JP2018138159A5

JP2018138159A5 -

Info

Publication number: JP2018138159A5
Application number: JP2017213801A
Authority: JP
Filing date: 2017-11-06
Publication date: 2020-04-02
Anticipated expiration: 2037-11-06

Description

本発明の更なる他の実施態様による画像処理方法は、被検体を光干渉断層撮像することにより取得された断層信号を用いて生成した断層画像を処理する画像処理方法であって、前記断層信号を取得する工程と、前記断層信号を用いて前記断層画像を生成する工程とを含み、前記断層画像を生成する工程は、前記断層信号を用いて、前記断層画像においてコントラストが低下する対象領域を特定する工程と、前記断層信号のうちの前記対象領域の断層信号に対して統計処理を行うことにより、推定値を推定する工程とを含み、前記断層画像を生成する工程は、前記対象領域では前記推定値を画素値として前記断層画像を生成する工程を含む。 An image processing method according to still another embodiment of the present invention is an image processing method for processing a tomographic image generated using a tomographic signal obtained by optical coherence tomographic imaging of a subject, wherein the tomographic signal is Obtaining the tomographic image using the tomographic signal, the step of generating the tomographic image, the step of generating the tomographic image, using the tomographic signal, the target area of the tomographic image in which the contrast is reduced in the tomographic image and specifying, by performing statistical processing on the tomographic signal of the target region of said fault signal, and a step of estimating the estimated value, the more engineering to generate the tomographic image, the target area In comprising the step of generating the tomographic images the estimated value as a pixel value.

Claims

An image processing apparatus that processes a tomographic image generated using a plurality of sets of tomographic signals obtained by performing optical coherence tomographic imaging a plurality of times using measurement light controlled to scan substantially the same portion of a subject. So,
An acquisition unit that acquires the plurality of sets of tomographic signals,
A generating unit that generates a representative value at each pixel position of the tomographic image using the plurality of sets of tomographic signals, and generates the tomographic image as a representative value at each pixel position as a pixel value;
With
The generation unit includes:
An area specifying unit that specifies a target area where contrast is reduced in the tomographic image using at least one set of tomographic signals of the plurality of sets of tomographic signals;
An estimating unit that estimates an estimated value by performing statistical processing on a plurality of tomographic signals corresponding to the pixel position in the plurality of sets of tomographic signals at each pixel position of the target region;
Including
The image processing device, wherein the generating unit generates the tomographic image using the estimated value as the representative value in the target area.

The estimating unit estimates a true value of the tomographic signal at the pixel position using the distribution of a predetermined model for the plurality of tomographic signals corresponding to each pixel position of the target region as the estimated value. The image processing apparatus according to claim 1.

The said estimation part estimates the said estimated value in the said pixel position by performing the maximum a posteriori probability ( MAP ) estimation process with respect to the said several tomographic signal corresponding to each pixel position of the said target area. 3. The image processing device according to 1 or 2.

The estimating unit includes:
For the plurality of tomographic signals corresponding to each pixel position of the target area, using a predetermined probability density function, calculate the probability density function of the plurality of tomographic signals corresponding to the pixel position,
Calculate the product of the probability density function for the plurality of tomographic signals corresponding to the same pixel position,
Determine the value of the tomographic signal at which the probability is the maximum in the product of the probability density function,
The image processing device according to claim 3, wherein the determined value of the tomographic signal is used as the estimated value.

The generation unit further includes a calculation unit that calculates a calculation value at the pixel position using a plurality of tomographic signals corresponding to a pixel position of the tomographic image, among the plurality of sets of tomographic signals,
The calculated value is one of an arithmetic mean, a median, a mode, and a maximum,
5. The image processing apparatus according to claim 1, wherein the generation unit generates the tomographic image using the calculated value as the representative value in a region other than the target region of the tomographic image. 6.

The subject is a subject's eye,
The image processing device according to claim 1, wherein the region specifying unit specifies the target region from at least one set of tomographic signals of the plurality of sets of tomographic signals and an eye structure.

The region specifying unit specifies a layer boundary of a fundus oculi in the tomographic image using at least one set of tomographic signals of the plurality of sets of tomographic signals, and determines the target region from the layer boundary and the structure of the eye. The image processing apparatus according to claim 6, which specifies the image processing apparatus.

The image processing device according to claim 5, wherein the region specifying unit specifies, as the target region, a region at a pixel position having the calculated value lower than a threshold set using the calculated value calculated for each pixel position.

6. The region specifying unit according to claim 1, wherein the region specifying unit specifies, as the target region, a region having a value of a tomographic signal lower than a threshold set using one set of tomographic signals among the plurality of sets of tomographic signals. The image processing device according to claim 1.

The image processing device according to any one of claims 1 to 9, further comprising a storage unit configured to store the plurality of sets of tomographic signals that have been subjected to gradation conversion into 8-bit information.

An image processing apparatus for processing a tomographic image generated using a tomographic signal obtained by performing optical coherence tomographic imaging of a subject,
An acquisition unit that acquires the tomographic signal,
A generation unit that generates the tomographic image using the tomographic signal,
With
The generation unit includes:
Using the tomographic signal, an area specifying unit that specifies a target area where contrast is reduced in the tomographic image,
An estimating unit that estimates an estimated value by performing statistical processing on the tomographic signal of the target region among the tomographic signals,
Including
The image processing device, wherein the generation unit generates the tomographic image using the estimated value as a pixel value in the target area.

An image processing apparatus for processing a tomographic image generated using a tomographic signal obtained by performing optical coherence tomographic imaging of a subject,
An acquisition unit that acquires the tomographic signal,
A generation unit that generates the tomographic image using the tomographic signal,
With
The generation unit includes:
An estimating unit that estimates an estimated value by performing statistical processing on a tomographic signal corresponding to a pixel position of the tomographic image in the tomographic signal,
A filter unit that applies a noise removal filter to a tomographic image generated using the estimated value as a pixel value,
An image processing apparatus, comprising:

An image processing apparatus for processing a tomographic image generated using a tomographic signal obtained by performing optical coherence tomographic imaging of a subject,
An acquisition unit that acquires the tomographic signal,
A generation unit that generates the tomographic image using the tomographic signal,
With
The generation unit includes an estimation unit that estimates an estimated value by performing statistical processing on a tomographic signal corresponding to a pixel position of the tomographic image in the tomographic signal,
The estimating unit estimates the estimated value by performing statistical processing on a tomographic signal corresponding to a pixel position that estimates the estimated value of the tomographic signal and a pixel position around the pixel position,
The image processing device, wherein the generation unit generates the tomographic image using the estimated value as a pixel value.

The subject is a moving eye,
14. The image processing apparatus according to claim 1, further comprising a controller configured to control a scanning unit of an imaging optical system so as to perform optical coherence tomographic imaging of the same part of the subject a plurality of times. 15. Image processing device.

The method according to any one of claims 1 to 14, wherein the generating unit generates the tomographic image using the estimated value in the vitreous region and using a value obtained by a process different from the estimation in the retinal region. The image processing apparatus according to any one of the preceding claims.

An imaging optical system for optical coherence tomography of the subject,
An image processing apparatus according to any one of claims 1 to 15 ,
Equipped with a,
The optical coherence tomographic imaging apparatus , wherein the imaging optical system has an imaging sensor for acquiring the tomographic signal .

An image processing method for processing a tomographic image generated using a tomographic signal obtained by performing optical coherence tomographic imaging of a subject,
Obtaining the tomographic signal;
Generating the tomographic image using the tomographic signal,
Including
The step of generating the tomographic image,
Using the tomographic signal, identifying a target area in the tomographic image where the contrast is reduced,
Estimating an estimated value by performing statistical processing on the tomographic signal of the target region among the tomographic signals,
Including
Wherein as engineering to produce a tomographic image, in the region of interest comprising the step of generating the tomographic images the estimated value as a pixel value, the image processing method.

An image processing method for processing a tomographic image generated using a tomographic signal obtained by performing optical coherence tomographic imaging of a subject,
Obtaining the tomographic signal;
Generating the tomographic image using the tomographic signal,
Including
The step of generating the tomographic image,
Estimating an estimated value by performing statistical processing on a tomographic signal corresponding to a pixel position of the tomographic image in the tomographic signal,
Applying a noise removal filter to the tomographic image generated using the estimated value as a pixel value,
An image processing method comprising:

An image processing method for processing a tomographic image generated using a tomographic signal obtained by performing optical coherence tomographic imaging of a subject,
Obtaining the tomographic signal;
Generating the tomographic image using the tomographic signal,
Including
The step of generating the tomographic image includes performing a statistical process on a tomographic signal corresponding to a pixel position of the tomographic image in the tomographic signal, thereby estimating an estimated value,
The more Engineering of estimating estimates, by performing statistical processing on the tomographic signal corresponding to the pixel positions around the pixel position and the pixel position to estimate the estimated value of the tomographic signal, the estimated value wherein the step of estimating,
Wherein as engineering to produce a tomographic image includes the step of generating the tomographic images the estimated value as a pixel value, the image processing method.

When executed by the processor, to the processor to execute the steps of the image processing method according to any one of claims 17 to 19, the program.