JP2018514562A - 小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 - Google Patents
小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 Download PDFInfo
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- JP2018514562A JP2018514562A JP2017556837A JP2017556837A JP2018514562A JP 2018514562 A JP2018514562 A JP 2018514562A JP 2017556837 A JP2017556837 A JP 2017556837A JP 2017556837 A JP2017556837 A JP 2017556837A JP 2018514562 A JP2018514562 A JP 2018514562A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/39—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by a specific adjuvant, e.g. cytokines or CpG
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021078488A JP7244570B2 (ja) | 2015-04-29 | 2021-05-06 | 小分子インテグリン受容体-リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562154554P | 2015-04-29 | 2015-04-29 | |
| US62/154,554 | 2015-04-29 | ||
| US15/140,711 US10342866B2 (en) | 2015-04-29 | 2016-04-28 | Compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants |
| US15/140,711 | 2016-04-28 | ||
| PCT/US2016/029683 WO2016176400A2 (en) | 2015-04-29 | 2016-04-28 | Novel compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021078488A Division JP7244570B2 (ja) | 2015-04-29 | 2021-05-06 | 小分子インテグリン受容体-リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018514562A true JP2018514562A (ja) | 2018-06-07 |
| JP2018514562A5 JP2018514562A5 (enExample) | 2019-06-06 |
Family
ID=57198770
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556837A Pending JP2018514562A (ja) | 2015-04-29 | 2016-04-28 | 小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 |
| JP2021078488A Active JP7244570B2 (ja) | 2015-04-29 | 2021-05-06 | 小分子インテグリン受容体-リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021078488A Active JP7244570B2 (ja) | 2015-04-29 | 2021-05-06 | 小分子インテグリン受容体-リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US10342866B2 (enExample) |
| JP (2) | JP2018514562A (enExample) |
| KR (3) | KR20240052078A (enExample) |
| CN (1) | CN107820429B (enExample) |
| AU (1) | AU2016254034B2 (enExample) |
| CA (1) | CA2984316A1 (enExample) |
| IL (1) | IL255297B (enExample) |
| MX (2) | MX2017013859A (enExample) |
| SG (2) | SG11201708846XA (enExample) |
| WO (1) | WO2016176400A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021121602A (ja) * | 2015-04-29 | 2021-08-26 | セヴン ヒルズ インタレスツ リミテッド ライアビリティ カンパニー | 小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 |
| JP2024531201A (ja) * | 2021-08-10 | 2024-08-29 | テキサス ハート インスティテュート | アミノアリール-インテグリンアゴニスト化合物 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11311619B2 (en) * | 2016-04-28 | 2022-04-26 | 7 Hills Pharma Inc. and Texas Heart Institute | Integrin activator vaccine compositions |
| JP7069032B2 (ja) * | 2016-03-24 | 2022-05-17 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | がん免疫治療における胃腸の免疫関連有害事象の治療方法 |
| WO2018112364A1 (en) * | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating melanoma |
| WO2018112360A1 (en) * | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating cancer |
| WO2021034697A1 (en) * | 2019-08-16 | 2021-02-25 | The Regents Of The University Of California | Combined cancer therapy involving chemical activation of integrins and targeted cell immunotherapy |
| US12109263B2 (en) * | 2020-09-10 | 2024-10-08 | 7 Hills Pharma LLC | Integrin agonists or activating compounds and methods for making and using same |
| CA3257474A1 (en) * | 2022-05-03 | 2023-11-09 | 7 Hills Pharma Inc. | NEW LIPID-BASED SMALL MOLECULES INTEGRN LIGAND-RECEPTOR AGONIST SUPPORT COMPOSITIONS, PHARMACEUTICAL INTEGRN AGONIST ADJUVANT COMPOSITIONS PREPARED FROM THESE, AND THEIR PROCESSES FOR MANUFACTURE AND USE |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501712A (ja) * | 2004-06-04 | 2008-01-24 | ジェネンテック・インコーポレーテッド | 多発性硬化症を処置するための方法 |
| JP2010530857A (ja) * | 2007-06-22 | 2010-09-16 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 神経系障害、特に感染性海綿状脳症及びアルツハイマー病を治療するためのcd52抗原に対する抗体の使用 |
| WO2012068251A2 (en) * | 2010-11-16 | 2012-05-24 | Texas Heart Institute | Agonists that enhance binding of integrin-expressing cells to integrin receptors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4505227B2 (ja) * | 2001-12-20 | 2010-07-21 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 1−アルキル−1−アゾニアビシクロ[2.2.2]オクタンカルバメート誘導体およびムスカリンレセプターアンタゴニストとしてのそれらの使用 |
| CN101227885A (zh) * | 2005-07-26 | 2008-07-23 | 株式会社资生堂 | 皱纹防止·改善剂 |
| WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| CA2760887A1 (en) * | 2009-06-12 | 2010-12-16 | Actelion Pharmaceuticals Ltd | Oxazole and thiazole derivatives as alx receptor agonists |
| US9023876B2 (en) | 2010-07-08 | 2015-05-05 | Adhaere Pharmaceuticals, Inc. | Compounds and methods for regulating integrins |
| AU2015217142B2 (en) | 2014-02-12 | 2020-04-09 | 7 Hills Pharma LLC | Compositions and methods to improve the homing and grafting of hematopoetic stem cells |
| CA2954175C (en) | 2014-07-01 | 2023-07-25 | Upendra K. Marathi | Compositions and methods to improve adoptive cell therapies |
| KR20240052078A (ko) * | 2015-04-29 | 2024-04-22 | 7 힐즈 인터레스츠 엘엘씨 | 소분자 인테그린 수용체-리간드 작용제 보강제를 포함하는 면역치료를 위한 새로운 조성물과 방법 |
-
2016
- 2016-04-28 KR KR1020247011631A patent/KR20240052078A/ko active Pending
- 2016-04-28 JP JP2017556837A patent/JP2018514562A/ja active Pending
- 2016-04-28 MX MX2017013859A patent/MX2017013859A/es unknown
- 2016-04-28 CA CA2984316A patent/CA2984316A1/en active Pending
- 2016-04-28 WO PCT/US2016/029683 patent/WO2016176400A2/en not_active Ceased
- 2016-04-28 KR KR1020247011632A patent/KR20240052079A/ko active Pending
- 2016-04-28 US US15/140,711 patent/US10342866B2/en active Active
- 2016-04-28 SG SG11201708846XA patent/SG11201708846XA/en unknown
- 2016-04-28 KR KR1020177034574A patent/KR20170136651A/ko not_active Ceased
- 2016-04-28 CN CN201680036891.3A patent/CN107820429B/zh active Active
- 2016-04-28 AU AU2016254034A patent/AU2016254034B2/en active Active
- 2016-04-28 SG SG10201911607YA patent/SG10201911607YA/en unknown
-
2017
- 2017-10-27 IL IL255297A patent/IL255297B/en unknown
- 2017-10-27 MX MX2024002456A patent/MX2024002456A/es unknown
-
2019
- 2019-04-25 US US16/394,270 patent/US10709780B2/en active Active
- 2019-04-25 US US16/394,277 patent/US10716849B2/en active Active
- 2019-07-19 US US16/516,907 patent/US10709781B2/en active Active
-
2021
- 2021-05-06 JP JP2021078488A patent/JP7244570B2/ja active Active
- 2021-06-29 US US17/362,512 patent/US12201686B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501712A (ja) * | 2004-06-04 | 2008-01-24 | ジェネンテック・インコーポレーテッド | 多発性硬化症を処置するための方法 |
| JP2010530857A (ja) * | 2007-06-22 | 2010-09-16 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 神経系障害、特に感染性海綿状脳症及びアルツハイマー病を治療するためのcd52抗原に対する抗体の使用 |
| WO2012068251A2 (en) * | 2010-11-16 | 2012-05-24 | Texas Heart Institute | Agonists that enhance binding of integrin-expressing cells to integrin receptors |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021121602A (ja) * | 2015-04-29 | 2021-08-26 | セヴン ヒルズ インタレスツ リミテッド ライアビリティ カンパニー | 小分子インテグリン受容体−リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 |
| JP7244570B2 (ja) | 2015-04-29 | 2023-03-22 | セヴン ヒルズ ファーマ リミテッド ライアビリティ カンパニー | 小分子インテグリン受容体-リガンドアゴニストアジュバントを含む免疫治療のための新規組成物及び方法 |
| JP2024531201A (ja) * | 2021-08-10 | 2024-08-29 | テキサス ハート インスティテュート | アミノアリール-インテグリンアゴニスト化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016176400A2 (en) | 2016-11-03 |
| US20220001009A1 (en) | 2022-01-06 |
| US12201686B2 (en) | 2025-01-21 |
| US10716849B2 (en) | 2020-07-21 |
| WO2016176400A3 (en) | 2016-12-08 |
| KR20170136651A (ko) | 2017-12-11 |
| JP7244570B2 (ja) | 2023-03-22 |
| MX2024002456A (es) | 2024-03-08 |
| KR20240052078A (ko) | 2024-04-22 |
| KR20240052079A (ko) | 2024-04-22 |
| IL255297A0 (en) | 2017-12-31 |
| US10709780B2 (en) | 2020-07-14 |
| AU2016254034A1 (en) | 2017-12-14 |
| US20190343952A1 (en) | 2019-11-14 |
| US10709781B2 (en) | 2020-07-14 |
| CN107820429B (zh) | 2022-08-16 |
| IL255297B (en) | 2021-10-31 |
| AU2016254034B2 (en) | 2021-11-04 |
| MX2017013859A (es) | 2018-07-06 |
| JP2021121602A (ja) | 2021-08-26 |
| SG10201911607YA (en) | 2020-01-30 |
| CN107820429A8 (zh) | 2018-06-01 |
| US20160339098A1 (en) | 2016-11-24 |
| US20200054743A1 (en) | 2020-02-20 |
| US20190351052A1 (en) | 2019-11-21 |
| SG11201708846XA (en) | 2017-11-29 |
| CN107820429A (zh) | 2018-03-20 |
| CA2984316A1 (en) | 2016-11-03 |
| US10342866B2 (en) | 2019-07-09 |
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