JP2018154620A5 - - Google Patents
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- Publication number
- JP2018154620A5 JP2018154620A5 JP2018046435A JP2018046435A JP2018154620A5 JP 2018154620 A5 JP2018154620 A5 JP 2018154620A5 JP 2018046435 A JP2018046435 A JP 2018046435A JP 2018046435 A JP2018046435 A JP 2018046435A JP 2018154620 A5 JP2018154620 A5 JP 2018154620A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- independently selected
- group
- benzimidazol
- substituent group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 146
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 229910052736 halogen Inorganic materials 0.000 claims 38
- 150000002367 halogens Chemical class 0.000 claims 38
- 125000003545 alkoxy group Chemical group 0.000 claims 35
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 125000004104 aryloxy group Chemical group 0.000 claims 13
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 12
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- CTSHCVLSZISSOJ-NSHDSACASA-N (3S)-2-methyl-3-[6-[5-(trifluoromethyl)pyridin-2-yl]oxybenzimidazol-1-yl]butan-2-ol Chemical compound CC(C)([C@H](C)N1C=NC2=C1C=C(C=C2)OC1=NC=C(C=C1)C(F)(F)F)O CTSHCVLSZISSOJ-NSHDSACASA-N 0.000 claims 2
- QCQSSZIRVCAQII-UHFFFAOYSA-N 1-[5-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]oxybenzimidazol-1-yl]-2-methylpropan-2-ol Chemical compound FC=1C(=NC=C(C=1)C(F)(F)F)OC1=CC2=C(N(C=N2)CC(C)(O)C)C=C1 QCQSSZIRVCAQII-UHFFFAOYSA-N 0.000 claims 2
- HZTINSOGTJLZDO-UHFFFAOYSA-N 1-[6-(4-chlorophenoxy)benzimidazol-1-yl]-2-methylpropan-2-ol Chemical compound ClC1=CC=C(OC=2C=CC3=C(N(C=N3)CC(C)(O)C)C=2)C=C1 HZTINSOGTJLZDO-UHFFFAOYSA-N 0.000 claims 2
- WHPPNBMQFKEPFQ-UHFFFAOYSA-N 1-[6-(4-fluorophenoxy)benzimidazol-1-yl]-2-methylpropan-2-ol Chemical compound FC1=CC=C(OC=2C=CC3=C(N(C=N3)CC(C)(O)C)C=2)C=C1 WHPPNBMQFKEPFQ-UHFFFAOYSA-N 0.000 claims 2
- WSKQGFLILOLDCX-UHFFFAOYSA-N 1-[6-[2-fluoro-4-(trifluoromethyl)phenyl]benzimidazol-1-yl]-2-methylpropan-2-ol Chemical compound FC1=C(C=CC(=C1)C(F)(F)F)C=1C=CC2=C(N(C=N2)CC(C)(O)C)C=1 WSKQGFLILOLDCX-UHFFFAOYSA-N 0.000 claims 2
- NBGOPIRZHIPQRD-UHFFFAOYSA-N 2-methyl-1-[5-[5-(trifluoromethyl)pyrazin-2-yl]oxybenzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=CC(=C2)OC1=NC=C(N=C1)C(F)(F)F)(C)O NBGOPIRZHIPQRD-UHFFFAOYSA-N 0.000 claims 2
- RLMNBUFULNLOPS-UHFFFAOYSA-N 2-methyl-1-[6-(6-methylpyridin-3-yl)oxybenzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)OC=1C=NC(=CC=1)C)(C)O RLMNBUFULNLOPS-UHFFFAOYSA-N 0.000 claims 2
- KVCQQTCXWKRGCX-UHFFFAOYSA-N 2-methyl-1-[6-[4-(trifluoromethoxy)phenoxy]benzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)OC1=CC=C(C=C1)OC(F)(F)F)(C)O KVCQQTCXWKRGCX-UHFFFAOYSA-N 0.000 claims 2
- JVOMABVXOFVUOL-UHFFFAOYSA-N 2-methyl-1-[6-[4-(trifluoromethyl)phenoxy]benzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)OC1=CC=C(C=C1)C(F)(F)F)(C)O JVOMABVXOFVUOL-UHFFFAOYSA-N 0.000 claims 2
- HVVOVNLIPDULFL-UHFFFAOYSA-N 2-methyl-1-[6-[4-(trifluoromethyl)phenyl]benzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)C1=CC=C(C=C1)C(F)(F)F)(C)O HVVOVNLIPDULFL-UHFFFAOYSA-N 0.000 claims 2
- WZPSQCIJYTVQAP-UHFFFAOYSA-N 2-methyl-1-[6-[5-(2,2,2-trifluoroethyl)pyridin-2-yl]oxybenzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)OC1=NC=C(C=C1)CC(F)(F)F)(C)O WZPSQCIJYTVQAP-UHFFFAOYSA-N 0.000 claims 2
- CQIHBEKHGJWJCS-UHFFFAOYSA-N 2-methyl-1-[6-[5-(trifluoromethyl)pyridin-2-yl]benzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)C1=NC=C(C=C1)C(F)(F)F)(C)O CQIHBEKHGJWJCS-UHFFFAOYSA-N 0.000 claims 2
- LBGUDZXEWCRTOF-UHFFFAOYSA-N 2-methyl-1-[6-[5-(trifluoromethyl)pyridin-2-yl]oxybenzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)OC1=NC=C(C=C1)C(F)(F)F)(C)O LBGUDZXEWCRTOF-UHFFFAOYSA-N 0.000 claims 2
- IBUAJFFFVSQDJY-UHFFFAOYSA-N 2-methyl-4-[6-[5-(trifluoromethyl)pyridin-2-yl]oxybenzimidazol-1-yl]butan-2-ol Chemical compound CC(C)(CCN1C=NC2=C1C=C(C=C2)OC1=NC=C(C=C1)C(F)(F)F)O IBUAJFFFVSQDJY-UHFFFAOYSA-N 0.000 claims 2
- YMSHWPHXUKHDTK-UHFFFAOYSA-N 3-[[5-[2-methoxy-4-(trifluoromethyl)phenyl]benzimidazol-1-yl]methyl]oxetan-3-ol Chemical compound COC1=C(C=CC(=C1)C(F)(F)F)C1=CC2=C(N(C=N2)CC2(COC2)O)C=C1 YMSHWPHXUKHDTK-UHFFFAOYSA-N 0.000 claims 2
- XVLYOFSDBMMBGI-UHFFFAOYSA-N 3-[[6-[2-methoxy-4-(trifluoromethyl)phenyl]benzimidazol-1-yl]methyl]oxetan-3-ol Chemical compound COC1=C(C=CC(=C1)C(F)(F)F)C=1C=CC2=C(N(C=N2)CC2(COC2)O)C=1 XVLYOFSDBMMBGI-UHFFFAOYSA-N 0.000 claims 2
- UGENHCOEIHLMNX-UHFFFAOYSA-N 3-[[6-[4-(trifluoromethoxy)phenoxy]benzimidazol-1-yl]methyl]oxetan-3-ol Chemical compound FC(OC1=CC=C(OC=2C=CC3=C(N(C=N3)CC3(COC3)O)C=2)C=C1)(F)F UGENHCOEIHLMNX-UHFFFAOYSA-N 0.000 claims 2
- ARHHCSGDZLRWOP-UHFFFAOYSA-N 4-[6-(4-chlorophenoxy)benzimidazol-1-yl]-2-methylbutan-2-ol Chemical compound ClC1=CC=C(OC=2C=CC3=C(N(C=N3)CCC(C)(O)C)C=2)C=C1 ARHHCSGDZLRWOP-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 101000654386 Homo sapiens Sodium channel protein type 9 subunit alpha Proteins 0.000 claims 2
- 102100031367 Sodium channel protein type 9 subunit alpha Human genes 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- RKTBASLBIOLEPQ-UHFFFAOYSA-N 1-(2-cyclopentyloxyethyl)-6-[4-(trifluoromethyl)phenyl]benzimidazole Chemical compound C1(CCCC1)OCCN1C=NC2=C1C=C(C=C2)C1=CC=C(C=C1)C(F)(F)F RKTBASLBIOLEPQ-UHFFFAOYSA-N 0.000 claims 1
- CFNGDNQQJBDFBB-UHFFFAOYSA-N 1-(2-cyclopentyloxyethyl)-6-[5-(trifluoromethyl)pyridin-2-yl]benzimidazole Chemical compound C1(CCCC1)OCCN1C=NC2=C1C=C(C=C2)C1=NC=C(C=C1)C(F)(F)F CFNGDNQQJBDFBB-UHFFFAOYSA-N 0.000 claims 1
- JABHSUCMPLVSCD-UHFFFAOYSA-N 1-(oxolan-2-ylmethyl)-6-[4-(trifluoromethyl)phenyl]benzimidazole Chemical compound O1C(CCC1)CN1C=NC2=C1C=C(C=C2)C1=CC=C(C=C1)C(F)(F)F JABHSUCMPLVSCD-UHFFFAOYSA-N 0.000 claims 1
- PCDYQWFOXJHSNV-UHFFFAOYSA-N 1-[5-(5-chloro-3-fluoropyridin-2-yl)oxybenzimidazol-1-yl]-2-methylpropan-2-ol Chemical compound ClC=1C=C(C(=NC=1)OC1=CC2=C(N(C=N2)CC(C)(O)C)C=C1)F PCDYQWFOXJHSNV-UHFFFAOYSA-N 0.000 claims 1
- JABLISBXBZCSSZ-UHFFFAOYSA-N 1-[5-[2-fluoro-4-(trifluoromethyl)phenyl]benzimidazol-1-yl]-2-methylpropan-2-ol Chemical compound FC1=C(C=CC(=C1)C(F)(F)F)C1=CC2=C(N(C=N2)CC(C)(O)C)C=C1 JABLISBXBZCSSZ-UHFFFAOYSA-N 0.000 claims 1
- HFFDNZJMPWMLGT-UHFFFAOYSA-N 1-[5-[2-methoxy-4-(trifluoromethyl)phenyl]benzimidazol-1-yl]-2-methylpropan-2-ol Chemical compound COC1=C(C=CC(=C1)C(F)(F)F)C1=CC2=C(N(C=N2)CC(C)(O)C)C=C1 HFFDNZJMPWMLGT-UHFFFAOYSA-N 0.000 claims 1
- UIXVQTQMCKPVBC-UHFFFAOYSA-N 1-[6-(4-chloro-2-fluorophenyl)benzimidazol-1-yl]-2-methylpropan-2-ol Chemical compound ClC1=CC(=C(C=C1)C=1C=CC2=C(N(C=N2)CC(C)(O)C)C=1)F UIXVQTQMCKPVBC-UHFFFAOYSA-N 0.000 claims 1
- QCUGSRDKQARTMF-UHFFFAOYSA-N 1-[[6-[5-(trifluoromethyl)pyridin-2-yl]oxybenzimidazol-1-yl]methyl]cyclobutan-1-ol Chemical compound FC(C=1C=CC(=NC=1)OC=1C=CC2=C(N(C=N2)CC2(CCC2)O)C=1)(F)F QCUGSRDKQARTMF-UHFFFAOYSA-N 0.000 claims 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 1
- PMMRKGLNGVJHIF-UHFFFAOYSA-N 2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]ethanol Chemical compound CC1=NOC(=C1C1=CC2=C(N(C=N2)CCO)C=C1)C PMMRKGLNGVJHIF-UHFFFAOYSA-N 0.000 claims 1
- IGYLLEJQDWYRTD-UHFFFAOYSA-N 2-[5-[2-(2-hydroxyethyl)-1,2,4-triazol-3-yl]benzimidazol-1-yl]ethanol Chemical compound OCCN1N=CN=C1C1=CC=C(N(CCO)C=N2)C2=C1 IGYLLEJQDWYRTD-UHFFFAOYSA-N 0.000 claims 1
- OOAWHBXKELGWND-UHFFFAOYSA-N 2-[5-[5-(oxolan-3-yl)-1h-1,2,4-triazol-3-yl]benzimidazol-1-yl]ethanol Chemical compound C=1C=C2N(CCO)C=NC2=CC=1C(N=1)=NNC=1C1CCOC1 OOAWHBXKELGWND-UHFFFAOYSA-N 0.000 claims 1
- ZWAMTGNERQARLM-UHFFFAOYSA-N 2-[5-[5-methyl-2-(1-methylpiperidin-4-yl)-1,2,4-triazol-3-yl]benzimidazol-1-yl]ethanol Chemical compound C1CN(C)CCC1N1C(C=2C=C3N=CN(CCO)C3=CC=2)=NC(C)=N1 ZWAMTGNERQARLM-UHFFFAOYSA-N 0.000 claims 1
- GBTDJIDXEOUIGK-UHFFFAOYSA-N 2-butyl-6-[3-(2-hydroxyethyl)benzimidazol-5-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one Chemical compound C(CCC)N1C(C=2N(CC1)C(=CC=2)C=1C=CC2=C(N(C=N2)CCO)C=1)=O GBTDJIDXEOUIGK-UHFFFAOYSA-N 0.000 claims 1
- VXHXTJVVYZHUEB-NRAVZPKASA-N 2-chloro-6-[7-fluoro-1-[(1s,3s)-3-methoxycyclohexyl]benzimidazol-5-yl]-9-(oxan-2-yl)purine Chemical compound C1[C@@H](OC)CCC[C@@H]1N1C2=C(F)C=C(C=3C=4N=CN(C=4N=C(Cl)N=3)C3OCCCC3)C=C2N=C1 VXHXTJVVYZHUEB-NRAVZPKASA-N 0.000 claims 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- LVVPWVQUOFIJAI-UHFFFAOYSA-N 2-methyl-1-[5-[4-(trifluoromethoxy)phenyl]benzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=CC(=C2)C1=CC=C(C=C1)OC(F)(F)F)(C)O LVVPWVQUOFIJAI-UHFFFAOYSA-N 0.000 claims 1
- IUPLQVAXUFVLJF-UHFFFAOYSA-N 2-methyl-1-[5-[5-(trifluoromethyl)pyrimidin-2-yl]oxybenzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=CC(=C2)OC1=NC=C(C=N1)C(F)(F)F)(C)O IUPLQVAXUFVLJF-UHFFFAOYSA-N 0.000 claims 1
- UFZDMZQUGMHNDE-UHFFFAOYSA-N 2-methyl-1-[6-(4-methylphenoxy)benzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)OC1=CC=C(C=C1)C)(C)O UFZDMZQUGMHNDE-UHFFFAOYSA-N 0.000 claims 1
- VHVXJURQGADTDV-UHFFFAOYSA-N 2-methyl-1-[6-[6-(trifluoromethyl)pyridin-3-yl]oxybenzimidazol-1-yl]propan-2-ol Chemical compound CC(CN1C=NC2=C1C=C(C=C2)OC=1C=NC(=CC=1)C(F)(F)F)(C)O VHVXJURQGADTDV-UHFFFAOYSA-N 0.000 claims 1
- LIAHDLGKTJXVPY-UHFFFAOYSA-N 3-[[6-(2-chloro-4-fluorophenoxy)benzimidazol-1-yl]methyl]oxetan-3-ol Chemical compound ClC1=C(OC=2C=CC3=C(N(C=N3)CC3(COC3)O)C=2)C=CC(=C1)F LIAHDLGKTJXVPY-UHFFFAOYSA-N 0.000 claims 1
- ZUETWPLDMQPJBT-UHFFFAOYSA-N 3-[[6-[4-(trifluoromethyl)phenoxy]benzimidazol-1-yl]methyl]oxetan-3-ol Chemical compound FC(C1=CC=C(OC=2C=CC3=C(N(C=N3)CC3(COC3)O)C=2)C=C1)(F)F ZUETWPLDMQPJBT-UHFFFAOYSA-N 0.000 claims 1
- OHKXSNDUEWTBDA-UHFFFAOYSA-N 3-[[6-[5-(trifluoromethyl)pyridin-2-yl]oxybenzimidazol-1-yl]methyl]oxetan-3-ol Chemical compound FC(C=1C=CC(=NC=1)OC=1C=CC2=C(N(C=N2)CC2(COC2)O)C=1)(F)F OHKXSNDUEWTBDA-UHFFFAOYSA-N 0.000 claims 1
- MOLMDKIAUNFARC-UHFFFAOYSA-N 4-[4-chloro-6-[3-(2-methoxyethyl)benzimidazol-5-yl]pyrimidin-2-yl]morpholine Chemical compound ClC1=CC(=NC(=N1)N1CCOCC1)C=1C=CC2=C(N(C=N2)CCOC)C=1 MOLMDKIAUNFARC-UHFFFAOYSA-N 0.000 claims 1
- WQHUWNUPVZZPAP-UHFFFAOYSA-N 4-[6-[2-methoxy-4-(trifluoromethyl)phenyl]benzimidazol-1-yl]-2-methylbutan-2-ol Chemical compound COC1=C(C=CC(=C1)C(F)(F)F)C=1C=CC2=C(N(C=N2)CCC(C)(O)C)C=1 WQHUWNUPVZZPAP-UHFFFAOYSA-N 0.000 claims 1
- HQJUHUUDHASPKB-UHFFFAOYSA-N 5-(2-chlorophenyl)-3-(2-hydroxyethyl)benzimidazole-4-carbonitrile Chemical compound N#CC1=C2N(CCO)C=NC2=CC=C1C1=CC=CC=C1Cl HQJUHUUDHASPKB-UHFFFAOYSA-N 0.000 claims 1
- FIALBLBZRZHFPX-UHFFFAOYSA-N 6-(4-fluorophenoxy)-1-(oxolan-2-ylmethyl)benzimidazole Chemical compound FC1=CC=C(OC=2C=CC3=C(N(C=N3)CC3OCCC3)C=2)C=C1 FIALBLBZRZHFPX-UHFFFAOYSA-N 0.000 claims 1
- CZDUOPAAVANXRO-UHFFFAOYSA-N 6-[3-(2-hydroxyethyl)benzimidazol-5-yl]-2-(3-methylbutyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one Chemical compound OCCN1C=NC2=C1C=C(C=C2)C1=CC=C2N1CCN(C2=O)CCC(C)C CZDUOPAAVANXRO-UHFFFAOYSA-N 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 229940123934 Reductase inhibitor Drugs 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229960003965 antiepileptics Drugs 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 206010013990 dysuria Diseases 0.000 claims 1
- 201000011384 erythromelalgia Diseases 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000004084 narcotic analgesic agent Substances 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 230000001314 paroxysmal effect Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 0 CC(*)(*)C(CC[n]1c(c(*)c(*)c(*)c2*)c2nc1)CN Chemical compound CC(*)(*)C(CC[n]1c(c(*)c(*)c(*)c2*)c2nc1)CN 0.000 description 7
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017050330 | 2017-03-15 | ||
| JP2017050330 | 2017-03-15 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018154620A JP2018154620A (ja) | 2018-10-04 |
| JP2018154620A5 true JP2018154620A5 (cg-RX-API-DMAC7.html) | 2021-03-18 |
| JP7165501B2 JP7165501B2 (ja) | 2022-11-04 |
Family
ID=63716133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018046435A Active JP7165501B2 (ja) | 2017-03-15 | 2018-03-14 | 新規ベンズイミダゾール化合物からなる医薬 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7165501B2 (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11242332B2 (en) * | 2017-03-15 | 2022-02-08 | Sumitomo Dainippon Pharma Co., Ltd. | Method for producing benzimidazole derivative |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018052817A (ja) | 2015-01-21 | 2018-04-05 | 大日本住友製薬株式会社 | 新規ベンズイミダゾール誘導体およびその医薬用途 |
| KR102784592B1 (ko) | 2015-08-12 | 2025-03-19 | 에피제네틱스, 인크. | 치환된 벤즈이미다졸, 그의 제조법 및 제약으로서의 그의 용도 |
| SI3348547T1 (sl) | 2015-09-11 | 2020-10-30 | Sumitomo Dainippon Pharma Co., Ltd. | Derivati benzimidazola kot zaviralci NAV 1.7 (natrijevi kanalčki, napetostno odvisni, tip IX, podenota alfa (SCN9A)) za zdravljenje bolečine, disurije in multiple skleroze |
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2018
- 2018-03-14 JP JP2018046435A patent/JP7165501B2/ja active Active