JP2018508530A5 - - Google Patents
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- JP2018508530A5 JP2018508530A5 JP2017546245A JP2017546245A JP2018508530A5 JP 2018508530 A5 JP2018508530 A5 JP 2018508530A5 JP 2017546245 A JP2017546245 A JP 2017546245A JP 2017546245 A JP2017546245 A JP 2017546245A JP 2018508530 A5 JP2018508530 A5 JP 2018508530A5
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- JP
- Japan
- Prior art keywords
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- polypeptide
- seq
- administered
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 20
- 210000000988 Bone and Bones Anatomy 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 3
- 238000010254 subcutaneous injection Methods 0.000 claims 3
- 239000007929 subcutaneous injection Substances 0.000 claims 3
- 208000010392 Bone Fractures Diseases 0.000 claims 2
- 206010012601 Diabetes mellitus Diseases 0.000 claims 2
- 208000001072 Type 2 Diabetes Mellitus Diseases 0.000 claims 2
- 210000000707 Wrist Anatomy 0.000 claims 2
- 230000037182 bone density Effects 0.000 claims 2
- 230000001054 cortical Effects 0.000 claims 2
- 208000006386 Bone Resorption Diseases 0.000 claims 1
- 210000001624 Hip Anatomy 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 230000024279 bone resorption Effects 0.000 claims 1
- 210000001981 hip bone Anatomy 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000037317 transdermal delivery Effects 0.000 claims 1
- 125000002306 tributylsilyl group Chemical group C(CCC)[Si](CCCC)(CCCC)* 0.000 claims 1
Claims (15)
- 非脊椎骨骨折の予防もしくは低減および/または骨密度(BMD)および/または海綿骨スコア(TBS)の向上を必要とする被験体においての該予防もしくは該低減および/または該向上における使用のための配列番号：1のポリペプチド。
- 被験体が高い皮質骨多孔率を有する、請求項１記載のポリペプチド。
- 非脊椎骨が、手首骨および寛骨からなる群より選択される、請求項１または２記載のポリペプチド。
- 該使用が、該被験体に骨吸収抑制剤の治療有効量を投与する工程をさらに含む、請求項１〜３いずれか一項記載のポリペプチド。
- 配列番号：1のポリペプチドが皮下注射により投与され、任意に、80μgの配列番号：1のポリペプチドが、被験体に投与される、請求項１〜４いずれか一項記載のポリペプチド。
- （ａ）被験体が女性である、または
（ｂ）被験体が骨粗鬆症を有する、
請求項１〜５いずれか一項記載のポリペプチド。 - 被験体が糖尿病を有し、任意に、被験体が二型糖尿病を有する、請求項１〜５いずれか一項記載のポリペプチド。
- 被験体が閉経後の女性である、請求項６または７記載のポリペプチド。
- 該使用が、高い皮質骨多孔率を有する被験体において非脊椎骨骨折を予防または低減するためのものである、請求項１〜８いずれか一項記載のポリペプチド。
- （ａ）被験体が正常BMDを有する、または
（ｂ）被験体が、少なくとも約-1の骨密度Tスコアを有する、
請求項９記載のポリペプチド。 - 被験体が糖尿病を有し、任意に、被験体が二型糖尿病を有する、請求項９または１０記載のポリペプチド。
- 80μgの配列番号：1のポリペプチドが、被験体に投与される、請求項９〜１１いずれか一項記載のポリペプチド。
- 配列番号：1のポリペプチドが、皮下注射または経皮送達により投与される、請求項１〜１２いずれか一項記載のポリペプチド。
- 配列番号：1のポリペプチドが皮下注射により投与される、請求項１２記載のポリペプチド。
- 該使用が、脊椎、股関節部および手首からなる群より選択される1つ以上の部位で少なくとも約3%のBMD増加を生じる、請求項１または９記載のポリペプチド。
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562127729P | 2015-03-03 | 2015-03-03 | |
| US62/127,729 | 2015-03-03 | ||
| US201562165841P | 2015-05-22 | 2015-05-22 | |
| US62/165,841 | 2015-05-22 | ||
| US201562201564P | 2015-08-05 | 2015-08-05 | |
| US62/201,564 | 2015-08-05 | ||
| US201562239733P | 2015-10-09 | 2015-10-09 | |
| US62/239,733 | 2015-10-09 | ||
| US201662278762P | 2016-01-14 | 2016-01-14 | |
| US62/278,762 | 2016-01-14 | ||
| PCT/US2016/020787 WO2016141250A1 (en) | 2015-03-03 | 2016-03-03 | USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020141522A Division JP7049412B2 (ja) | 2015-03-03 | 2020-08-25 | 骨折リスクの低減におけるＰＴＨｒＰアナログの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508530A JP2018508530A (ja) | 2018-03-29 |
| JP2018508530A5 true JP2018508530A5 (ja) | 2019-04-11 |
| JP6755256B2 JP6755256B2 (ja) | 2020-09-16 |
Family
ID=56849024
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546245A Active JP6755256B2 (ja) | 2015-03-03 | 2016-03-03 | 骨折リスクの低減におけるＰＴＨｒＰアナログの使用 |
| JP2020141522A Active JP7049412B2 (ja) | 2015-03-03 | 2020-08-25 | 骨折リスクの低減におけるＰＴＨｒＰアナログの使用 |
| JP2022050196A Pending JP2022075999A (ja) | 2015-03-03 | 2022-03-25 | 骨折リスクの低減におけるＰＴＨｒＰアナログの使用 |
| JP2023117588A Pending JP2023129523A (ja) | 2015-03-03 | 2023-07-19 | 骨折リスクの低減におけるＰＴＨｒＰアナログの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020141522A Active JP7049412B2 (ja) | 2015-03-03 | 2020-08-25 | 骨折リスクの低減におけるＰＴＨｒＰアナログの使用 |
| JP2022050196A Pending JP2022075999A (ja) | 2015-03-03 | 2022-03-25 | 骨折リスクの低減におけるＰＴＨｒＰアナログの使用 |
| JP2023117588A Pending JP2023129523A (ja) | 2015-03-03 | 2023-07-19 | 骨折リスクの低減におけるＰＴＨｒＰアナログの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US20170065682A1 (ja) |
| EP (2) | EP4137147A3 (ja) |
| JP (4) | JP6755256B2 (ja) |
| AU (3) | AU2016226103A1 (ja) |
| CA (1) | CA2977812A1 (ja) |
| DK (1) | DK3265115T3 (ja) |
| ES (1) | ES2927067T3 (ja) |
| WO (1) | WO2016141250A1 (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3998061A1 (en) | 2016-04-18 | 2022-05-18 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
| EP3548012A4 (en) * | 2016-11-30 | 2020-07-22 | Purdue Research Foundation | BONE REGENERATION TARGETED ON A FRACTURE BY STIMULATION OF THE PARATHYROID HORMONE RECEPTOR |
| JP7499249B2 (ja) * | 2019-01-11 | 2024-06-13 | ラジウス ヘルス，インコーポレイテッド | 副甲状腺ホルモン（ｐｔｈ）および副甲状腺ホルモン関連ペプチド（ｐｔｈｒｐ）アナログに対する中和抗体を検出するための方法 |
| WO2020166561A1 (ja) | 2019-02-14 | 2020-08-20 | 富士フイルム株式会社 | 骨折リスク評価値取得装置及びその作動方法並びに骨折リスク評価値取得プログラム |
| EP4027899A4 (en) * | 2019-09-12 | 2023-08-16 | Radius Health, Inc. | METHODS OF ENHANCING SPINE FUSION USING ABALOPARATIDE |
| CN112646042A (zh) * | 2019-10-10 | 2021-04-13 | 陕西麦科奥特科技有限公司 | 活性多肽化合物 |
| WO2022149066A1 (en) * | 2021-01-05 | 2022-07-14 | Radius Health, Inc. | Treatment of long bone fractures with abaloparatide |
| US20220378881A1 (en) * | 2021-05-25 | 2022-12-01 | Radius Health, Inc. | Treatment and prevention of osteoporosis in high body mass index individuals |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702401D0 (sv) * | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| EP1531855A4 (en) * | 2002-01-10 | 2009-07-22 | Osteotrophin Llc | TREATMENT OF BONE DISEASES WITH SKELETTAL ANABOLIKA |
| WO2008023063A2 (en) * | 2006-08-25 | 2008-02-28 | Ares Trading S.A. | Treatment of cartilage disorders with fgf-18 |
| US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| WO2010022176A1 (en) * | 2008-08-19 | 2010-02-25 | Ferring International Center S.A. | Methods of treatment for skeletal conditons |
| WO2012145665A2 (en) * | 2011-04-22 | 2012-10-26 | Radius Health, Inc. | Method of drug delivery for pth, pthrp and related peptides |
| HUE035607T2 (en) * | 2012-06-25 | 2018-05-28 | Brigham & Womens Hospital Inc | Targeted therapeutic agents |
| SG11201802871UA (en) * | 2015-10-09 | 2018-05-30 | Radius Health Inc | Formulations of pthrp analogues, transdermal patches thereof, and uses thereof |
-
2016
- 2016-03-03 EP EP22179423.3A patent/EP4137147A3/en active Pending
- 2016-03-03 ES ES16759540T patent/ES2927067T3/es active Active
- 2016-03-03 CA CA2977812A patent/CA2977812A1/en active Pending
- 2016-03-03 EP EP16759540.4A patent/EP3265115B1/en not_active Revoked
- 2016-03-03 DK DK16759540.4T patent/DK3265115T3/da active
- 2016-03-03 WO PCT/US2016/020787 patent/WO2016141250A1/en active Application Filing
- 2016-03-03 AU AU2016226103A patent/AU2016226103A1/en not_active Abandoned
- 2016-03-03 JP JP2017546245A patent/JP6755256B2/ja active Active
- 2016-08-31 US US15/253,545 patent/US20170065682A1/en not_active Abandoned
-
2017
- 2017-09-01 US US15/694,658 patent/US20170368148A1/en not_active Abandoned
-
2019
- 2019-09-10 US US16/566,499 patent/US20200061160A1/en not_active Abandoned
-
2020
- 2020-06-16 US US16/903,256 patent/US20200376088A1/en not_active Abandoned
- 2020-08-25 JP JP2020141522A patent/JP7049412B2/ja active Active
- 2020-11-10 AU AU2020267182A patent/AU2020267182A1/en not_active Abandoned
-
2021
- 2021-09-10 US US17/471,543 patent/US20220125887A1/en not_active Abandoned
-
2022
- 2022-03-25 JP JP2022050196A patent/JP2022075999A/ja active Pending
-
2023
- 2023-04-06 US US18/296,801 patent/US20230381283A1/en not_active Abandoned
- 2023-05-19 US US18/320,638 patent/US20230321199A1/en not_active Abandoned
- 2023-07-19 JP JP2023117588A patent/JP2023129523A/ja active Pending
-
2024
- 2024-05-03 AU AU2024202952A patent/AU2024202952A1/en active Pending
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