JP2018514562A - 小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 - Google Patents

小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 Download PDF

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JP2018514562A
JP2018514562A JP2017556837A JP2017556837A JP2018514562A JP 2018514562 A JP2018514562 A JP 2018514562A JP 2017556837 A JP2017556837 A JP 2017556837A JP 2017556837 A JP2017556837 A JP 2017556837A JP 2018514562 A JP2018514562 A JP 2018514562A
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ダーレン ジー ウッドサイド
ダーレン ジー ウッドサイド
ピーター ヴァンダースライス
ピーター ヴァンダースライス
ウペンドラ ケイ マラーティー
ウペンドラ ケイ マラーティー
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セヴン ヒルズ インタレスツ リミテッド ライアビリティ カンパニー
セヴン ヒルズ インタレスツ リミテッド ライアビリティ カンパニー
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JP2017556837A 2015-04-29 2016-04-28 小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 Pending JP2018514562A (ja)

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JP2021078488A JP7244570B2 (ja) 2015-04-29 2021-05-06 小分子インテグリン受容体-リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法

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US201562154554P 2015-04-29 2015-04-29
US62/154,554 2015-04-29
US15/140,711 US10342866B2 (en) 2015-04-29 2016-04-28 Compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants
US15/140,711 2016-04-28
PCT/US2016/029683 WO2016176400A2 (en) 2015-04-29 2016-04-28 Novel compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants

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JP2021078488A Active JP7244570B2 (ja) 2015-04-29 2021-05-06 小分子インテグリン受容体-リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法

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US (5) US10342866B2 (enExample)
JP (2) JP2018514562A (enExample)
KR (3) KR20240052078A (enExample)
CN (1) CN107820429B (enExample)
AU (1) AU2016254034B2 (enExample)
CA (1) CA2984316A1 (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021121602A (ja) * 2015-04-29 2021-08-26 セヴン ヒルズ インタレスツ リミテッド ライアビリティ カンパニー 小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法
JP2024531201A (ja) * 2021-08-10 2024-08-29 テキサス ハート インスティテュート アミノアリール-インテグリンアゴニスト化合物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11311619B2 (en) * 2016-04-28 2022-04-26 7 Hills Pharma Inc. and Texas Heart Institute Integrin activator vaccine compositions
JP7069032B2 (ja) * 2016-03-24 2022-05-17 ミレニアム ファーマシューティカルズ, インコーポレイテッド がん免疫治療における胃腸の免疫関連有害事象の治療方法
WO2018112364A1 (en) * 2016-12-16 2018-06-21 Evelo Biosciences, Inc. Combination therapies for treating melanoma
WO2018112360A1 (en) * 2016-12-16 2018-06-21 Evelo Biosciences, Inc. Combination therapies for treating cancer
WO2021034697A1 (en) * 2019-08-16 2021-02-25 The Regents Of The University Of California Combined cancer therapy involving chemical activation of integrins and targeted cell immunotherapy
US12109263B2 (en) * 2020-09-10 2024-10-08 7 Hills Pharma LLC Integrin agonists or activating compounds and methods for making and using same
CA3257474A1 (en) * 2022-05-03 2023-11-09 7 Hills Pharma Inc. NEW LIPID-BASED SMALL MOLECULES INTEGRN LIGAND-RECEPTOR AGONIST SUPPORT COMPOSITIONS, PHARMACEUTICAL INTEGRN AGONIST ADJUVANT COMPOSITIONS PREPARED FROM THESE, AND THEIR PROCESSES FOR MANUFACTURE AND USE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008501712A (ja) * 2004-06-04 2008-01-24 ジェネンテック・インコーポレーテッド 多発性硬化症を処置するための方法
JP2010530857A (ja) * 2007-06-22 2010-09-16 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 神経系障害、特に感染性海綿状脳症及びアルツハイマー病を治療するためのcd52抗原に対する抗体の使用
WO2012068251A2 (en) * 2010-11-16 2012-05-24 Texas Heart Institute Agonists that enhance binding of integrin-expressing cells to integrin receptors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4505227B2 (ja) * 2001-12-20 2010-07-21 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 1−アルキル−1−アゾニアビシクロ[2.2.2]オクタンカルバメート誘導体およびムスカリンレセプターアンタゴニストとしてのそれらの使用
CN101227885A (zh) * 2005-07-26 2008-07-23 株式会社资生堂 皱纹防止·改善剂
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
CA2760887A1 (en) * 2009-06-12 2010-12-16 Actelion Pharmaceuticals Ltd Oxazole and thiazole derivatives as alx receptor agonists
US9023876B2 (en) 2010-07-08 2015-05-05 Adhaere Pharmaceuticals, Inc. Compounds and methods for regulating integrins
AU2015217142B2 (en) 2014-02-12 2020-04-09 7 Hills Pharma LLC Compositions and methods to improve the homing and grafting of hematopoetic stem cells
CA2954175C (en) 2014-07-01 2023-07-25 Upendra K. Marathi Compositions and methods to improve adoptive cell therapies
KR20240052078A (ko) * 2015-04-29 2024-04-22 7 힐즈 인터레스츠 엘엘씨 소분자 인테그린 수용체-리간드 작용제 보강제를 포함하는 면역치료를 위한 새로운 조성물과 방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008501712A (ja) * 2004-06-04 2008-01-24 ジェネンテック・インコーポレーテッド 多発性硬化症を処置するための方法
JP2010530857A (ja) * 2007-06-22 2010-09-16 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 神経系障害、特に感染性海綿状脳症及びアルツハイマー病を治療するためのcd52抗原に対する抗体の使用
WO2012068251A2 (en) * 2010-11-16 2012-05-24 Texas Heart Institute Agonists that enhance binding of integrin-expressing cells to integrin receptors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021121602A (ja) * 2015-04-29 2021-08-26 セヴン ヒルズ インタレスツ リミテッド ライアビリティ カンパニー 小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法
JP7244570B2 (ja) 2015-04-29 2023-03-22 セヴン ヒルズ ファーマ リミテッド ライアビリティ カンパニー 小分子インテグリン受容体-リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法
JP2024531201A (ja) * 2021-08-10 2024-08-29 テキサス ハート インスティテュート アミノアリール-インテグリンアゴニスト化合物

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WO2016176400A2 (en) 2016-11-03
US20220001009A1 (en) 2022-01-06
US12201686B2 (en) 2025-01-21
US10716849B2 (en) 2020-07-21
WO2016176400A3 (en) 2016-12-08
KR20170136651A (ko) 2017-12-11
JP7244570B2 (ja) 2023-03-22
MX2024002456A (es) 2024-03-08
KR20240052078A (ko) 2024-04-22
KR20240052079A (ko) 2024-04-22
IL255297A0 (en) 2017-12-31
US10709780B2 (en) 2020-07-14
AU2016254034A1 (en) 2017-12-14
US20190343952A1 (en) 2019-11-14
US10709781B2 (en) 2020-07-14
CN107820429B (zh) 2022-08-16
IL255297B (en) 2021-10-31
AU2016254034B2 (en) 2021-11-04
MX2017013859A (es) 2018-07-06
JP2021121602A (ja) 2021-08-26
SG10201911607YA (en) 2020-01-30
CN107820429A8 (zh) 2018-06-01
US20160339098A1 (en) 2016-11-24
US20200054743A1 (en) 2020-02-20
US20190351052A1 (en) 2019-11-21
SG11201708846XA (en) 2017-11-29
CN107820429A (zh) 2018-03-20
CA2984316A1 (en) 2016-11-03
US10342866B2 (en) 2019-07-09

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