JP2018126222A - Organism-related information measurement device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an organism-related information measurement device capable of measuring stably and accurately, when measuring, organism-related information by irradiating an analyte with light.SOLUTION: An organism-related information measurement device in one embodiment includes: a light emission part provided on one surface of a substrate, for emitting light having a prescribed wavelength toward an analyte; a light receiving part provided on the one surface, for receiving light passing through the analyte; and a light diffusion adhesive member having an adhesive surface, and provided so as to cover an emission passage of light emitted from the light emission part, for diffusing the light.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a living body related information measuring apparatus, and more particularly to a living body related information measuring apparatus that measures information related to substances in blood while being in close contact with a human body (skin).

  As an apparatus for measuring living body related information such as blood pressure, an apparatus that performs measurement using light is disclosed. For example, Patent Document 1 discloses a light emitting element that emits light toward the inside of a body, a light receiving element that receives reflected light from the body, a data conversion unit that converts reflected light received by the light receiving element into data, and data An apparatus is disclosed that includes wireless transmission means for wirelessly transmitting the signal as a signal, and an adhesive layer for attachment to the measurement subject. Patent Document 2 discloses a transcutaneous sensor including a biochemical sensor unit that comes into contact with the skin and a suction chamber that sucks the surface of the living body.

JP 2006-087209 A JP 61-115538 A

  In an apparatus that irradiates a subject with light and measures biological information, it is necessary to irradiate the subject with light and receive light via the subject under conditions suitable for measurement. For example, if the distance between the subject and the measurement device is not stable, light cannot be transmitted and received at an accurate angle, leading to a decrease in measurement accuracy and inability to measure.

  An object of the present invention is to provide a living body related information measuring apparatus capable of performing stable and accurate measurement in measuring living body related information by irradiating a subject with light.

  In order to solve the above problems, a living body-related information measurement device according to one embodiment of the present invention is provided on one surface of a substrate, and emits light of a predetermined wavelength toward a subject, and on one surface of the substrate. A light receiving part that is provided and receives a light that passes through the subject; and a light diffusion adhesive member that is provided so as to cover the emission path of the light emitted from the light emitting part and diffuses the light and has adhesiveness on the surface; It is provided with.

  According to such a configuration, the living body related information measuring device can be tightly fixed to the subject by the adhesiveness of the light diffusion adhesive member. The light emitted from the light emitting part is diffused by the light diffusion adhesive member and irradiated to the subject. That is, the distance between the light emitting unit and the subject and the distance between the light receiving unit and the subject can be stabilized by the light diffusion adhesive member, and the light emitted from the light emitting unit is diffused and irradiated to the subject. Can do. Thereby, transmission / reception of light under conditions suitable for measurement can be performed.

  In the living body-related information measuring device, a housing provided on one surface of the substrate and having a discharge opening provided in the light emission path and a light reception opening provided in the light reception path by the light receiving unit is further provided. You may have. The light diffusion adhesive member is provided so as to cover the discharge opening. Thereby, the light emitted from the light emitting part passes through the emission opening of the housing and is diffused through the light diffusion adhesive member. Therefore, it is possible to effectively suppress the light emitted from the light emitting unit from reaching the light receiving unit without passing through the subject.

  The living body-related information measuring device may further include a translucent member that is provided on the housing so as to cover at least the emission opening and can transmit light. The light diffusing adhesive member is provided on the translucent member. Thereby, a light-diffusion adhesive member can be accurately attached using a translucent member as a base material.

  In the living body related information measuring apparatus, the translucent member may have a lens portion that is provided on the light receiving opening and has a convergence property to light. Thereby, the light can be converged by the lens portion and can be efficiently received by the light receiving portion.

  In the living body-related information measuring device, the tip position of the lens portion may protrude beyond the surface position of the light diffusion adhesive member. Thereby, when the living body related information measuring device is attached to the subject via the light diffusion adhesive member, the lens portion can be surely pressed against the subject.

  In the living body related information measuring apparatus, the elastic modulus of the lens portion may be higher than the elastic modulus of the light diffusion adhesive member. Thereby, when the living body related information measuring device is attached to the subject via the light diffusion adhesive member, the deformation of the lens portion is suppressed and can be reliably pressed against the subject.

  In the living body related information measuring apparatus, the light emitting unit may include a first light emitting element that emits light including first near infrared light having an emission wavelength of 806 nanometers (nm) to 995 nm. Thus, various information related to blood can be acquired from the living body related information of the subject by light including the first near infrared light having a wavelength of 806 nm to 995 nm.

  The living body related information measuring apparatus may include a second light emitting element that emits light including second near infrared light having an emission wavelength of 600 nm to 804 nm. In this way, by using the first near-infrared light having a wavelength of 806 nm to 995 nm and the second near-infrared light having a wavelength of 600 nm to 804 nm, information related to blood among the biological related information of the subject can be obtained. The number can be increased.

  ADVANTAGE OF THE INVENTION According to this invention, when irradiating light to a subject and measuring biological body related information, it becomes possible to provide the biological body related information measuring device which can perform a stable and accurate measurement.

(A) And (b) is a perspective view which illustrates the living body relevant information measuring device concerning this embodiment. (A) And (b) is a schematic diagram which illustrates the biological body related information measuring device which concerns on this embodiment. It is a block diagram which illustrates the composition of a sensor module. It is a schematic cross section which illustrates the use condition of a measuring device. It is a schematic cross section which illustrates other embodiment.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In the following description, the same members are denoted by the same reference numerals, and the description of the members once described is omitted as appropriate.

(Configuration of biological information measuring device)
1A and 1B are perspective views illustrating a living body related information measuring device according to this embodiment.
FIG. 1A shows a perspective view seen from the side opposite to the light emitting / receiving surface, and FIG. 1B shows a perspective view seen from the light receiving / emitting surface.
2A and 2B are schematic views illustrating the living body related information measuring apparatus according to this embodiment.
2A shows a plan view seen from the light emitting / receiving surface, and FIG. 2B shows a cross-sectional view.

  A living body related information measuring device (hereinafter simply referred to as “measuring device”) 1 according to the present embodiment is a device that measures information related to substances in blood while being in close contact with the skin of a human body, for example. The measuring device 1 includes a sensor module 10. The sensor module 10 includes a light emitting unit 11 and a light receiving unit 12 provided on one surface of the substrate 100. Here, in this embodiment, the direction away from the substrate 100 on one surface side of the substrate 100 is referred to as “upper”.

  The light emitting unit 11 emits light having a predetermined wavelength toward the subject. The light receiving unit 12 is emitted from the light emitting unit 11 and receives light passing through the subject. In the measurement apparatus 1, one surface side of the substrate 100 is a light emitting / receiving surface 10a. A pair of light emitting elements included in the light emitting unit 11 and a light receiving element included in the light receiving unit 12 are arranged side by side on the light receiving and emitting surface 10a. Details of the sensor module 10 having the light emitting unit 11 and the light receiving unit 12 will be described later.

  The measuring device 1 includes a light diffusing adhesive member 20 provided so as to cover the emission path of light emitted from the light emitting unit 11. The light diffusion adhesive member 20 has a function of diffusing the light emitted from the light emitting unit 11 and has adhesiveness on the surface. By providing the light diffusion adhesive member 20, the measuring device 1 is fixed with a state of being in close contact with the subject due to the adhesiveness of the surface of the light diffusion adhesive member 20. By using such a light diffusion adhesive member 20, the measuring apparatus 1 can be easily and reliably fixed to the subject without using a fastener such as a belt or a suction mechanism.

  Further, the light emitted from the light emitting unit 11 is diffused by the light diffusing adhesive member 20 and irradiated to the subject. The distance between the light emitting unit 11 and the subject and the distance between the light receiving unit 12 and the subject can be stabilized by fixing the measuring device 1 with the light diffusion adhesive member 20, and the light emitted from the light emitting unit 11 is The object can be irradiated by being diffused by the light diffusion adhesive member 20. As a result, light can be transmitted and received under conditions suitable for measurement.

  The measuring apparatus 1 according to the present embodiment further includes a housing 50. The housing 50 is provided on one side of the substrate 100. The housing 50 includes a discharge opening 55 provided in the light emission path of the light emitting unit 11 and a light reception opening 56 provided in the light reception path of the light receiving unit 12. The housing 50 is made of, for example, metal, and is provided so as to surround the periphery of the light emitting unit 11 and the light receiving unit 12 on one surface of the substrate 100. The housing 50 functions as a heat radiating member that releases heat generated by the light emitting unit 11 and the light receiving unit 12 to the outside.

  The light diffusing adhesive member 20 is provided so as to cover the discharge opening 55 in the housing 50. The light diffusion adhesive member 20 has a characteristic of diffusing and transmitting light emitted from the light emitting unit 11 and traveling through the emission opening 55. The light diffused and transmitted by the light diffusing adhesive member 20 enters the subject at various angles. The light incident at various angles includes light having conditions suitable for measurement. By receiving this light at the light receiving unit 12, a wide and accurate measurement can be performed for various conditions such as the positional relationship between the measuring apparatus 1 and the subject and the surface of the subject. .

  In the measurement apparatus 1 of the present embodiment, the translucent member 30 may be provided on the housing 50. The translucent member 30 is provided so as to cover at least the discharge opening 55. In the present embodiment, the translucent member 30 is provided so as to cover the light receiving opening 56 in addition to the emission opening 55. The translucent member 30 is provided so as to transmit light emitted from the light emitting unit 11. For the translucent member 30, for example, PET (polyethylene terephthalate) is used. The translucent member 30 is connected to the housing 50 by the adhesive layer 40. For the adhesive layer 40, for example, a double-sided tape is used.

  When the translucent member 30 is provided, the light diffusing adhesive member 20 is attached on the translucent member 30. The thickness of the translucent member 30 on the discharge opening 55 is constant. Thereby, the light diffusing adhesive member 20 can be accurately attached to a flat surface using the translucent member 30 as a base material.

  In addition, a lens portion 31 having a light convergence property may be provided in a portion provided on the light receiving opening 56 in the translucent member 30. The lens portion 31 has, for example, a lens shape that is convex upward. As a result, the light captured by the lens portion 31 can be converged and received efficiently by the light receiving unit 12.

  A first light shielding portion 51 may be provided between the portion of the translucent member 30 that covers the emission opening 55 and the lens portion 31. For example, the first light shielding unit 51 may be configured by projecting a part of the housing 50, or the first light shielding unit 51 may be provided on the housing 50 separately from the housing 50. By providing the first light-shielding part 51, the light (stray light) propagating through the translucent member 30 among the light emitted from the light-emitting part 11 enters the light-receiving part 12 without passing through the subject. Can be suppressed. By suppressing the capture of stray light, it becomes easier to extract necessary information and high-precision measurement is possible.

(Configuration of sensor module)
FIG. 3 is a block diagram illustrating the configuration of the sensor module.
The sensor module 10 includes a pair of light emitting units 11, a light receiving unit 12 provided between the pair of light emitting units 11, a control unit 13, and an input / output interface unit 14.

  The light emitting unit 11 includes a first light emitting element 11a1 that emits light including first near infrared light having an emission wavelength of 806 nm or more and 995 nm or less. In addition, the light emitting unit 11 may include a second light emitting element 11a2 that emits light including second near infrared light having an emission wavelength of 600 nm to 804 nm, preferably 758 nm to 762 nm. The first light emitting element 11a1 and the second light emitting element 11a2 are light emitting diode elements or laser elements. In the present embodiment, the light emitting unit 11 is configured to emit the first near-infrared light and the second near-infrared light, but may be configured to emit at least the first near-infrared light.

  The light receiving unit 12 includes a light receiving element 12a that receives first near-infrared light that is emitted from the light emitting unit 11 and passes through blood flowing through the blood vessel of the subject and converts the light into an electrical signal. The light receiving element 12a is, for example, a photodiode. In the present embodiment, the light receiving element 12a has a sensitivity to receive not only the first near-infrared light but also the second near-infrared light and output an electrical signal corresponding to the amount of received light.

  The light emitting unit 11 and the light receiving unit 12 together constitute a light receiving / emitting unit 15. The sensor module 10 may be a package of the light emitting / receiving unit 15 (the light emitting unit 11 and the light receiving unit 12), the control unit 13, and the input / output interface unit 14.

  The light emitting unit 11 includes a drive circuit 11b that drives the first light emitting element 11a1 and the second light emitting element 11a2. In addition, the light receiving unit 12 includes an amplification circuit 12b that amplifies a light reception signal output from the light receiving element 12a. These circuits may be formed into chips.

  The control unit 13 is composed of a microcomputer. The control unit 13 can transmit a timing signal to the drive circuit 11b of the light emitting unit 11 and control to emit near infrared light from the first light emitting element 11a1 and the second light emitting element 11a2. In addition, the control unit 13 converts the amplified received light signal output from the amplifier circuit 12b of the light receiving unit 12 into digital signal information that can be processed using the built-in analog-digital conversion circuit, and performs the conversion. Based on the signal information, information about blood passing through the blood vessel of the subject is estimated.

  For example, in the measurement using the first near-infrared light, information obtained from blood passing through the blood vessel of the subject, for example, pulsation of blood flow, blood flow rate, flow velocity, and the like can be obtained. Further, in measurement using both the first near-infrared light and the second near-infrared light, blood hemoglobin change (Hb change amount), blood oxygen ratio change (oxygen level), and the like can be obtained.

  Here, the absorbances of oxygenated hemoglobin and deoxygenated hemoglobin are equal at a wavelength of 805 nm, the absorbance of oxygenated hemoglobin is greater than that of deoxygenated hemoglobin at a wavelength longer than 805 nm, and oxygen at a wavelength shorter than 805 nm. The absorbance of oxyhemoglobin is smaller than the absorbance of deoxygenated hemoglobin. Therefore, oxygenated hemoglobin is preferentially measured by using light including first near infrared light having a wavelength of 806 nm or more and 995 nm or less, preferably light having an emission peak in the wavelength range of the first near infrared light. Can do.

  Moreover, since the sensor module 10 can measure at a sampling rate of about 10 milliseconds, information about blood can be obtained continuously.

  Further, when measurement is performed using light including light having a wavelength shorter than 805 nm, deoxygenated hemoglobin can be measured preferentially. Examples of such light include light including second near-infrared light having a wavelength of 600 nm to 804 nm (preferably 758 nm to 762 nm), and light having an emission peak in the wavelength range of the second near-infrared light is preferable. Illustrated as light. Then, it is possible to derive blood oxygen ratio change (oxygen level) or related information from the measurement result by the light including the first near infrared light and the measurement result by the light including the second near infrared light. is there.

  In order to perform measurement using such near infrared light, the light diffusing adhesive member 20 and the translucent member 30 are preferably opaque to the wavelength of light received and emitted by the light emitting and receiving unit 15.

  Here, in general, the emission opening 55 which is a path of light emitted from the light emitting unit 11 is not covered with a member. However, in the present embodiment, the light diffusion adhesive member 20 is provided so as to cover the discharge opening 55. The light diffusion adhesive member 20 fixes the measurement apparatus 1 to the subject and diffuses the light, so that the light receiving unit 12 can easily receive light having conditions suitable for measurement.

  That is, in the measurement apparatus 1 according to the present embodiment, (1) the distance between the light emitting unit 11 and the subject and the distance between the light receiving unit 12 and the subject are stable, and (2) the light emitted from the light emitting unit 11. It is possible to obtain a merit that light can be diffused and irradiated on a subject to transmit and receive light under conditions suitable for measurement.

FIG. 4 is a schematic cross-sectional view illustrating the usage state of the measuring device.
The measurement apparatus 1 is closely fixed to the subject S using the adhesiveness of the light diffusion adhesive member 20. Thereby, the measuring device 1 can be reliably mounted without using a fixing tool such as a belt.

  In the measuring device 1, the tip position (the position of the upper protruding end) of the lens portion 31 of the translucent member 30 protrudes from the surface position (the upper surface position) of the light diffusion adhesive member 20. For this reason, in a state where the measurement apparatus 1 is fixed to the subject S, the lens portion 31 is reliably pressed against the subject S.

  Further, by making the elastic modulus of the lens portion 31 higher than the elastic modulus of the light diffusing adhesive member 20, the lens portion 31 is not deformed while the light diffusing adhesive member 20 and the subject S are brought into close contact with each other. It can be pressed against the specimen S. By being pressed against the subject S while maintaining the shape of the lens portion 31, the light passing through the subject S can be effectively captured by the lens portion 31 and converged on the light receiving unit 12. Thereby, erroneous detection due to stray light is suppressed, and measurement accuracy can be improved.

(Other embodiments)
FIG. 5 is a schematic cross-sectional view illustrating another embodiment.
The measurement apparatus 1B illustrated in FIG. 5 includes a second light shielding unit 52. The second light shielding portion 52 is provided between the light diffusion adhesive member 20 and the lens portion 31. The second light shielding part 52 is provided on the first light shielding part 51. By providing the second light shielding part 52, it is possible to prevent stray light propagating through the light diffusing adhesive member 20 out of the light emitted from the light emitting part 11 from being taken in from the lens part 31 and entering the light receiving part 12. it can.

  Since the light diffusing adhesive member 20 has a function of diffusing the light emitted from the light emitting portion 11, a part of the diffused light propagates through the light diffusing adhesive member 20 and exits from the side end face. Some will go. If this light does not go to the subject S but goes directly to the lens portion 31, it becomes stray light. The second light shielding unit 52 suppresses such stray light from being taken in from the lens portion 31. As a result, out of the light diffused by the light diffusing adhesive member 20, the light passing through the subject S toward the subject S can be accurately received by the lens portion 31, and the measurement accuracy can be improved.

  As described above, it is possible to provide the measuring apparatuses 1 and 1B that can perform stable and accurate measurement when the living body related information is measured by irradiating the subject S with light.

  Although the present embodiment has been described above, the present invention is not limited to these examples. For example, the light diffusion adhesive member 20 may be provided so as to be peeled off. Thereby, when the adhesiveness with respect to the test object S falls, it can be easily replaced with a new light diffusion adhesive member 20. In addition, those in which those skilled in the art appropriately added, deleted, and changed the design of the above-described embodiments, and combinations of the features of each embodiment as appropriate also include the gist of the present invention. As long as they are within the scope of the present invention.

DESCRIPTION OF SYMBOLS 1,1B ... Measuring device 10 ... Sensor module 10a ... Light-receiving / emitting surface 11 ... Light-emitting part 11a1 ... 1st light-emitting element 11a2 ... 2nd light-emitting element 11b ... Drive circuit 12 ... Light-receiving part 12a ... Light-receiving element 12b ... Amplifying circuit 13 ... Control Unit 14 ... input / output interface unit 15 ... light emitting / receiving unit 20 ... light diffusion adhesive member 30 ... translucent member 31 ... lens part 40 ... adhesive layer 50 ... housing 51 ... first light shielding part 52 ... second light shielding part 55 ... Emission opening 56 ... Light receiving opening 100 ... Substrate S ... Subject

Claims (8)

A light-emitting unit that is provided on one surface of the substrate and emits light of a predetermined wavelength toward the subject;
A light receiving portion that is provided on one surface of the substrate and receives the light via the subject;
A light diffusion adhesive member that is provided so as to cover the emission path of the light emitted from the light emitting unit, diffuses the light, and has adhesiveness on the surface;
A living body related information measuring device comprising: A housing having a discharge opening provided on the one surface of the substrate and provided in the discharge path; and a light receiving opening provided in the light receiving path of the light by the light receiving unit;
The living body related information measuring device according to claim 1, wherein the light diffusion adhesive member is provided so as to cover the opening for release. A light transmissive member provided on the housing so as to cover at least the emission opening, and capable of transmitting the light;
The living body related information measuring apparatus according to claim 2, wherein the light diffusing adhesive member is provided on the translucent member.   The living body-related information measuring device according to claim 3, wherein the translucent member includes a lens portion that is provided on the light receiving opening and has a convergence property with respect to the light.   The living body related information measuring device according to claim 4, wherein a tip position of the lens portion protrudes from a surface position of the light diffusion adhesive member.   The living body related information measuring device according to claim 5, wherein an elastic modulus of the lens portion is higher than an elastic modulus of the light diffusion adhesive member.   The said light emission part has a 1st light emitting element which discharge | releases the light containing the 1st near-infrared light whose light emission wavelength is 806 nanometer (nm) or more and 995 nm or less. Living body related information measuring device. The living body-related information measuring device according to claim 7, wherein the light emitting unit includes a second light emitting element that emits light including second near infrared light having an emission wavelength of 600 nm to 804 nm.

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