JP2018503618A5 - - Google Patents
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- Publication number
- JP2018503618A5 JP2018503618A5 JP2017533836A JP2017533836A JP2018503618A5 JP 2018503618 A5 JP2018503618 A5 JP 2018503618A5 JP 2017533836 A JP2017533836 A JP 2017533836A JP 2017533836 A JP2017533836 A JP 2017533836A JP 2018503618 A5 JP2018503618 A5 JP 2018503618A5
- Authority
- JP
- Japan
- Prior art keywords
- vedolizumab
- therapeutic agent
- patient
- concentration
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960004914 vedolizumab Drugs 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 13
- 229940124597 therapeutic agent Drugs 0.000 claims 13
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 10
- 210000002966 serum Anatomy 0.000 claims 7
- 102000009027 Albumins Human genes 0.000 claims 4
- 108010088751 Albumins Proteins 0.000 claims 4
- 102000007562 Serum Albumin Human genes 0.000 claims 3
- 108010071390 Serum Albumin Proteins 0.000 claims 3
- 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 claims 2
- 108010069316 Leukocyte L1 Antigen Complex Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000002550 fecal effect Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 238000003118 sandwich ELISA Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021024874A JP7530314B2 (ja) | 2014-12-24 | 2021-02-19 | 抗α４β７インテグリン抗体による治療の結果の予測 |
| JP2024022738A JP2024069231A (ja) | 2014-12-24 | 2024-02-19 | 抗α４β７インテグリン抗体による治療の結果の予測 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462096636P | 2014-12-24 | 2014-12-24 | |
| US62/096,636 | 2014-12-24 | ||
| US201562117750P | 2015-02-18 | 2015-02-18 | |
| US62/117,750 | 2015-02-18 | ||
| US201562132917P | 2015-03-13 | 2015-03-13 | |
| US62/132,917 | 2015-03-13 | ||
| PCT/US2015/000476 WO2016105572A1 (en) | 2014-12-24 | 2015-12-23 | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-α4β7 INTEGRIN ANTIBODY |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021024874A Division JP7530314B2 (ja) | 2014-12-24 | 2021-02-19 | 抗α４β７インテグリン抗体による治療の結果の予測 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503618A JP2018503618A (ja) | 2018-02-08 |
| JP2018503618A5 true JP2018503618A5 (enExample) | 2019-02-07 |
| JP6904905B2 JP6904905B2 (ja) | 2021-07-21 |
Family
ID=56151288
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533836A Active JP6904905B2 (ja) | 2014-12-24 | 2015-12-23 | 抗α４β７インテグリン抗体による治療の結果の予測 |
| JP2021024874A Active JP7530314B2 (ja) | 2014-12-24 | 2021-02-19 | 抗α４β７インテグリン抗体による治療の結果の予測 |
| JP2024022738A Pending JP2024069231A (ja) | 2014-12-24 | 2024-02-19 | 抗α４β７インテグリン抗体による治療の結果の予測 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021024874A Active JP7530314B2 (ja) | 2014-12-24 | 2021-02-19 | 抗α４β７インテグリン抗体による治療の結果の予測 |
| JP2024022738A Pending JP2024069231A (ja) | 2014-12-24 | 2024-02-19 | 抗α４β７インテグリン抗体による治療の結果の予測 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20170360926A1 (enExample) |
| EP (1) | EP3237004B1 (enExample) |
| JP (3) | JP6904905B2 (enExample) |
| WO (1) | WO2016105572A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| WO2012154987A1 (en) | 2011-05-10 | 2012-11-15 | Nestec Sa | Methods of disease activity profiling for personalized therapy management |
| WO2016086147A1 (en) | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US9862760B2 (en) | 2015-09-16 | 2018-01-09 | Novartis Ag | Polyomavirus neutralizing antibodies |
| JP7069032B2 (ja) | 2016-03-24 | 2022-05-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | がん免疫治療における胃腸の免疫関連有害事象の治療方法 |
| WO2017192867A1 (en) | 2016-05-04 | 2017-11-09 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating inflammatory bowel disease |
| MA45245A (fr) | 2016-06-12 | 2019-04-17 | Millennium Pharm Inc | Méthode de traitement de maladie intestinale inflammatoire |
| WO2018104893A1 (en) * | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | Alpha4-beta7 antibodies with incrased fcrn binding and/or half-life |
| US20200087401A1 (en) * | 2017-05-26 | 2020-03-19 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of chronic pouchitis |
| CA3064529C (en) | 2017-05-31 | 2021-12-14 | Prometheus Biosciences, Inc. | Methods for assessing mucosal healing in crohn's disease patients |
| JP7328960B2 (ja) * | 2017-10-10 | 2023-08-17 | プロメテウス バイオサイエンシーズ インコーポレイテッド | ベドリズマブ処置をモニタリングするための方法 |
| US20210031012A1 (en) | 2018-01-26 | 2021-02-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| EP3810268A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| US12171764B2 (en) | 2018-06-20 | 2024-12-24 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| WO2019246313A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| WO2020117795A1 (en) * | 2018-12-04 | 2020-06-11 | Prometheus Biosciences, Inc. | Assessment and monitoring of mucosal healing in children and adults with crohn's disease |
| CN116096746A (zh) * | 2020-06-12 | 2023-05-09 | 维拉治疗公司 | 多瘤病毒中和抗体的给药 |
| CN114974595A (zh) * | 2022-05-13 | 2022-08-30 | 江苏省人民医院（南京医科大学第一附属医院） | 一种克罗恩病患者黏膜愈合预测模型及方法 |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
| WO2025101973A1 (en) * | 2023-11-09 | 2025-05-15 | Cedars-Sinai Medical Center | Systems and methods for disease classification and treatment recommendation using large language models |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| PT808367E (pt) | 1995-02-10 | 2007-10-22 | Millennium Pharm Inc | Adressinas vasculares da mucosa e suas utilizações |
| US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US6197582B1 (en) | 1998-03-18 | 2001-03-06 | The Trustees Of Columbia University In The City Of New York | Development of human monoclonal antibodies and uses thereof |
| US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| US7811610B2 (en) * | 2003-05-22 | 2010-10-12 | Metaproteomics, Llc | Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment or prevention of gastric toxicity |
| AU2006316629A1 (en) | 2005-11-17 | 2007-05-31 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with alpha 4 beta 7 integrin |
| JP2012507723A (ja) * | 2008-11-03 | 2012-03-29 | シェーリング コーポレイション | 炎症性腸疾患生物マーカーおよび関連治療方法 |
| CN109734807A (zh) | 2011-03-31 | 2019-05-10 | 豪夫迈·罗氏有限公司 | 施用β7整联蛋白拮抗剂的方法 |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| KR101875155B1 (ko) | 2011-05-02 | 2018-07-09 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
| WO2016086147A1 (en) | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| CA2916283C (en) * | 2015-01-09 | 2024-07-02 | Pfizer | Dosage regimen for madcam antagonists |
-
2015
- 2015-12-23 US US15/538,869 patent/US20170360926A1/en not_active Abandoned
- 2015-12-23 JP JP2017533836A patent/JP6904905B2/ja active Active
- 2015-12-23 EP EP15873834.4A patent/EP3237004B1/en not_active Revoked
- 2015-12-23 WO PCT/US2015/000476 patent/WO2016105572A1/en not_active Ceased
-
2019
- 2019-06-27 US US16/455,103 patent/US11596688B2/en active Active
-
2021
- 2021-02-19 JP JP2021024874A patent/JP7530314B2/ja active Active
-
2023
- 2023-01-18 US US18/156,279 patent/US20240173402A1/en active Pending
-
2024
- 2024-02-19 JP JP2024022738A patent/JP2024069231A/ja active Pending
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