JP2018168177A5 - - Google Patents

Claims (6)

Composition for inhibiting the activity of matrix metalloproteinase MMP-1 in the skin, applied topically to the skin surface, in a synergistically effective ratio of amount of alkyl hydroxamic acid, its salt and / or its complex and glycol the saw including a quantity, the hydroxamic acid, its salts and / or complexes thereof has a carbon chain selected from chains and chains of 6 to 12 carbon atoms having 2 to 22 carbon atoms, the composition. The ratio of weight percent of hydroxamic acid, its salt and / or its complex to weight percent of glycol (weight percent is based on the weight of the whole composition) is about 1 to 1.4, about 1 to about 1 The composition according to claim 1, which is selected from 3, about 1-5. The skin surface is selected from the skin surface of the human face, the skin surface of the human hand, the skin surface of the human decoretage, the skin surface of the human ear, the skin surface of the human leg, and the skin surface of the human neck The composition according to claim 1 or 2, which is A composition according to any of the preceding claims, wherein the hydroxamic acid, its salt and / or its complex are synthesized from a natural oil. The glycol is propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, heptylene glycol, caprylyl glycol, glycerin, ethylhexylglycerin, 1,2-hexanediol, propanediol, methylpropanediol, sorbitol, resorcinol, The composition according to any one of claims 1 to 4 , which is selected from and mixtures thereof . A method for inhibiting the activity of matrix metalloproteinase MMP-1 in the skin, comprising a composition comprising a synergistically effective ratio of the amount of alkyl hydroxamic acid, its salt and / or its complex and the amount of glycol Topically applying to the method, wherein said hydroxamic acid, its salt and / or its complex has a carbon chain selected from a C.sub.2-22 chain and a C.sub.6-12 chain; Except the act).