |
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JP2009515948A (ja) * | 2005-11-18 | 2009-04-16 | レノビズ・カンパニー・リミテッド | 有機粘土を含む腐食防止用コーティング剤組成物およびその製造方法 |
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US6713501B1 (en) | 1998-03-13 | 2004-03-30 | The Johns Hopkins University | Supplement for dialysis patients |
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JP2007197363A (ja) * | 2006-01-26 | 2007-08-09 | Beta Shokuhin Kk | 栄養補助剤 |
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