JP2018517151A5 - - Google Patents
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- Publication number
- JP2018517151A5 JP2018517151A5 JP2018511342A JP2018511342A JP2018517151A5 JP 2018517151 A5 JP2018517151 A5 JP 2018517151A5 JP 2018511342 A JP2018511342 A JP 2018511342A JP 2018511342 A JP2018511342 A JP 2018511342A JP 2018517151 A5 JP2018517151 A5 JP 2018517151A5
- Authority
- JP
- Japan
- Prior art keywords
- filamin
- acetylglucosamine
- sulfatase
- subject
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000013366 Filamin Human genes 0.000 claims 18
- 108060002900 Filamin Proteins 0.000 claims 18
- 108010023320 N-acetylglucosamine-6-sulfatase Proteins 0.000 claims 16
- 102000056067 N-acetylglucosamine-6-sulfatases Human genes 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 238000003556 assay Methods 0.000 claims 7
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 238000002965 ELISA Methods 0.000 claims 4
- 102100037850 Interferon gamma Human genes 0.000 claims 4
- 108010074328 Interferon-gamma Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 230000000890 antigenic effect Effects 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 230000001900 immune effect Effects 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000009257 reactivity Effects 0.000 claims 4
- 230000028327 secretion Effects 0.000 claims 4
- 230000006052 T cell proliferation Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 2
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010039343 HLA-DRB1 Chains Proteins 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 239000012228 culture supernatant Substances 0.000 claims 2
- 238000010166 immunofluorescence Methods 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 102000005262 Sulfatase Human genes 0.000 claims 1
- 230000004520 agglutination Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000003119 immunoblot Methods 0.000 claims 1
- 210000005087 mononuclear cell Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 108060007951 sulfatase Proteins 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562160320P | 2015-05-12 | 2015-05-12 | |
| US62/160,320 | 2015-05-12 | ||
| US201562162295P | 2015-05-15 | 2015-05-15 | |
| US62/162,295 | 2015-05-15 | ||
| PCT/US2016/032077 WO2016183310A1 (en) | 2015-05-12 | 2016-05-12 | Autoantigens for diagnosis of rheumatoid arthritis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018517151A JP2018517151A (ja) | 2018-06-28 |
| JP2018517151A5 true JP2018517151A5 (enExample) | 2019-06-13 |
| JP6663000B2 JP6663000B2 (ja) | 2020-03-11 |
Family
ID=57248470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511342A Active JP6663000B2 (ja) | 2015-05-12 | 2016-05-12 | 関節リウマチの診断のための自己抗原 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10429379B2 (enExample) |
| EP (1) | EP3294901B1 (enExample) |
| JP (1) | JP6663000B2 (enExample) |
| AU (1) | AU2016261939A1 (enExample) |
| CA (1) | CA2985637A1 (enExample) |
| WO (1) | WO2016183310A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10908159B2 (en) | 2016-06-07 | 2021-02-02 | The General Hospital Corporation | Identification of a T cell epitope of Prevotella copri that induces T cell responses in patients with Rheumatoid arthritis |
| US20180280503A1 (en) * | 2017-04-04 | 2018-10-04 | The Johns Hopkins University | Anti-pad2 antibody for treating and evaluating rheumatoid arthritis |
| US11774447B2 (en) * | 2017-07-06 | 2023-10-03 | University Of Tsukuba | Detection of citrullinated inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) |
| KR102839146B1 (ko) * | 2018-10-22 | 2025-07-29 | 에프. 호프만-라 로슈 아게 | 류마티스 관절염 자가항체 레퍼토리의 프로파일링 및 그의 펩타이드 분류자 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1105734B (it) * | 1977-07-14 | 1985-11-04 | Syva Co | Prova di legame di competizione di antienzima omogeneo |
| US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| US5248595A (en) | 1991-10-08 | 1993-09-28 | Eastman Kodak Company | Wash composition, test kit and method for determination of microorganisms associated with periodontal diseases |
| US5750356A (en) * | 1996-05-31 | 1998-05-12 | Anergen, Inc. | Method for monitoring T cell reactivity |
| WO2002048310A2 (en) | 2000-12-15 | 2002-06-20 | Genetics Institute, Llc | Methods and compositions for diagnosing and treating rheumatoid arthritis |
| AU2002362436A1 (en) | 2001-10-03 | 2003-04-14 | Rigel Pharmaceuticals, Inc. | Modulators of lymphocyte activation and migration |
| US8198401B2 (en) | 2003-03-07 | 2012-06-12 | London Health Sciences Centre Research Inc. | Peptides associated with HLA-DR MHC class II molecule and involved in rheumatoid arthritis |
| JP4711963B2 (ja) | 2003-09-15 | 2011-06-29 | オクラホマ メディカル リサーチ ファウンデーション | 炎症性疾患および自己免疫疾患を診断、治療および評価するためにサイトカインアッセイを用いる方法 |
| PT1882946E (pt) | 2003-12-23 | 2010-04-21 | Roche Diagnostics Gmbh | Método para avaliar artrite reumatóide através da medição de anti-ccp e interleucina 6 |
| CA2552420A1 (en) | 2004-02-27 | 2005-09-15 | F. Hoffmann-La Roche Ag | Method of assessing rheumatoid arthritis by measuring anti-ccp and serum amyloid a |
| WO2006008183A1 (en) | 2004-07-23 | 2006-01-26 | Novartis Ag | Biomarkers for rheumatoid arthritis (ra) |
| US20070148704A1 (en) | 2005-10-06 | 2007-06-28 | Ursula Klause | Anti-CCPand antinuclear antibodies in diagnosis of rheumatoid arthritis |
| MX2012002766A (es) * | 2009-09-03 | 2012-04-02 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| US20130302329A1 (en) | 2010-09-21 | 2013-11-14 | Trustees Of Boston University | Diagnostic tests for immune reactivity with human endothelial cell growth factor |
| AU2011372528C1 (en) * | 2011-07-01 | 2017-01-19 | Inova Diagnostics, Inc. | Method for increasing specificity of diagnostic tests for autoimmune diseases |
| KR20250076678A (ko) * | 2013-03-13 | 2025-05-29 | 코어 파마슈티칼스 디벨롭먼트 컴퍼니 인크. | 염증 치료용 면역-변형된 입자 |
| US10908159B2 (en) | 2016-06-07 | 2021-02-02 | The General Hospital Corporation | Identification of a T cell epitope of Prevotella copri that induces T cell responses in patients with Rheumatoid arthritis |
-
2016
- 2016-05-12 JP JP2018511342A patent/JP6663000B2/ja active Active
- 2016-05-12 WO PCT/US2016/032077 patent/WO2016183310A1/en not_active Ceased
- 2016-05-12 EP EP16793518.8A patent/EP3294901B1/en active Active
- 2016-05-12 CA CA2985637A patent/CA2985637A1/en not_active Abandoned
- 2016-05-12 AU AU2016261939A patent/AU2016261939A1/en not_active Abandoned
- 2016-05-12 US US15/571,734 patent/US10429379B2/en active Active
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