JP2018165639A - Biological information acquisition device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a biological information acquisition device which realizes a reduction in size and can measure density of a target substance of a living body with excellent reliability.SOLUTION: A biological information acquisition device comprises a detection element embedded into a living body, and it is for acquiring information of a target substance in the living body. The detection element includes: an organic electroluminescence layer exciting excitation light; an indicator layer receiving the excitation light and emitting emission light according to density of the target substance in the living body; and a first light-receiving layer for receiving the emission light. The organic electroluminescence layer and the first light-receiving layer are included in a laminate laminated in a thickness direction of the organic electroluminescence layer and the first light-receiving layer. A light-emitting region emitting the excitation light of the organic electroluminescence layer and a first light-receiving region receiving the emission light of the first light-receiving layer include regions not overlapping with each other as viewed in the thickness direction.SELECTED DRAWING: Figure 3

Description

  Along with the recent improvement in health-consciousness, blood glucose, lactic acid levels, antibody levels, and enzyme levels in body fluids such as blood, interstitial fluid, saliva, and sweat in specific individuals are measured over time to improve health. Management is carried out.

  For example, for diabetics, measuring blood glucose levels over time (monitoring) is particularly important.

  Here, diabetic patients are classified into type I and type II depending on their symptoms, but both do not have normal insulin secretion from the pancreas, which prevents the body organs from taking glucose (glucose) normally, Metabolic abnormalities cause weight loss. Furthermore, if a high blood glucose level is maintained for a long time, serious symptoms such as “diabetic retinopathy”, “diabetic nephropathy”, “diabetic microangiopathy”, “diabetic neuropathy”, etc. It is known that complications will develop. In order to prevent the onset of such serious complications, patients with persistent hyperglycemia are treated with insulin to administer insulin by injection to maintain blood glucose levels within the normal range. is the current situation.

  Since patients with type I diabetes have no secretion of insulin due to pancreatic disease, they must measure blood sugar levels by blood sampling several times a day (minimum before meals and 4 times before going to bed) and administer insulin. As for the timing of administration, in order to suppress an excessive increase in postprandial blood glucose level, the blood glucose level before meal is measured, the calorie of the meal amount is calculated, the dose of insulin is determined, and injection is administered before meal . In addition, what is known as an increase in blood glucose level is a symptom called a “disease phenomenon”, and the blood glucose level increases at dawn 8 to 10 hours after going to bed. However, in order to cope with this physiological phenomenon, it is necessary to wake up once before dawn, measure blood sugar level by blood sampling, and administer insulin if blood sugar level is high.

  From the above, there is a need for a device that can measure blood glucose level at a desired timing. As this device, for example, using a blood glucose level sensor, the glucose concentration in a patient's blood or interstitial fluid can be measured using excitation light. Proposals have been made for measurement using a luminescent substance that emits fluorescence upon irradiation.

  As a basic principle of glucose quantitative measurement using this fluorescent substance, the fluorescent substance emits fluorescence having different wavelengths (peak wavelengths) when glucose is bonded and when glucose is not bonded. Therefore, irradiate the fluorescent material with excitation light, measure the emission intensity of the fluorescence emitted when the fluorescent substance is bound to glucose, and calculate the amount of glucose based on this emission intensity. Is possible. This is because it is possible to monitor the blood glucose level by using such a fluorescent substance.

  By the way, in recent years, as a measuring device that automatically monitors a blood glucose level, which is required to be measured at the timing as described above, over time (continuously) in order to improve the QOL of the patient and the patient's family. , Proposal of a device for the purpose of monitoring the glucose concentration in the interstitial fluid of a patient over a long period of time by embedding a blood glucose level sensor in the body (subcutaneous tissue), so-called continuous glucose monitor (CGM) device using a fluorescent substance Has been made.

  In this continuous glucose monitor (CGM) device, for example, glucose in an interstitial fluid using a fluorescent substance is obtained by placing the above-described film (sensor) containing the fluorescent substance in a subcutaneous tissue. It has been proposed to carry out concentration measurements over time (continuous) and automatically.

  For example, in Patent Document 1, the main body of the measuring device (reading device) is formed in a capsule shape as a whole, and a film containing a fluorescent substance (fluorescent indicator molecule) is provided on the outer periphery of the main body. And a measuring device configured to embed this body in the body (subcutaneous tissue), including a light source that irradiates the fluorescent material with excitation light and a light receiving unit (photodetector) that receives fluorescence emitted from the fluorescent material. Proposed.

  Moreover, in patent document 2, the main body of a measuring apparatus (fluorescence sensor), the fluorescent substance (indicator) which consists of hydrogel in the housing | casing, and the light source (light emitting element) which irradiates excitation light to a fluorescent substance And a light receiving unit (photoelectric conversion element) that receives the fluorescence emitted from the fluorescent substance, and a measuring apparatus configured to embed this body in the body has been proposed.

  However, in the measuring apparatus of the cited document 1, the light source and the light receiving unit are arranged along the surface direction on the substrate in the inside of the main body. There was a problem of inviting.

  Moreover, in the measuring apparatus of the cited document 2, the gel-like fluorescent material, the light source, and the light receiving unit are arranged in this order in the thickness direction of the housing, and the light source emits the fluorescent material. By setting the size to be included in the region, the light receiving unit can receive light emitted from the fluorescent material. However, in such a configuration, in a region where the light source and the light emitting region of the fluorescent material overlap, the light receiving unit cannot receive the light emission of the fluorescent material, and as a result, the light receiving unit emits light from the light source with high intensity. There is a problem that light cannot be received, that is, the glucose concentration cannot be measured with excellent reliability.

  In addition to such a problem, in addition to the measurement device (biological information acquisition device) that calculates the glucose concentration in the interstitial fluid based on the measured emission intensity of the fluorescent substance, the lactic acid value in the body fluid, the amount of antibody, This also occurs in a measuring apparatus (biological information acquisition apparatus) that calculates a target substance such as an enzyme amount based on the emission intensity of a fluorescent substance.

JP 2013-178258 A JP 2012-255707 A

  One of the objects of the present invention is to provide a biological information acquisition apparatus that can be miniaturized and can measure the concentration of a target substance in a living body with excellent reliability.

Such an object is achieved by the present invention described below.
The biological information acquisition apparatus of the present invention is a biological information acquisition apparatus that includes a detection element embedded in a living body, and obtains information on a target substance in the living body,
The detection element includes an organic electroluminescence layer that excites excitation light, and
An indicator layer that receives the excitation light and emits emitted light according to the concentration of the target substance in the living body;
A first light receiving layer for receiving the emitted light,
The organic electroluminescence layer and the first light receiving layer are included in a stacked body laminated in the thickness direction of the organic electroluminescence layer and the first light receiving layer,
A region where a light emitting region that emits the excitation light of the organic electroluminescence layer and a first light receiving region that receives the light emitted from the first light receiving layer do not overlap each other when viewed from the thickness direction. It is characterized by including.

  Thereby, miniaturization of the biological information acquisition device is realized, and the biological information acquisition device can measure the concentration of the target substance in the living body with excellent reliability.

  In the biological information acquiring apparatus of the present invention, it is preferable that the indicator layer is located on the organic electroluminescence layer side with respect to the laminate.

  At this time, the patterning of the light emitting region is applied to the organic electroluminescence layer. Since this patterning can be easily and finely performed on the organic electroluminescence layer, the patterning of the organic electroluminescence layer and the first layer is performed. It is possible to reduce the size of the stacked body in which the light receiving layer is stacked, and thus to reduce the size of the biological information acquisition device.

  In the biological information acquisition apparatus of the present invention, it is preferable that the detection element includes an optical filter that allows transmission of the emitted light between the indicator layer and the first light receiving layer.

  Thereby, since this optical filter allows the emitted light from the indicator layer to selectively pass through, the light emitting layer can be selectively received by the first light receiving layer.

  In the biological information acquisition apparatus of the present invention, it is preferable that the detection element includes an optical filter that allows transmission of the excitation light between the indicator layer and the organic electroluminescence layer.

  As a result, the optical filter allows the excitation light from the organic electroluminescence layer to selectively pass through, so that the indicator layer can be selectively irradiated with the excitation light.

  In the biological information acquisition apparatus of the present invention, it is preferable that the light emitting region and the first light receiving region do not overlap each other when viewed from the thickness direction.

  Such a configuration is realized by performing patterning of the first light receiving layer in addition to patterning of the organic electroluminescence layer. Thereby, it can prevent reliably that the area | region which overlaps with the organic electroluminescent layer of a 1st light reception layer stops functioning as a light reception area | region. For this reason, there is no useless light-receiving region in the first light-receiving layer. From this point of view, the biological information acquisition apparatus can measure the target substance with excellent reliability.

  In the biological information acquisition device of the present invention, the stacked body further receives the excitation light, which is arranged side by side with respect to the first light receiving layer along the surface direction of the organic electroluminescence layer. It is preferable that the second light receiving layer is included.

  As described above, the excitation light is received by the second light receiving layer, and the information on the target substance is calculated in consideration of the intensity of the excitation light. Therefore, the information on the target substance is measured with higher reliability. be able to.

  In the biological information acquisition apparatus of the present invention, it is preferable that the detection element includes an optical filter that allows transmission of the emitted light between the indicator layer and the second light receiving layer.

  Thereby, since this optical filter allows the excitation light from the organic electroluminescence layer to selectively pass through, the second light receiving element can selectively receive this excitation light. Therefore, the detection accuracy of excitation light by the second light receiving element can be improved.

  In the biological information acquiring apparatus of the present invention, the indicator layer preferably contains a boronic acid compound.

  When such a boronic acid compound is adjacent to glucose, a weak action is generated between the boronic acid compound and glucose, thereby generating a hydrogen-bonded intermolecular bond. As a result, since the fluorescence of the boronic acid compound (fluorescent substance) changes, the interstitial fluid is measured by measuring this fluorescence, that is, the intensity of fluorescence emitted when irradiated with the excitation light of the boronic acid compound. The glucose concentration in the medium can be calculated.

  In the biological information acquiring apparatus of the present invention, it is preferable that the information on the target substance is a glucose concentration in the living body.

  The biological information acquisition apparatus of the present invention is suitably applied to the calculation of the concentration of glucose as the target substance, and can measure the glucose concentration as the target substance with excellent reliability.

It is a perspective view showing typically a 1st embodiment of a living body information acquisition device of the present invention. It is a side view which shows the state which mounted | wore the skin with the detection element which 1st Embodiment of the biometric information acquisition apparatus of this invention has. It is a longitudinal cross-sectional view of the detection element shown in FIG. It is a longitudinal cross-sectional view which shows the 1st structure of the laminated body of the organic EL element with which the detection element shown in FIG. 3 is equipped, and a 1st light receiving element. It is a longitudinal cross-sectional view which shows the 2nd structure of the laminated body of the organic EL element with which the detection element shown in FIG. 3 is equipped, and a 1st light receiving element. It is a top view which shows the 1st pattern of the shape of the light emission surface of the organic EL element with which the detection element shown in FIG. 3 is provided, and the shape of the 1st light receiving surface of a 1st light receiving element. It is a top view which shows the 2nd pattern of the shape of the light emission surface of the organic EL element with which the detection element shown in FIG. 3 is provided, and the shape of the 1st light receiving surface of a 1st light receiving element. It is a top view which shows the 3rd pattern of the shape of the light emission surface of the organic EL element with which the detection element shown in FIG. 3 is provided, and the shape of the 1st light receiving surface of a 1st light receiving element. It is a top view which shows the 4th pattern of the shape of the light emission surface of the organic EL element with which the detection element shown in FIG. 3 is provided, and the shape of the 1st light receiving surface of a 1st light receiving element. It is a top view which shows the 5th pattern of the shape of the light emission surface of the organic EL element with which the detection element shown in FIG. 3 is provided, and the shape of the 1st light receiving surface of a 1st light receiving element. It is a top view which shows the 6th pattern of the shape of the light emission surface of the organic EL element with which the detection element shown in FIG. 3 is provided, and the shape of the 1st light receiving surface of a 1st light receiving element. It is a block diagram which shows the circuit structure of the biometric information acquisition apparatus shown in FIG. It is a flowchart which shows the measuring method which measures glucose concentration using the biometric information acquisition apparatus of 1st Embodiment. It is a longitudinal cross-sectional view which shows the detection element which 2nd Embodiment of the biometric information acquisition apparatus of this invention has. The seventh pattern of the shape of the light emitting surface of the organic EL element included in the detection element shown in FIG. 14, the shape of the first light receiving surface of the first light receiving element, and the shape of the second light receiving surface of the first light receiving element. FIG. The eighth pattern of the shape of the light emitting surface of the organic EL element provided in the detection element shown in FIG. 14, the shape of the first light receiving surface of the first light receiving element, and the shape of the second light receiving surface of the first light receiving element. FIG. The ninth pattern of the shape of the light-emitting surface of the organic EL element provided in the detection element shown in FIG. 14, the shape of the first light-receiving surface of the first light-receiving element, and the shape of the second light-receiving surface of the first light-receiving element FIG. The tenth pattern of the shape of the light emitting surface of the organic EL element included in the detection element shown in FIG. 14, the shape of the first light receiving surface of the first light receiving element, and the shape of the second light receiving surface of the first light receiving element. FIG. It is a block diagram which shows the circuit structure of 2nd Embodiment of the biometric information acquisition apparatus of this invention. It is a flowchart which shows the measuring method which measures glucose concentration using the biometric information acquisition apparatus of 2nd Embodiment.

  Hereinafter, the biological information acquisition apparatus of the present invention will be described in detail based on embodiments shown in the accompanying drawings.

  In addition, although the biological information acquisition apparatus 101 (measurement apparatus) of this invention is used in order to obtain the information of the target substance in the living body, in this embodiment, the biological information acquisition apparatus (measurement apparatus) of this invention. The glucose concentration in the interstitial fluid is continuously and automatically over a long period based on the intensity (fluorescence intensity) of the fluorescence (emitted light) emitted from the indicator layer 120 in contact with the interstitial fluid. A case where the present invention is applied to a continuous glucose monitor (CGM) device (implantable continuous blood glucose meter) to be monitored will be described as an example.

  That is, a case where the glucose concentration as information on the target substance in the living body is automatically measured with time using a continuous glucose monitor (CGM) device will be described as an example. In this continuous glucose monitor (CGM) device, the fluorescence contained in the indicator layer 120 emits (releases) fluorescence having a predetermined wavelength in accordance with the glucose concentration as information on the target substance in the living body. It is calculated by measuring the intensity of fluorescence (emission intensity) of the substance and using this intensity.

<Biological information acquisition device (measurement device)>
<< First Embodiment >>
First, a first embodiment of the biological information acquisition apparatus of the present invention will be described.

  FIG. 1 is a perspective view schematically showing a first embodiment of the biological information acquisition apparatus of the present invention, and FIG. 2 is a state in which the detection element of the first embodiment of the biological information acquisition apparatus of the present invention is attached to the skin. FIG. 3 is a longitudinal sectional view of the detection element shown in FIG. 2, and FIG. 4 is a first configuration of a laminate of the organic EL element and the first light receiving element included in the detection element shown in FIG. FIG. 5 is a longitudinal sectional view showing a second configuration of the laminate of the organic EL element and the first light receiving element included in the detection element shown in FIG. 3, and FIG. 6 is shown in FIG. FIG. 7 is a plan view showing a first pattern of the shape of the light emitting surface of the organic EL element included in the detection element and the shape of the first light receiving surface of the first light receiving element, and FIG. 7 shows the organic included in the detection element shown in FIG. FIG. 8 is a plan view showing a second pattern of the shape of the light emitting surface of the EL element and the shape of the first light receiving surface of the first light receiving element. FIG. 9 is a plan view showing a third pattern of the shape of the light-emitting surface of the organic EL element included in the detection element shown in FIG. 3 and the shape of the first light-receiving surface of the first light-receiving element, and FIG. 9 shows the detection element shown in FIG. FIG. 10 is a plan view showing a fourth pattern of the shape of the light emitting surface of the organic EL element included in FIG. 4 and the shape of the first light receiving surface of the first light receiving element, and FIG. 10 is an organic EL element included in the detection element shown in FIG. FIG. 11 is a plan view showing a fifth pattern of the shape of the light emitting surface and the shape of the first light receiving surface of the first light receiving element, and FIG. 11 shows the shape of the light emitting surface of the organic EL element included in the detection element shown in FIG. FIG. 12 is a block diagram showing a circuit configuration of the biological information acquisition apparatus shown in FIG. 1. FIG. In the following description, the upper side in FIGS. 2 to 5 is “upper”, the lower side is “lower”, the front side of the paper in FIGS. 6 to 11 is “upper”, and the rear side of the paper is “lower”. say. Moreover, the light emitting surface and the first light receiving surface in FIGS. 6 to 11 are hatched for convenience of explanation.

  As shown in FIGS. 1 and 2, the biological information acquisition apparatus 101 (optical sensor) calculates the glucose concentration by controlling the detection element 100 embedded in the dermis 502 (in vivo) and the operation of the detection element 100. Control unit 210, a monitor (display unit) 151 that displays a measurement value (glucose concentration) obtained by calculation by the control unit 210, and an operation unit 212 that performs each operation such as input. In the present embodiment, the control unit 210, the monitor 151, and the operation unit 212 included in the biological information acquisition apparatus 101 are provided in the main body 155, and the detection element 100 and the main body 155 are electrically connected via communication means. Has been.

  As shown in FIGS. 1 to 3, the entire detection element 100 included in the biological information acquisition apparatus 101 is used by being embedded (indwelled) in the dermis 502 (in vivo) of the skin.

  In this detection element 100, excitation light is irradiated from the inside of the casing 150 to the indicator layer 120 included in the casing 150, which will be described in detail later, by the organic EL element 320 in the casing 150. Then, the fluorescent material contained in the indicator layer 120 emits fluorescence by the excitation light, and the fluorescence (first light) is received by the first light receiving element 330 inside the housing 150.

  At this time, the wavelength (peak wavelength) of the fluorescence emitted from the fluorescent material is different when glucose is bonded to the fluorescent material and when it is not bonded. The intensity at the peak wavelength of the fluorescence emitted when glucose is bound to the fluorescent substance depends on the glucose concentration contained in the interstitial fluid contained in the dermis 502. That is, the fluorescence intensity of the fluorescent substance changes according to the glucose concentration. Therefore, the glucose concentration is calculated based on this intensity.

  The detection element 100 is disposed in a casing 150 whose overall shape is a capsule shape and a hollow portion included in the casing 150, and irradiates the indicator layer 120 included in the casing 150 with excitation light (second light). And a detector 300 that receives the fluorescence (first light) from the indicator layer 120.

  The case 150 has the detection unit 300 disposed in the hollow portion thereof, and prevents the detection unit 300 from coming into contact with the interstitial fluid when the detection element 100 is embedded in the dermis 502. Further, a part of the housing 150 is configured by the indicator layer 120.

  In this embodiment, the indicator layer 120 (sensor substance) forms a part of the housing 150 at a position facing an organic EL element 320 included in the detection unit 300 described later, and comes into contact with the interstitial liquid. . Then, upon receiving the excitation light irradiated from the organic EL element 320, glucose (target substance) contained in the interstitial liquid is combined to emit fluorescence having a specific wavelength (peak wavelength: first wavelength) ( And a fluorescent substance (signal substance) that emits fluorescence (emission light) at an intensity (fluorescence intensity) corresponding to the glucose concentration in the interstitial fluid.

  The fluorescent substance is not particularly limited as long as its fluorescence changes when glucose is bound. For example, 9, 10-bis [N- [2- (5,5-dimethylborinane- Boronate compounds such as 2-yl) benzyl] -N- [6 ′-[(acryloylpolyethyleneglycol-3400) carbonylamino] -n-hexylamino] methyl] -2-acetylanthracene (F-PEG-AAm) (Phenylboronic acid compound) is preferably included. When such a boronic acid compound (boron-based compound) is adjacent to glucose, a weak action is generated between the boronic acid compound and glucose, thereby generating a hydrogen-bonded intermolecular bond. As a result, since the fluorescence of the boronic acid compound (fluorescent substance) changes, the interstitial fluid is measured by measuring this fluorescence, that is, the intensity of fluorescence emitted when irradiated with the excitation light of the boronic acid compound. The glucose concentration in the medium can be calculated.

  The F-PEG-AAm emits fluorescence having a peak wavelength in the vicinity of about 480 nm or more and 490 nm or less when irradiated with excitation light of about 400 nm (particularly 405 nm). By measuring the intensity of fluorescence at a nearby wavelength, the glucose concentration in the interstitial fluid is calculated.

  As shown in FIG. 3, the detection unit 300 includes a substrate 310, an organic EL element 320 that emits excitation light, a first light receiving element 330 that receives fluorescence emitted from a fluorescent material by irradiation of excitation light, and a detection unit. 300, a temperature sensor 350 that measures the temperature, a power supply 360 that supplies electricity to each unit provided on the substrate 310 of the detection unit 300, a detection unit control unit 370 that drives each unit provided on the substrate 310, and a detection unit And a transceiver 380 that performs communication between the main body 155 and the main body 155.

  The substrate 310 (base substrate) supports the components constituting the detection unit 300, that is, the organic EL element 320, the first light receiving element 330, the temperature sensor 350, the power supply 360, the detection unit control unit 370, and the transceiver 380. It is. In addition, a circuit (not shown) is formed on the substrate 310, thereby electrically connecting each unit constituting the detection unit 300.

  The organic EL element 320 (organic electroluminescence element) emits fluorescence or phosphorescence as excitation light, and thereby irradiates the indicator layer 120 included in the detection element 100 with excitation light.

  The organic EL element 320 irradiates the indicator layer 120 with excitation light including a wavelength at which the fluorescent material included in the indicator layer 120 emits fluorescence. The excitation light emitted from the organic EL element 320 may include any of infrared light, visible light, and ultraviolet light.

  In the present embodiment, light including the peak wavelength of excitation light (second light) is transmitted (transmitted) on the light emitting surface of the organic EL element 320, that is, between the indicator layer 120 and the organic EL element 320. An optical filter 325 such as a high-pass filter, a low-pass filter or a band-pass filter is provided. As a result, the optical filter 325 allows light including the peak wavelength of the excitation light (second light) from the organic EL element 320 to pass through, so that this light is applied to the fluorescent material included in the indicator layer 120. Can be irradiated.

  The first light receiving element 330 receives the fluorescence (first light) emitted from the fluorescent material when the indicator layer 120 is irradiated with the excitation light, and measures the intensity (first intensity) of the fluorescence. belongs to.

  The first light receiving element 330 is not particularly limited and includes, for example, a photodiode, a phototransistor, a photoconductive cell, an image sensor, and the like, and is preferably a photodiode. In the case of a photodiode, the photosensitive surface of the first light receiving element 330 can be easily patterned. Therefore, as described in detail later, the photosensitive of the first light receiving element 330 that does not overlap the light emitting surface 321 of the organic EL element 320. A reliable surface can be formed. Since such an effect can be obtained particularly in a PIN type photodiode, a case where the first light receiving element 330 is formed of a PIN type photodiode will be described below as an example.

  In the present embodiment, the peak of the fluorescence (first light) emitted from the fluorescent material on the photosensitive surface of the first light receiving element 330, that is, between the indicator layer 120 and the first light receiving element 330. An optical filter 335 such as a high-pass filter, a low-pass filter, or a band-pass filter that allows passage of light including a wavelength is provided. The optical filter 335 is preferably one that cuts light including the peak wavelength of excitation light (second light). As a result, the optical filter 335 allows light including the peak wavelength of fluorescence (first light) from the indicator layer 120 to be selectively transmitted. The light receiving element 330 can receive light. Therefore, the detection accuracy of fluorescence (first light) by the first light receiving element 330 is improved.

  As described above, the organic EL element 320 that emits fluorescence as excitation light (second light) and the first light receiving element 330 that receives fluorescence (first light) from the indicator layer 120 include: In the present embodiment, as shown in FIGS. 3 to 5, a stacked body is configured in which the organic EL element 320 is on the indicator layer 120 (housing 150) side and the first light receiving element 330 is on the substrate 310 side. ing.

In such a stacked body, the region A in which the light emitting region of the excitation light of the organic EL element 320 and the light receiving region of the first light receiving element 330 do not overlap each other when viewed from the thickness direction of the stacked body (in plan view). ₀ is included (see FIGS. 4 and 5). Thereby, the function of the organic EL element 320 and the first light receiving element 330 in the detection element 100, that is, the function of the organic EL element 320 that irradiates the indicator layer 120 with excitation light, and the fluorescence emitted by the indicator layer 120 are obtained. Both functions of the first light receiving element 330 that receives light can be surely exhibited.

  Thus, when it is set as the structure containing the area | region which does not mutually overlap when it sees from the thickness direction of a laminated body, the light emission area | region of the excitation light of the organic EL element 320, and the light reception area | region of the 1st light receiving element 330, In the laminated body in which the organic EL element 320 is on the indicator layer 120 (housing 150) side and the first light receiving element 330 is on the substrate 310 side, a part of the light receiving region of the first light receiving element 330 is the organic EL element 320 side. Examples include a first configuration that overlaps the light emission region of excitation light, and a second configuration in which the light emission region of excitation light of the organic EL element 320 and the light reception region of the first light receiving element 330 do not overlap each other.

  In the first configuration and the second configuration, the organic EL element 320 provided with the optical filter 325 and the first light receiving element 330 provided with the optical filter 335 are organic through an adhesive layer 80. The EL element 320 is stacked on the indicator layer 120 (housing 150) side, and the first light receiving element 330 is stacked on the substrate 310 side. Hereinafter, the configurations of the organic EL element 320 and the first light receiving element 330 in the first configuration and the second configuration will be described, respectively.

[First configuration]
As shown in FIG. 4, the organic EL element 320 includes a reflective layer 31, an anode 32, a hole injection layer 33, a light emitting layer 34, an electron transport layer 35, and a cathode 36. And the laminated body 30 by which these were laminated | stacked in this order from the board | substrate 310 side is provided on the board | substrate 20, and is sealed with the sealing member 40. FIG. The organic EL element 320 may have either a top emission structure or a bottom emission structure, but FIG. 4 shows a case where the organic EL element 320 has a top emission structure.

Reflective layer 31
The reflective layer 31 reflects the fluorescence or phosphorescence emitted from the light emitting layer 34 as excitation light to the indicator layer 120 side located above the organic EL element 320 without transmitting it to the first light receiving element 330 side. It's a thing. By providing the reflective layer 31 in the stacked body 30, it is possible to improve the irradiation efficiency of the excitation light on the indicator layer 120 and to appropriately suppress or prevent the generation of noise in the first light receiving element 330. it can.

  Examples of the reflective layer 31 include thin layers of various metals such as aluminum, gold, silver, copper, copper alloy, iron, iron alloy, and nickel.

・ Anode 32
The anode 32 is an electrode that injects holes into the hole injection layer 33.

Examples of the constituent material of the anode 32 include ITO (Indium Tin Oxide), IZO (Indium Zinc Oxide), In ₂ O ₃ , SnO ₂ , fluorine-added SnO ₂ , Sb-added SnO ₂ , ZnO, Al-added ZnO, and Ga-added. Examples thereof include metal oxides such as ZnO, Au, Pt, Ag, Cu, and alloys containing these, and one or more of these can be used in combination.

  The average thickness of the anode 32 is not particularly limited, but is preferably about 10 nm to 200 nm, and more preferably about 30 nm to 150 nm.

  In addition, when the organic EL element 320 is an organic EL element 320 having a bottom emission structure, the anode 32 is required to have light transmittance. Therefore, among the above-described constituent materials, a metal oxide having light transmittance is preferable. Used.

-Hole injection layer 33
The hole injection layer 33 has a function of facilitating hole injection from the anode 32. Thereby, the luminous efficiency of the organic EL element 320 can be improved. Here, the hole injection layer 33 also has a function of transporting holes injected from the anode 32 to the light emitting layer 34 (that is, has a hole transport property). Therefore, it can also be said that the hole injection layer 33 is a hole transport layer.
The hole injection layer 33 includes a material having a hole injection property (hole injection material).

  The hole injecting material contained in the hole injecting layer 33 is not particularly limited. For example, copper phthalocyanine, 4,4 ′, 4 ″ -tris (N, N-phenyl-3-methylphenylamino) And amine-based materials such as triphenylamine (m-MTDATA) and N, N′-bis- (4-diphenylamino-phenyl) -N, N′-diphenyl-biphenyl-4-4′-diamine.

  Among these, as the hole injecting material contained in the hole injecting layer 33, it is preferable to use an amine-based material from the viewpoint of excellent hole injecting property and hole transporting property, and a diaminobenzene derivative, a benzidine derivative (benzidine) A material having a skeleton), a triamine compound having both a “diaminobenzene” unit and a “benzidine” unit in the molecule, and a tetraamine compound (specifically, for example, those represented by the following formulas HIL-1 to HIL-27): It is more preferable to use such a compound.

  The average thickness of the hole injection layer 33 is not particularly limited, but is preferably about 5 nm to 90 nm and more preferably about 10 nm to 70 nm.

  The hole injection layer 33 can be omitted depending on the combination of the types of constituent materials of the anode 32 and the light emitting layer 34 constituting the organic EL element 320 and the film thickness thereof.

・ Light emitting layer 34 (organic electroluminescence layer)
The light emitting layer 34 (organic EL layer) includes a light emitting material that emits fluorescence or phosphorescence as excitation light, and emits excitation light by applying a voltage between the anode 32 and the cathode 36 (excitation). It is a layer to do.

  The constituent material (light emitting material) of the light emitting layer 34 is not particularly limited, but when a boronic acid compound such as F-PEG-AAM is used as the fluorescent substance contained in the indicator layer 120, excitation of about 400 nm is performed. When irradiated with light, it emits fluorescence having a peak wavelength in a wavelength range of about 480 nm to 490 nm. Therefore, as the constituent material of the light emitting layer 34, a material that emits excitation light having a peak wavelength of about 400 nm is preferably used.

  Examples of the constituent material of the light emitting layer 34 include spirobifluorene compounds, polyphenyl compounds such as p-quarterphenyl, phenylene vinylene polymers, 4,4′-bis (9-carbazoyl) biphenyl, and the like. Among them, among them, a spirobifluorene compound is preferable. Since the spirobifluorene compound is a thermally stable compound, it is preferably used as a constituent material (light-emitting material) of the light-emitting layer 34, and the heat resistance of the light-emitting layer 34 can be improved.

  Examples of the spirobifluorene compound include those represented by the following general formula (1), and specifically, 1,3-bis (9,9′-spiro represented by the following formula (1A). -Fluoren-2-yl) benzene is preferably used.

［一般式（１）中、Ｒは炭素数１〜８のアルキル基を表し、各Ｘは、それぞれ独立して、水素原子、ハロゲン原子、シアノ基および炭素原子数１〜８のアルキル基のうちのいずれかを表し、ｎは、２〜６の整数を表し、ｍは、０〜４の整数を表す。ただし、ｎ＋ｍは６であり、Ｒが複数ある場合は、それらは同一であっても、異なっていてもよい。］

[In General Formula (1), R represents an alkyl group having 1 to 8 carbon atoms, and each X independently represents a hydrogen atom, a halogen atom, a cyano group, or an alkyl group having 1 to 8 carbon atoms. N represents an integer of 2 to 6, and m represents an integer of 0 to 4. However, n + m is 6, and when there are a plurality of R, they may be the same or different. ]

  When 1,3 bis (9,9′-spiro-fluoren-2-yl) benzene represented by the formula (1A) is used as the light emitting material, the light emitting layer 34 has a peak wavelength of 405 nm as excitation light. The excitation light is emitted to the indicator layer 120.

Moreover, the light emitting layer 34 may contain the host material which uses the light emitting material mentioned above as a guest material. Examples of the host material include acene-based materials such as distyrylarylene derivatives, naphthacene derivatives, anthracene derivatives, perylene derivatives, distyrylbenzene derivatives, distyrylamine derivatives, bis (2-methyl-8-quinolinolato) (p- Phenylphenolato) aluminum (BAlq), quinolinolato-based metal complexes such as tris (8-quinolinolato) aluminum complex (Alq ₃ ), triarylamine derivatives such as tetraphenylamine tetramers, oxadiazole derivatives, rubrene and the like Derivatives, silole derivatives, dicarbazole derivatives, oligothiophene derivatives, benzopyran derivatives, triazole derivatives, benzoxazole derivatives, benzothiazole derivatives, quinoline derivatives, 4,4'-bis (2,2'-diphenylvinyl) And carbazole derivatives such as biphenyl (DPVBi), 3-phenyl-4- (1′-naphthyl) -5-phenylcarbazole, 4,4′-N, N′-dicarbazole biphenyl (CBP), and the like. Among them, one kind can be used alone or two or more kinds can be used in combination.

  When such a guest material and host material are used, the content (dope amount) of the guest material in the light emitting layer 34 is about 0.1% or more and 20% or less by weight ratio with respect to the host material. It is more preferable that it is about 0.5% or more and 10% or less. Luminous efficiency can be optimized by setting the content of the guest material in such a range.

  The average thickness of the light emitting layer 34 is not particularly limited, but is preferably about 10 nm or more and 150 nm or less, and more preferably about 20 nm or more and 100 nm or less.

-Electron transport layer 35
The electron transport layer 35 has a function of transporting electrons injected from the cathode 36 to the light emitting layer 34.

Examples of the constituent material (electron transporting material) of the electron transport layer 35 include phenanthroline derivatives such as 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline (BCP), and tris (8-quinolinolato) aluminum. Quinoline derivatives such as organometallic complexes having 8-quinolinol or a derivative thereof such as (Alq ₃ ) as a ligand, azaindolizine derivatives, oxadiazole derivatives, perylene derivatives, pyridine derivatives, pyrimidine derivatives, quinoxaline derivatives, diphenylquinone Examples include derivatives, nitro-substituted fluorene derivatives, and acene-based materials such as anthracene-based materials, and one or more of these can be used in combination.

  Among these, as the electron transporting material used for the electron transport layer 35, it is preferable to use a compound having an anthracene skeleton. Further, it is preferable to use a nitrogen-containing compound having a nitrogen atom in the skeleton, such as a phenanthroline derivative and a phenanthroline derivative. In view of these, it is particularly preferable to use an azaindolizine compound having both an azaindolizine skeleton and an anthracene skeleton in the molecule (hereinafter also simply referred to as “azaindolizine compound”). Thereby, electrons can be efficiently transported and injected into the light emitting layer 34. As a result, the light emission efficiency of the organic EL element 320 can be increased.

  Examples of the azaindolizine compounds include compounds represented by the following formulas ETL1-1 to 24, compounds represented by the following formulas ETL1-25 to 36, and compounds represented by the following formulas ETL1-37 to 56. Is preferably used.

  Further, the average thickness of the electron transport layer 35 is preferably about 1 nm to 50 nm, and more preferably about 5 nm to 30 nm.

  Note that the electron transport layer 35 may be omitted depending on the combination of constituent materials of the cathode 36 and the light emitting layer 34.

・ Cathode 36
The cathode 36 is an electrode that injects electrons into the electron transport layer 35.
Examples of the constituent material of the cathode 36 include Li, Mg, Ca, Sr, La, Ce, Er, Eu, Sc, Y, Yb, Ag, Cu, Al, Cs, Rb, and alloys containing these. These can be used alone or in combination of two or more thereof (for example, as a multi-layer laminate, a multi-layer mixed layer, or the like).

  When the organic EL element 320 has a top emission structure as in this embodiment, it is preferable to use a metal or alloy such as MgAg, MgAl, MgAu, AlAg as the constituent material of the cathode 36. By using such a metal or alloy as a constituent material of the cathode 36, it is possible to improve the electron injection efficiency and stability of the cathode 36 while maintaining the light transmittance of the cathode 36.

  Further, when the organic EL element 320 has a bottom emission structure, the cathode 36 is not required to have light transmittance, and examples of the constituent material of the cathode 36 include metals such as Al, Ag, AlAg, AlNd, and alloys. Is preferably used. By using such a metal or alloy as the constituent material of the cathode 36, the electron injection efficiency and stability of the cathode 36 can be improved. Further, the cathode 36 can also be given a function as a reflective layer.

The average thickness of the cathode 36 is not particularly limited, but is preferably about 1 nm to 50 nm and more preferably about 5 nm to 20 nm.
An arbitrary layer is provided between the anode 32, the hole injection layer 33, the light emitting layer 34, the electron transport layer 35, and the cathode 36 of the organic EL element 320 (laminated body 30) having such a configuration. Also good.

・ Substrate 20
The substrate 20 supports the stacked body 30. The substrate 20 is substantially transparent (colorless transparent, colored transparent, or translucent) in order to guide the fluorescence from the indicator layer 120 to the first light receiving element 330.

  Examples of the constituent material of the substrate 20 include resin materials such as polyethylene terephthalate, polyethylene naphthalate, polypropylene, cycloolefin polymer, polyamide, polyether sulfone, polymethyl methacrylate, polycarbonate, and polyarylate, quartz glass, and soda glass. Such glass materials can be used, and one or more of these can be used in combination.

  The average thickness of the substrate 20 is not particularly limited, but is preferably about 0.1 mm or more and 30 mm or less, and more preferably about 0.1 mm or more and 10 mm or less.

・ Sealing member 40
The sealing member 40 is provided so as to cover the substrate 20 and the laminate 30, and has a function of hermetically sealing them and blocking oxygen and moisture. By providing the sealing member 40, effects such as improvement of the reliability of the organic EL element 320 and prevention of deterioration / deterioration (improvement of durability) can be obtained.

  Examples of the constituent material of the sealing member 40 include Al, Au, Cr, Nb, Ta, Ti, alloys containing these, silicon oxide, various resin materials, and the like. In addition, when using the material which has electroconductivity as a constituent material of the sealing member 40, in order to prevent a short circuit, an insulating film is provided between the sealing member 40 and the laminated body 30 as needed. It is preferable to provide it.

  In the organic EL element 320 having such a configuration, the laminated body 30 in which the reflective layer 31, the anode 32, the hole injection layer 33, the light emitting layer 34, the electron transport layer 35, and the cathode 36 are laminated as described above is formed. In the thickness direction, the region where the laminate 30 (the light emitting layer 34) is formed constitutes a light emitting region that emits excitation light.

  In the present embodiment, as shown in FIG. 4, the first light receiving element 330 includes a lower electrode 61, a semiconductor layer 62, and an upper electrode 63, which are stacked in this order from the substrate 310 side. Is a PIN type photodiode provided on the substrate 50 and sealed with a sealing member 70.

・ Lower electrode 61
The lower electrode 61 is an electrode that receives carriers (holes or electrons) from the semiconductor layer 62.
Examples of the constituent material of the lower electrode 61 include Mo.

  The average thickness of the lower electrode 61 is not particularly limited, but is preferably about 10 nm to 200 nm, and more preferably about 30 nm to 150 nm.

・ Semiconductor layer 62
The semiconductor layer 62 is a layer through which current flows by receiving fluorescence (emitted light) from the indicator layer 120, that is, a light receiving layer (first light receiving layer) through which generated carriers flow.

  Such a semiconductor layer 62 is formed of a PIN-type stacked body including an n + layer, an i layer, and a p + layer, which are sequentially stacked from the lower electrode 61 side.

  In this stacked body, the n + layer and the p + layer are both made of, for example, amorphous silicon, the n + layer has holes as carriers, and the p + layer has electrons as carriers. The i layer is made of, for example, microcrystal silicon.

  The semiconductor layer 62 may be formed by stacking a p + layer, an i layer, and an n + layer in this order from the lower electrode 61 side.

  Further, the average thickness of the semiconductor layer 62 is not particularly limited, but is preferably about 10 nm to 150 nm, and more preferably about 20 nm to 100 nm.

-Upper electrode 63
The upper electrode 63 is an electrode that receives carriers (electrons or holes) from the semiconductor layer 62. When the lower electrode 61 receives electrons, the upper electrode 63 receives holes, and when the lower electrode 61 receives holes, the upper electrode 63 receives electrons.

Examples of the constituent material of the upper electrode 63 include oxides such as ITO (Indium Tin Oxide), IZO (Indium Zinc Oxide), In ₂ O ₃ , SnO ₂ , Sb-containing SnO ₂ , and Al-containing ZnO. One or more of these can be used in combination.

  The average thickness of the upper electrode 63 is not particularly limited, but is preferably about 1 nm to 50 nm and more preferably about 5 nm to 20 nm.

・ Substrate 50
The substrate 50 supports the stacked body 60.

  Examples of the constituent material of the substrate 50 include resin materials such as polyethylene terephthalate, polyethylene naphthalate, polypropylene, cycloolefin polymer, polyamide, polyethersulfone, polymethyl methacrylate, polycarbonate, and polyarylate, quartz glass, and soda glass. Such glass materials can be used, and one or more of these can be used in combination.

  The average thickness of the substrate 50 is not particularly limited, but is preferably about 0.1 mm to 30 mm, and more preferably about 0.1 mm to 10 mm.

-Sealing member The sealing member 70 is provided so that the laminated body 60 may be covered, and has a function which airtightly seals the laminated body 60, and interrupts | blocks oxygen and a water | moisture content. By providing the sealing member 70, it is possible to obtain effects such as improvement in reliability of the first light receiving element 330 and prevention of deterioration / deterioration (improvement in durability).

  Examples of the constituent material of the sealing member 70 include Al, Au, Cr, Nb, Ta, Ti, alloys containing these, silicon oxide, various resin materials, and the like. In addition, when using the material which has electroconductivity as a constituent material of the sealing member 70, in order to prevent a short circuit, an insulating film is provided between the sealing member 70 and the laminated body 60 as needed. It is preferable to provide it.

In the first light receiving element 330 having such a configuration, the stacked body 60 in which the lower electrode 61, the semiconductor layer 62, and the upper electrode 63 are stacked as described above is configured, and the stacked body 60 (semiconductor) is formed in the thickness direction. The layer 62) has a function of receiving fluorescence (first light) from the indicator layer 120, but in the stacked body 60 of the first light receiving element 330, the region A ₀ that does not overlap with the stacked body 30 of the organic EL element 320. However, the fluorescence from the indicator layer 120 can reach the stacked body 60 of the first light receiving elements 330. Therefore, the region A _{0 of} the stacked body 60 that does not overlap the stacked body 30 constitutes a light receiving region that receives the fluorescence from the indicator layer 120.

[Second configuration]
In the second configuration, the organic EL element 320 has the same configuration as the organic EL element 320 of the first configuration, whereas the first light receiving element 330 has the first light reception of the first configuration. The structure is different from that of the element 330.

  That is, in the second configuration, the first light receiving element 330 includes the stacked body 60 as in the first light receiving element 330 of the first configuration, but the formation region in the thickness direction is different. Except for the above, the configuration is the same as the first light receiving element 330 of the first configuration.

Specifically, in the second configuration, as shown in FIG. 5, in the first light receiving element 330, the stacked body 60 is formed with the stacked body 30 of the organic EL elements 320 in the thickness direction. region A1 are selectively formed on the substrate 50 so as not to overlap with the (light emission region), by which the whole of the stack 60 region a ₀ where (semiconductor layer 62) is formed from the indicator layer 120 A light receiving region (first light receiving region) for receiving the fluorescence of the light.

As described above, the organic EL element 320 (light emitting layer 34 (organic electroluminescence layer)) and the first light receiving element 330 (semiconductor layer 62 (first light receiving layer)) are stacked in the thickness direction. In the stacked body, the functions of both the organic EL element 320 and the first light receiving element 330 are exhibited because the organic EL element 320 emits excitation light and the first light receiving element 330 has fluorescence ( This is realized by including a region A ₀ that does not overlap each other when viewed from the thickness direction of the stacked body. This is a stacked body in which an organic EL element 320 (light emitting layer 34 (organic electroluminescence layer)) and a first light receiving element 330 (semiconductor layer 62 (first light receiving layer)) are stacked in the thickness direction. On the other hand, the indicator layer 120 is positioned on the organic EL element 320 side. At this time, the stacked body 30 (the light emitting layer 34) included in the organic EL element 320 is patterned in both the first configuration and the second configuration. By doing so, the stacked body 30 included in the organic EL element 320 and the stacked body 60 included in the first light receiving element 330 are configured to include a region that does not overlap each other. Then, the patterning of the stacked body 30, that is, the patterning of the light emitting region can be easily and finely implemented by applying it to the organic EL element 320 as a light emitting element that emits excitation light. And the first light receiving element 330 can be reduced in size, and thus the detection element 100 (biological information acquisition apparatus 101) can be reduced in size. In addition, since the laminated body 30 included in the organic EL element 320 can be finely patterned (processed), a light emitting region that emits excitation light (second light) and light reception that receives fluorescence (first light). Since both areas can be sufficiently secured, the detection element 100 (biological information acquisition apparatus 101) can measure the glucose concentration with excellent reliability.

Further, in the second configuration, in addition to the patterning of the stacked body 30 included in the organic EL element 320, the patterning of the stacked body 60 included in the first light receiving element 330 is further performed, thereby the first light receiving element. It is set so that the stacked body 60 included in 330 and the stacked body 30 included in the organic EL element 320 do not overlap. Thus, regions A ₁ overlapping the laminate 30 of the stacked body 60 can be reliably prevented from being wasted as a light-receiving region. For this reason, in the stacked body 60 of the first light receiving elements 330, there is no useless light receiving region, and from this point of view, the detection element 100 (biological information acquisition apparatus 101) can be used to increase the glucose concentration with excellent reliability. It can be measured. Further, the patterning of the stacked body 60, that is, the patterning of the light receiving region can be easily and finely implemented by applying the patterning of the light receiving region to the PIN photodiode as the first light receiving element 330. In particular, a PIN photodiode is preferably used as the first light receiving element 330.

  In the second configuration, the stacking order of the organic EL element 320 and the first light receiving element 330 is the same as described above except that the organic EL element 320 is on the indicator layer 120 side, and the top and bottom are switched. One light receiving element 330 may be on the indicator layer 120 side.

  By making the laminate in which the organic EL element 320 and the first light receiving element 330 are laminated into the first configuration and the second configuration as described above, a light emission region of excitation light of the organic EL element 320, The light receiving region of the first light receiving element 330 may have a region that does not overlap with each other when viewed from the thickness direction of the stacked body. At this time, when viewed from the thickness direction (plan view), a region where the light emitting region of the organic EL element 320 does not overlap is defined as a light emitting surface 321, and a region where the light receiving region of the first light receiving element 330 does not overlap is first. Assuming that the light receiving surface 331 is used, the shape of the light emitting surface 321 and the shape of the first light receiving surface 331 are not particularly limited, and examples thereof include the following first to sixth patterns.

  That is, in the first pattern, as shown in FIG. 6, a light emitting surface 321 having one rectangular shape (line shape) and a first light receiving surface 331 having one rectangular shape (line shape) are mutually connected. They are arranged in parallel with the long sides facing each other.

  In the second pattern, as shown in FIG. 7, a plurality of strip-shaped (line-shaped) light-emitting surfaces 321 and a plurality of strip-shaped first light-receiving surfaces 331 are alternately arranged with each other. Are arranged in parallel so that their long sides are opposed to each other.

  In the third pattern, as shown in FIG. 8, four circular light emitting surfaces 321 are arranged at equal intervals in two rows and two columns (grid shape), and a quadrangle formed by these four light emitting surfaces 321 ( A first light-receiving surface 331 having a cross shape is disposed at the center of the square.

  In the fourth pattern, as shown in FIG. 9, the first light-receiving surface 331 having four circular shapes is arranged in two rows and two columns (grid shape) at equal intervals, which is opposite to the third pattern. A light emitting surface 321 having a cross shape is arranged at the center of a quadrangle (square) formed by these four first light receiving surfaces 331.

  In the fifth pattern, as shown in FIG. 10, one annular light emitting surface 321 is arranged so as to surround the outer periphery of one circular first light receiving surface 331.

  Further, in the sixth pattern, as shown in FIG. 11, the first pattern has an annular shape so as to surround the outer periphery of the light emitting surface 321 having one circular shape, which is opposite to the fifth pattern. A light receiving surface 331 is disposed.

  Note that in the third to sixth patterns, the combination of the light emitting surface 321 and the first light receiving surface 331 is not one set as described above, but a plurality of combinations of the organic EL element 320 and the first light receiving element 330. May be provided in a laminated body in which and are laminated.

  Among the first to sixth patterns as described above, in the first and second patterns, the light emitting surface 321 and the first light receiving surface 331 form a line shape and have a simple shape. Therefore, these patterning, that is, formation of the stacked body 30 and the stacked body 60 in the organic EL element 320 and the first light receiving element 330 can be easily performed.

  In the second pattern, since the light emitting surfaces 321 and the first light receiving surfaces 331 having a plurality of lines are alternately arranged, excitation light having uniform intensity is emitted from the plurality of light emitting surfaces 321. Can do. Therefore, the fluorescence of the indicator layer 120 that emits light upon receiving this excitation light also has a uniform intensity, and furthermore, the fluorescence having this uniform intensity can be uniformly received by the plurality of first light receiving surfaces 331. .

  In the fifth and sixth patterns, one of the light emitting surface 321 and the first light receiving surface 331 has a circular shape, and the other has an annular shape, and has a relatively simple shape. Therefore, these patterning, that is, formation of the stacked body 30 and the stacked body 60 in the organic EL element 320 and the first light receiving element 330 can be easily performed. In particular, in the sixth pattern, the light emitting surface 321 has a circular shape and a simpler shape, so that the stacked body 30 in the organic EL element 320 can be formed more easily.

  Furthermore, in the fifth pattern, the first light receiving surface 331 having a circular shape is disposed inside the light emitting surface 321 having an annular shape, and thus the light receiving efficiency of the fluorescence from the indicator layer 120 is improved. Therefore, even if the intensity of the excitation light from the light emitting surface 321 is relatively low, the fluorescence from the indicator layer 120 can be reliably received by the first light receiving surface 331.

  In the sixth pattern, the first light receiving surface 331 having an annular shape is arranged outside the light emitting surface 321, and it is easy to increase the area of the first light receiving surface 331 by design. The area of the first light receiving surface 331 can be set according to the sensitivity required for the light receiving element 330.

As described above, the biological information acquisition apparatus 101 of the present invention includes the detection element 100 embedded in the living body and is used to obtain information on the target substance in the living body. A light emitting layer 34 (organic electroluminescence layer) that excites the light, an indicator layer 120 that receives the excitation light and emits light according to the concentration of the target substance in the living body, and a semiconductor layer 62 (for receiving the light emitted). The light emitting layer 34 (organic electroluminescence layer) and the semiconductor layer 62 (first light receiving layer) are stacked in the thickness direction of the light emitting layer 34 and the semiconductor layer 62. A region A ₀ that is included in the stack and in which the light emitting region that emits the excitation light of the light emitting layer 34 and the first light receiving region that receives the light emitted from the semiconductor layer 62 do not overlap each other when viewed from the thickness direction. The It is characterized by including. The biological information acquisition apparatus according to the present invention has such a configuration, so that the biological information acquisition apparatus can be downsized, and the biological information acquisition apparatus can measure the concentration of the target substance in the living body with excellent reliability. Can and can be.

  The temperature sensor 350 measures the temperature inside the detection unit 300, that is, the housing 150, and detects the ambient temperature when measuring the glucose concentration.

  The temperature sensor 350 is not particularly limited, and an example is a thermistor.

  The power supply 360 is for supplying electricity to each part of the detection unit 300 when measuring the glucose concentration.

  The power source 360 is preferably a self-contained power source that self-contains electricity when measuring the glucose concentration. The self-contained power source is not particularly limited. For example, an inductor through which current flows by electromagnetic induction, a piezoelectric element through which current flows by supplying mechanical energy, and current by applying vibration such as ultrasonic waves are applied. The drive generator etc. which flow is mentioned.

  The transceiver 380 constitutes a communication unit that realizes an electrical connection between the detection element 100 and the main body 155 by a transceiver (not shown) that the main body 155 can have.

  The transceiver 380 is preferably composed of an inductor. Thereby, communication between the detection element 100 and the main body 155 is reliably performed.

  The detection unit control unit 370 is configured by combining, for example, a CPU, a memory, and the like. The operation of each unit provided on the substrate 310 of the detection unit 300, that is, the entire operation of the detection element 100 embedded in the dermis 502 To control.

  Specifically, an organic EL element driving unit 370A that controls driving of the organic EL element 320 and a first light receiving driving unit 370B that controls driving of the first light receiving element 330 are provided.

  In the detection unit control unit 370 having such a configuration, first, the organic EL element 320 is used to irradiate the indicator layer 120 which is a part of the housing 150 with excitation light by the operation of the organic EL element driving unit 370A. Then, by the operation of the first light receiving drive unit 370B, the first light receiving element 330 receives the fluorescence emitted from the fluorescent material by the excitation light irradiation, whereby the intensity (first light) of the fluorescence (first light) is received. ) And then transmitted to the control unit 210 via the transceiver 380.

  The depth at which the detection element 100 is embedded (detained) in the dermis 502 is usually set such that the distance from the epidermis 501 is preferably about 1 mm to 10 mm, more preferably about 2 mm to 4 mm.

  The control unit 210 is provided in the main body 155, and is configured by combining, for example, a CPU, a memory, and the like. The overall operation of the information acquisition apparatus 101 is controlled.

  As illustrated in FIG. 12, the control unit 210 includes a storage unit 261, a detection unit drive unit 400 that drives each unit of the detection unit 300, a data display instruction unit 299, and a calculation unit 200.

  The storage unit 261 controls the glucose concentration based on the OS for controlling the overall operation of the biological information acquisition apparatus 101, the program for realizing various functions, and the first intensity measured by the first light receiving element 330. Various data including a calibration curve for calculating the value are stored. The storage unit 261 includes a temporary storage area for temporarily storing the measured first intensity and the like.

  The storage unit 261 stores data indicating a change over time in the glucose concentration calculated using the calibration curve based on the measured first intensity.

  The data display instruction unit 299 causes the monitor (display unit) 151 to display the glucose concentration calculated by the calculation unit 200 using the calibration curve, the date and time when the glucose concentration was measured, and the like.

  The detection unit driving unit 400 sends, for example, a condition for driving the detection unit 300 based on the measurement conditions set by the measurement person operating the operation unit 212 to the detection unit control unit 370 via the communication unit. introduce. And based on these conditions etc., the detection part control part 370 controls the action | operation of each part with which the detection part 300 is provided.

  The calculation unit 200 executes a calculation process by reading a program stored in the storage unit 261, and includes a glucose concentration calculation unit 200A.

  The glucose concentration calculation unit 200A reads a calibration curve indicating the relationship between the first intensity acquired by the first light receiving element 330 and the glucose concentration from the storage unit 261, and further, the calibration curve and the first light receiving element. This is for obtaining the glucose concentration (target substance) in the interstitial fluid from the first intensity acquired in 330.

  That is, the glucose concentration calculation unit 200A is for obtaining the corrected glucose (target substance) concentration based on the fluorescence intensity (first intensity) received by the first light receiving element 330.

  The glucose concentration calculated by the calculation unit 200 is displayed on the monitor 151 by the operation of the data display instruction unit 299.

(Measuring method)
The measurement of the glucose concentration in the interstitial fluid using the biological information acquisition apparatus 101 of the first embodiment as described above is specifically performed by the following measurement method, for example.
FIG. 13 is a flowchart illustrating a measurement method for measuring a glucose concentration using the biological information acquisition apparatus according to the first embodiment.

  [1A] First, the measurer (user) embeds the detection element 100 in the dermis 502, and stabilizes the interstitial fluid by contacting the indicator layer 120 which is a part of the casing 150 of the detection element 100. (S1a).

  At this time, the measurer inputs measurement conditions such as a period (time) for measuring the glucose concentration by operating the operation unit 212.

  [2A] Next, the detection unit control unit 370 operates the organic EL element driving unit 370A to operate the organic EL element 320, and the indicator layer 120 is irradiated with excitation light (excitation light irradiation step; S2a). ).

  As a result, it is included in the indicator layer 120 that receives excitation light (second light) from the organic EL element 320 and emits fluorescence (first light) according to the concentration of glucose (target substance) in the living body. The fluorescent material is irradiated with excitation light (first light). As a result, the fluorescent material emits fluorescence (first light) having a peak wavelength at the first wavelength by the excitation light (first light).

  [3A] Next, the control unit 210 activates the first light receiving drive unit 370B, so that the fluorescence (first light) emitted from the fluorescent material in the step [2A] is converted into the first light receiving element. 330 receives light and measures the intensity (first intensity; light reception result of the first light receiving element 330) of the fluorescence at the first wavelength (first light receiving step; S3a). Then, the first intensity is temporarily stored in the storage unit 261.

  [4A] Next, the control unit 210 operates the calculation unit 200 (glucose concentration calculation unit 200A) to show the relationship between the first intensity acquired by the first light receiving element 330 and the glucose concentration. A calibration curve is extracted from the storage unit 261. Further, the first intensity measured in the step [3A] is extracted from the storage unit 261, and the glucose concentration in the interstitial fluid is obtained using the extracted calibration curve (S4a).

  That is, the glucose concentration (concentration of the target substance) in the interstitial fluid is obtained based on the intensity of the fluorescence received by the first light receiving element 330 (first intensity).

  [5A] Next, the control unit 210 operates the data display instruction unit 299 to display the glucose concentration calculated in the step [4A] on the monitor 151 (display unit) (S5a).

  In addition to this display, the glucose concentration is stored in the storage unit 261 as necessary.

  The step [2A] to the step [4A] may be performed once, but the step [2A] to the step [4A] are repeatedly performed, and the average value of the glucose concentration measured during this time is repeated. Since the glucose concentration is averaged by determining the glucose concentration, the glucose concentration can be determined with higher reliability.

  Then, the steps [2A] to [4A] as described above are repeatedly performed at a predetermined interval, whereby the glucose concentration in the interstitial fluid is continuously measured.

<< Second Embodiment >>
Next, a second embodiment of the biological information acquisition apparatus of the present invention will be described.

  FIG. 14 is a longitudinal sectional view showing a detection element included in the second embodiment of the biological information acquisition apparatus of the present invention. FIG. 15 shows the shape of the light emitting surface of the organic EL element included in the detection element shown in FIG. FIG. 16 is a plan view showing a seventh pattern of the shape of the first light receiving surface of the first light receiving element and the shape of the second light receiving surface of the first light receiving element, and FIG. 16 is an organic EL element included in the detection element shown in FIG. FIG. 17 is a plan view showing an eighth pattern of the shape of the light emitting surface, the shape of the first light receiving surface of the first light receiving element, and the shape of the second light receiving surface of the first light receiving element. 9 shows a ninth pattern of the shape of the light-emitting surface of the organic EL element included in the detection element shown in FIG. 3, the shape of the first light-receiving surface of the first light-receiving element, and the shape of the second light-receiving surface of the first light-receiving element. FIG. 18 is a plan view showing the shape of the light emitting surface of the organic EL element included in the detection element shown in FIG. 14 and the first light receiving element. FIG. 19 is a plan view showing a tenth pattern of the shape of the first light receiving surface and the shape of the second light receiving surface of the first light receiving element, and FIG. 19 is a circuit configuration of the second embodiment of the biological information acquiring apparatus of the present invention. FIG. In the following description, the upper side in FIG. 14 is referred to as “upper”, the lower side is referred to as “lower”, the front side in FIG. 15 to FIG. 18 is referred to as “upper”, and the rear side in FIG. In addition, for convenience of explanation, the light emitting surface, the first light receiving surface, and the second light receiving surface in FIGS.

  Hereinafter, the biometric information acquisition apparatus 101 according to the second embodiment will be described with a focus on differences from the biometric information acquisition apparatus 101 according to the first embodiment, and description of similar matters will be omitted.

  The biological information acquisition apparatus 101 according to the second embodiment uses the configuration of the detection unit 300 included in the detection element 100 illustrated in FIG. 14, the configuration of the detection unit control unit 370 illustrated in FIG. 19, and the biological information acquisition apparatus 101. Except that the measuring method of the glucose concentration in the calculating part 200 differs, it is the same as that of the biometric information acquisition apparatus 101 of 1st Embodiment.

  That is, in the biological information acquisition apparatus 101 of the second embodiment, the detection unit 300 further includes a second light receiving element 340, and the detection unit control unit 370 further includes a second light reception driving unit 370C.

  The second light receiving element 340 receives excitation light (second light) from the organic EL element 320 and measures the excitation intensity (second intensity) of the excitation light.

  The second light receiving element 340 is arranged side by side with respect to the first light receiving element 330 (semiconductor layer 62) along the surface direction of the organic EL element 320.

  As such a second light receiving element 340, the same one as mentioned in the first light receiving element 330 is used, and it has a lower electrode, a semiconductor layer (second light receiving layer), and an upper electrode. A stacked body in which these layers are stacked in this order from the substrate side is a PIN type photodiode provided on the substrate and sealed with a sealing member, and the semiconductor layer is the organic EL element 320 (light emitting layer 34). ) Constitutes a light receiving layer (second light receiving layer) that receives the excitation light emitted.

  Further, in the present embodiment, excitation light is formed on the photosensitive surface of the second light receiving element 340, that is, between the indicator layer 120 and the second light receiving element 340 in the same manner as on the light emitting surface of the organic EL element 320. An optical filter 345 such as a high-pass filter, a low-pass filter, or a band-pass filter that allows passage of light including the peak wavelength of (second light) is provided. The optical filter 345 preferably cuts light including the peak wavelength of fluorescence (first light) emitted from the fluorescent material. As a result, the optical filter 345 allows light including the peak wavelength of the excitation light (second light) from the organic EL element 320 to be selectively transmitted. Two light receiving elements 340 can receive light. Therefore, the detection accuracy of excitation light (second light) by the second light receiving element 340 can be improved.

  In the detection unit 300 including the second light receiving element 340, in the present embodiment, as shown in FIG. 14, the organic EL element 320 is on the indicator layer 120 (housing 150) side, and the first light receiving element 330 and the first light receiving element 330 The light receiving element 340 of the second side is the substrate 310 side, and in the state where the first light receiving element 330 and the second light receiving element 340 are arranged in parallel, a stacked body is formed so that both of them are covered with the organic EL element 320. doing.

In such a stacked body, the light emitting region of the excitation light of the organic EL element 320 and the light receiving region of the first light receiving element 330 include a region A ₀ that does not overlap with each other when viewed from the thickness direction of the stacked body. further, a light emitting region of the excitation light of the organic EL element 320, and the light receiving area of the second light receiving element 340 includes a region a ₀ does not overlap each other when viewed from the thickness direction of the laminate. Accordingly, the function of the organic EL element 320, the first light receiving element 330, and the second light receiving element 340 in the detection element 100, that is, the function of the organic EL element 320 that irradiates the indicator layer 120 with the excitation light, the indicator layer 120. Thus, the function of the first light receiving element 330 that receives the fluorescence emitted by and the function of the second light receiving element 340 that receives the excitation light emitted by the organic EL element 320 can be reliably exhibited.

As described above, the excitation light emission region of the organic EL element 320 and the light reception region of the first light receiving element 330 include the region A ₀ that does not overlap each other when viewed from the thickness direction of the stacked body. In such a stacked body, the organic EL element 320 and the first light receiving element 330 can be realized by using the first configuration or the second configuration described in the first embodiment. Further, in order to configure the light emitting region of the excitation light of the organic EL element 320 and the light receiving region of the second light receiving element 340 to include a region A ₀ that does not overlap with each other when viewed from the thickness direction of the stacked body. In the laminated body, the first configuration or the second configuration applied to the organic EL element 320 and the second light receiving element 340 in the organic EL element 320 and the first light receiving element 330 in the first embodiment. The configuration can be realized by applying. That is, it can be realized by applying the first configuration or the second configuration to the second light receiving element 340 instead of the first light receiving element 330.

By adopting such a first configuration and a second configuration as a stacked body in which the organic EL element 320, the first light receiving element 330, and the second light receiving element 340 are stacked, the organic EL element 320 is excited. and the light emitting region of the light, and having a light receiving area of the first light receiving element 330, the region a ₀ does not overlap each other when the light-receiving region, as seen from the thickness direction of the laminate of the second light receiving element 340 can do. At this time, when viewed from the thickness direction (in plan view), the region where the light emitting region of the organic EL element 320 does not overlap is defined as the light emitting surface 321, and the region where the light receiving region of the first light receiving element 330 does not overlap is the first. Assuming that the first light receiving surface 331 and the second light receiving surface 341 do not overlap with the light receiving region of the second light receiving element 340, the shape of the light emitting surface 321, the shape of the first light receiving surface 331, and the shape of the second light receiving surface 341 are as follows. Although not particularly limited, for example, the following seventh to tenth patterns may be mentioned.

  That is, in the seventh pattern, as shown in FIG. 15, the first light receiving surface 331 having one rectangular shape (line shape), the light emitting surface 321 having one rectangular shape (line shape), and one rectangular shape The second light receiving surfaces 341 having a shape (line shape) are arranged in parallel in this order so that their long sides face each other. That is, it arrange | positions in parallel so that the light emission surface 321 may be located in the center part.

  In the eighth pattern, as shown in FIG. 16, a plurality of strip-shaped (line-shaped) light emitting surfaces 321, a plurality of strip-shaped first light receiving surfaces 331, and a plurality of strip-shaped first patterns are formed. The two light receiving surfaces 341 are arranged in parallel so as to be sandwiched between the first light receiving surface 331 and the second light receiving surface 341 with the light emitting surface 321 at the center, and their long sides are opposed to each other.

  In the ninth pattern, as shown in FIG. 17, 20 circular light emitting surfaces 321 are arranged at equal intervals in 5 rows and 4 columns (grid shape). A first cross-shaped first light-receiving surface 331 is arranged at the center of a quadrangle (square) formed by the four light-emitting surfaces 321, and further formed by four adjacent light-emitting surfaces 321. A second light receiving surface 341 having a cross shape is disposed at the center of the square (square), and the first light receiving surface 331 is disposed at the center of the square (square) so as to satisfy these relationships. And six second light receiving surfaces 341 are arranged respectively.

  In the tenth pattern, as shown in FIG. 18, a first light receiving surface 331 having an annular shape is disposed so as to surround the outer periphery of the second light receiving surface 341 having a circular shape, and this annular shape is further provided. A single light emitting surface 321 is disposed so as to surround the outer periphery of the first light receiving surface 331.

  In the tenth pattern, the combination of the light emitting surface 321, the first light receiving surface 331, and the second light receiving surface 341 is not one set as described above, but a plurality of combinations are combined with the organic EL element 320 and the first light receiving surface 341. A stacked body in which the light receiving element 330 and the second light receiving element 340 are stacked may be provided.

  Among the seventh to tenth patterns as described above, in the seventh and eighth patterns, the light emitting surface 321, the first light receiving surface 331, and the second light receiving surface 341 are in a line shape, and thus described above. Similar to the first and second patterns, these patterns can be easily performed.

  Further, in the eighth pattern, the light emitting surface 321 is arranged so as to be sandwiched between the first light receiving surface 331 and the second light receiving surface 341 with the light emitting surface 321 as a central portion, and therefore, according to the same principle as the above-described second pattern. Excitation light and fluorescence having uniform intensity can be uniformly received by the plurality of first light receiving surfaces 331 and the plurality of second light receiving surfaces 341, respectively.

  Further, in the ninth pattern, since the light emitting surface 321, the first light receiving surface 331, and the second light receiving surface 341 are each formed in plural, even if a leak or the like occurs in these, the first light receiving surface It is possible to accurately suppress or prevent a decrease in detection sensitivity of fluorescence and excitation light detected at 331 and the second light receiving surface 341, respectively.

  In the tenth pattern, the second light receiving surface 341 has a circular shape, the light emitting surface 321 and the first light receiving surface 331 have an annular shape, and have a relatively simple shape. Similar to the fifth pattern, the patterning can be easily performed.

  Further, in the tenth pattern, the first light receiving surface 331 having an annular shape and the first light receiving surface 331 having a circular shape are disposed inside the light emitting surface 321 having an annular shape. Even if the intensity of the excitation light from the light emitting surface 321 is relatively low, the fluorescence and the excitation light from the indicator layer 120 are respectively reflected on the first light receiving surface 331 and the second light receiving surface 341 by the same principle as the five patterns. Light can be received reliably.

  In the biological information acquisition apparatus 101 of the second embodiment, the detection unit control unit 370 includes, in addition to the organic EL element driving unit 370A and the first light receiving driving unit 370B, the second light receiving element 340. A second light receiving drive unit 370C that controls driving is provided.

  In the detection unit control unit 370 having such a configuration, in addition to the acquisition of the fluorescence intensity (first intensity) using the first light receiving element 330 by the operation of the first light reception driving unit 370B, the second light reception driving unit 370B is further operated. By operating the light receiving drive unit 370C and causing the second light receiving element 340 to receive the excitation light (second light), the intensity of the excitation light (second intensity) is acquired. The intensity of fluorescence (first intensity) and the intensity of excitation light (second intensity) obtained as described above are transmitted to the control unit 210 (calculation unit 200) via the transceiver 380.

  Then, based on the fluorescence intensity (first intensity) and excitation light intensity (second intensity) transmitted to the control unit 210, the glucose concentration calculation unit 200A included in the calculation unit 200 determines the excitation light intensity ( Among the calibration curves showing the relationship between the fluorescence intensity (first intensity) acquired by the first light receiving element 330 and the glucose concentration, prepared in correspondence with the magnitude of the (second intensity), A value that matches the intensity of the excitation light (second intensity) acquired by the second light receiving element 340 is read from the storage unit 261. The glucose concentration (target substance) in the interstitial fluid is obtained from this calibration curve and the first intensity acquired by the first light receiving element 330.

  In the biological information acquisition apparatus 101 of this embodiment having such a configuration, a plurality of first information prepared in correspondence with the intensity of the excitation light (second intensity) stored in advance in the storage unit 261 is provided. Of the calibration curve indicating the relationship between the fluorescence intensity (first intensity) acquired by the light receiving element 330 and the glucose concentration, the intensity of the excitation light (second intensity) acquired by the second light receiving element 340. Load the one that matches the size of. Then, based on the read calibration curve, the glucose concentration as the target substance is determined in the glucose concentration calculation unit 200A using the fluorescence intensity (first intensity) measured using the first light receiving element 330. Calculate.

  Thus, the glucose concentration as the target substance is calculated in the glucose concentration calculation unit 200A in consideration of the intensity of the excitation light irradiated to the fluorescent substance. That is, the light reception result of the first light receiving element 330 is corrected by the light reception result of the second light receiving element 340, and the glucose concentration (target substance) is calculated, so that the glucose concentration can be more reliably improved. Can be measured.

  In addition, it is assumed that external light such as sunlight or illumination light passes through the lower surface of the detection element 100 and reaches the detection unit 300, and both the first light receiving element 330 and the second light receiving element 340 receive light. However, both sides receive light and this becomes the baseline. Therefore, it is possible to accurately suppress or prevent adverse effects on the calculated glucose concentration. Therefore, from this point of view, according to the biological information acquisition apparatus 101, the glucose concentration can be measured with excellent reliability.

(Measuring method)
The measurement of the glucose concentration in the interstitial fluid using the biological information acquisition apparatus 101 of the second embodiment as described above is specifically performed by, for example, the following measurement method.
FIG. 20 is a flowchart illustrating a measurement method for measuring a glucose concentration using the biological information acquisition apparatus according to the second embodiment.

  [1B] First, the measurer (user) embeds the detection element 100 in the dermis 502, and stabilizes the interstitial fluid by contacting the indicator layer 120 which is a part of the casing 150 of the detection element 100. (S1b).

  At this time, the measurer inputs measurement conditions such as a period (time) for measuring the glucose concentration by operating the operation unit 212.

  [2B] Next, the detection unit control unit 370 operates the organic EL element driving unit 370A to operate the organic EL element 320, and the indicator layer 120 is irradiated with excitation light (excitation light irradiation step; S2b). ).

  As a result, it is included in the indicator layer 120 that receives excitation light (second light) from the organic EL element 320 and emits fluorescence (first light) according to the concentration of glucose (target substance) in the living body. The fluorescent material is irradiated with excitation light (first light). As a result, the fluorescent material emits fluorescence (first light) having a peak wavelength at the first wavelength by the excitation light (first light).

  [3B] Next, the control unit 210 activates the first light receiving drive unit 370B, so that the fluorescence (first light) emitted from the fluorescent material in the step [2B] is converted into the first light receiving element. 330 receives light, and measures the intensity (first intensity; light reception result of the first light receiving element 330) at the first wavelength (peak wavelength) of this fluorescence (first light) (first light reception). Step; S3b). Then, the first intensity is temporarily stored in the storage unit 261.

  [4B] Next, the control unit 210 operates the second light receiving drive unit 370C, so that the excitation light (second light) emitted from the organic EL element 320 in the step [2B] is second received. Light is received using the element 340, and the intensity (second intensity; light reception result of the second light receiving element 340) at the second wavelength (peak wavelength) of the excitation light (second light) is measured (first light receiving element 340). 2 light receiving step; S4b). Then, the second intensity is temporarily stored in the storage unit 261.

  Note that the order of the step [3B] and the main step [4B] may be almost the same or reversed.

  [5B] Next, the control unit 210 operates the calculation unit 200 (glucose concentration calculation unit 200A), so that the organic EL element 320 measured by the second light receiving element 340 in the step [4B] emits light. The intensity (first light) of the fluorescence (first light) emitted by the luminescent material, acquired by the first light receiving element 330, corresponding to the intensity (second intensity) of the excitation light (second light). A calibration curve indicating the relationship between the intensity of 1) and the glucose concentration is extracted from the storage unit 261. Further, the intensity (first intensity) of the fluorescence (first light) emitted from the luminescent material, measured in the step [3B], is taken out from the storage unit 261, and the extracted calibration curve is used for the stroma. The glucose concentration in the liquid is determined (S5b).

  That is, the correction is made based on the intensity of the excitation light received by the second light receiving element 340 (second intensity) and the intensity of the fluorescence received by the first light receiving element 330 (first intensity). Determine the glucose concentration (concentration of the target substance) in the interstitial fluid.

  As described above, in consideration of the intensity (second intensity) of the excitation light (second light) emitted from the organic EL element 320 measured by the second light receiving element 340 in the step [4B], this process is performed. In [5B], the glucose concentration calculation unit 200A calculates the glucose concentration as the target substance. Therefore, the glucose concentration can be measured with excellent reliability without being affected by the position where the indicator layer 120 is embedded or the position where the detection element 100 is mounted.

  In the step [3B] and the step [4B], external light such as sunlight or illumination light passes through the lower surface of the detection element 100 and reaches the detection unit 300, and the first light receiving element 330 and Even if both of the light receiving elements 340 receive light, both of them receive light and become a baseline, so that it is possible to accurately suppress or prevent adverse effects on the calculated glucose concentration. Therefore, from this point of view, according to the biological information acquisition apparatus 101, the glucose concentration can be measured with excellent reliability.

  [6B] Next, the control unit 210 operates the data display instruction unit 299 to display the glucose concentration calculated in the step [5B] on the monitor 151 (display unit) (S6b).

  In addition to this display, the glucose concentration is stored in the storage unit 261 as necessary.

  In addition, although said process [2B]-said process [5B] may be performed once, the said process [2B]-the said process [5B] were repeated, and the average value of the glucose concentration measured in the meantime is performed. Since the glucose concentration is averaged by determining the glucose concentration, the glucose concentration can be determined with higher reliability.

  Then, the steps [2B] to [5B] as described above are repeatedly performed at a predetermined interval, whereby the glucose concentration in the interstitial fluid is continuously measured.

  The biological information acquisition apparatus of the present invention has been described based on the illustrated embodiment, but the present invention is not limited to this.

  For example, the configuration of each unit in the biological information acquisition apparatus (measurement apparatus) of the present invention can be replaced with an arbitrary configuration having the same function. In addition, any other component may be added to the present invention.

  In addition, the indicator layer 120 (sensor substance) may be inserted into the subcutaneous tissue 503 in addition to being inserted into the dermis 502.

  In addition, the biological information acquisition device of the present invention can be applied to a measuring device that automatically calculates the glucose concentration in the interstitial fluid over time based on the measured intensity, as well as the lactic acid value in the body fluid, the antibody The present invention can be similarly applied to a measuring apparatus that calculates automatically over time based on the strength of the target substance such as the amount and the amount of enzyme.

  Furthermore, the emitted light emitted by irradiating the fluorescent material and the reference material with excitation light is not limited to fluorescence but may be phosphorescence.

DESCRIPTION OF SYMBOLS 20 ... Board | substrate, 30 ... Laminated body, 31 ... Reflection layer, 32 ... Anode, 33 ... Hole injection layer, 34 ... Light emitting layer, 35 ... Electron carrying layer, 36 ... Cathode, 40 ... Sealing member, 50 ... Substrate, DESCRIPTION OF SYMBOLS 60 ... Laminated body, 61 ... Lower electrode, 62 ... Semiconductor layer, 63 ... Upper electrode, 70 ... Sealing member, 80 ... Adhesive layer, 100 ... Detection element, 101 ... Biological information acquisition apparatus, 120 ... Indicator layer, 150 ... Case, 151 ... Monitor, 155 ... Main body, 200 ... Calculation section, 200A ... Glucose concentration calculation section, 210 ... Control section, 212 ... Operation section, 261 ... Storage section, 299 ... Data display instruction section, 300 ... Detection section , 310 substrate, 320 organic EL element, 321 light emitting surface, 325 optical filter, 330 first light receiving element, 331 first light receiving surface, 335 optical filter, 340 second light receiving element, 341 ... 2 light receiving surface, 345... Optical filter, 350... Temperature sensor, 360... Power supply, 370. 380: Transmitter / receiver, 400: Detector drive unit, 501 ... Epidermis, 502 ... Dermis, 503 ... Subcutaneous tissue

Claims (9)

A biological information acquisition device comprising a detection element embedded in a living body, for obtaining information on a target substance in the living body,
The detection element includes an organic electroluminescence layer that excites excitation light, and
An indicator layer that receives the excitation light and emits emitted light according to the concentration of the target substance in the living body;
A first light receiving layer for receiving the emitted light,
The organic electroluminescence layer and the first light receiving layer are included in a stacked body laminated in the thickness direction of the organic electroluminescence layer and the first light receiving layer,
A region where a light emitting region that emits the excitation light of the organic electroluminescence layer and a first light receiving region that receives the light emitted from the first light receiving layer do not overlap each other when viewed from the thickness direction. A biometric information acquisition apparatus comprising:   The biological information acquiring apparatus according to claim 1, wherein the indicator layer is positioned on the organic electroluminescence layer side with respect to the stacked body.   The biological information acquisition apparatus according to claim 1, wherein the detection element includes an optical filter that allows transmission of the emitted light between the indicator layer and the first light receiving layer.   The biological information acquisition apparatus according to claim 1, wherein the detection element includes an optical filter that allows transmission of the excitation light between the indicator layer and the organic electroluminescence layer.   The biological information acquisition apparatus according to any one of claims 1 to 4, wherein the light emitting region and the first light receiving region do not overlap each other when viewed from the thickness direction.   The stacked body further includes a second light receiving layer for receiving the excitation light, which is arranged along the surface direction of the organic electroluminescence layer with respect to the first light receiving layer. The biological information acquisition apparatus according to any one of claims 1 to 5.   The biological information acquisition apparatus according to claim 6, wherein the detection element includes an optical filter that allows transmission of the emitted light between the indicator layer and the second light receiving layer.   The biological information acquiring apparatus according to claim 1, wherein the indicator layer contains a boronic acid compound.   The biological information acquisition apparatus according to claim 1, wherein the information on the target substance is a glucose concentration in the living body.

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