JP2018157964A - Blood sampling device, blood sampling kit, blood sampling system, blood sampling method, and inactivation processing method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood sampling device, a blood sampling kit, a blood sampling system, a blood sampling method, and an inactivation processing method capable of reducing time and cost of inactivation processing by performing inactivation processing for pathogens when sampling blood.SOLUTION: A blood sampling device 10A is configured so that a blood sampling kit 14 having a blood sampling line 24 and a blood sampling bag 26 is arranged, and includes a housing part (second arrangement part 112) capable of housing the blood sampling bag 26, a decompression pump 98 for sucking blood into the blood sampling bag 26 through the blood sampling line 24 by decompressing the inside of the housing part, an arrangement part (first arrangement part 110) in which an inactivation processing part 36A provided on the blood sampling line 24 can be arranged, and a light irradiation part (first light irradiation part 122) provided in the arrangement part for irradiating a light of a wavelength that makes pathogens inactivated to the blood flowing in the inactivation processing part 36A, to which a pathogen inactivation agent is added.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a blood collection device, a blood collection kit, a blood collection system, a blood collection method, and an inactivation processing method that collect blood in a blood collection bag from a blood collection needle punctured by a donor through a blood collection line.

  In recent years, in blood transfusion, component blood transfusion has been performed in which components of blood (whole blood) obtained by blood donation or the like are separated to provide only the components required by the patient. According to the component transfusion, the burden on the circulatory system and side effects can be reduced for the patient, and the donated blood can be effectively used.

  The blood (whole blood) collected in the blood bag from the donor by blood donation is centrifuged into the necessary blood products (erythrocyte product, platelet product and plasma product) and transferred to multiple bags for each blood product. Inactivation treatment of pathogens such as viruses is performed. In Patent Document 1, a pathogen inactivating agent is activated by adding a photoactive agent (pathogen inactivating agent) to a bag containing a blood product and irradiating light of a predetermined wavelength to inactivate the pathogen. The technical idea is disclosed.

Japanese Patent No. 4154191

  However, in the above-described prior art, after the blood collected in the blood bag is separated into a plurality of blood products, each blood product is inactivated with a pathogen. Therefore, it is necessary to inactivate the number of blood products, and there is a problem that much time and cost are required.

  The present invention has been made in view of such problems, and a blood collection device, a blood collection kit, and a blood collection that can reduce the time and cost of the inactivation treatment by performing the inactivation treatment of the pathogen at the time of blood collection. An object is to provide a system, a blood collection method, and an inactivation treatment method.

  In order to achieve the above object, a blood collection apparatus according to the present invention is configured such that a blood collection kit including a blood collection line and a blood collection bag is arranged, and the blood collection line is collected from a blood collection needle punctured by a donor through the blood collection line. A blood collection device for collecting blood in a bag, a housing part capable of housing the blood collection bag, and a decompression means for sucking blood into the blood collection bag via the blood collection line by decompressing the housing part , A disposing unit capable of disposing an inactivation processing unit provided on the blood collection line, and a wavelength provided in the disposing unit, to which a pathogen inactivating agent is added and the pathogen is inactivated in blood flowing through the inactivation processing unit A light irradiating unit that irradiates the light.

  According to such a configuration, since the blood flowing through the inactivation processing unit is irradiated with light having a wavelength that inactivates the pathogen, the blood after the inactivation processing is stored in the blood collection bag. . That is, pathogen inactivation treatment can be performed during blood collection. Thereby, after separating the blood collected in the blood collection bag into a plurality of blood products, the time and cost of the inactivation processing can be reduced as compared with the case where the inactivation processing is performed for each blood product.

  In the blood collection apparatus, the light irradiation unit may irradiate ultraviolet rays having a wavelength in a range of 200 nm to 400 nm.

  According to such a structure, the inactivation process of a pathogen can be performed effectively.

  In the blood collection apparatus, the light irradiation unit may be configured to emit a plurality of light emission units configured to irradiate the light from both sides sandwiching the inactivation processing unit in a state where the inactivation processing unit is disposed in the arrangement unit. May have a part.

  According to such a configuration, light can be efficiently irradiated to the blood flowing through the inactivation processing unit.

  In the blood collection apparatus, the inactivation processing unit is configured in a tube shape, and the light emitting unit is arranged in a circumferential direction of the inactivation processing unit in a state where the inactivation processing unit is arranged in the arrangement unit. Four may be provided at equal intervals.

  According to such a configuration, it is possible to more efficiently irradiate the blood flowing through the inactivation processing unit with light.

  In the blood collection apparatus, the light irradiation unit may include a support part in which a groove into which the inactivation processing part can be inserted is formed, and the plurality of light emitting parts may be fixed to the support part.

  According to such a configuration, the position of the inactivation processing unit with respect to the light emitting unit can be made substantially constant. Therefore, light can be stably irradiated to the blood flowing through the inactivation processing unit.

  In the blood collection apparatus, the light emitting unit may be a light emitting diode.

  According to such a configuration, since heat generation can be suppressed as compared with the case where the light emitting unit is configured by a mercury lamp, the light emitting unit can be brought close to the inactivation processing unit. Thereby, light can be more efficiently irradiated with respect to the inactivating agent addition blood.

  In the above blood collection device, a first light irradiation unit as the light irradiation unit, a second light irradiation unit that irradiates the blood that is contained in the blood collection bag and to which the pathogen inactivating agent is added, and May be provided.

  According to such a structure, the inactivation process of a pathogen can be performed with respect to the blood accommodated in the blood collection bag. Therefore, the pathogen inactivation process for blood can be more reliably performed.

  In the blood collection apparatus, the placement unit may be provided adjacent to the storage unit in the horizontal direction.

  According to such a configuration, the configuration of the blood collection device can be simplified.

  In the blood collection apparatus, the arrangement portion may be provided adjacent to the upper portion of the storage portion.

  According to such a configuration, the installation area of the blood collection device can be reduced as compared with the case where the arrangement portion is provided in the horizontal direction with respect to the storage portion.

  The blood collection method according to the present invention is a blood collection method for collecting blood in a blood collection bag through a blood collection line from a blood collection needle punctured by a donor, and an addition step of adding a pathogen inactivating agent to the blood flowing through the blood collection line And a light irradiation step of irradiating the blood to which the pathogen inactivating agent has been added with light having a wavelength that inactivates the pathogen, and a storing step of storing the blood irradiated with the light in the blood collection bag. It is characterized by that.

  In the above blood collection method, in the light irradiation step, ultraviolet rays having a wavelength in a range of 200 nm to 400 nm may be irradiated.

  In the above blood collection method, in the light irradiation step, the light may be irradiated from both sides sandwiching an inactivation treatment part through which the blood to which the pathogen inactivating agent is added flows.

  In the blood collection method, the inactivation processing unit is configured in a tube shape, and in the light irradiation step, the blood is orthogonal to the blood flow direction of the inactivation processing unit through which the blood to which the pathogen inactivating agent is added flows. The light may be irradiated from both sides sandwiching the inactivation processing unit in the first direction and from both sides sandwiching the inactivation processing unit in the second direction orthogonal to the flow direction and the first direction.

  A blood collection kit according to the present invention is a blood collection kit for collecting blood from a blood collection needle punctured by a donor through a blood collection line, a storage bag in which a pathogen inactivating agent is stored, and the above-described storage bag An introduction tube that guides the pathogen inactivating agent to the blood collection line, and blood that has been added with the pathogen inactivating agent circulates through the blood collection line and is irradiated with light having a wavelength that inactivates the pathogen. An activation processing unit is provided.

  In the blood sampling kit, the processing flow path of the inactivation processing unit is formed such that the width direction perpendicular to the blood flow direction is longer than the flow direction and the height direction perpendicular to the width direction. May be.

  According to such a configuration, it is possible to efficiently irradiate light to the blood flowing through the processing channel from the height direction of the processing channel.

  In the blood collection kit, the height direction dimension of the processing flow path of the inactivation processing unit may be set to 50 μm or more and 400 μm or less.

  According to such a configuration, it is possible to efficiently irradiate the entire blood flowing through the processing flow path of the inactivation processing unit with light.

  In the blood sampling kit, a wall extending in a direction crossing a blood flow direction may be provided in the processing flow path of the inactivation processing unit.

  According to such a configuration, since the flow of blood in the processing channel is hindered by the wall, the irradiation time of light to the blood flowing in the processing channel (as compared to the case where no wall is provided) ( The integrated light dose per unit area of blood) can be increased.

  In the blood sampling kit, the processing flow path of the inactivation processing unit may extend so as to meander.

  According to such a configuration, it is possible to lengthen the irradiation time of light with respect to the blood flowing in the processing flow channel.

A blood collection system according to the present invention comprises a blood collection kit for collecting blood from a blood collection needle punctured by a donor through a blood collection line, and a blood collection apparatus configured to arrange the blood collection kit. The blood collection kit is provided in a storage bag in which a pathogen inactivating agent is stored, an introduction tube for guiding the pathogen inactivating agent in the storage bag to the blood collection line, and the blood collection line. And an inactivation processing part through which the blood to which the pathogen inactivating agent has been added circulates, and the blood collection device accommodates the blood collection bag, and the blood collection by decompressing the inside of the accommodation part Pressure reducing means for sucking blood into the blood collection bag via a line, an arrangement part where the inactivation processing part can be arranged, and a disease that affects the blood flowing through the inactivation processing part. Has a light irradiation unit for irradiating light of a wavelength that inactivates the body, wherein the inactivation treatment unit and the light irradiation unit, 30J / L · cm ² or more with respect to the blood flowing through the inactivation treatment unit The integrated light quantity can be irradiated.

  According to such a structure, the inactivation process of a pathogen can be reliably performed at the time of blood collection.

  The inactivation processing method according to the present invention includes a blood collection needle for collecting whole blood from a donor, a storage bag that stores the whole blood, a blood collection line that connects the blood collection needle and the storage bag, and the blood collection line A method for inactivating the whole blood using a blood collection kit comprising an inactivation processing unit provided on the collection method, wherein the whole blood is collected from the donor via the blood collection needle, and the collection An addition step of adding a pathogen inactivating agent to the whole blood, an introduction step of introducing the collected whole blood into the inactivation processing portion, and an introduction step introduced into the inactivation processing portion by the introduction step. And a light irradiation step of irradiating the whole blood to which the pathogen inactivating agent has been added with light having a wavelength that inactivates the pathogen.

  According to the present invention, the light flowing through the inactivation processing unit is irradiated with light having a wavelength that inactivates the pathogen, so that the time and cost of the inactivation processing can be reduced.

It is a schematic block diagram of the blood collection kit which concerns on one Embodiment of this invention. 2A is a longitudinal sectional view of the inactivation processing portion of FIG. 1, and FIG. 2B is a sectional view taken along line IIB-IIB of FIG. 2A. 1 is a partially omitted perspective view of a blood collection system in which a blood collection kit is incorporated in a blood collection apparatus according to an embodiment of the present invention. 4A is a partial cross-sectional plan view of the blood collection device of FIG. 3, and FIG. 4B is a cross-sectional view taken along line IVB-IVB of FIG. 4A. FIG. 5A is a plan view of the first irradiation unit, and FIG. 5B is a schematic cross-sectional view showing a state where blood flowing through the processing flow path is inactivated. 6A is a partially omitted cross-sectional view showing a modification of the inactivation processing unit, FIG. 6B is a partially omitted cross-sectional view showing another modification of the inactivation processing unit, and FIG. 6C is an inactivation FIG. 6D is a partially omitted cross-sectional view illustrating another modification of the inactivation processing unit. 7A is a partially omitted schematic diagram illustrating another modification of the inactivation processing unit and a modification of the first light irradiation unit, and FIG. 7B is a cross-sectional view taken along the line VIIB-VIIB in FIG. 7A. . FIG. 8A is a plan view illustrating another modification of the inactivation processing unit, and FIG. 8B is a schematic plan view illustrating another modification of the first light irradiation unit. 9A is a schematic plan view illustrating a state where the inactivation processing unit of FIG. 8A is mounted on the first light irradiation unit of FIG. 8B, and FIG. 9B is a cross-sectional view taken along line IXB-IXB of FIG. 9A. is there. It is a partial cross section explanatory view explaining a modification of a blood collection system.

  Hereinafter, preferred embodiments of a blood collection device, a blood collection kit, a blood collection system, a blood collection method, and an inactivation processing method according to the present invention will be described with reference to the accompanying drawings.

  As shown in FIGS. 1 and 3, a blood collection system 12A according to the present embodiment collects blood from a blood collection needle 22 punctured by a donor into a blood collection bag 26 via a blood collection line 24, and includes a blood collection kit. 14 and a blood collection device 10A. First, the blood collection kit 14 will be described.

  As shown in FIG. 1, the blood collection kit 14 has a blood collection unit 16 that collects blood (whole blood) from a donor, a pretreatment unit 18 that removes predetermined blood components from the whole blood, and predetermined components removed. The remaining blood component is centrifuged to divide it into a plurality of blood components, and each component is stored (stored) in a different bag.

  The blood collection unit 16 includes a blood collection needle 22, blood collection tubes 28a to 28d, branch connectors 30, 50, an initial blood bag 32, a storage bag 34, an inactivation processing unit 36A, and a blood collection bag 26.

  A cap 38 is attached to the blood collection needle 22 before use, and a needle guard 40 is attached after use. The needle guard 40 is disposed on the blood collection tube 28a so as to be movable along the longitudinal direction. One end of a blood collection tube 28a is connected to the blood collection needle 22, and the first port 30a of the branch connector 30 is connected to the other end of the blood collection tube 28a. The second port 30b of the branch connector 30 is connected to the other end of the branch tube 42 to which the initial blood bag 32 is connected at one end. A clamp 44 that closes and opens the flow path of the branch tube 42 is provided in the middle of the branch tube 42.

  The initial blood bag 32 is made of, for example, a flexible sheet material made of a soft resin such as polyvinyl chloride or polyolefin, and is fused (heat fusion, high frequency fusion) or bonded at the peripheral seal portion. It is configured in a bag shape. The storage bag 34 and the blood collection bag 26 are similarly configured in a bag shape. A sampling port 46 is connected to the first blood bag 32.

  A sealing member 48 is provided at the third port 30 c of the branch connector 30. In the initial state, the sealing member 48 is configured such that the flow path is closed by performing a breaking operation. One end of the blood collection tube 28b is connected to the sealing member 48, and the first port 50a of the branch connector 50 is connected to the other end of the blood collection tube 28b. The second port 50b of the branch connector 50 is connected to the other end of the branch tube 53 having one end connected to the accommodation bag 34 via the sealing member 51. A clamp 55 that closes and opens the flow path of the branch tube 53 is provided in the middle of the branch tube 53. The sealing member 51 is configured similarly to the sealing member 48 described above. The same applies to sealing members 62, 86, and 88 described later.

  The accommodation bag 34 contains a pathogen inactivating agent (hereinafter referred to as “inactivating agent”) that is activated by irradiation with light of a predetermined wavelength to inactivate the pathogen. Examples of pathogens include viruses, bacteria, parasites, and prions. As an inactivating agent, for example, rehobravin solution which is vitamin B2 can be mentioned.

  One end of the blood collection tube 28c is connected to the third port 50c of the branch connector 50, and the inactivation processing part 36A is connected to the other end of the blood collection tube 28c. As shown in FIGS. 1 and 2A, the inactivation processing unit 36A includes a rectangular processing main body 52 in plan view, and an inlet provided at one end of the processing main body 52 and connected to the other end of the blood collection tube 28c. It has a port 54 and an outlet port 56 provided at the other end of the processing body 52 and connected to one end of the blood collection tube 28d.

  The processing body 52 is formed in a plate shape by a transparent hard resin material that hardly absorbs ultraviolet rays. That is, as a material constituting the processing body 52, for example, a transparent plastic that does not contain an ultraviolet absorber such as an acrylic resin can be cited. The processing main body 52 is formed with a processing channel 58 through which blood to which an inactivating agent is added flows.

  The processing flow path 58 communicates with each of the inner hole of the inlet port 54 and the inner hole of the outlet port 56. The processing flow path 58 includes an introduction portion 58a that is gradually widened from one end to the other end of the processing body portion 52, an intermediate portion 58b that is connected to the introduction portion 58a and has a constant width dimension, and an intermediate portion 58b. And a lead-out portion 58c that is gradually narrowed toward the other end of the processing body 52.

  As shown in FIGS. 2A and 2B, the width dimension w of the intermediate portion 58b is larger than the inner diameter d of the blood collection tube 28d. A height dimension h of the processing channel 58 (a gap along the thickness direction of the processing body 52) is smaller than the width dimension w of the intermediate part 58b and smaller than the inner diameter d of the blood collection tube 28d. Specifically, in order to efficiently irradiate light to the entire blood flowing through the processing channel 58, the height h of the processing channel 58 is preferably set to 50 μm or more and 400 μm or less. However, the width dimension w and the height dimension h of the processing channel 58 can be arbitrarily set. Further, in order to reduce light absorption by the processing body 52, the thickness of the wall portion of the processing body 52 that sandwiches the processing channel 58 from the height direction is approximately the same as the height dimension h of the processing channel 58. Or it is formed smaller than the height dimension h.

In addition, the process flow path 58 should just be comprised so that the light quantity more than predetermined amount can be integrated | integrated with respect to the blood to which the inactivating agent was added. In this case, the blood per unit amount is preferably irradiated with an integrated light amount of 30 J / L · cm ² or more. For example, at the time of 400 ml blood collection, it is configured to irradiate 12000 mJ / cm ² or more as an integrated light quantity on 400 mL of blood to be collected.

  As shown in FIG. 1, the other end of the blood collection tube 28 d is connected to the blood collection bag 26. The blood collection bag 26 is a bag for containing (reserving) blood (whole blood) collected from a donor. It is preferable that an anticoagulant is placed in the blood collection bag 26 in advance. This anticoagulant is usually a liquid, and examples thereof include an ACD-A solution, a CPD solution, a CPDA-1 solution, and a heparin sodium solution. The amount of these anticoagulants is an appropriate amount according to the planned blood collection amount.

  The pretreatment unit 18 includes a filter 60 for removing predetermined cells (white blood cells and platelets), and an inlet side tube 64 having one end connected to the blood collection bag 26 via a sealing member 62 and the other end connected to the inlet of the filter 60. And an outlet side tube 66 having one end connected to the outlet of the filter 60 and the other end connected to the separation processing unit 20. A clamp 68 that closes and opens the flow path of the outlet side tube 66 is provided in the middle of the outlet side tube 66.

  The separation processing unit 20 is configured to centrifuge the remaining blood components obtained by removing white blood cells and platelets from whole blood into two components, plasma and concentrated red blood cells, and store and store the plasma and concentrated red blood cells in different bags. Has been. The separation processing unit 20 is obtained by centrifuging the first bag 70 (red blood cell bag) that stores (stores) the remaining blood from which predetermined cells have been removed by the filter 60, and the blood in the first bag 70. It has the 2nd bag 72 (plasma bag) which accommodates and preserve | saves a clear component, the 3rd bag 74 (chemical | medical solution bag) in which the erythrocyte preservation solution was accommodated, and the transfer line 76 which connects these bags.

  The first bag 70 is a bag for storing (reserving) residual blood from which predetermined cells have been removed by the filter 60, and a sediment component (concentrated red blood cell) obtained by centrifuging the blood. Also serves as a bag.

  The transfer line 76 includes transfer tubes 78, 80, 82 and a branch connector 84. One end of the transfer tube 78 is connected to the first bag 70 via the sealing member 86, and the other end of the transfer tube 78 is connected to the first port 84 a of the branch connector 84. One end of the transfer tube 80 is connected to the second port 84 b of the branch connector 84, and the other end of the transfer tube 80 is connected to the second bag 72. One end of the transfer tube 82 is connected to the third port 84 c of the branch connector 84, and the other end of the transfer tube 82 is connected to the third bag 74 via the sealing member 88.

  Next, the blood collection device 10A will be described. As shown in FIGS. 3 to 4B, the blood collection device 10 </ b> A is configured such that a blood collection kit 14 including a blood collection line 24 and a blood collection bag 26 is arranged. The blood collection device 10A is box-shaped, and includes a main body 90 and a cover 92 that opens and closes the upper surface of the main body 90. The cover 92 is provided with a handle portion 92a. A power switch 94 is provided at the lower front portion of the main body 90, and an operation panel 96 is provided at the upper front portion. A decompression pump 98 (decompression unit) is disposed inside the main body 90 (see FIG. 4B).

  The operation panel 96 is provided with a plurality of switches. Examples of the switch include a start switch for starting blood collection, a stop switch for stopping blood collection, a mixing switch for mixing, a blood collection volume selection switch for selecting a blood collection volume, a selection switch for selecting light irradiation, and the like.

  Above the operation panel 96 in the main body 90, a tube passage 100 through which the blood collection tube 28c passes, a clamp 102 for closing and opening the blood collection tube 28c in the tube passage 100, a clamp lever 104 for closing the clamp 102, And a clamp release lever 106 that opens the clamp 102 in the closed state.

  As shown in FIGS. 4A and 4B, the blood collection apparatus 10A can arrange (accommodate) the first arrangement unit 110 in which the inactivation processing unit 36A can be arranged, the blood collection bag 26, the preprocessing unit 18, and the separation processing unit 20. 2nd arrangement | positioning part 112 (accommodating part). The first placement unit 110 and the second placement unit 112 are partitioned by a partition wall 108. The partition wall 108 is formed with an insertion hole 114 through which a blood collection tube 28d that connects the inactivation processing part 36A and the blood collection bag 26 to each other is inserted. The second placement unit 112 is provided with a tray 116 capable of measuring the amount of blood collected in the blood collection bag 26 (blood collection amount). The tray 116 is configured to be swingable by a swing mechanism (not shown) in order to prevent blood in the blood collection bag 26 from clotting.

  The location where the first placement portion 110 is located and the location where the second placement portion 112 is located become substantially closed spaces when the cover 92 is closed, and the first accommodation chamber 118 and the second accommodation chamber 120 are formed. . The cover 92 contacts the upper surface of the main body 90 and the partition wall 108 so that each of the first storage chamber 118 and the second storage chamber 120 is substantially airtight when closed.

  The first placement unit 110 is provided with a first light irradiation unit 122 that irradiates the inactivation processing unit 36 </ b> A with light of a predetermined wavelength, and the second placement unit 112 irradiates the blood collection bag 26 with light of a predetermined wavelength. A second light irradiation unit 124 is provided. The first light irradiation unit 122 includes a first irradiation unit 122 a provided in the main body 90 and a second irradiation unit 122 b provided on the inner surface of the cover 92.

  As shown in FIGS. 5A and 5B, the first irradiation unit 122a includes a plate-like support part 126a on which the inactivation processing part 36A is placed, and a plurality of light emitting parts 128a fixed to the support part 126a. . The support part 126a is formed in a rectangular shape larger than the inactivation processing part 36A in plan view (see FIG. 4A). The plurality of light emitting portions 128a are configured as light emitting diodes, and a plurality of light emitting portions 128a are arranged in the longitudinal direction and the short direction of the support portion 126a (see FIG. 5A).

  Each light emitting unit 128a emits ultraviolet light. Specifically, the peak wavelength of the ultraviolet light irradiated by the light emitting unit 128a is set in a range of 200 nm to 400 nm, preferably in a range of 290 nm to 330 nm, or in a range of 360 nm to 380 nm, preferably 300 nm to 315 nm. A range is more preferred. When the peak wavelength is in the range of 300 nm to 315 nm, red blood cells can be suitably transmitted.

  4B and 5B, the first irradiation unit 122a contacts one surface (lower surface) of the inactivation processing unit 36A. The 1st irradiation unit 122a irradiates an ultraviolet-ray over the whole process flow path 58 of the inactivation process part 36A. The 2nd irradiation unit 122b has the plate-shaped support part 126b and the some light emission part 128b fixed to the support part 126b. The support part 126b and the light emitting part 128b are configured similarly to the support part 126a and the light emitting part 128a.

  The second irradiation unit 122b is provided on the cover 92 so as to cover the other surface (upper surface) of the inactivation processing unit 36A in a state where the cover 92 is closed. At this time, the second irradiation unit 122b contacts the other surface of the inactivation processing unit 36A. However, the second irradiation unit 122b may be close to the other surface of the inactivation processing unit 36A with the cover 92 closed. The 2nd irradiation unit 122b irradiates an ultraviolet-ray over the whole process flow path 58 of the inactivation process part 36A. That is, the first irradiation unit 122a and the second irradiation unit 122b are irradiated with ultraviolet rays from both sides in the thickness direction of the inactivation processing unit 36A (the direction orthogonal to the blood flow direction in the processing channel 58). Is provided.

  As shown in FIGS. 4A and 4B, the second light irradiation unit 124 includes a third irradiation unit 124 a provided on the tray 116 and a fourth irradiation unit 124 b provided on the inner surface of the cover 92. The third irradiation unit 124a includes a plate-like support part 127a and a plurality of light emitting parts 129a fixed to the support part 127a. The support part 127a and the light emitting part 129a are configured similarly to the support part 126a and the light emitting part 128a. The third irradiation unit 124a contacts one surface (lower surface) of the blood collection bag 26. The 3rd irradiation unit 124a irradiates an ultraviolet-ray over the whole part in which the blood is accommodated among the blood collection bags 26. FIG.

  The fourth irradiation unit 124b includes a plate-like support portion 127b and a plurality of light emitting portions 129b fixed to the support portion 127b. The support part 127b and the light emitting part 129b are configured similarly to the support part 126a and the light emitting part 128a. The fourth irradiation unit 124b is disposed so as to cover the other surface (upper surface) of the blood collection bag 26 with the cover 92 closed. At this time, the fourth irradiation unit 124 b comes into contact with the other surface of the blood collection bag 26. However, the fourth irradiation unit 124b may be close to the other surface of the blood collection bag 26 with the cover 92 closed. The 4th irradiation unit 124b irradiates an ultraviolet-ray over the whole part in which the blood is accommodated among the blood collection bags 26. FIG. That is, the third irradiation unit 124 a and the fourth irradiation unit 124 b are provided so that ultraviolet rays are irradiated from both sides in the thickness direction of the blood collection bag 26.

  The decompression pump 98 decompresses the inside of the first storage chamber 118 and the second storage chamber 120. However, the decompression pump 98 may decompress only the inside of the second storage chamber 120 in which the blood collection bag 26 is disposed.

  Next, a blood collection method according to this embodiment will be described.

  First, as shown in FIGS. 4A and 4B, the blood collection bag 26 is placed on the third irradiation unit 124 a, and the pretreatment unit 18 and the separation treatment unit 20 are placed in a place that does not interfere with the second storage chamber 120. To do. Further, the blood collection tube 28d is passed through the insertion hole 114 of the partition wall 108, and the inactivation processing part 36A is placed on the first irradiation unit 122a. Subsequently, the blood collection tube 28c is passed through the tube passage 100, the cover 92 is closed, and the inside of the first storage chamber 118 and the second storage chamber 120 is kept airtight. Then, the power switch 94 is turned on to set a blood collection amount (for example, 200 ml or 400 ml).

  As shown in FIG. 1, the blood collection needle 22 is then punctured into the blood vessel of the donor, and blood is collected from the donor (collection process). Here, prior to the collection of blood into the blood collection bag 26, a predetermined amount of the initial blood flow (initial blood collection flow) from the donor is accommodated in the initial blood bag 32. In this case, the clamp 44 is opened while the sealing member 48 is in a closed state (initial state). This prevents the initial blood flow from flowing into the blood collection tube 28b side, that is, the blood collection bag 26 side, while the initial blood collection bag is passed through the blood collection tube 28a, the branch connector 30 and the branch tube 42. 32.

  Next, by attaching a blood collection tube (not shown) to the sampling port 46, the initial blood collection flow is collected in the blood collection tube. The collected initial blood stream is used as test blood. Depending on the application, the portion from the branch connector 30 to the sampling port 46 may be omitted.

  When the initial blood collection is collected, the branch tube 42 is closed by the clamp 44, and the sealing member 48 is broken to open the flow path of the blood collection tube 28b. Thereby, blood flows into the blood collection tube 28b. Further, the sealing member 51 is broken and the clamp 55 is opened. Thereby, the inactivating agent in the storage bag 34 suspended from the suspension base flows into the blood collection tube 28c due to a drop, and is added to the blood in the blood collection tube 28c (addition process).

  Further, the blood collection process is started by pressing the start switch of the blood collection apparatus 10A. That is, the tray 116 starts to swing, and the decompression pump 98 is driven to decompress the interior of the first storage chamber 118 and the second storage chamber 120. Further, the first light irradiation unit 122 and the second light irradiation unit 124 are driven.

  When the inside of the second storage chamber 120 is depressurized, the blood to which the inactivating agent is added is guided into the processing channel 58 of the inactivation processing unit 36A through the blood collection tube 28c (introduction process). As shown in FIGS. 4A, 4B, and 5B, in the inactivation processing unit 36A, light (ultraviolet rays) having a wavelength that inactivates the pathogen is irradiated from the first light irradiation unit 122 to the blood flowing through the processing channel 58. (Light irradiation process). At this time, the first light irradiation unit 122 irradiates ultraviolet rays from both sides (vertical direction) across the inactivation processing unit 36A. Thereby, the inactivating agent which received the ultraviolet rays is activated, and the pathogen in the blood is inactivated. The inactivated blood is guided into the blood collection bag 26 through the blood collection tube 28d.

  In the blood collection bag 26, ultraviolet light is irradiated from the second light irradiation unit 124 to the blood in the blood collection bag 26. At this time, the second light irradiation unit 124 irradiates ultraviolet rays from both sides (vertical direction) sandwiching the blood collection bag 26. Thereby, the pathogen of the blood in the blood collection bag 26 will be inactivated more reliably.

  When a predetermined amount of blood is collected in the blood collection bag 26, the blood collection tube 28d is welded and sealed with a tube sealer or the like, and then cut at a portion where the blood collection tube 28d is sealed. Next, a filtration process for removing predetermined cells from the whole blood is performed. In the filtration step, the blood collection bag 26 is set at a relatively upper position, the first bag 70 is set at a relatively lower position, and the filter 60 is disposed at an intermediate position thereof, and then provided at one end of the inlet side tube 64. A breaking operation is performed on the sealing member 62 to open the flow path of the inlet side tube 64. As a result, the whole blood in the blood collection bag 26 flows into the filter 60 through the inlet side tube 64, and white blood cells and platelets are removed in the process of passing through the filter 60, and then into the first bag 70 through the outlet side tube 66. Inflow and collected.

  Thereafter, the outlet side tube 66 is welded and sealed at a position downstream of the clamp 68 with a tube sealer or the like, and then the outlet side tube 66 is cut at the sealed portion.

  Next, the blood components collected in the first bag 70 are separated into plasma and concentrated erythrocytes using a centrifugal transfer device (not shown) and stored in predetermined bags. Thereby, a plurality of blood products subjected to the inactivation treatment can be obtained.

  Next, effects of the blood collection device 10A, the blood collection kit 14, the blood collection system 12A, the blood collection method, and the inactivation processing method according to the present embodiment will be described.

  The blood collection apparatus 10A is configured such that a blood collection kit 14 including a blood collection line 24 and a blood collection bag 26 is disposed, and collects blood into the blood collection bag 26 from the blood collection needle 22 punctured by the donor via the blood collection line 24. . The blood collection device 10 </ b> A has a second collection unit 112 (container) that can accommodate the blood collection bag 26 and a blood collection bag 26 via the blood collection line 24 by decompressing the second arrangement unit 112 (second storage chamber 120). A decompression pump 98 that sucks blood into the inside, a first placement unit 110 capable of placing the inactivation processing part 36A provided on the blood collection line 24, and a first placement unit 110 provided with an inactivating agent. A first light irradiation unit 122 that irradiates blood flowing through the inactivation processing unit 36A with light having a wavelength that inactivates the pathogen.

  The blood collection kit 14 includes a storage bag 34 in which an inactivation agent is stored, and a branch tube 53 (introduction tube) that guides the inactivation agent in the storage bag 34 to the blood collection line 24. The blood collection line 24 is provided with an inactivation processing unit 36A through which blood to which an inactivating agent is added circulates and irradiated with light having a wavelength that inactivates the pathogen.

  As a result, the blood flowing through the inactivation processing unit 36A is irradiated with light having a wavelength that inactivates the pathogen, and thus the blood after the inactivation processing is stored in the blood collection bag 26. That is, pathogen inactivation treatment can be performed during blood collection. Thereby, after separating the blood collected in the blood collection bag 26 into a plurality of blood products, the time and cost of the inactivation process can be reduced as compared with the case where the inactivation process is performed for each blood product.

  Since the 1st light irradiation part 122 is irradiating the ultraviolet-ray which has a wavelength of the range of 200 nm or more and 400 nm or less, it can perform the inactivation process of a pathogen effectively.

  The first light irradiation unit 122 is configured to irradiate ultraviolet rays from both sides (vertical direction) sandwiching the inactivation processing unit 36A in a state where the inactivation processing unit 36A is arranged in the first arrangement unit 110. The light emitting units 128a and 128b are provided. Thereby, the ultraviolet rays can be efficiently irradiated to the blood flowing through the inactivation processing unit 36A.

  The light emitting units 128a and 128b are light emitting diodes. Thereby, since heat generation can be suppressed as compared with the case where the light emitting units 128a and 128b are configured by mercury lamps, the light emitting units 128a and 128b can be brought close to the inactivation processing unit 36A. Thereby, it is possible to more efficiently irradiate the blood flowing through the processing channel 58 with ultraviolet rays.

  10 A of blood collection apparatuses are provided with the 1st light irradiation part 122 and the 2nd light irradiation part 124 which irradiates light to the blood accommodated in the blood collection bag 26. FIG. Thereby, the inactivation process of a pathogen can be performed with respect to the blood accommodated in the blood collection bag 26. FIG. Therefore, the pathogen inactivation process for blood can be more reliably performed. The light emitting units 129a and 129b are light emitting diodes. Therefore, it is possible to more efficiently irradiate the blood in the blood collection bag 26 with ultraviolet rays.

  The first placement unit 110 is provided adjacent to the second placement unit 112 in the horizontal direction. Therefore, the configuration of the blood collection device 10A can be simplified.

  The processing channel 58 of the inactivation processing unit 36A has a dimension in the width direction (width dimension w) orthogonal to the blood flow direction and a height direction dimension (height dimension h) orthogonal to the flow direction and width direction. It is formed long. As a result, it is possible to efficiently irradiate the blood flowing through the processing channel 58 from the height direction of the processing channel 58 with ultraviolet rays.

  The height h of the processing flow path 58 of the inactivation processing unit 36A is set to 50 μm to 400 μm or less. Thereby, light can be efficiently irradiated to the whole blood flowing through the processing flow path 58 of the inactivation processing unit 36A.

In a blood collection system 12A comprising a blood collection kit 14 for collecting blood from a blood collection needle 22 punctured by a donor into a blood collection bag 26 via a blood collection line 24, and a blood collection apparatus 10A configured to arrange the blood collection kit 14 The inactivation processing unit 36A and the first light irradiation unit 122 are configured to be capable of irradiating the blood flowing through the inactivation processing unit 36A with an integrated light amount of 30 J / L · cm ² or more. Thereby, the inactivation process of a pathogen can be reliably performed at the time of blood collection.

  The blood collection method is a method of collecting blood from a blood collection needle 22 punctured by a donor into a blood collection bag 26 via a blood collection line 24, an addition step of adding an inactivating agent to the blood flowing through the blood collection line 24, and inactivation A light irradiation step of irradiating the blood to which the agent is added with light having a wavelength that inactivates the pathogen and a housing step of storing the light irradiated blood in the blood collection bag 26 are performed.

  Further, the inactivation treatment method includes a blood collection needle 22 for puncturing whole blood from a donor, a blood collection bag 26 (accommodation bag) for accommodating whole blood, a blood collection line 24 connecting the blood collection needle 22 and the blood collection bag 26, The pathogen of whole blood is inactivated using the blood collection kit 14 including the inactivation processing unit 36A provided on the blood collection line 24. In this inactivation processing method, a collection step of collecting whole blood from a donor through a blood collection needle 22, an addition step of adding an inactivating agent to the collected whole blood, and the collected whole blood to the inactivation processing section 36A. An introduction process to be introduced, and a light irradiation process to irradiate light having a wavelength that inactivates the pathogen to the whole blood introduced into the inactivation processing unit 36A by the introduction process and added with the inactivation agent by the addition process. Thereby, the inactivation process of a pathogen can be performed at the time of blood collection.

  The blood collection kit 14 may include inactivation processing units 36B to 36G shown in FIGS. 6A to 9B instead of the inactivation processing unit 36B. Note that, in the inactivation processing units 36B and 36C, the same reference numerals are given to the same configurations as the inactivation processing unit 36A described above, and detailed description thereof is omitted.

  As shown in FIG. 6A, the inactivation processing part 36 </ b> B includes three central wall portions 130 a to 130 c provided at the center in the width direction of the processing channel 58, and two on each side in the width direction of the processing channel 58. Side wall portions 132 and 134 provided. The central wall portions 130 a to 130 c and the side wall portions 132 and 134 extend over the entire length of the processing channel 58. However, the height dimension of each of the central wall portions 130a to 130c and the side wall portions 132 and 134 (the dimension along the thickness direction of the processing main body portion 52) is smaller than the height dimension of the processing channel 58. Also good.

  The central wall portions 130a to 130c are separated from each other in the blood flow direction (longitudinal direction of the processing body portion 52). The central wall portion 130 a is curved in an arc shape so as to protrude toward the inlet port 54. The central wall portions 130 b and 130 c are curved in an arc shape so as to protrude toward the outlet port 56. Each of the two side wall portions 132 and the two side wall portions 134 is separated from each other in the longitudinal direction of the processing main body portion 52. The side wall portions 132 and 134 extend from the side surface constituting the processing channel 58 so as to be inclined toward the inlet port 54 toward the center in the width direction of the processing channel 58.

  The processing flow path 58 of the inactivation processing unit 36B is provided with wall portions (central wall portions 130a to 130c and side wall portions 132 and 134) extending in a direction intersecting with the blood flow direction. As a result, the blood flow in the processing flow path 58 is blocked by the central wall portions 130a to 130c and the side wall portions 132 and 134, so that the central wall portions 130a to 130c and the side wall portions 132 and 134 are provided. Compared with the case where there is not, the time for blood to flow from the inlet port 54 to the outlet port 56 becomes longer. Therefore, it is possible to lengthen the irradiation time of light (integrated irradiation amount of light per unit area of blood) with respect to blood flowing in the processing channel 58. Therefore, inactivation of blood pathogens in the processing flow path 58 can be performed more reliably.

  As illustrated in FIG. 6B, the inactivation processing unit 36 </ b> C includes two central wall portions 136 a and 136 b provided at the center in the width direction of the processing flow channel 58, and side wall portions 132 and 134. The central wall portion 136a includes a central extending portion 138 extending along the width direction, and an inclined portion 140 inclined to the side where the outlet port 56 is located outward from the both ends of the central extending portion 138 in the width direction. ,including. The central wall portion 136 b extends in the width direction of the processing flow path 58. According to the inactivation processing unit 36C, the same effects as the inactivation processing unit 36B are achieved.

  As illustrated in FIG. 6C, the inactivation processing unit 36 </ b> D includes a processing body 150 that is rectangular in plan view, an inlet port 54, and an outlet port 56. The inlet port 54 is provided at one end of one long side of the processing body 150, and the outlet port 56 is provided at the other end of the other long side of the processing body 150. The processing main body 150 is formed with a processing flow path 152 extending so as to meander. The processing flow path 152 is curved in a semicircular shape so that the straight flow path 154a extending along the short direction of the processing main body 150 and the end of the processing main body 150 in the short direction are turned 180 °. And a bent flow path 154b. The interval between the adjacent straight channels 154a is narrower than the width dimension of the straight channels 154a.

  The processing flow path 152 of the inactivation processing unit 36D extends so as to meander. Thereby, the irradiation time of the ultraviolet rays with respect to the blood flowing through the processing channel 152 can be lengthened.

  As illustrated in FIG. 6D, the inactivation processing unit 36 </ b> E includes a processing body unit 160 that is rectangular in plan view, an inlet port 54, and an outlet port 56. The processing main body 160 is formed with a processing flow path 162 extending so as to meander. The processing flow path 162 includes a curved flow path 164a that is curved so as to protrude toward one long side of the processing main body 160, and a curved flow that is curved so as to protrude toward the other long side of the processing main body 160. The paths 164b are formed so as to be alternately provided along the longitudinal direction of the processing main body 160. The interval between the curved channels 164a adjacent in the longitudinal direction is wider than the channel width of the curved channel 164a. According to the inactivation processing unit 36E, the same effect as the inactivation processing unit 36D is obtained.

  As shown in FIG. 7A, the inactivation processing unit 36F includes a tube-shaped processing body 170, an inlet port 172 provided at one end of the processing body 170, and an outlet provided at the other end of the processing body 170. Port 174. The processing body 170 has a processing channel 175 (see FIG. 7B). The processing body 170 includes an inlet-side straight portion 176a that extends linearly from the inlet port 172, an intermediate curved portion 176b that curves in a semicircular shape from the inlet-side straight portion 176a, and from the intermediate curved portion 176b to the outlet port 174. And an outlet-side straight portion 176c extending linearly. The inlet-side straight portion 176a and the outlet-side straight portion 176c extend in parallel to each other.

  As shown in FIGS. 7A and 7B, in this case, the blood collection apparatus 10 </ b> A uses the first light irradiation unit 180 instead of the first light irradiation unit 122. The first irradiation unit 182a of the first light irradiation unit 180 includes a support unit 186a in which a groove 184 into which the inactivation processing unit 36F can be inserted is formed, and a plurality of light emitting units 188a to 188c fixed to the support unit 186a. Have. The groove 184 is formed in a shape corresponding to the shape of the inactivation processing part 36F. The light emitting units 188a to 188c are arranged along the groove 184 so as to surround the groove 184 from three directions. That is, the light emitting part 188 a is located below the groove 184, and the light emitting parts 188 b and 188 c are located on the left and right sides of the groove 184.

  7B, the second irradiation unit 182b of the first light irradiation unit 180 includes a support unit 186b provided on the inner surface of the cover 92 and a plurality of light emitting units 188d. The plurality of light emitting units 188d are arranged along the processing body 170 so as to cover the processing body 170 from above with the cover 92 closed.

  In this case, the processing main body 170 is configured in a tube shape, and the light emitting units 188a to 188d are arranged in the circumferential direction of the processing main body 170 in a state where the inactivation processing unit 36F is arranged in the first arrangement unit 110. It is provided at intervals. Therefore, the inactivation processing unit 36F is sandwiched between both sides of the inactivation processing unit 36F sandwiching the inactivation processing unit 36F in the first direction orthogonal to the blood flow direction and the second direction orthogonal to the distribution direction and the first direction. Light is emitted from both sides. Therefore, it is possible to more efficiently irradiate the blood flowing through the processing flow path 175 of the inactivation processing unit 36F with light.

  Moreover, the 1st light irradiation part 180 has the support part 186a in which the groove | channel 184 which can insert the inactivation process part 36F was formed, and the several light emission parts 188a-188c are being fixed to the support part 186a. Therefore, the position of the inactivation processing unit 36F with respect to the light emitting units 188a to 188c can be made substantially constant. Therefore, it is possible to stably irradiate the blood flowing through the processing channel 175 with ultraviolet rays.

  As shown in FIG. 8A, the inactivation processing unit 36G includes a plurality of (seven in FIG. 8A) plate-like processing main body portions 190 extending in one direction, one end of each processing main body portion 190, and a blood collection tube 28c. A first connecting part 192 that connects the other end of each processing body 190 and the blood collection tube 28d, a holding part 196 that holds a plurality of processing body parts 190, and a holding part 196. And a handle 198 provided on the head. In FIG. 9B, each processing body 190 has a rectangular cross section. In each processing body 190, two processing channels 200 are formed over the entire length. These processing flow paths 200 communicate with the inner hole of the blood collection tube 28c via a flow path (not shown) of the first connection part 192, and communicate with the inner hole of the blood collection tube 28d via a flow path (not shown) of the second connection part 194. Communicate. The two processing channels 200 are arranged side by side in the width direction, which is the longitudinal direction of the cross section of the processing main body 190. Further, the processing channel 200 has a width dimension larger than a height dimension (a dimension along the thickness direction of the processing body 190).

  In this case, as shown in FIG. 8B, the blood collection apparatus 10 </ b> A uses a first light irradiation unit 202 instead of the first light irradiation unit 122. The first light irradiation unit 202 includes a support unit 206 in which a plurality of (seven in FIG. 8B) grooves 204 are formed, and a plurality of light emitting units 208 fixed to the support unit 206. The 1st light irradiation part 202 is formed in the rectangular shape by planar view. Each groove 204 extends over the entire length of the first light irradiation unit 202 in the longitudinal direction. In FIG. 9B, each groove 204 is formed in a size that allows each processing body 190 to be inserted. The light emitting unit 208 is provided so as to sandwich the processing flow channel 200 from the width direction of the groove 204 in a state where the processing main body 190 is inserted into the groove 204. That is, two light emitting portions 208 are arranged in parallel along the depth direction of the groove 204.

  As shown in FIGS. 9A and 9B, in the inactivation processing unit 36 </ b> G and the first light irradiation unit 202, the plurality of processing main body units 190 are connected to the plurality of first light irradiation units 202 while holding the handle 198. It can be simultaneously inserted into the groove 204. Thereby, mounting | wearing with respect to the 1st light irradiation part 202 of the inactivation process part 36G can be performed easily. In addition, according to this configuration, since ultraviolet rays are irradiated from both sides of the processing channel 200, it is possible to efficiently irradiate light to the blood flowing through the inactivation processing unit 36G.

  Next, a blood collection system 12B according to a modification will be described with reference to FIG. As shown in FIG. 10, in the blood collection apparatus 10B of the blood collection system 12B, the first arrangement unit 110 in which the inactivation processing unit 36A can be arranged is located above the second arrangement unit 112 in which the blood collection bag 26 can be arranged. In this case, the cover 92 includes a first cover part 210 that opens and closes the first placement part 110 and a second cover part 212 that opens and closes the second placement part 112. The second cover portion 212 is formed with an insertion hole 214 through which the blood collection tube 28d is inserted. According to such a configuration, the first placement unit 110 is provided adjacently above the second placement unit 112. Therefore, the installation area of the blood collection device 10B can be reduced as compared with the case where the first arrangement unit 110 and the second arrangement unit 112 are arranged adjacent to each other in the horizontal direction.

  The present invention is not limited to the configuration described above. In the blood collection systems 12A and 12B, the blood collection devices 10A and 10B may include a mechanism for adding an inactivating agent to the blood flowing in the blood collection line 24 or the blood in the inactivation processing units 36A to 36G.

  The blood collection device, the blood collection kit, the blood collection system, the blood collection method, and the inactivation processing method according to the present invention are not limited to the above-described embodiments, and various configurations can be adopted without departing from the gist of the present invention. is there.

DESCRIPTION OF SYMBOLS 10A, 10B ... Blood collection apparatus 12A, 12B ... Blood collection system 14 ... Blood collection kit 26 ... Blood collection bag 36A-36G ... Inactivation processing part 110 ... 1st arrangement part 112 ... 2nd arrangement part 122, 180, 202 ... 1st light irradiation Unit 124 ... second light irradiation unit

Claims (20)

A blood collection device configured to arrange a blood collection kit including a blood collection line and a blood collection bag, and for collecting blood into the blood collection bag from the blood collection needle punctured by a donor through the blood collection line,
An accommodating portion capable of accommodating the blood collection bag;
Decompression means for sucking blood into the blood collection bag via the blood collection line by depressurizing the inside of the container;
An arrangement part capable of arranging an inactivation processing part provided on the blood collection line;
A light irradiating unit that irradiates light having a wavelength that inactivates the pathogen to blood flowing through the inactivation processing unit to which the pathogen inactivating agent is added, provided in the arrangement unit;
A blood collection apparatus characterized by the above. The blood collection device according to claim 1, wherein
The light irradiation unit irradiates ultraviolet rays having a wavelength in a range of 200 nm to 400 nm.
A blood collection apparatus characterized by the above. The blood collection device according to claim 1 or 2,
The light irradiation unit has a plurality of light emitting units configured to irradiate the light from both sides sandwiching the inactivation processing unit in a state where the inactivation processing unit is arranged in the arrangement unit,
A blood collection apparatus characterized by the above. The blood collection device according to claim 3,
The inactivation processing unit is configured in a tube shape,
Four of the light emitting units are provided at equal intervals in the circumferential direction of the inactivation processing unit in a state where the inactivation processing unit is arranged in the arrangement unit.
A blood collection apparatus characterized by the above. The blood collection device according to claim 4,
The light irradiation part has a support part formed with a groove into which the inactivation processing part can be inserted,
The plurality of light emitting units are fixed to the support unit,
A blood collection apparatus characterized by the above. The blood collection device according to any one of claims 3 to 5,
The light emitting unit is a light emitting diode.
A blood collection apparatus characterized by the above. The blood collection device according to any one of claims 1 to 6,
A first light irradiation unit as the light irradiation unit;
A second light irradiating unit that irradiates the light that is contained in the blood collection bag and to which the pathogen inactivating agent is added,
A blood collection apparatus characterized by the above. The blood collection device according to any one of claims 1 to 7,
The arrangement portion is provided adjacent to the housing portion in the horizontal direction.
A blood collection apparatus characterized by the above. The blood collection device according to any one of claims 1 to 7,
The arrangement part is provided adjacent to the upper part of the housing part.
A blood collection apparatus characterized by the above. A blood collection method for collecting blood in a blood collection bag through a blood collection line from a blood collection needle punctured by a donor,
An addition step of adding a pathogen inactivating agent to the blood flowing through the blood collection line;
A light irradiation step of irradiating the blood to which the pathogen inactivating agent has been added with light having a wavelength that inactivates the pathogen;
A housing step of housing the blood irradiated with the light in the blood collection bag,
A blood collection method characterized by the above. The blood collection method according to claim 10, wherein
In the light irradiation step, an ultraviolet ray having a wavelength in a range of 200 nm to 400 nm is irradiated.
A blood collection method characterized by the above. The blood collection method according to claim 10 or 11,
In the light irradiation step, the light is irradiated from both sides sandwiching an inactivation treatment part through which blood to which the pathogen inactivating agent is added is circulated,
A blood collection method characterized by the above. The blood collection method according to any one of claims 10 to 12,
The inactivation processing unit is configured in a tube shape,
In the light irradiation step, both sides of the inactivation treatment unit sandwiched in a first direction orthogonal to the blood circulation direction of the inactivation treatment unit through which the blood to which the pathogen inactivating agent is added circulates, the flow direction and Irradiating the light from both sides sandwiching the inactivation processing part in a second direction orthogonal to the first direction;
A blood collection method characterized by the above. In a blood collection kit for collecting blood into a blood collection bag from a blood collection needle punctured by a donor through a blood collection line,
A storage bag containing a pathogen inactivating agent; and
An introduction tube for guiding the pathogen inactivating agent in the containing bag to the blood collection line,
The blood collection line is provided with an inactivation processing unit through which blood to which the pathogen inactivating agent is added is circulated and irradiated with light having a wavelength that inactivates the pathogen.
A blood collection kit characterized by the above. The blood collection kit according to claim 14,
The processing flow path of the inactivation processing part is formed such that the dimension in the width direction orthogonal to the blood flow direction is longer than the dimension in the height direction orthogonal to the flow direction and the width direction.
A blood collection kit characterized by the above. The blood collection kit according to claim 15,
The dimension in the height direction of the processing flow path of the inactivation processing unit is set to 50 μm or more and 400 μm or less,
A blood collection kit characterized by the above. The blood collection kit according to any one of claims 14 to 16,
The processing flow path of the inactivation processing part is provided with a wall part extending in a direction crossing the blood flow direction,
A blood collection kit characterized by the above. The blood collection kit according to any one of claims 14 to 16,
The processing flow path of the inactivation processing unit extends to meander,
A blood collection kit characterized by the above. A blood collection system comprising: a blood collection kit for collecting blood in a blood collection bag from a blood collection needle punctured by a donor through a blood collection line; and a blood collection device configured to arrange the blood collection kit,
The blood collection kit includes
A storage bag containing a pathogen inactivating agent; and
An introduction tube for guiding the pathogen inactivating agent in the containing bag to the blood collection line;
An inactivation treatment part that is provided in the blood collection line and in which the blood to which the pathogen inactivating agent is added circulates,
The blood collection device comprises:
An accommodating portion capable of accommodating the blood collection bag;
Decompression means for sucking blood into the blood collection bag via the blood collection line by depressurizing the inside of the container;
An arrangement part capable of arranging the inactivation processing part;
A light irradiation unit that is provided in the arrangement unit and irradiates light having a wavelength that inactivates a pathogen to blood flowing through the inactivation processing unit, and
The inactivation processing unit and the light irradiation unit are configured to be capable of irradiating an integrated light amount of 30 J / L · cm ² or more to the blood flowing through the inactivation processing unit.
A blood collection system characterized by that. A blood collection needle for collecting whole blood from a donor, a storage bag for storing the whole blood, a blood collection line for connecting the blood collection needle and the storage bag, and an inactivation processing section provided on the blood collection line; An inactivation treatment method for inactivating the whole blood pathogen using a blood collection kit comprising:
A collection step of collecting whole blood from the donor via the blood collection needle;
An addition step of adding a pathogen inactivating agent to the collected whole blood;
An introduction step of introducing the collected whole blood into the inactivation processing unit;
Performing a light irradiation step of irradiating light of a wavelength that inactivates the pathogen to the whole blood introduced into the inactivation processing unit by the introduction step and to which the pathogen inactivation agent has been added by the addition step.
The inactivation processing method characterized by the above-mentioned.

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