JP2018510190A - 複素環式化合物及びそれらの細菌感染症の予防または治療のための使用 - Google Patents
複素環式化合物及びそれらの細菌感染症の予防または治療のための使用 Download PDFInfo
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- JP2018510190A JP2018510190A JP2017551331A JP2017551331A JP2018510190A JP 2018510190 A JP2018510190 A JP 2018510190A JP 2017551331 A JP2017551331 A JP 2017551331A JP 2017551331 A JP2017551331 A JP 2017551331A JP 2018510190 A JP2018510190 A JP 2018510190A
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15305479.6A EP3075734A1 (en) | 2015-03-31 | 2015-03-31 | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP15305479.6 | 2015-03-31 | ||
| EP16305059 | 2016-01-22 | ||
| EP16305059.4 | 2016-01-22 | ||
| PCT/EP2016/056845 WO2016156346A1 (en) | 2015-03-31 | 2016-03-30 | Heterocyclic compounds and their use in preventing or treating bacterial infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510190A true JP2018510190A (ja) | 2018-04-12 |
| JP2018510190A5 JP2018510190A5 (enExample) | 2019-04-11 |
Family
ID=55642466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551331A Pending JP2018510190A (ja) | 2015-03-31 | 2016-03-30 | 複素環式化合物及びそれらの細菌感染症の予防または治療のための使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10570131B2 (enExample) |
| EP (1) | EP3277685B1 (enExample) |
| JP (1) | JP2018510190A (enExample) |
| KR (1) | KR20170131687A (enExample) |
| CN (1) | CN107438610A (enExample) |
| AU (1) | AU2016239207A1 (enExample) |
| BR (1) | BR112017020826A2 (enExample) |
| CA (1) | CA2980109A1 (enExample) |
| CL (1) | CL2017002449A1 (enExample) |
| HK (1) | HK1244791A1 (enExample) |
| MX (1) | MX2017012539A (enExample) |
| RU (1) | RU2715058C2 (enExample) |
| TW (1) | TW201639853A (enExample) |
| WO (2) | WO2016156344A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3300736B1 (en) * | 2016-09-30 | 2021-05-05 | Mutabilis | Composition comprising antibiotic compound and an heterocyclic compound and their use in preventing or treating bacterial infections |
| EP3357924A1 (en) | 2017-02-06 | 2018-08-08 | Mutabilis | Novel heterocyclic compounds and their use in preventing or treating bacterial infections |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| EP4272831A3 (en) | 2018-08-09 | 2024-02-21 | Antabio SAS | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5038509B2 (ja) * | 2008-01-18 | 2012-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | β−ラクタマーゼ阻害剤 |
| BR112013028813B1 (pt) | 2011-08-27 | 2020-10-20 | Wockhardt Limited | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e composições farmacêuticas que os compreendem |
| CN103649088B (zh) | 2011-08-30 | 2016-05-11 | 沃克哈特有限公司 | 1, 6- 二氮杂双环[3, 2, 1]辛- 7- 酮衍生物及其在治疗细菌感染中的用途 |
| AR090539A1 (es) | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| HUE046893T2 (hu) | 2012-05-30 | 2020-04-28 | Meiji Seika Pharma Co Ltd | Új ß-laktamáz inhibitor és eljárás elõállítására |
| US9271446B2 (en) * | 2012-06-28 | 2016-03-01 | Forage Innovations B.V. | Self-aligning apparatus and methods for gathering bales |
| ES2672100T3 (es) * | 2012-08-25 | 2018-06-12 | Wockhardt Limited | Derivados de 1,6-diazabiciclo[3,2,1]octano-7-ona y su uso en el tratamiento de infecciones bacterianas |
| CN104994860A (zh) | 2013-02-06 | 2015-10-21 | 阿斯利康(瑞典)有限公司 | 用于治疗医院性肺炎的组合疗法 |
| WO2014141132A1 (en) * | 2013-03-14 | 2014-09-18 | Naeja Pharmaceutical Inc. | NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS |
| MA41850A (fr) | 2015-03-31 | 2018-02-06 | Takeda Pharmaceuticals Co | Nouvelles utilisations pharmaceutiques |
| EP3075734A1 (en) * | 2015-03-31 | 2016-10-05 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP3075733A1 (en) | 2015-03-31 | 2016-10-05 | Mutabilis | Novel heterocyclic compounds and their use in preventing or treating bacterial infections |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| RU2679652C1 (ru) | 2015-03-31 | 2019-02-12 | Лабораториос Баго С. А. | Способ получения гранул с энтеросолюбильным покрытием, содержащих ингибитор протонного насоса, и фармацевтических композиций, состоящих из множества частиц и содержащих эти гранулы |
-
2016
- 2016-03-30 HK HK18104010.8A patent/HK1244791A1/zh unknown
- 2016-03-30 RU RU2017133745A patent/RU2715058C2/ru active
- 2016-03-30 US US15/563,483 patent/US10570131B2/en active Active
- 2016-03-30 BR BR112017020826-1A patent/BR112017020826A2/pt not_active Application Discontinuation
- 2016-03-30 AU AU2016239207A patent/AU2016239207A1/en not_active Abandoned
- 2016-03-30 EP EP16712866.9A patent/EP3277685B1/en active Active
- 2016-03-30 MX MX2017012539A patent/MX2017012539A/es unknown
- 2016-03-30 JP JP2017551331A patent/JP2018510190A/ja active Pending
- 2016-03-30 KR KR1020177031506A patent/KR20170131687A/ko not_active Withdrawn
- 2016-03-30 WO PCT/EP2016/056842 patent/WO2016156344A1/en not_active Ceased
- 2016-03-30 TW TW105110155A patent/TW201639853A/zh unknown
- 2016-03-30 WO PCT/EP2016/056845 patent/WO2016156346A1/en not_active Ceased
- 2016-03-30 CA CA2980109A patent/CA2980109A1/en not_active Abandoned
- 2016-03-30 CN CN201680020427.5A patent/CN107438610A/zh active Pending
-
2017
- 2017-09-28 CL CL2017002449A patent/CL2017002449A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20170131687A (ko) | 2017-11-29 |
| TW201639853A (zh) | 2016-11-16 |
| CA2980109A1 (en) | 2016-10-06 |
| CN107438610A (zh) | 2017-12-05 |
| EP3277685A1 (en) | 2018-02-07 |
| US20180086760A1 (en) | 2018-03-29 |
| BR112017020826A2 (pt) | 2018-07-03 |
| WO2016156344A1 (en) | 2016-10-06 |
| CL2017002449A1 (es) | 2018-04-20 |
| RU2017133745A (ru) | 2019-03-28 |
| HK1244791A1 (zh) | 2018-08-17 |
| RU2017133745A3 (enExample) | 2019-09-09 |
| EP3277685B1 (en) | 2021-01-13 |
| AU2016239207A1 (en) | 2017-10-12 |
| MX2017012539A (es) | 2018-09-28 |
| RU2715058C2 (ru) | 2020-02-25 |
| US10570131B2 (en) | 2020-02-25 |
| WO2016156346A1 (en) | 2016-10-06 |
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