JP2018510911A - Keratin treatment - Google Patents

Abstract

The present disclosure relates generally to keratin treatments. More specifically, but not by way of limitation, the present disclosure relates to skin, nail, hair and eyelash treatments comprising keratin peptide / dendrimer compositions for improving nail condition. The keratin peptide can be keratin or hydrolyzed or partially hydrolyzed keratin. The keratin peptide and the dendrimer may associate by an interaction selected from the group consisting of van der Waals interaction, dipole-dipole interaction, covalent bond, ionic bond and hydrogen bond.

Description

(Field)
The present disclosure relates generally to keratin treatments. More particularly, but not by way of limitation, the present disclosure relates to skin, nail, hair and eyelash treatments comprising a keratin peptide / dendrimer composition for improving skin, nail, hair or eyelash conditions.

(background)
The information provided below is not recognized as prior art to the present invention, but is provided only to assist the reader in understanding.

  Keratin is a term used to describe various structural proteins found in some living animals, particularly mammals and humans. For example, keratin is present in the outer layer of the skin and is the main component of hair, including eyelashes, and nails, including fingernails and toenails. In non-human animals, keratin is the main component of horns, claws, hoofs, shells, wings and beaks.

  In humans, hair, nails and other keratin-containing structures in humans can become brittle or cracked and can be destroyed, resulting in loss of appeal. One way to reduce this loss of appeal is by covering the defect with, for example, nail polish. Alternatively, a temporary product such as a hair conditioner can be applied to hide or mask the condition. There are several available treatments to improve such conditions, such as the application of hydrolyzed keratin. However, such treatments are very temporary and are often removed during hand or hair washing, or even simply rinsing.

  There remains a need for keratin treatments that include effective and long lasting structures.

(Summary)
To meet this need, the present disclosure provides keratin repair compositions. The keratin repair composition of the present invention comprises a keratin peptide and a dendrimer. The weight ratio of keratin peptide to dendrimer may be from about 4: 1 to about 1:60. Keratin peptides can include partially hydrolyzed keratins. The dendrimer can include one or more functional groups that can associate, interact with, or react with one or more functional groups on the keratin peptide. For example, the one or more functional groups on the dendrimer can be selected from OH, NH ₂ , SH, CO ₂ H or others. Keratin peptides and dendrimers can associate by covalent, ionic or hydrogen bond formation, or through other intermolecular interactions such as van der Waals forces, dipole-dipole interactions. In some embodiments, the keratin peptide remains at least partially exposed for interaction or reaction with the keratinous substrate keratin, and the dendrimer functionality extends in one direction from the keratin peptide component. ing. Exemplary schematics representing keratin peptide / dendrimer compositions and dendrimers are shown in FIGS. 1 and 2, respectively. The dendrimer used in the keratin repair composition of the present invention may comprise at least one hydrophobic group. Hydrophobic group may comprise, for example, one or more C ₆ -C ₂₀ straight or branched hydrocarbon chain optionally substituted with a functional group.

  The keratin repair composition according to the present invention may further comprise a solvent. Additional components in the keratin repair composition may include one or more of a film-forming polymer, a reactive (meth) acrylate, an epoxidized esterified vegetable oil, a polyhedral oligomeric silsesquioxane, and a colorant. The film-forming polymer may be, for example, cellulose ester, nitrocellulose or cellulose acetate alkylate.

  The present invention includes a method for improving the state of a keratinous substrate by applying the keratin repair composition of the present invention to the keratinous substrate. Keratinous substrates can be skin, nails and hair. The improved condition can be nail detachment, brittleness, cracking, chipping, splitting, drying and touch.

  The keratin repair composition of the present invention can be made by combining a keratin peptide and a dendrimer. Combining can include chemically reacting by forming covalent, ionic or hydrogen bonds. Combining can also include a mixture of keratin peptides and dendrimers. The bond between the keratin peptide and the dendrimer can be formed by the association of the reactive functional groups of the keratin peptide and the dendrimer.

  Further objects and advantages, as well as the structure and function of the preferred embodiments, will be apparent from consideration of the description, drawings, and examples.

  The foregoing and other features and advantages of the invention will become apparent from the following more detailed description of embodiments of the invention, as illustrated in the accompanying drawings.

FIG. 1 is a schematic structure of a keratin peptide / dendrimer composition useful in a composition according to the present invention.

FIG. 2 is a schematic diagram of a dendrimer unit useful in preparing the composition of the present invention.

(Description)
Embodiments of the present invention are discussed in detail below. In describing embodiments, specific terminology is used for the sake of clarity. However, it is not intended that the present invention be limited to the specific terminology so selected. Although specific exemplary embodiments are discussed, it should be understood that this is done for illustrative purposes only. Those skilled in the art will recognize that other components and configurations can be used without departing from the spirit and scope of the present invention. Although several embodiments and features are described herein, the various features and embodiments of the present invention are described separately, unless they are mutually exclusive or contrary to the specific description. It should be understood that they may be combined even if All references cited herein are incorporated by reference as if each was individually incorporated.

  Hydrolyzed keratin has been used as a cosmetic treatment for keratinous materials such as skin. One of the disadvantages of using hydrolyzed keratin is its water solubility. Hydrolyzed keratin can interact with keratin, for example in the skin, hair or nails, but it remains a water-soluble compound that can be removed and rinsed off by water or other aqueous systems. The same drawbacks may be observed with the use of other keratin-derived materials. The present invention contrasts with treatment and restoration compositions that overcome this and other shortcomings associated with the use of existing hydrolyzed keratin treatments.

  The present invention provides a treatment composition or formulation, a method of making the treatment composition or formulation, and a method of using the treatment composition or formulation. The terms “treatment”, “repair treatment”, “keratin treatment”, “repair keratin treatment” and the like are used interchangeably throughout this specification. These terms are compositions applied to keratinous substrates to prevent, treat or ameliorate keratin materials or keratinous substrates delamination, drying, brittleness, cracking, chipping, splitting and other natural degradation And refers to a blend. Compositions and formulations can also be applied to keratinous substrates to improve or enhance appearance, attractiveness or feel.

  The treatment composition according to the present invention comprises a combination of keratin peptides and dendrimers. Keratin peptides and dendrimers can be combined to form a keratin peptide / dendrimer composition in which the keratin peptides and dendrimers are associated, as described further below. For example, a keratin peptide / dendrimer composition can include a keratin peptide with a dendrimer unit attached to it.

  Keratin peptide. As used in this disclosure, the term keratin peptide refers to keratin, a peptide derived from keratin, a peptide that is structurally similar to or structurally similar to keratin. For example, a keratin peptide can refer to a peptide having a high cystine content. An exemplary keratin peptide is hydrolyzed keratin. In certain embodiments, at least a portion of the cystine present in the keratin peptide is in the S-sulfonated form. A non-limiting, suitable keratin peptide is commercially available as ProSina ™ (Keratec Ltd., Canterbury, NZ), which is a wool that leaves the natural cystine content of keratin in the active S-sulfo form. Is described as a purified protein fraction isolated from

  According to certain embodiments, the present invention relates to keratinous substrates to prevent or repair exfoliation, drying, brittleness, fracture or cracking, bumps, splitting and touching, or other degradation or defects in keratinous substrates. Compositions having dendrimers and keratin peptides for binding or coating it are provided. As used herein, a keratinous substrate is a material that contains or consists of keratin. Examples of keratinous substrates include, for example, skin, hair (including eyelashes), and nails (including toenails and fingernails). According to certain embodiments, the keratin peptide comprises a plurality of cystine units present in S-sulfonated form. According to a further aspect, the keratin peptide comprises partially hydrolyzed keratin. Exemplary keratin peptides can be extracted from keratinous substrates. For example, a suitable keratin peptide is keratin extracted from wool and sold under the trademark ProSina ™.

  Without being bound by theory, it is believed that the keratin peptides used in the treatment composition of the present invention interact with keratin in the keratinous substrate upon application of the treatment composition. This interaction may be, for example, by the formation of a bond between keratin in the keratinous substrate and the keratin peptide in the treatment composition, or by physically coating the keratinous substrate. As used herein, the term “binding” is broadly construed to include intermolecular interactions that cause an association between keratin in a keratinous substrate and keratin peptides in a treatment composition. I want. For example, as used herein, the term bond includes van der Waals interactions, as well as covalent, ionic and hydrogen bonds. The interaction between the keratin substrate and the keratin peptide may further provide cross-linking or other reinforcement of the keratinous substrate to provide physical and structural support and reinforcement. Alternatively, the compositions of the present invention can provide a physical coating of a keratin peptide / dendrimer composition on a keratinous substrate.

  Dendrimer. Dendrimers are molecules that are repeatedly branched. Typically, dendrimers associate symmetrically around the core and can assume a three-dimensional structure. Dendrimers can be prepared from individual dendrimer units, where the first dendrimer unit is attached to the core or base molecule, and two (or more) second dendrimer units are the first dendrimer units. Adhere to. This process is repeated to add two dendrimer units to each of the second dendrimer units until the desired size and branching of the overall structure is achieved.

In some embodiments, the dendrimer component may contain a hydrophobic group. Such a structure is shown schematically in FIG. 2 and comprises a hydrophobic group 3 on the dendrimer unit. The groups Y ₁ , Y ₂ and Y ₃ interact, associate or react with complementary functional groups on the keratin peptide, additional dendrimer units to increase branching, or additional hydrophobic groups Is a functional group used to For example, Y ₁ , Y ₂ and Y ₃ can independently be OH, NH ₂ , SH or COOH and others. When a hydrophobic group R ′ is present, Y ₁ , Y ₂ and Y ₃ are independently, for example, OH, NH ₂ , SH, COOH, OR ′, NHR ′, SR′H, COOR ′ or NR ′. Can be ₂ . The hydrophobic group R ′ is, for example, a linear or molecular group that can have additional functional groups present, for example, unless the additional functional groups adversely affect the hydrophobic nature of the hydrophobic portion of the dendrimer unit. Edakusarijo _C 6 _-C may comprise ₂₀ carbon chain. In the schematic of FIG. 2, two hydrophobic groups 3 are illustrated. However, a dendrimer, or an individual dendrimer within a mixture of dendrimers, may not have a hydrophobic group, has one hydrophobic group, two hydrophobic groups, or three or more hydrophobic groups. May be. Furthermore, the bond vertex illustrated in FIG. 2 is not intended to be limited to C, but may be N, S, O, or any other suitable atom. The dendrimer unit may also contain other functional groups such as carboxyl groups.

Suitable dendrimers can be prepared via modification of existing dendrimer units by incorporating hydrophobic units to provide a hydrophobic moiety to the molecule. Alternatively, after combining the dendrimer and keratin peptide, the hydrophobic moiety can be attached to the dendrimer portion of the keratin peptide / dendrimer composition. The hydrophobic part is, for example, linear or branched, which can have, for example, additional functional groups present unless the additional functional groups adversely affect the hydrophobic nature of the hydrophobic part of the dendrimer unit. It may comprise a chain C ₆ -C ₂₀ carbon chain. As can be appreciated by those skilled in the art, the structure includes some smaller and less hydrophobic groups to provide overall hydrophobicity to the hydrophobic portion and / or part of the dendrimer or as a whole dendrimer. It can be mounted on one or more dendrimer units. In some embodiments, the carbon chain is derived from a fatty acid and can be attached to the dendrimer through the formation of an ester or amide bond. In other embodiments, a suitably functionalized dendrimer unit can be reacted with a 1-alkene in an addition reaction. In yet another embodiment, the 1-alkene is epoxidized and reacted via a ring-opening reaction with a suitably functionalized dendrimer unit to provide a 2-hydroxy substituent on the hydrophobic portion of the dendrimer unit. Can do. It can be appreciated that one, two, three, four or more hydrophobic groups may be incorporated into the dendrimer when performing such reactions or others. One skilled in the art can recognize many other coupling reactions that can be used to incorporate hydrophobic groups into dendrimer units or preformed keratin peptide / dendrimer compositions.

In an exemplary embodiment, the dendrimer unit can have the structure shown in Formula I, wherein R can be a functional group such as OH, NH ₂ , SH, or COOH. Exemplary dendrimers have the structure shown in Formula I, wherein R = NH ₂ , Dendrichtech, Inc. Polyamide amine (PAMAM) dendrimer available from (Midland, MI, USA).

  Suitable hydrophobic dendrimers can be prepared by reacting an “arm” of a dendrimer unit with one or more hydrophobic units. For example, if the dendrimer unit contains a reactive hydroxyl group or amino group at the end of one or more “arms”, the modification will modify one of the pendent hydroxyl groups or one of the amino group hydrogens to a suitable one. This is accomplished by replacing the hydrophobic unit and providing the hydrophobic part to the dendrimer unit. An exemplary structure resulting from such a modification prepared from a hydroxyl group is shown as Formula II.

In an exemplary embodiment, the hydrophobic dendrimer is reacted with a dendrimer unit, eg, a molecule as shown in Formula I, for example by reaction with a hydrophobic precursor epoxide to form a structure as shown in Formula II below: Prepared. The reaction product can comprise a mixture of compounds, including unreacted dendrimer units and dendrimer units to which 1, 2 or 3 hydrophobic units are attached. For the purposes of the present invention, it is preferred to use this reaction product mixture as a dendrimer component. In certain embodiments, the reaction product contains about 50 mol% or less unreacted dendrimer units, about 25% or less dendrimers containing one hydrophobic unit, and two hydrophobic units. About 25% or less dendrimer and about 10 mol% or less dendrimer containing 3 hydrophobic units. The product may contain an approximately equimolar amount of a dendrimer containing one hydrophobic unit and a dendrimer containing two hydrophobic units. As can be appreciated by those skilled in the art, the ratios and amounts of the various components in the reaction product can be controlled by adjusting the molar ratio of dendrimer units to hydrophobic precursor, as well as the reaction conditions. In addition, by controlling the reaction conditions, it may be possible to prepare dendrimers with two different hydrophobic groups that can lead to more complex mixtures.

式ＩＩ、ＩＩＩおよびＩＶのいずれにおいても、Ｒは、追加の疎水性ユニットと反応していてもいなくてもよい官能基であってよい。例えば、Ｒは、ＯＨ、ＮＨ_２、ＳＨ、ＣＯＯＨ、ＯＲ’、ＮＨＲ’、ＳＲ’Ｈ、ＣＯＯＲ’またはＮＲ’_２であってよく、ここで、Ｒ’は、疎水性ユニットである。疎水性基Ｒ’は、例えば、存在する追加の官能基を有し得る、直鎖状または分枝鎖状Ｃ_６〜Ｃ_２０炭素鎖を含むことができる。 In other embodiments, the dendrimer unit may comprise a reactive amino group at the end of one or more “arms”, and the dendrimer unit is reacted with one or more hydrophobic chains at the amino terminus, It may be modified by forming secondary or tertiary amine hydrophobic dendrimers. As a result, suitable dendrimers may be unreacted dendrimers, secondary amine-containing hydrophobic dendrimers or a mixture of tertiary amine-containing hydrophobic dendrimers. Exemplary structures of secondary amine-containing branched hydrophobic dendrimers and tertiary amine-containing hydrophobic dendrimers are shown as Formulas III and IV, respectively.

In any of formulas II, III and IV, R may be a functional group that may or may not react with an additional hydrophobic unit. For example, R can be OH, NH ₂ , SH, COOH, OR ′, NHR ′, SR′H, COOR ′ or NR ′ ₂ where R ′ is a hydrophobic unit. The hydrophobic group R ′ can include, for example, a linear or branched C ₆ -C ₂₀ carbon chain that can have additional functional groups present.

  Composition. The composition of the present invention is formed by mixing a keratin peptide with a dendrimer. The resulting keratin peptide / dendrimer composition can exist in various forms and combinations of forms. For example, when mixing keratin peptides and dendrimers, the functional groups of the two components may interact with each other. This interaction may be, for example, a chemical bond or other association of functional groups. Chemical bonds may include covalent bonds, ionic bonds, and hydrogen bonds. The association of keratin peptides and dendrimers can be via van der Waals interactions, dipole-dipole interactions or other intermolecular interactions. Further, the dendrimer can interact with one or more of the keratin peptide units, resulting in a keratin peptide / dendrimer composition with a mixture of keratin peptide / dendrimer complexes as described below.

The dendrimer may comprise a functional group that can react or associate with a complementary functional group on the keratin peptide. A “complementary functional group” is a moiety that can react or associate with a functional group on another molecule. Examples of functional groups capable of association and complementary functional groups are, for example, carboxylic acids and alcohols (to form esters), carboxylic acids and amines (to form amides), secondary amines to form Amino groups (NH ₂ ) and leaving groups (for example, tosylate, halide, mesylate, etc.), hydroxyl groups and leaving groups (for example, tosylate, halide, mesylate, etc.) to form ethers, and the like. Functional groups and complementary functional groups can also be polar groups (eg, OH, SH, etc.) or ionizable groups (eg, NH ₂ , COOH, etc.). In such embodiments, association can occur by formation of ionic bonds, hydrogen bonds, and the like. One skilled in the art can recognize that there are numerous functional / complementary functional group combinations that can be used to couple dendrimers with keratin peptides.

In some embodiments, the dendrimer interacts with the keratin peptide in such a way that the keratin peptide component remains at least partially exposed for interaction or reacts with the keratinous substrate keratin. A keratin peptide / dendrimer composition is schematically illustrated in FIG. 1, which comprises a keratin peptide component 1 [where X is a functional group on the keratin peptide component] and a dendrimer part 2 [where A and B represent sites available for interaction with additional keratin peptide molecules or for additional functionalization with hydrophobic groups]. For example, A and B may independently be OH, NH ₂ , SH, COOH, OR ′, NHR ′, SR′H, COOR ′ or NR ′ ₂ where R ′ is as defined above. That's right. Functional groups such as X on keratin peptide component 1 remain available to bind to, associate with, coat with, adhere to or attach to keratin in keratinous substrates. The broken line in FIG. 1 is intended to represent the interaction between the dendrimer part 2 and the keratin peptide 1. This interaction may be, for example, via van der Waals interactions, dipole-dipole interactions, hydrogen bonds, ionic bonds or covalent bonds.

  In some embodiments, the preformed dendrimer may have a reactive functional group that can be coupled with a keratin peptide. Coupling can occur through a reactive functional group on the dendrimer and a complementary functional group on the keratin peptide. The coupling of the keratin peptide and the dendrimer may be through a mixture of the two, where one or more of the functional groups on the dendrimer are through an interaction such as van der Waals interaction or hydrogen bonding. Can be associated with keratin peptides. Alternatively, preformed dendrimers can be reacted to include or include groups that interact and couple with groups on the keratin peptide by forming a covalent bond. For example, oppositely charged groups on dendrimers and keratin peptides can form ionic bonds. Either of these schemes will similarly create the structure shown schematically in FIG.

  In other embodiments, one or more keratin peptides may interact with the dendrimer without forming a chemical bond. Accordingly, the keratin repair composition comprises an unreacted keratin peptide, an unreacted dendrimer, a single keratin peptide / dendrimer complex, a secondary keratin peptide / dendrimer complex and / or a tertiary keratin peptide / dendrimer complex. May be included. As used herein, the term “complex” should be taken to mean keratin peptides and dendrimers that are coupled or associated to form a unit. For example, FIG. 1 is an example of a single keratin peptide / dendrimer complex. A secondary keratin peptide / dendrimer complex may be present when one dendrimer interacts with two keratin peptides or when two dendrimers interact with one keratin peptide. A tertiary keratin peptide / dendrimer complex may be present when the dendrimer interacts with three keratin peptides or when three dendrimers interact with one keratin peptide.

  A keratin peptide / dendrimer composition comprising a dendrimer component and a keratin peptide component offers several advantages as a treatment composition. For example, a keratin peptide component is realized using the first application of hydrolyzed keratin, reacting with keratin in a keratinous substrate, for example via a functional group such as X as shown in FIG. Remain available to provide similar enhancement of keratinous substrates. However, unlike the use of hydrolyzed keratin alone, in an exemplary embodiment of the invention, the keratin peptide / dendrimer composition also includes a dendrimer with a hydrophobic region. The keratin peptide component interacts with or binds to the nail keratin, while the dendrimer moiety is exposed to the environment. This can occur regardless of whether the keratin peptides and dendrimers are mixed, associated, bound, or chemically bound. When this environment includes water, the dendrimer portion essentially forms a “shield” that prevents water from penetrating the keratin peptide component. Thus, keratin peptide components are prevented from solubilizing by water and the treatment composition remains intact for extended periods of time until additional treatment is required. In exemplary embodiments, the nail treatment remains intact for 2 days or more, 3 days or more, 4 days or more, 5 days or more, or 1 week or more. When used as a nail treatment, the composition remains intact regardless of whether there is any additional coating placed on the nail from above the nail treatment.

  The keratin peptide / dendrimer may be present in the formulation from about 0.01 to about 15% by weight. For example, the keratin peptide / dendrimer may be present in the formulation from about 0.1 to about 10% by weight, or from about 0.1 to about 5% by weight. Keratin peptides and dendrimers may be present in a weight ratio of about 4: 1 to about 1:60, based on the weight of solvent-free keratin and dendrimer. For example, keratin peptides and dendrimers may be present in a weight ratio of about 2: 1, about 1: 1, about 1:10, about 1:26, about 1:45, or about 1:52. In certain embodiments, the keratin peptide and dendrimer are about 2: 1 or more, about 1: 1 or more, about 1:10 or more, about 1:26 or more, about 1:45 or more. Or in a weight ratio of about 1:52 or greater. In certain embodiments, the keratin peptide and dendrimer are about 2: 1 or less, about 1: 1 or less, about 1:10 or less, about 1:26 or less, about 1:45 or less. Or a weight ratio of about 1:52 or less.

  In some embodiments, the amount of keratin peptide can range from about 0.0002-12% by weight, about 0.008-12% by weight. About 0.001 to 1.5 weight percent, or about 0.002 to 0.25 weight percent. For example, the keratin peptide may be present in the formulation in an amount greater than about 0.0002 wt%, greater than about 0.002 wt%, greater than about 0.001 wt%, or greater than about 0.01 wt%. . In certain embodiments, the keratin peptide is less than about 12%, less than about 10%, less than about 7.5%, less than about 4%, less than about 2.5%, less than about 1% by weight in the formulation. It may be present in an amount less than wt%, less than about 0.5 wt%, or less than about 0.25 wt%.

  In some embodiments, the amount of dendrimer can range from about 0.0002 to 14.75% by weight, about 0.002 to 3% by weight. About 0.01 to 13.5 wt%, or about 0.01 to 14.75 wt%. For example, the dendrimer may be present in the formulation in an amount greater than about 0.002 wt%, greater than about 0.02 wt%, or greater than about 0.01 wt%. In certain embodiments, the dendrimer is less than about 14.75 wt%, less than about 10 wt%, less than about 7.5 wt%, less than about 4 wt%, less than about 2.5 wt% in the formulation, or It may be present in an amount less than about 1% by weight.

  The system of the present invention allows the use of keratin peptides in oil-based carriers to penetrate the nail, condition it and plasticize it. At the same time, the keratin peptide / dendrimer composition binds to and seals with the keratin substrate, providing protection against common solvents such as acetone and water that are detrimental to the structure of the keratin substrate and improving resistance. This reduces the severity of existing imperfections by providing additional binding and protection, and their imperfections by stopping the propagation of cracks and weak points between cells in the keratin matrix. Reduces recovery time from sex.

  The treatment composition of the present invention may further comprise one or more solvents. The solvent may be present in an amount up to about 99% of the composition, for example about 90% of the composition. Typically, but not necessarily, the solvent is a non-polar or lipophilic solvent including, but not limited to, ketones, alkyl acetates, alcohols, alkanes, alkenes, vegetable or nut oils and mixtures thereof. Specific non-limiting examples of solvents include acetone, ethyl acetate, butyl acetate, isopropyl alcohol, ethanol, methyl ethyl ketone, toluene, hexane, tonsil oil, jojoba oil, rice bran oil, vitamin E acetate and mixtures thereof. The solvent used will depend in part on the use of the composition and can be readily determined by one skilled in the art.

  The treatment composition of the present invention is applied to a keratinous surface and provides additional adhesion when cured, such as an epoxy resin substantially composed of an ester fraction of an epoxidized esterified vegetable oil, or a derivative thereof. Can be included. In such components, the ester fraction includes one or more epoxidized fatty acid esters, or derivatives thereof. Each of the one or more fatty acid esters is not a mono-, di- or triglyceride. The fatty acid ester or derivative thereof can be an alkyl ester such as a methyl ester. The resin may comprise an ester fraction of one or more additional epoxidized esterified vegetable oils, or a derivative thereof.

  The treatment composition of the present invention may also include at least one polyhedral oligomeric silsesquioxane (POSS). Polyhedral oligomeric silsesquioxanes, as well as other components that can be used in the compositions of the present invention, are described in US Patent Application Publication No. 2014/0053859 A1, which is incorporated herein by reference in its entirety. .

  how to use. The treatment compositions and formulations according to the invention can be used in various products, in particular cosmetic products. The composition can be rubbed, poured, sprinkled or sprayed, introduced, or otherwise applied to cleanse, beautify, promote attractiveness or change appearance. The treatment compositions and formulations of the present invention are particularly suitable for application to keratinous substrates such as skin, hair and nails. Compositions containing keratin peptides and dendrimers or keratin peptides / dendrimers of the present invention include, for example, moisturizers, perfumes, lipsticks, eye and face makeup preparations, cleansing shampoos, hair conditioners, permanent waves, hair colors, nails It can be incorporated into coatings, nail treatments and other cosmetic products or ingredients of cosmetic products. Accordingly, the treatment composition according to the present invention comprises additional ingredients that are satisfactory for use in these and other cosmetic compositions and products, unless the additional ingredients adversely affect the benefits of the present invention. Can do.

  According to one aspect, the disclosed compositions and formulations are for preventing, treating or ameliorating peeling, drying, brittleness, cracking, chipping, splitting, touching or other degradation of nail material. A nail treatment or nail repair composition for fingernails or toenails. According to certain embodiments, the disclosed compositions and formulations are exposed to treat nail material to prevent nail brittleness, delamination, drying, cracking, chipping, touch or other defects. Applies to fingernails or toenails. According to certain embodiments, the disclosed compositions and formulations can be used to expose exposed fingers to improve the appearance of the nail by bonding structures together thereby removing imperfections in the nail. Applies to nails or toenails. According to certain aspects, the disclosed compositions and formulations are applied periodically from multiple times per day to once a week in a program for minimizing nail crushing or other damage. It's okay.

  The nail treatment composition of the present invention can also serve as a decorative coating by incorporation into a nail enamel, varnish or artificial nail system. For example, in some embodiments, the nail treatment composition may include a film-forming polymer such as a cellulose ester. Non-limiting examples of cellulose esters include nitrocellulose and cellulose acetate alkylates such as cellulose acetate propionate and cellulose acetate butyrate. In some embodiments, the nail treatment composition may also include a reactive (meth) acrylate that can be cured to form an acrylic coating. As known in the art, the term (meth) acrylate encompasses acrylates and / or methacrylates including reactive monomers and / or oligomers and / or polymers. In some embodiments, the (meth) acrylate is acrylic acid; methacrylic acid; alkyl acrylates and methacrylates such as methyl methacrylate, ethyl methacrylate, propyl methacrylate, methyl acrylate, ethyl acrylate, propyl acrylate; hydroxypropyl methacrylate (HPMA); Hydroxyethyl methacrylate (can also serve as HEMA, solvent or co-solvent); THFMA; pyromellitic dianhydride di (meth) acrylate; pyromellitic dianhydride glyceryl dimethacrylate; pyromellitic dimethacrylate; methacryloyloxyethyl Maleate; 2-hydroxyethyl methacrylate / succinate; 1,3-glycerol dimethacrylate / succinate adduct; monophthalate Chill methacrylate; acetoacetoxyethyl methacrylate (AAEMA); and may be selected from the group consisting of mixtures thereof. The nail treatment composition may include other ingredients used in nail coatings as is known in the art.

  The nail treatment composition of the present invention may further contain a colorant. The colorant can be, for example, a pigment or a dye. In some embodiments, the composition may include up to 10 wt% pigments and / or dyes.

  The disclosed composition may be applied to the nail using a medicinal dropper or brush. The composition may be rubbed against the surface of the nail or left to penetrate or coat without mechanical assistance.

  According to certain embodiments, the disclosed compositions and formulations are used on hair to prevent, treat or improve dryness, brittleness, breakage or cracking, or to improve hair feel or appearance. Hair treatment or restorative composition. According to certain embodiments, the disclosed compositions and formulations are applied to the hair to prevent dryness, brittleness, breakage or cracking, or to improve the feel or appearance of the hair. Compositions and formulations for application to the hair include, but are not limited to, shampoos, conditioners, permanent waves, hair colors, hair sprays and hair treatments. The compositions and formulations of the present invention can be applied to the hair, for example, by pouring, rubbing, spraying or brushing on the hair. The hair treatment or restorative compositions and formulations of the present invention contain other ingredients used in hair products, including, for example, colorants, fragrances, surfactants, emollients, emulsifiers, solvents, propellants and the like. Can be included. Those skilled in the art know suitable ingredients that are necessary or useful for a particular application.

  According to certain embodiments, the disclosed compositions and formulations are for use on the skin to prevent, treat or improve dryness or cracking, or to improve skin feel or appearance. A skin treatment or repair composition. According to certain embodiments, the disclosed compositions and formulations are applied to the skin to prevent dryness or cracking or to improve skin feel or appearance. Compositions and formulations for application to the skin include, but are not limited to, humectants, perfumes, lipsticks, eye and face makeup preparations, sprays and skin treatments. The compositions and formulations of the present invention can be applied to the skin, for example, by pouring, rubbing, sprinkling, spraying or brushing onto the skin. The skin treatment or restoration compositions and formulations of the present invention contain other ingredients used in dermatological products, including, for example, colorants, fragrances, surfactants, emollients, emulsifiers, solvents, propellants and the like. Can be included. Those skilled in the art know suitable ingredients that are necessary or useful for a particular application.

The embodiments of the present invention have been demonstrated by the following examples, which are only empirical and are not intended to limit the present invention.
Example 1

（実施例２） Described below is an exemplary range of ingredients that may be included in a keratin treatment according to the present invention. Keratin treatments may be incorporated into a wide range of products, including curable nail treatments, enamels, nail treatments such as artificial nails, such as base coats, top coats and color treatments. Keratin treatments may be incorporated into hair products such as conditioners, moisturizers, shampoos, gels, mousses and the like. Keratin treatments may be incorporated into topical treatments such as lotions, moisturizers, skin creams and treatments, makeup, lipsticks and the like. Based on the present disclosure and the exemplary ingredients listed below, one of ordinary skill in the art will recognize the amounts applicable for use and the particular use.

(Example 2)

  Hydrophobic dendrimers were prepared from polyamidoamine (PAMAM) and epoxidized hydrophobic precursor in isopropanol. The reaction products were analyzed using high performance liquid chromatography (HPLC) and matrix assisted laser desorption / ionization-time of flight mass spectrometry (MALDI-TOF). MALDI-TOF data reflects the typical distribution that occurs during hydrophobic material reactions using epoxide chemistry. The presence of the parent mass peak and the Na + and K + adducts commonly seen by this technique is reflected as a “triple” peak. It is important to note that due to the nonlinear detection inherent in this technique, the relative heights of the various species do not necessarily reflect the actual amount present in the sample.

  In HPLC it is assumed that the components elute in order of hydrophobicity, and comparison with MALDI-TOF allows for the general assignment of the main components related to their hydrophobic substance content. The earliest eluting peak is suspected to be the unreacted component and the subsequent major peaks are assumed to be mono, di and triepoxidized adducts. The MALDI-TOF results do not appear clearly in the HPLC method and indicate the presence of more highly epoxidized species that are expected to be trace components in any case.

Assuming the above assumption is correct, it is possible to estimate the relative amounts of different species present based on the further assumption that the HPLC peak area represents the molar area. These estimates are shown below.

The embodiments illustrated and discussed herein are intended only to teach those skilled in the art the best technique known to the inventors for making and using the invention. Nothing in this specification should be considered as limiting the scope of the present invention. All examples presented are representative and non-limiting. The above-described embodiments of the present invention can be modified or changed without departing from the invention, as will be apparent to those skilled in the art in light of the above teachings. It is therefore to be understood that within the scope of the appended claims and their equivalents, the invention may be practiced otherwise than as specifically described.

Claims (20)

Keratin peptides and
A keratin repair composition comprising a dendrimer.   The keratin repair composition of claim 1, wherein the weight ratio of keratin peptide to dendrimer is from about 4: 1 to about 1:60.   The keratin repair composition of claim 1, wherein the keratin peptide comprises partially hydrolyzed keratin.   The keratin repair composition of claim 1 comprising a mixture of the keratin peptide and the dendrimer.   The keratin repair composition of claim 1, wherein the keratin peptide and the dendrimer are associated.   6. The keratin peptide and the dendrimer are associated by an interaction selected from the group consisting of van der Waals interaction, dipole-dipole interaction, covalent bond, ionic bond and hydrogen bond. Keratin repair composition.   The keratin repair composition of claim 1, wherein the dendrimer comprises a functional group that interacts and reacts with the keratin peptide. The keratin repair composition of claim 1, wherein the dendrimer comprises a functional group selected from the group consisting of OH, NH ₂ , SH, and COOH.   The keratin peptide remains at least partially exposed for interaction or reaction with a keratinous substrate keratin, and the functional group of the dendrimer extends in one direction from a component of the keratin peptide, The keratin repair composition according to claim 1.   The keratin repair composition of claim 1, wherein the dendrimer comprises at least one hydrophobic group. The hydrophobic group is one or more functional groups containing a linear or branched C ₆ -C ₂₀ carbon chain is optionally substituted by, keratin restorative composition of claim 10. The dendrimer has a structure

Wherein R is selected from the group consisting of OH, NH ₂ , SH, COOH, OR ′, NHR ′, SR′H, COOR ′ and NR ′ ₂ ;
R ′ is a hydrophobic group,
The dendrimer contains at least one hydrophobic group]
The keratin repair composition according to claim 10, comprising a compound having:   The keratin repair composition according to claim 1, further comprising a solvent.   The keratin of claim 1 further comprising one or more components selected from the group consisting of a film-forming polymer, a reactive (meth) acrylate, an epoxidized esterified vegetable oil, a polyhedral oligomeric silsesquioxane, and a colorant. Restoration composition. A method for improving the state of a keratinous substrate, comprising:
Keratin peptides and
Applying a keratin repair composition comprising a dendrimer to the keratinous substrate.   The method of claim 15, wherein the condition is selected from the group consisting of nail detachment, brittleness, cracking, chipping, splitting, drying and touch.   16. A method according to claim 15, wherein the keratinous substrate is selected from skin, nails and hair.   A method of making a keratin repair composition comprising mixing a keratin peptide and a dendrimer.   The method of claim 18, wherein the mixing step comprises chemically reacting.   The method of claim 18, wherein the mixing step includes forming a covalent, ionic or hydrogen bond.

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