JP2018130207A - Body fluid control device and body fluid control system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To (1) reduce a burden on a patient as much as possible when using a capsule endoscope in an examination of the inside of the large intestinal tract, and to (2) reduce a burden on a patient as much as possible when injecting fluid in an intragastric balloon to effectively decrease an intragastric capacity in an obesity treatment.SOLUTION: A body fluid control device (a fluid control pump P) includes: a body fluid control part (a screw 1) for controlling a flow direction of body fluid according to a direction that it is driven magnetically; and an intra-device support part (a screw rotation shaft 2, an inflow/outflow port opening member 3, an inflow/outflow port connection member 4, and a rotation shaft support member 5) for supporting the body fluid control part (the screw 1) in the body fluid control device (the fluid control pump P).SELECTED DRAWING: Figure 1

Description

  The present disclosure relates to a technique for controlling a flow direction of a body fluid.

  Colonoscopy is performed using an endoscope. Here, when a tube-shaped endoscope is used, it is necessary to insert the endoscope tube from the anus, which places a heavy burden on the patient. On the other hand, when the capsule endoscope is used, it is only necessary to swallow the capsule from the mouth, so that it is not necessary to place a heavy burden on the patient (see, for example, Patent Document 1).

  Treatment of obesity has been carried out by reducing the stomach volume. Here, when the stomach and / or esophageal mucosa is excised to reduce the gastric volume itself, a heavy burden is placed on the patient. On the other hand, when a fluid is injected into the intragastric balloon from outside the body to effectively reduce the intragastric volume, it is not necessary to place a great burden on the patient (see, for example, Patent Document 2).

JP 2008-503310 A JP 2009-148578 A

  However, as disclosed in Patent Document 1, when using a capsule endoscope in a large intestine inspection, a large amount of laxative is required for cleaning the large intestine, and a long time is required for moving the capsule. It may occur and puts some burden on the patient.

  In the treatment of obesity, as disclosed in Patent Document 2, when a fluid is injected into the intragastric balloon from outside the body to effectively reduce the intragastric volume, a catheter is inserted into the intragastric balloon from the mouth or nose. It is necessary and puts some burden on the patient.

  Therefore, in order to solve the above-described problems, the present disclosure includes (1) avoiding a burden on a patient as much as possible when using a capsule endoscope in an inspection of a large intestine, and (2) obesity In the treatment, when the fluid is injected into the intragastric balloon to effectively reduce the intragastric volume, the object is to minimize the burden on the patient.

  In order to achieve the above object, the flow direction of fluid such as water in the large intestine can be controlled according to the magnetically driven direction. And according to the direction driven magnetically, it decided to control the flow direction (outflow / inflow with respect to a gastric balloon) of fluids, such as gastric acid in the stomach.

  Specifically, the present disclosure includes an in-vivo fluid control unit that controls a flow direction of a bodily fluid according to a magnetically driven direction, an in-device support unit that supports the in-vivo fluid control unit in the device, An in-vivo fluid control apparatus comprising:

  According to this configuration, by reciprocating the fluid such as water in the large intestine, a small amount of laxative is sufficient for cleaning the large intestine, and by moving the fluid such as water in the large intestine in one direction, it is short in capsule movement. Time is sufficient, and the fluid in the large intestine, such as water, moves in the reverse direction, so that no oversight in the large intestine occurs. Therefore, when using a capsule endoscope in an inspection of the large intestine, it is possible to minimize the burden on the patient.

  Then, by allowing fluid such as stomach acid in the stomach to flow into the stomach balloon, the capacity of the stomach balloon can be expanded to strengthen obesity treatment, and fluid such as stomach acid flows out of the stomach balloon. By doing so, the intragastric balloon volume can be deflated to alleviate obesity treatment. Therefore, in the treatment of obesity, when the fluid is injected into the intragastric balloon and the intragastric volume is effectively reduced, the burden on the patient can be minimized.

  In addition, the present disclosure is an in-vivo fluid control device further comprising a dissolvable sealing portion that seals the in-vivo fluid control portion and the flexible in-device support portion.

  According to this configuration, since the entire device is pushed into the dissolvable sealing portion after the support member is bent in the dissolvable sealing portion, it is possible to reduce the swallowing burden on the entire device.

  Further, the present disclosure includes an in-body fluid storage unit that variably stores in-vivo fluid inhaled by the in-body fluid control unit, and the in-body fluid after the in-body fluid control unit inhales in-body fluid into the in-body fluid storage unit. A body fluid discharge preventing unit that prevents the body fluid stored in the body fluid storage unit from being discharged from the body fluid storage unit when the control unit is not magnetically driven; It is the body fluid control apparatus characterized by these.

  According to this configuration, fluid such as gastric acid in the stomach can be prevented from being discharged without fluid control by magnetic drive, and fluid such as gastric acid in the stomach can be stored in the gastric balloon.

  Further, the present disclosure provides that the in-vivo fluid reservoir is stored when the in-vivo fluid controller is magnetically driven so that the in-vivo fluid controller discharges the in-vivo fluid from the in-vivo fluid reservoir. A bodily fluid control apparatus further comprising a bodily fluid discharge facilitating part for facilitating discharge of bodily fluid from the bodily fluid storage part.

  According to this configuration, the prevention of the discharge of fluid such as stomach acid in the stomach can be stopped, the discharge of fluid such as stomach acid in the stomach can be promoted, and the fluid such as stomach acid in the stomach can be discharged from the stomach balloon. .

  The present disclosure is a body fluid control system comprising the body fluid control device described above and a magnetic drive device that magnetically drives the body fluid control unit.

  According to this configuration, the in-vivo fluid control device arranged inside the body can be magnetically driven using the magnetic drive device arranged outside the body. Therefore, when using a capsule endoscope in an inspection of the large intestine, it is possible to minimize the burden on the patient. In obesity treatment, when a fluid is injected into the intragastric balloon to effectively reduce the intragastric volume, the burden on the patient can be minimized.

  In addition, the present disclosure is an in-vivo fluid control system further comprising a magnetic polarity detection device that detects a magnetic polarity of the in-vivo fluid control unit.

  According to this configuration, the magnetic polarity of the in-vivo fluid control device arranged inside the body can be detected using the magnetic polarity detection device arranged outside the body. Therefore, if the direction of driving the magnetic drive device arranged outside the body is set to any direction, the direction in which the in-body fluid control device arranged in the body is driven becomes a desired direction, and thus the flow of the in-body fluid. Whether the direction is a desired direction or not can be grasped more reliably even from outside the body.

  As described above, the present disclosure includes (1) avoiding a burden on a patient as much as possible when using a capsule endoscope in an inspection of a large intestine, and (2) an intragastric balloon in treating obesity. When the fluid is injected into the stomach to effectively reduce the gastric volume, the burden on the patient can be minimized.

It is a figure showing the composition at the time of deployment outside a capsule of the fluid control pump of this indication. It is a figure which shows the structure at the time of accommodation in the capsule of the fluid control pump of this indication. It is a figure which shows the 1st operation | movement of the fluid control pump and magnetic drive device of this indication. It is a figure which shows the 2nd operation | movement of the fluid control pump and magnetic drive unit of this indication. It is a figure which shows the operation | movement at the time of washing | cleaning before the colonic-tube inspection of the fluid control pump of this indication. It is a figure which shows operation | movement at the time of the capsule endoscope movement of the fluid control pump of this indication. It is a figure which shows the operation | movement at the time of capsule endoscope retrograde of the fluid control pump of this indication. It is a figure which shows the operation | movement at the time of intragastric balloon capacity expansion of the fluid control pump of this indication. It is a figure which shows the operation | movement at the time of intragastric balloon capacity | capacitance maintenance of the fluid control pump of this indication. It is a figure showing operation at the time of intragastric balloon capacity contraction of a fluid control pump of this indication.

  Embodiments of the present disclosure will be described with reference to the accompanying drawings. The embodiments described below are examples of the present disclosure, and the present disclosure is not limited to the following embodiments.

(Configuration of fluid control pump of the present disclosure)
The configuration of the fluid control pump of the present disclosure when deployed outside the capsule is shown in FIG. The fluid control pump P corresponds to the in-vivo fluid control device and includes a screw 1, a screw rotation shaft 2, an outflow / inlet opening member 3, an outflow / inlet connection member 4, a rotation shaft support member 5, and an indwelling member 6. The

  The screw 1 corresponds to the above-described body fluid control unit, and controls the flow direction of the body fluid in accordance with the magnetically driven direction. For example, the screw 1 is obtained by applying a magnetic disk or the like to the screw and coating the magnetic disk or the like so that the magnetic disk or the like is not corroded by stomach acid or the like. Alternatively, the screw 1 is obtained by sintering a magnetic powder into a screw shape and coating the screw so that the screw is not corroded by stomach acid or the like.

  The screw rotation shaft 2, the inlet / outlet opening member 3, the outlet / inlet connection member 4, and the rotation shaft support member 5 correspond to the in-device support portion described above, and support the screw 1 in the fluid control pump P. Here, the screw rotating shaft 2 is a flexible fiber or rubber. The outflow / inlet opening member 3, the outflow / inlet connection member 4 and the rotary shaft support member 5 are made of flexible rubber or the like.

  The screw rotating shaft 2 is a rotating shaft of the screw 1. The inflow / outlet opening member 3 is a member that causes the in-vivo fluid to flow out and / or inflow, and has a ring shape or the like. The outflow inlet connecting member 4 is a member for connecting the outflow inlet opening members 3 on both sides, and has a rod shape or the like. The rotating shaft support member 5 is a member that supports the screw rotating shaft 2 and has a rod shape or the like. The center of each rotary shaft support member 5 such as a bar shape is connected to one end of the screw rotary shaft 2. Both ends of each rotary shaft support member 5 such as a rod shape are connected to a circumference such as a ring shape of each outflow inlet opening member 3 in a diameter direction such as a ring shape of each outflow inlet opening member 3.

  The indwelling member 6 covers a side surface but does not cover a bottom surface among a cylindrical shape formed by the outflow / inlet opening member 3 and the outflow / inlet connection member 4, and has a flexible balloon or sponge. It is. The indwelling member 6 causes the fluid control pump P to be indwelled on the inner wall surface of the large intestine or the like, and does not allow the body fluid to flow out and / or into the side surface of the fluid control pump P.

  Thus, the screw 1 is supported in the fluid control pump P by the screw rotation shaft 2, the outflow / inlet opening member 3, the outflow / inlet connection member 4, and the rotation shaft support member 5. Then, the body fluid is caused to flow into the fluid control pump P by the screw 1 through the one inlet / outlet opening member 3, and is driven in the fluid control pump P in a direction substantially parallel to the axial direction of the fluid control pump P. It flows out from the fluid control pump P at the outflow inlet opening member 3.

  A configuration of the fluid control pump of the present disclosure when accommodated in a capsule is shown in FIG. The pump capsule C includes a fluid control pump P and a dissolvable capsule 7.

  The dissolvable capsule 7 corresponds to the dissolvable sealing portion described above, and includes the screw 1 and the flexible screw rotating shaft 2, the inflow / outlet opening member 3, the outflow / inlet connection member 4, the rotating shaft support member 5 and the indwelling body. The member 6 is sealed. That is, the fluid control pump P is accommodated in the size of about the screw 1 by the contraction of the flexible member when the dissolvable capsule 7 is accommodated before dissolution. Then, the fluid control pump P is expanded into the cylindrical shape shown in FIG. 1 or the like by expansion of the flexible member when the soluble capsule 7 is expanded after being dissolved.

  In this way, the above-described flexible member is bent in the dissolvable capsule 7 and the entire fluid control pump P is pushed into the dissolvable capsule 7. Therefore, the pump including the fluid control pump P and the dissolvable capsule 7 is used. The swallowing burden on the entire capsule C can be reduced.

(Operation of Fluid Control Pump and Magnetic Drive Device of Present Disclosure)
The body fluid control system of the present disclosure includes a fluid control pump P, a magnetic drive device D illustrated in FIGS. 3 and 4, and a magnetic polarity detection device not illustrated in FIGS.

  The magnetic drive device D magnetically drives the screw 1 and is composed of drive magnets 8-1 and 8-2, a magnet support member 9 and a magnet rotation shaft 10. The magnetic polarity detection device can detect the magnetic polarity of the screw 1 and use a magnetic polarity detection device of a capsule endoscope.

  The operation of the fluid control pump and magnetic drive of the present disclosure is shown in FIGS. The magnetic drive device D is disposed in the vicinity of the stomach or the large intestine outside the body. The fluid control pump P is deployed inside the stomach or large intestine in the body and is drawn to the magnetic drive device D.

  In FIG. 3, the magnetization directions of the drive magnets 8-1 and 8-2 are substantially perpendicular to the magnet rotation shaft 10, and the magnetization directions of the screw blades 1-1 and 1-2 are substantially perpendicular to the screw rotation shaft 2. Direction. The screw blades 1-1 and 1-2 are attracted to the drive magnets 8-1 and 8-2, respectively, and the screw rotation shaft 2 is aligned in a direction substantially parallel to the magnet rotation shaft 10.

  In FIG. 4, the magnetization directions of the drive magnets 8-1 and 8-2 are substantially parallel to the magnet rotation shaft 10, and the magnetization directions of the screw blades 1-1 and 1-2 are substantially parallel to the screw rotation shaft 2. Direction. The screw blades 1-1 and 1-2 are attracted to the drive magnets 8-1 and 8-2, respectively, and the screw rotation shaft 2 is aligned in a direction substantially parallel to the magnet rotation shaft 10.

  Thus, the magnetic polarity of the fluid control pump P can be grasped to some extent only by bringing the magnetic drive device D close to the body surface. However, the magnetic polarity of the fluid control pump P can be detected more reliably by using the magnetic polarity detection device.

  And after grasping | ascertaining the magnetic polarity of the fluid control pump P, by setting the direction which drives the magnetic drive device D, the screw blades 1-1 and 1-2 are respectively set to the drive magnets 8-1 and 8-2. After drawing, the direction in which the fluid control pump P is driven can be set to a desired direction, and the direction in which the in-body fluid flows can be set to a desired direction.

(Operation of the fluid control pump of the present disclosure in the large intestine)
FIG. 5 shows the operation of the fluid control pump of the present disclosure at the time of cleaning before inspection in the large intestine. The pump capsule C is swallowed from the mouth, and the arrival to the vicinity of the cecum is detected by the detection of the screw 1 by the magnetic polarity detection device. The dissolvable capsule 7 is dissolved in the vicinity of the cecum or is broken in the vicinity of the cecum by the drive of the screw 1 by the magnetic driving device D. The indwelling member 6 is a balloon or the like that inflates for a predetermined time, and indwells the fluid control pump P on the inner wall surface near the cecum. The fluid control pump P is placed on the inner wall near the cecum, and is caught by the ileocecal valve protruding from the small intestine outlet and the meniscus opposite to the ileocecal valve, and does not block the small intestine outlet. The endoscope capsule E described later can pass from the exit of the small intestine to the ascending colon without being obstructed by the fluid control pump P.

  The magnetic drive device D repeatedly switches the direction of driving the drive magnets 8-1 and 8-2. Then, the fluid control pump P can repeatedly switch the direction in which the screw 1 is driven. That is, a fluid such as water W in the large intestine I is reciprocated in the direction from the cecum to the rectum and from the rectum to the cecum. Therefore, a small amount of laxative is sufficient for cleaning the large intestine. Here, when the fluid control pump P moves the fluid such as the water W in the large intestine I in the direction from the cecum to the rectum, the fluid control pump P is pressed toward the cecum from the law of conservation of momentum, and the fluid such as the water W in the large intestine I When moving in the direction from the rectum to the cecum, the ileocecal valve protruding from the exit of the small intestine and the meniscus opposite to the ileocecal valve are caught.

  The operation of the fluid control pump of the present disclosure when the capsule endoscope moves is shown in FIG. The endoscope capsule E is swallowed from the mouth, and arrival at the vicinity of the cecum is detected by detection of the endoscope by the magnetic polarity detection device. The magnetic drive device D sets the direction in which the drive magnets 8-1 and 8-2 are driven to a certain predetermined direction. Then, the fluid control pump P sets the direction in which the screw 1 is driven to a predetermined direction. A fluid such as water W in the large intestine I is moved in one direction from the cecum to the rectum. Therefore, a short time is sufficient for the movement of the endoscope capsule E. Here, the fluid control pump P is pressed toward the cecum from the momentum conservation law when the fluid such as water W in the large intestine I moves in one direction from the cecum to the rectum.

  FIG. 7 shows the operation of the fluid control pump of the present disclosure when the capsule endoscope is retrograde. Depending on the rotational speed of the screw 1, an oversight in the large intestine I may occur depending on the moving speed of the endoscope capsule E. The magnetic drive device D sets the direction for driving the drive magnets 8-1 and 8-2 to be opposite to that in FIG. 6. Then, in the fluid control pump P, the direction in which the screw 1 is driven is set in the direction opposite to that in FIG. A fluid such as water W in the large intestine I is moved backward in the direction from the rectum to the cecum. Therefore, oversight in the large intestine I does not occur. Here, when the fluid control pump P moves the fluid such as the water W in the large intestine I in the reverse direction from the rectum to the cecum, the half-moon that is opposite to the ileocecal valve and the ileocecal valve that protrudes from the exit of the small intestine. I get caught in a bag.

  Thus, when using the capsule endoscope E in the large intestine examination, a small amount of laxative is sufficient for cleaning the large intestine, and a short time is sufficient for the movement of the endoscope capsule E, resulting in oversight in the large intestine. Without overloading the patient as much as possible.

(Operation of the fluid control pump of the present disclosure in the stomach)
FIG. 8 shows the operation of the fluid control pump of the present disclosure when expanding the intragastric balloon volume. The pump capsule C is swallowed from the mouth and reaches the stomach S, but the arrival in the stomach S may be detected by detection of the screw 1 by the magnetic polarity detection device. The dissolvable capsule 7 is dissolved in the stomach S or is broken in the stomach S by driving the screw 1 by the magnetic drive device D.

  The fluid control pump P further includes a balloon 11. The balloon 11 corresponds to the above-described body fluid reservoir, and stores the body fluid inhaled by the screw 1 in a variable volume.

  The magnetic drive device D sets the direction in which the drive magnets 8-1 and 8-2 are driven to a certain predetermined direction. Then, the fluid control pump P sets the direction in which the screw 1 is driven to a predetermined direction. A fluid such as stomach acid in the stomach is moved in one direction from the outside of the balloon 11 to the inside of the balloon 11. Here, as will be described later, the discharge prevention unit 12 is a backflow prevention valve or the like that uses the pressure in the balloon 11 and does not block the inflow of gastric acid or the like from the outside of the balloon 11 into the balloon 11. Therefore, by allowing a fluid such as stomach acid in the stomach to flow into the balloon 11, the capacity of the balloon in the stomach can be expanded to enhance the obesity treatment.

  FIG. 9 shows the operation of the fluid control pump of the present disclosure when maintaining the intragastric balloon volume. The fluid control pump P further includes a discharge prevention unit 12. The discharge prevention unit 12 detects that the body fluid stored in the balloon 11 is discharged from the balloon 11 when the screw 1 is not magnetically driven after the screw 1 sucks the body fluid into the balloon 11. To prevent.

  The magnetic drive device D stops driving the drive magnets 8-1 and 8-2. Then, the fluid control pump P stops driving the screw 1. Here, the discharge prevention unit 12 is a backflow prevention valve or the like that uses the pressure in the balloon 11, and prevents the outflow of stomach acid or the like from the balloon 11 to the outside of the balloon 11. Therefore, the fluid such as stomach acid in the stomach can be prevented from being discharged without fluid control by magnetic driving, and the fluid such as stomach acid in the stomach can be stored in the balloon 11.

  The operation of the fluid control pump of the present disclosure when the intragastric balloon capacity is contracted is shown in FIG. The fluid control pump P further includes a discharge promoting unit 13. The discharge promoting unit 13 allows the body fluid stored in the balloon 11 to be discharged from the balloon 11 when the screw 1 is magnetically driven so that the screw 1 discharges the body fluid from the balloon 11. Promote.

  The magnetic drive device D sets the direction for driving the drive magnets 8-1 and 8-2 to be opposite to that in FIG. 8. Then, the fluid control pump P sets the direction in which the screw 1 is driven to the direction opposite to that in FIG. Then, fluid such as stomach acid in the stomach is moved in the reverse direction from the inside of the balloon 11 to the outside of the balloon 11. Here, the discharge promoting unit 13 has a mechanism that determines whether or not the discharge preventing unit 12 is operable according to the driving direction of the screw 1, and promotes outflow of gastric acid and the like from the balloon 11 to the outside of the balloon 11. Therefore, by allowing fluid such as stomach acid in the stomach to flow out of the balloon 11, the intragastric balloon volume can be contracted to alleviate obesity treatment.

  In addition, the discharge prevention part 12 and the discharge promotion part 13 are realizable as follows, for example. The backflow prevention valve using the pressure in the balloon 11 has a disk to which the pressure in the balloon 11 is applied on a path connecting the inside and outside of the balloon 11. This disk has a semicircular opening and the remaining disk-shaped part, and depending on the direction in which the screw 1 is driven, either the semicircular opening or the remaining disk-shaped part is moved inside or outside the balloon 11. It is placed on the connecting path.

  When the screw 1 is driven in the direction shown in FIG. 8, the remaining disk-shaped portion of the disk is placed on the path connecting the inside and the outside of the balloon 11, but fluid such as stomach acid in the stomach The remaining disk-shaped portion is pushed open to flow into the balloon 11 from the outside of the balloon 11. When the screw 1 is not driven as shown in FIG. 9, the remaining disk-shaped portion of the disk is placed on a path connecting the inside and the outside of the balloon 11, so that fluid such as gastric acid in the stomach is allowed to flow in the disk. The remaining disk-shaped portion is not pushed open, and the balloon 11 does not flow out of the balloon 11. When the screw 1 is driven in the direction shown in FIG. 10, the semicircular opening of this disk is placed on the path connecting the inside and the outside of the balloon 11, so that fluids such as stomach acid in the stomach Through the semicircular opening of the balloon 11 and out of the balloon 11.

  Thus, in the treatment of obesity, when the fluid is injected into the balloon 11 to effectively reduce the intragastric volume, the burden on the patient can be minimized.

  An internal fluid control device and an internal fluid control system according to the present disclosure are (1) less burdening a patient as much as possible when using a capsule endoscope in an inspection of a large intestine, and (2) obesity During treatment, fluid can be injected into the intragastric balloon to effectively reduce the intragastric volume so that the patient is not burdened as much as possible.

P: fluid control pump C: pump capsule D: magnetic drive device I: large intestine W: water E: endoscope capsule S: stomach 1: screw 1-1, 1-2: screw blade 2: screw rotating shaft 3: outflow Inlet opening member 4: Outlet inlet connection member 5: Rotating shaft support member 6: Indwelling member 7: Dissolvable capsule 8-1, 8-2: Driving magnet 9: Magnet supporting member 10: Magnet rotating shaft 11: Balloon 12 : Emission prevention unit 13: Emission promotion unit

Claims (6)

A body fluid control unit for controlling the flow direction of the body fluid in accordance with the magnetically driven direction;
An in-device support unit for supporting the in-vivo fluid control unit in the device;
An intracorporeal fluid control apparatus comprising: A dissolvable sealing portion that seals the in-body fluid control portion and the flexible in-device support portion;
The in-vivo fluid control device according to claim 1, further comprising: A bodily fluid reservoir that variably stores the bodily fluid inhaled by the bodily fluid control unit; and
After the bodily fluid control unit sucks the bodily fluid into the bodily fluid storage part, the bodily fluid stored in the bodily fluid storage part is stored in the bodily fluid when the bodily fluid control part is not magnetically driven. A body fluid discharge prevention unit for preventing discharge from the fluid storage unit;
The in-vivo fluid control device according to claim 1, further comprising: When the body fluid control unit is magnetically driven so that the body fluid control unit discharges the body fluid from the body fluid storage unit, the body fluid stored in the body fluid storage unit is A body fluid discharge facilitator that promotes discharge from the body fluid reservoir,
The in-vivo fluid control device according to claim 3, further comprising: An in-vivo fluid control device according to any one of claims 1 to 4,
A magnetic driving device for magnetically driving the in-body fluid control unit;
An in-vivo fluid control system comprising: A magnetic polarity detection device for detecting the magnetic polarity of the in-body fluid control unit;
The body fluid control system according to claim 5, further comprising:

Images