JP2018175709A - Microneedle array unit and microneedle array container - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a microneedle array unit facilitating the insertion and removal of a microneedle array, and also to provide a microneedle array container.SOLUTION: The microneedle array unit comprises: a microneedle array having a sheet part and a plurality of needle parts arranged on an inner side of an outer peripheral surface of one side of the sheet part; a case body having an accommodation part for accommodating the microneedle array; and a lid for covering the case body. The accommodation part includes: a first recessed portion which has a first opening, a first side surface, and a first bottom surface supporting the outer peripheral surface, the distance from the first opening to the first bottom surface being shorter than the height of the needle parts, and which has a tapered shape in which the first side surface gradually widens from the first bottom surface toward the first opening; a second recessed portion which is arranged inside the first bottom surface to receive the needle parts, and which has a second opening, a second side surface, and a second bottom surface, the distance from the second opening to the second bottom surface being longer than the height of the needle parts; and a notched portion provided at a portion of the first and second side surfaces.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a microneedle array unit and a container for microneedle arrays.

  In recent years, Micro-Needle Array has been known as a novel dosage form capable of delivering a drug into the skin without pain. The microneedle array is an array of biodegradable microneedles (also referred to as microneedles or microneedles) containing drugs. By pressing the microneedle array against the skin, each microneedle pierces the skin. The microneedles are absorbed in the skin, and the drug contained in each microneedle is administered into the skin.

  Because the microneedles are microstructured, there is a need to prevent the microneedles from being damaged. For example, as described in Patent Documents 1 and 2, the microneedle array may be transported and stored in a container.

JP, 2013-013558, A Patent 5 884 954

  However, in the techniques of Patent Documents 1 and 2, it is not easy to insert the microneedle array into the container because the difference between the dimension of the inner wall of the container and the outer dimension of the microneedle array is small. Therefore, when inserting the microneedle array into the container, there is a concern that the microneedles may be deformed or the microneedle array may be cracked. Removing the microneedle array from the container is not as easy as insertion.

  The present invention was made in view of such circumstances, and an object thereof is to provide a microneedle array unit capable of facilitating insertion and removal of the microneedle array, and a container for the microneedle array.

  A microneedle array unit according to a first aspect includes: a microneedle array having a seat portion and a plurality of needle portions disposed inside the outer peripheral surface of one surface of the seat portion; and a housing portion for housing the microneedle array And a lid covering the case body, the housing portion having a first opening, a first side surface, and a first bottom surface supporting the outer circumferential surface, and a distance from the first opening to the first bottom surface A first recess whose length is shorter than the height of the needle portion and whose first side is a tapered shape extending from the first bottom to the first opening, and is disposed inside the first bottom, a second opening, a second side, And a second bottom surface, the distance from the second opening to the second bottom surface being longer than the height of the needle portion, and provided in a second recess for receiving the needle portion, the first side surface, and part of the second side surface And a notch.

  In the microneedle array unit according to the second aspect, the case body is provided on the outer periphery of the open end defining the first opening, and further has a convex portion higher than the open end.

  In the microneedle array unit according to the third aspect, the distance between the convex portion and the open end is less than 0.5 mm.

  In the microneedle array unit according to the fourth aspect, the notch is provided in a region where the distance between the open end and the protrusion is long.

  In the microneedle array unit according to the fifth aspect, the third concave portion is provided between the open end and the convex portion.

  In the microneedle array unit according to the sixth aspect, the lid is welded to the projection.

  In the microneedle array unit according to the seventh aspect, the taper angle of the first side surface is 5 ° or more and 20 ° or less.

  In the microneedle array unit according to the eighth aspect, when the outer peripheral surface is supported by the first bottom surface, the distance from the first side surface to the outer edge of the microneedle array is shorter than the distance from the second side surface to the needle portion .

  In the microneedle array unit according to the ninth aspect, the lid has a protrusion that protrudes from the case body.

  In the microneedle array unit according to the tenth aspect, the lid has a melting point lower than that of the second lid surface opposite to the first lid surface on the side facing the sheet portion.

  A container for a microneedle array according to an eleventh aspect is a case having a seat portion and a housing portion for housing a microneedle array having a plurality of needle portions disposed inside the outer peripheral surface of one surface of the seat portion. The housing includes a main body and a lid covering the case main body, the housing portion has a first opening, a first side surface, and a first bottom surface for supporting the outer peripheral surface, and the first side surface is a first bottom surface A first recess having a tapered shape expanding toward the one opening; a second recess disposed inside the first bottom and for receiving a needle having a second opening, a second side, and a second bottom; And a notch provided in a part of the one side surface and the second side surface.

  According to the microneedle array unit of the present invention and the container for microneedle arrays, the microneedle array can be easily inserted into the case body, and the microneedle array can be easily removed from the case body.

FIG. 1 is an exploded perspective view of the microneedle array unit of the first embodiment. FIG. 2 is a perspective view of a microneedle array. FIG. 3 is a cross-sectional view taken along the line I-I in FIG. FIG. 4 is a cross-sectional view taken along the line II-II in FIG. FIG. 5 is an exploded perspective view of the microneedle array unit of the second embodiment. 6 is a cross-sectional view taken along the line III-III in FIG. FIG. 7 is an exploded perspective view of the microneedle array unit of the third embodiment. FIG. 8 is a cross-sectional view taken along the line IV-IV in FIG. FIG. 9 is a cross-sectional view taken along the line V-V in FIG. FIG. 10 is an exploded perspective view of the microneedle array unit of the fourth embodiment. FIG. 11 is an exploded perspective view of the microneedle array unit of the fifth embodiment.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the attached drawings. The invention is illustrated by the following preferred embodiments. Changes can be made in a number of ways without departing from the scope of the present invention, and other embodiments than the present embodiment can be used. Therefore, all the modifications within the scope of the present invention are included in the claims.

First Embodiment
The microneedle array unit 1 of the first embodiment will be described with reference to FIGS. 1 to 4. FIG. 1 is an exploded perspective view of the microneedle array unit 1. As shown in FIG. 1, the microneedle array unit 1 is configured of a microneedle array container 30 having a microneedle array 20, a lid 40 and a case main body 50.

  FIG. 2 is a perspective view of the microneedle array 20. FIG. The microneedle array 20 includes a circular seat portion 21 having one surface 22 and another surface 23 facing each other, and a plurality of needle portions 24 disposed on the one surface 22 of the seat portion 21. The needle portion 24 constitutes a microneedle. The plurality of needle portions 24 are disposed on the inner surface 22 B inside the outer peripheral surface 22 A of the one surface 22. As shown in FIG. 2, the boundary between the outer peripheral surface 22A and the inner surface 22B is an imaginary line 22C connecting the needle portions 24 disposed outermost among the plurality of needle portions 24. Although the sheet portion 21 is illustrated to be circular in the embodiment, it may be rectangular.

  The shape and size of the seat portion 21 and the needle portion 24 may be selected according to the application of the microneedle array 20. Moreover, the sheet part 21 and the needle part 24 may be comprised from the same material, and may differ. The microneedle array 20 can be manufactured by integrally forming the sheet portion 21 and the needle portion 24, but may be separately formed.

  The needle portion 24 has, for example, a substantially conical shape, but may have a columnar shape or a frustum shape. In the embodiment, the needle portion 24 is configured in the order of the truncated cone portion and the cone from the one surface 22 toward the tip, but it is not particularly limited as long as it can pierce the skin. The needles 24 are preferably arranged in an array with uniformly spaced columns (rows) and rows (columns).

  Each needle portion 24 may be formed of a metal material, but is preferably formed of a material which, after being punctured in the skin or mucous membrane, dissolves after being inserted into the body. Therefore, as a material which constitutes needle part 24, a water soluble polymer is preferred, and it is more preferred that it is a polysaccharide. The material constituting the needle portion 24 is, for example, at least one selected from the group consisting of hydroxyethyl starch, dextran, chondroitin sulfate, sodium hyaluronate, carboxymethyl cellulose, polyvinyl pyrrolidone, polyoxyethylene polyoxypropylene glycol, polyethylene glycol Preferably, it is formed of

  The drug is applied to or contained in each needle 24. When the sheet portion 21 is attached to the skin surface, each needle portion 24 penetrates the skin and is inserted into the body. When a drug is applied to each needle 24, the drug is administered into the body from the surface of each needle 24. In addition, when the medicine is contained in each needle portion 24, each needle portion 24 is formed of a material that dissolves after being inserted into the body, so that the needle portion 24 in the body is dissolved, so Drugs are administered to the body.

  As shown in FIG. 1, the microneedle array container 30 includes a lid 40 and a case main body 50. The lid 40 covers the case body 50. The lid 40 and the case main body 50 are formed of, for example, polyethylene resin, polypropylene resin, or a mixture thereof, but is not limited thereto. It is preferable that each of these materials satisfy the Japanese Pharmacopoeia "plastic aqueous injection container specification (hereinafter simply referred to as injection container grade)". In addition, the lid 40 and the case main body 50 may be formed of various resin materials that meet the same standards other than these.

  The case main body 50 is formed, for example, by injection molding. The case body 50 is, for example, substantially square in top view, but is not limited thereto. The case main body 50 includes a housing 52 for housing the microneedle array 20. The housing portion 52 includes a first recess 54, a second recess 56 formed inside the first recess 54, and a notch 58 connected to the first recess 54 and the second recess 56. Further, the lid 40 can be made of, for example, a single layer film formed of the above-described resin material.

  3 is a cross-sectional view taken along the line II in FIG. 1, and FIG. 4 is a cross-sectional view taken along the line II-II in FIG. As shown in FIGS. 1 and 3, the first recess 54 has a first opening 54A, a first bottom surface 54B supporting the outer peripheral surface 22A of the microneedle array 20, and a first bottom surface 54B to the first opening 54A. It has a first side 54C extending toward it. As shown in FIG. 3, the distance L1 from the first opening 54A to the first bottom surface 54B is shorter than the height H of the needle portion 24. The height of the needle portion 24 means the height from one surface 22 of the sheet portion 21 to the tip end portion of the needle portion 24. When a plurality of needle portions 24 are provided, the height is an average height. Further, in order to accommodate the sheet portion 21 in the first recess 54, the distance L1 is preferably longer than the thickness of the sheet portion 21.

  The first side surface 54C has a tapered shape extending from the first bottom surface 54B toward the first opening 54A. Since the accommodation portion 52 accommodates the microneedle array 20, the first opening 54A of the first recess 54 is circular as in the sheet portion 21 of the microneedle array 20 in top view, and the projection area of the sheet portion 21 large.

  As shown in FIGS. 1 and 3, the second recess 56 is provided on the inside of the first bottom surface 54B of the first recess 54. The second recess 56 includes a second opening 56A, a second bottom surface 56B opposite to the second opening 56A, and a second side surface 56C extending from the second bottom surface 56B toward the second opening 56A. Since the second recess 56 receives the plurality of needle portions 24 of the microneedle array 20, the second opening 56A is larger than the projection area of the inner surface 22B of the microneedle array 20. The distance L2 from the second opening 56A to the second bottom surface 56B is longer than the height H of the needle portion 24.

  As shown in FIG. 3, with the outer peripheral surface 22A of the microneedle array 20 supported by the first bottom surface 54B, the distance L3 from the first side surface 54C to the outer edge of the microneedle array 20 is the second side surface 56C It is preferable to be shorter than the distance L4 to the needle portion.

  The microneedle array 20 is accommodated in the accommodation portion 52 of the case main body 50 from the side of the one surface 22 on which the plurality of needle portions 24 are disposed. First, the needle portion 24 of the microneedle array 20 passes through the first opening 54A. Next, the sheet portion 21 of the microneedle array 20 passes through the first opening 54A. The microneedle array 20 is inserted into the housing portion 52 until the outer peripheral surface 22A of the sheet portion 21 contacts the first bottom surface 54B.

  When the first bottom surface 54B and the first side surface 54C are vertical, the microneedle array 20 may be hooked on the first side surface 54C if the microneedle array 20 is not inserted along the wall but is inclined. There is a concern that 20 may not be easily inserted into the receptacle 52.

  On the other hand, in the first embodiment, in order to enable easy insertion of the microneedle array 20 into the housing portion 52, the first recess 54 has a tapered first side surface 54C. Since the gap between the outer edge of the microneedle array 20 and the first side surface 54C gradually decreases until the outer peripheral surface 22A of the sheet portion 21 contacts the first bottom surface 54B, the micro needle array 20 is hooked on the first side surface 54C. It can be smoothly inserted into the accommodating portion 52 without.

  The taper angle of the first side surface 54C is preferably in the range of 5 ° to 20 °. By setting this range, the free movement of the microneedle array 20 is restricted by the tapered first side surface 54C until the outer peripheral surface 22A of the sheet portion 21 contacts the first bottom surface 54B. This restriction can prevent the collision of the needle portion 24 with the first bottom surface 54B or the first side surface 54C. The taper angle means the inclination of the first side surface 54C with respect to the perpendicular perpendicular to the first bottom surface 54B.

  Further, it is preferable that the second side surface 56C also have a tapered shape that spreads from the second bottom surface 56B toward the second opening 56A. When the case body 50 is manufactured by clamping two molds forming a cavity and injecting resin into the cavity, the tapered second side face 56C makes it easy to take the case body 50 out of the mold Make it The taper angle of the second side face 56C is preferably in the range of 3 ° to 5 °.

  In the first embodiment, in order to prevent the needle portion 24 from riding on the first bottom surface 54B even if the micro needle array 20 moves along the extending direction of the needle portion 24 during transportation, the first opening 54A The distance L1 to the bottom surface 54B is set shorter than the height H of the needle portion 24.

  In the first embodiment, the distance L2 from the second opening 56A to the second bottom surface 56B is set longer than the height H of the needle portion 24 so that the needle portion 24 of the microneedle array 20 does not contact the second bottom surface 56B. Ru.

  In the first embodiment, since the needle portion 24 does not contact the second side surface 56C even when the microneedle array 20 moves in the direction orthogonal to the extending direction of the needle portion 24 during transportation, the microneedle from the first side surface 54C Preferably, the distance L3 to the outer edge of the array 20 is less than the distance L4 from the second side 56C to the outermost needle portion 24.

  As shown in FIGS. 1 and 3, an open end 54D defining the first opening 54A of the first recess 54 is formed on the side of the first recess 54 of the case main body 50. The opening end 54D has a step 51 with respect to the peripheral edge portion 53 of the case main body 50. The lid 40 is formed on the case body 50 and is welded to the open end 54D. Since the first opening 54A is closed by the lid 40, the receiving portion 52 for receiving the microneedle array 20 is sealed. The housing 52 is preferably sealed in an aseptic environment.

  The distance from the first opening 54A to the first bottom surface 54B is the distance from the opening end 54D to the first bottom surface 54B.

  As shown in FIGS. 1 and 4, the notch 58 is disposed in connection with the first recess 54 and the second recess 56. The cutout portion 58 is a recess formed by cutting out a part of the first side surface 54C and a part of the second side surface 56C, and extending from the open end 54D to the second bottom surface 56B.

  When the microneedle array 20 is taken out of the housing portion 52, the lid 40 is peeled off from the case main body 50. The user can place a finger, an extraction tool or the like in the cutout 58. A finger, a tool or the like can grip or pull the outer peripheral surface 22A of the microneedle array 20 from the side of the notch 58. The microneedle array 20 can be easily removed from the housing 52 by pulling up a finger, a tool or the like from the notch 58.

  In consideration of easy insertion of a finger, a tool or the like into the notch 58, the recess space of the notch 58 is preferably large. In the first embodiment, it is preferable that the notch 58 be formed from the first recess 54 and the second recess 56 toward the corner of the rectangular case main body 50. Since the space not used as the housing portion 52 of the case main body 50 can be effectively utilized, the cutout portion 58 can realize a large recessed space.

Second Embodiment
The microneedle array unit 2 of the second embodiment will be described with reference to FIGS. 5 and 6. The same components as those in the first embodiment may be assigned the same reference numerals and descriptions thereof may be omitted. FIG. 5 is an exploded perspective view of the microneedle array unit 2. As shown in FIG. 5, the microneedle array unit 2 is configured of a microneedle array 20 and a container 30 for microneedle array. The container for microneedle array 30 comprises a lid 40 and a case main body 50.

  The micro needle array unit 2 of the second embodiment differs from the micro needle array unit 1 of the first embodiment in the shape of the case main body 50.

  As shown in FIGS. 5 and 6, the case body 50 has a convex portion 55 higher than the open end 54D on the outer periphery of the open end 54D that defines the first opening 54A. With the convex portion 55 higher than the open end 54D, when the second concave portion 56 side of the case main body 50 is installed, the height from the installation surface to the convex portion 55 is higher than the height from the installation surface to the open end 54D. It means high. The convex portion 55 is formed in, for example, a rectangular shape along the outer shape of the case main body 50, but is not limited thereto.

  As shown in FIG. 6, in the micro needle array unit 2, the lid 40 is welded to the convex portion 55, so the heat when welding the lid 40 to the case main body 50 affects the open end 54D. It is preferable.

  When the lid 40 and the convex portion 55 are welded, even if the convex portion 55 melts to the side of the first opening 54A, it is possible to prevent the molten material from narrowing the size of the first opening 54A. Therefore, the microneedle array 20 can be taken out more smoothly from the housing portion 52.

  The distance L5 between the projection 55 and the opening end 54D is preferably less than 0.5 mm. When the lid 40 is welded to the convex portion 55, the distance of the gap 60 between the lid 40 and the open end 54D is less than 0.5 mm. The sheet portion 21 of the microneedle array 20 preferably has a thickness of less than 0.5 mm, preferably 0.2 mm or more and 0.3 mm or less, for flexibility.

  Therefore, even when the microneedle array 20 moves in any direction in the housing portion 52, the sheet portion 21 can be avoided from entering the clearance 60 by setting the clearance 60 to a distance L5 less than 0.5 mm, which is preferable. . When the sheet portion 21 of the microneedle array 20 enters the gap 60, the needle portion 24 of the microneedle array 20 may interfere with the first side surface 54C or the second side surface 56C and may be damaged.

  In the second embodiment, the notch 58 is preferably provided in a region where the distance between the open end 54D and the protrusion 55 is long. Specifically, the notch 58 can be provided from the first recess 54 and the second recess 56 toward the corner of the rectangular protrusion 55, for example. Since the space not used as the housing portion 52 of the case main body 50 can be effectively utilized, the cutout portion 58 can realize a large recessed space. However, it is preferable that the notch 58 does not reach the convex portion 55. Since the housing portion 52 of the case main body 50 is sealed by welding the lid 40 and the convex portion 55, it is preferable that the convex portion 55 be continuous to the entire circumference of the case main body 50.

Third Embodiment
The microneedle array unit 3 according to the third embodiment will be described with reference to FIGS. 7 to 9. The same components as those in the first embodiment and the second embodiment may be assigned the same reference numerals and descriptions thereof may be omitted. FIG. 7 is an exploded perspective view of the microneedle array unit 3. As shown in FIG. 7, the microneedle array unit 3 includes a microneedle array 20 and a container 30 for microneedle array. The container for microneedle array 30 comprises a lid 40 and a case main body 50.

  The microneedle array unit 3 of the third embodiment differs from the microneedle array unit 2 of the second embodiment in the shape of the case main body 50. As shown in FIGS. 7 and 8, the case body 50 of the third embodiment has a third recess 62 between the open end 54 </ b> D and the protrusion 55. The third concave portion 62 can reduce the influence of the heat at the time of welding the lid 40 and the convex portion 55 to the open end 54D. Even when the distance between the open end 54D and the protrusion 55 is short in the top view, the distance between the open end 54D and the protrusion 55 is substantially increased by the third recess 62, and heat during welding is transmitted to the open end 54D. It can be difficult to communicate.

  In the third embodiment, as shown in FIG. 7 and FIG. 9, it is preferable that the notches 58 be provided in a region where the distance between the open end 54 D and the protrusion 55 is long. Specifically, the notch 58 can be provided in a region where the area of the third recess 62 is large, that is, from the first recess 54 and the second recess 56 toward the corner of the rectangular protrusion 55. Since the space not used as the housing portion 52 of the case main body 50 can be effectively utilized, the cutout portion 58 can realize a large recessed space.

Fourth Embodiment
The microneedle array unit 4 of the fourth embodiment will be described with reference to FIG. The same components as those in the first to third embodiments may be assigned the same reference numerals and descriptions thereof may be omitted. FIG. 10 is an exploded perspective view of the microneedle array unit 4. As shown in FIG. 10, the microneedle array unit 4 is composed of a microneedle array 20 and a container 30 for microneedle array. The container for microneedle array 30 comprises a lid 40 and a case main body 50.

  The microneedle array unit 4 of the fourth embodiment differs from the microneedle array unit 3 of the third embodiment in the shape of the case main body 50.

  As shown in FIG. 10, for example, the substantially rectangular case main body 50 can have a cut surface 64 at one corner unlike the other corners. The lid 40 can have, for example, a square shape having substantially the same shape as the case main body 50. The lid 40 is preferably welded to the projection 55 of the case main body 50. At a position corresponding to the cut surface 64 of the case main body 50, a part of the lid 40 can constitute a protrusion 40A that protrudes from the case main body 50. When peeling the lid 40 from the case main body 50, the protrusion 40A can function as, for example, a peeling knob. The protrusion 40A protrudes from the case main body 50, so the lid 40 may be easily grasped, and peeling of the lid 40 from the case main body 50 may be facilitated.

  In the fourth embodiment, the case main body 50 has the cut surface 64 at the corner, for example, so that a part of the substantially square lid 40 constitutes the protrusion 40A. However, the fourth embodiment is not limited to this, as long as the case main body 50 does not inhibit the grip of the lid 40. For example, the case main body 50 may have a substantially square shape without the cut surface 64, and the lid 40 may have a substantially square shape having the projecting portion 40A in part. The protrusion 40A protruding from the substantially square lid 40 can function as, for example, a knob.

Fifth Embodiment
The microneedle array unit 5 of the fifth embodiment will be described with reference to FIG. The same components as those in the first to fourth embodiments may be assigned the same reference numerals and descriptions thereof may be omitted. FIG. 11 is an exploded perspective view of the microneedle array unit 5. As shown in FIG. 11, the microneedle array unit 5 is composed of a microneedle array 20 and a container 30 for microneedle array. The container for microneedle array 30 comprises a lid 40 and a case main body 50.

  The micro needle array unit 5 of the fifth embodiment differs from the micro needle array unit 4 of the fourth embodiment in the configuration of the lid 40.

  As shown in FIG. 11, the lid 40 can have, for example, a three-layer structure. The lid 40 has, for example, a mixed resin layer 41, an aluminum layer 42, and a polyethylene terephthalate (PET) layer 43 from the first lid surface 40B opposite to the sheet portion 21 toward the opposite second lid surface 40C. Not limited to this. Although lid 40 can be manufactured by dry laminating mixed resin layer 41, aluminum layer 42, and PET layer 43, it is not restricted to this.

  The mixed resin layer 41 is preferably formed of a mixed resin in which a polyethylene resin and a polypropylene resin satisfying injection container grade are mixed. In order to improve the openability of the lid 40, for example, in the mixed resin layer 41, it is preferable to adjust the ratio of the polyethylene resin to 30% and the ratio of the polypropylene resin to 70%. The melting point of the mixed resin layer 41 is lower than the melting point of the PET layer 43 because polyethylene and polypropylene have lower melting points than PET. Therefore, when the lid 40 is welded to the case main body 50, only the mixed resin layer 41 can be selectively welded onto the convex portion 55 by appropriately adjusting the temperature.

  Although the lid 40 having a three-layer structure has been described as an example in the fifth embodiment, a lid having two or four or more layers may be used instead. Also in this case, it is preferable to form the layer of the first lid surface so that the melting point is lower than the layer of the second lid surface.

  The embodiments of the present invention have been described based on the first to fifth embodiments. However, it is not limited to these embodiments. Therefore, other combinations are acceptable without departing from the present invention.

1, 2, 3, 4, 5 microneedle array unit 20 microneedle array 21 sheet portion 22 one surface 22A outer peripheral surface 22B inner surface 22C imaginary line 23 other surface 24 needle portion 30 container for microneedle array 40 lid 40A protrusion portion 40B 1 lid surface 40C second lid surface 41 mixed resin layer 42 aluminum layer 43 polyethylene terephthalate (PET) layer 50 case main body 51 step difference 52 housing portion 53 peripheral portion 54 first recess 54A first opening 54B first bottom surface 54C first side surface 54D Opening end 55 Convex part 56 Second concave part 56A Second opening 56B Second bottom face 56C Second side face 58 Notched part 60 Gap 62 Third concave part 64 Cut surface H Height L1 Distance L2 Distance L3 Distance L3 Distance L4 Distance L5 Distance

Claims (11)

A microneedle array having a seat portion and a plurality of needle portions disposed inside an outer peripheral surface of one surface of the seat portion;
A case body having a receiving portion for receiving the microneedle array;
A lid covering the case body,
The storage unit is
A first opening, a first side, and a first bottom supporting the outer peripheral surface, wherein the distance from the first opening to the first bottom is shorter than the height of the needle portion, and the first side is the first side A first recess having a tapered shape that spreads from a first bottom surface toward the first opening;
The needle is disposed inside the first bottom and has a second opening, a second side, and a second bottom, and the distance from the second opening to the second bottom is longer than the height of the needle, and the needle A second recess for receiving the part;
A notch provided on a part of the first side surface and a part of the second side surface;
A microneedle array unit comprising:   The microneedle array unit according to claim 1, wherein the case body is provided on an outer periphery of an open end defining the first opening, and further having a convex portion higher than the open end.   The micro needle array unit according to claim 2, wherein a distance between the convex portion and the open end is less than 0.5 mm.   The microneedle array unit according to claim 2 or 3, wherein the notch is provided in a region where the distance between the open end and the convex portion is long.   The microneedle array unit according to any one of claims 2 to 4, further comprising a third recess between the open end and the protrusion.   The micro needle array unit according to any one of claims 2 to 5, wherein the lid is welded to the convex portion.   The microneedle array unit according to any one of claims 1 to 6, wherein a taper angle of the first side surface is 5 ° or more and 20 ° or less.   The distance between the first side and the outer edge of the microneedle array is shorter than the distance between the second side and the needle in a state where the outer peripheral surface is supported by the first bottom surface. The microneedle array unit according to any one of the above.   The microneedle array unit according to any one of claims 1 to 8, wherein the lid has a protrusion which protrudes from the case body.   The microneedle according to any one of claims 1 to 9, wherein the lid has a melting point lower than that of the second lid surface opposite to the first lid surface on the side opposite to the sheet portion. Array unit. A case body having a seat portion and a housing portion for housing a microneedle array having a plurality of needle portions disposed inside the outer peripheral surface of one surface of the seat portion;
A lid covering the case body,
The storage unit is
A first recess having a first opening, a first side surface, and a first bottom surface for supporting the outer circumferential surface, wherein the first side surface is tapered from the first bottom surface to the first opening. When,
A second recess disposed inside the first bottom surface and having a second opening, a second side surface, and a second bottom surface for receiving the needle portion;
A notch provided on a part of the first side surface and a part of the second side surface;
A container for microneedle array comprising:

Images