JP2018118956A - Powder composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve dispersibility of powder.SOLUTION: A powder composition contains the following components (A) and (B): (A) a polymer particle containing a cellulose derivative or a salt thereof; and (B) powder.SELECTED DRAWING: None

Description

  The present invention relates to a powder composition.

  Conventionally, powders to be blended in cosmetics and paints are used by coating their surfaces according to various purposes such as dispersibility, coating state and durability, and improvement in color tone. In particular, for cosmetic applications, powders are also used for purposes such as improving dry feeling, reducing physical irritation to the skin, and improving makeup.

  In general, it is known that the more the powder is dispersed in a state close to primary particles, the functions such as adhesion to the skin, touch, hiding power, and optical properties are exhibited to the maximum. For this reason, if the dispersibility in the dispersion medium is poor, the powder aggregates and cannot perform its original function.

  Under such a background, it is desired to improve the dispersibility of the powder.

  For example, Patent Document 1 describes a water-soluble polyoxyalkylene glycol derivative as a dispersant for organic powder. Patent Document 2 describes an organosilicon compound as a dispersant for inorganic powder. However, Patent Documents 1 and 2 do not describe the use of polymer particles as a powder dispersant.

  In Patent Document 3, (1) a mixture containing nanoparticles having an average particle size of less than 1000 nm and drug powder having an average particle size larger than the nanoparticles is obtained by a fluidized bed dry granulation method or a dry mechanical particle composite method. Compound-containing composite particles in which the surface of the drug powder is modified are manufactured by complexing, and (2) the drug-containing composite particles are manufactured to replace the surface modification of the nanoparticles with a lubricant. And (3) that the drug-containing composite particles are used for the production of a powder formulation.

  In Patent Document 4, (1) at least one of a drug and a biocompatible polymer is prepared as nanoparticles having an average particle size of less than 1000 nm, and then the mixture containing the prepared nanoparticles is fluidized bed dried granulation method Alternatively, drug-containing composite particles are manufactured by compounding using a dry mechanical particle compounding method, and (2) the drug-containing composite particles are manufactured to suppress adhesion and aggregation between the nanoparticles constituting the drug-containing composite particles. And (3) that the drug-containing composite particles are used for the production of a powder formulation.

  However, in Patent Documents 3 and 4, in order to solve the problem of nanoparticles (surface modification, or suppression of adhesion / aggregation between nanoparticles), instead of using the particles themselves, the drug containing aggregates of particles are contained. Although it describes the use of composite particles to improve the dispersibility of the nanoparticles themselves, a powder mixture containing particles and other powders (especially those having a higher content ratio than other particles) ) Does not describe the use of particles for improving dispersibility. Further, the particles of Patent Documents 3 and 4 are composite particles in which a plurality of particles are aggregated, and the size tends to increase. Therefore, it is considered that the particles can be not a nanoscale but a microscale. Furthermore, Patent Documents 3 and 4 do not describe application of particles to the skin (eg, external use such as cosmetics).

International Publication No. 2007/007521 JP-A-8-104606 JP 2003-277295 A JP 2003-275281 A

  The object of the present invention is to improve the dispersibility of the powder.

  As a result of intensive studies, the present inventors have not used the cellulose derivative or its salt together with the powder as it is, but instead of using it together with the powder after forming polymer particles containing the cellulose derivative or its salt. The present inventors have found that the dispersibility of the powder can be improved and have completed the present invention. The prior art does not describe or suggest the use of polymer particles (especially polymer particles containing cellulose derivatives or salts thereof) as a dispersant for powder mixtures containing particles and other powders.

That is, the present invention is as follows.
[1] A powder composition comprising the following components (A) and (B):
(A) polymer particles containing a cellulose derivative or a salt thereof; and (B) a powder.
[2] The powder composition according to [1], wherein the polymer particles have a volume distribution average particle diameter of 1 to 1000 nm.
[3] The powder composition according to [1] or [2], wherein the polymer particles are non-composite particles.
[4] The powder composition according to any one of [1] to [3], wherein the powder composition contains only the same kind of polymer particles as the polymer particles.
[5] The powder composition according to any one of [1] to [4], wherein the polymer particles have one or more properties selected from the group consisting of (i) to (iii) below:
(I) the contact angle of water on the particle film is 20 to 70 degrees;
(Ii) the ratio of the water contact angle on the particle film to the water contact angle on the polystyrene substrate is in the range of 0.2 to 0.9; and (iii) the absolute value of mobility by electrophoresis. Is 2 μmcm / Vs or more.
[6] The cellulose derivative is hydroxyalkyl cellulose, hydroxy cellulose, carboxyalkyl cellulose, carboxy cellulose, alkyl cellulose, hydroxyalkyl alkyl cellulose, cationized cellulose, hydrophobic cellulose, or an ester derivative thereof. The powder composition according to any one of [5].
[7] The powder composition according to any one of [1] to [6], wherein the cellulose derivative is hydroxypropylcellulose, ethylcellulose, hypromellose, or an ester derivative thereof.
[8] The ester derivative is an ester derivative selected from the group consisting of acetate, butyrate, succinate, glycolate, propionate, phthalate, and combinations of two or more of these esters. [6] or [7] powder composition.
[9] The powder composition according to any one of [1] to [8], wherein the polymer particles include a mixture of two or more kinds of polymers.
[10] The powder composition according to any one of [1] to [9], wherein the polymer particles contain an active ingredient.
[11] The powder composition according to [10], wherein the active ingredient is one or more ingredients selected from the group consisting of a humectant, a whitening agent, and a hair restorer.
[12] The powder composition according to any one of [1] to [11], wherein the powder is an inorganic powder.
[13] The powder composition according to any one of [1] to [12], wherein the powder is coated with the polymer particles.
[14] A cosmetic comprising the powder composition according to any one of [1] to [13].

  The powder composition of the present invention is excellent in powder dispersibility and usability (eg, uniformity during coating, adhesion, and sustained effect). Moreover, since the polymer particles contained in the powder composition of the present invention can contain an active ingredient (eg, humectant), the function of the active ingredient can be imparted to the powder composition of the present invention.

FIG. 1 is a view showing a scanning electron micrograph of the particles obtained in Reference Example 1 (see Reference Example 1). FIG. 2 is a view showing a scanning electron micrograph after natural drying of the particles prepared in Reference Example 3 (see Reference Test Example 3).

1. Powder Composition The present invention provides a powder composition comprising the following components (A) and (B):
(A) polymer particles containing a cellulose derivative or a salt thereof; and (B) a powder.

(A) Polymer particle containing cellulose derivative or salt thereof (A1) Polymer particle As a polymer constituting the polymer particle, cellulose derivative or salt thereof is contained in the polymer particle. Examples of the cellulose derivative include hydroxyalkyl cellulose, hydroxy cellulose, carboxyalkyl cellulose, carboxy cellulose, alkyl cellulose, hydroxyalkyl alkyl cellulose, cationized cellulose, hydrophobic cellulose, and ester derivatives thereof, and ester derivatives of cellulose. It is done. As alkyl in hydroxyalkyl cellulose, carboxyalkyl cellulose, alkyl cellulose, and hydroxyalkyl alkyl cellulose, alkyl having 1 to 12 carbon atoms is preferable, alkyl having 1 to 6 carbon atoms is more preferable, and alkyl having 1 to 4 carbon atoms. More preferred is alkyl. The number of carbon atoms of the substituent is not included in the number of carbon atoms. Examples of the alkyl having 1 to 12 carbon atoms include methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, isobutyl, t-butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl. , Dodecyl.

  Examples of the hydroxyalkyl cellulose include hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxybutyl cellulose, hydroxypentyl cellulose, and hydroxyhexyl cellulose.

  Examples of the carboxyalkyl cellulose include carboxymethyl cellulose, carboxyethyl cellulose, carboxypropyl cellulose, carboxybutyl cellulose, carboxypentyl cellulose, and carboxyhexyl cellulose.

  Examples of the alkyl cellulose include methyl cellulose, ethyl cellulose, propyl cellulose, butyl cellulose, pentyl cellulose, and hexyl cellulose.

  Hydroxyalkyl alkyl cellulose is a cellulose having both hydroxyalkyl and alkyl. Examples of the hydroxyalkylalkylcellulose include cellulose having hydroxymethyl and alkyl (eg, hydroxymethylmethylcellulose, hydroxymethylethylcellulose, hydroxymethylpropylcellulose, hydroxymethylbutylcellulose), cellulose having hydroxyethyl and alkyl (eg, hydroxyethyl). Methylcellulose, hydroxyethylethylcellulose, hydroxyethylpropylcellulose, hydroxyethylbutylcellulose), cellulose having hydroxypropyl and alkyl (eg, hydroxypropylmethylcellulose (hypromellose), hydroxypropylethylcellulose, hydroxypropylpropylcellulose, hydroxyprolbutylcellulose), Hide Cellulose having a Kishibuchiru and alkyl (e.g., hydroxybutyl methylcellulose, hydroxybutyl cellulose, hydroxybutyl cellulose, and hydroxybutyl butyl cellulose) and the like.

  The cationized cellulose refers to cellulose having a cationic group or a derivative thereof. Examples of the cationic group include trialkylammonium. The three alkyls in the trialkylammonium may be the same or different and are the same as the alkyls described above in the hydroxyalkylcellulose, carboxyalkylcellulose, alkylcellulose, and hydroxyalkylalkylcellulose, and the preferred ranges are also the same. is there.

  Hydrophobized cellulose refers to cellulose having a hydrophobic group or a derivative thereof. Examples of the hydrophobic cellulose include acetylated cellulose.

  The ester derivative is a derivative in which a hydrogen atom in hydroxy in the cellulose derivative is substituted with R—C (═O) — (R represents a monovalent group which may be substituted) to form an ester moiety. It is. One or more ester moieties may be present in the cellulose, and it is not always necessary to exist in all the monomer units of cellulose, but a predetermined number of esters such as 1 to 3 in all the monomer units of cellulose. A portion may be present. Examples of the monovalent group represented by R include a monovalent chain hydrocarbon group (eg, alkyl, alkenyl, and alkynyl) and a monovalent alicyclic hydrocarbon group (eg, cycloalkyl, cycloalkenyl, Cycloalkynyl), monovalent aromatic hydrocarbon groups (eg, aryl such as phenyl, naphthyl, etc.), monovalent aromatic heterocyclic groups (eg, pyrenyl, pyrrolyl, furanyl, thiophenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, Triazinyl), monovalent non-aromatic heterocyclic groups (eg, oxiranyl, aziridinyl, azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, dihydrofuranyl, tetrahydrofuranyl), and two or more thereof (eg, 2, 3 or 4) Combinations are listed. The monovalent group preferably has 1 to 12 carbon atoms, more preferably 1 to 10 carbon atoms, and still more preferably 1 to 6 carbon atoms. Among these, the monovalent group is preferably alkyl, cycloalkyl (eg, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl), or aryl (eg, phenyl, naphthyl), and more preferably alkyl. Examples of alkyl as the monovalent group and preferred examples thereof are the same as the alkyl described above in hydroxyalkyl cellulose, carboxyalkyl cellulose, alkyl cellulose, and hydroxyalkylalkyl cellulose.

  Examples of the substituent that the monovalent group as R may have include, for example, a halogen atom (eg, fluorine atom, chlorine atom, bromine atom, iodine atom), carboxy, sulfo, cyano, nitro, mercapto, oxo , Guanidino, hydroxy, alkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, alkylcarbonyloxy, amino optionally mono- or di-substituted with alkyl (eg, amino), and mono- or di-substituted with alkyl Good amino-carbonyls (eg amides) are mentioned. Examples of alkyl in alkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, alkylcarbonyloxy, amino optionally mono- or disubstituted with alkyl, and amino-carbonyl optionally mono- or di-substituted with alkyl and preferred Examples are similar to the alkyls described above in hydroxyalkylcellulose, carboxyalkylcellulose, alkylcellulose, and hydroxyalkylalkylcellulose.

  More specifically, examples of the ester derivatives include acetate esters (eg, cellulose monoacetate, cellulose diacetate, cellulose triacetate), butyric acid esters, succinic acid esters, glycolic acid esters, propionic acid esters, phthalic acid esters, and A combination of two or more of these esters may be mentioned. Examples of particularly preferred ester derivatives are cellulose acetate, (acetic acid / propionic acid) cellulose, (acetic acid / butyric acid) cellulose, cellulose acetate phthalate, (acetic acid / succinic acid) hydroxypropylmethylcellulose.

  The cellulose derivative or a salt thereof can be produced by any method known in the art. For example, since various glucose derivatives are known, a cellulose derivative can be obtained by appropriately polymerizing such a glucose derivative. Moreover, since various modification methods are known for cellulose, such cellulose derivatives can be obtained by appropriately modifying cellulose.

  The polymer constituting the polymer particles may be only one type of polymer, or may be a mixture of two or more types (for example, 2, 3, 4, or 5). Therefore, the polymer particles may contain one or more of the above cellulose derivatives or salts thereof. Alternatively, the polymer particles may contain other polymers such as natural polymers, semi-synthetic polymers, or synthetic polymers in addition to the cellulose derivatives or salts thereof described above. Examples of natural polymers include polysaccharides (eg, cellulose, guar gum, locust bean gum, quinseed gum, carrageenan, pectin, mannan, starch, agar, xanthan gum, succinoglycan, curdlan, hyaluronic acid, dextran), protein (Eg, gelatin, casein, albumin, collagen, alginic acid), and salts thereof. Examples of semi-synthetic polymers include modified polysaccharides obtained by modifying the above polysaccharides (eg, starch derivatives (eg, solubilized starch, carboxymethyl starch)), modified proteins obtained by modifying the above proteins (eg, alginic acid). Base polymers (eg, propylene glycol alginate)], and salts thereof. Synthetic polymers include, for example, vinyl polymers (eg, acrylic acid polymers, methacrylic acid polymers), polyalkylene oxides (eg, polyethylene oxide (PEO), polypropylene oxide (PPO), polybutylene oxide (PBO)), polyalkylenes. Glycols (eg, polyethylene glycol (PEG), polypropylene glycol (PPG), polybutylene glycol (PBG)), and copolymers thereof, and salts thereof.

  The polymer constituting the polymer particle is not particularly limited as long as the shape of the polymer particle can be stabilized, and is a homopolymer composed of the same monomer unit or a heteropolymer composed of different monomer units (for example, Random copolymers, alternating copolymers, block copolymers, graft copolymers, comb copolymers). Such polymers are also linear polymers whose main chain is linear, or branched polymers whose main chain is non-linear (eg, graft polymers, comb polymers, hyperbranched polymers, ladder polymers) Linear polymers are preferred.

  The polymer constituting the polymer particle is not particularly limited as long as it has an arbitrary weight average molecular weight capable of stabilizing the form of the polymer particle. For example, 10,000 or more, preferably 20,000 or more, more preferably 30 , 000 or more, even more preferably 40,000 or more. The weight average molecular weight is, for example, 1,000,000 or less, 800,000 or less, 600,000 or less, 400,000 or less, 300,000 or less, or 200,000 from the viewpoint of easy availability of materials. It may be the following.

  Examples of the salt include metal salts, acid addition salts, and salts with bases. Examples of metal salts include salts with monovalent metals (eg, sodium and potassium) and salts with divalent metals (eg, calcium and magnesium). Examples of acid addition salts include salts with inorganic acids (eg, hydrogen chloride, hydrogen bromide, sulfuric acid, and phosphoric acid), and organic acids (eg, acetic acid, lactic acid, citric acid, tartaric acid, maleic acid, fumaric acid) And salts with monomethyl sulfate). Examples of salts with bases include salts with inorganic bases (eg, ammonia), and organic bases (eg, ethylenediamine, propylenediamine, ethanolamine, monoalkylethanolamine, dialkylethanolamine, diethanolamine, triethanolamine) Of the salt.

  In preferred embodiments, the polymer particles comprise a mixture of two or more polymers. By including a mixture of two or more kinds of polymers, there is an advantage that moderate hydrophobicity can be added to the particle surface while having a hydrophilic portion familiar with the hydrophilic substance inside the particle. Preferably, the mixture of two or more polymers is a mixture of two or more (eg, 2, 3, 4 or 5) polymers including a hydrophilic polymer and a hydrophobic polymer.

  In the present invention, the hydrophilic polymer refers to a polymer having a solubility in an aqueous solution (preferably water) of 1% (wt) or more. About the water-soluble polymer, the solubility with respect to aqueous solution (preferably water) becomes like this. Preferably it is 5% (wt) or more, More preferably, it is 7% (wt) or more. Examples of the hydrophilic polymer include polymers containing, as monomer units, hydroxyalkyl, hydroxy, carboxyalkyl, carboxy, or a saccharide substituted with a cationic group. Hydrophilic polymers include hydroxyalkyl cellulose, hydroxycellulose, carboxyalkylcellulose, such as carboxycellulose, cationized cellulose, and ester derivatives thereof, and the like, depending on the types of specific substituents and the like that the hydrophilic polymer has. Of the salt.

  Preferably, the hydrophilic polymer may be a hydrophilic polymer (amphiphilic polymer) that easily migrates to an organic solvent. An amphiphilic polymer has an aggregation site consisting of a hydrophilic functional group and an aggregation site consisting of a hydrophobic functional group in one molecule, and forms a polymer micelle at the water-oil interface like a surfactant. Say. Examples of the amphiphilic polymer include polymers containing, as monomer units, hydroxyalkyl, carboxyalkyl, or a saccharide substituted with a cationic group. Examples of the amphiphilic polymer include hydroxyalkyl cellulose, carboxyalkyl cellulose, cationized cellulose, and ester derivatives thereof, and salts thereof, depending on the types of specific substituents and the like. .

  In the present invention, the hydrophobic polymer refers to a polymer having a solubility in an aqueous solution (preferably water) of less than 1% (wt). About the water-soluble polymer, the solubility with respect to aqueous solution (preferably water) becomes like this. Preferably it is 0.1% (wt) or less, More preferably, it is 0.01% (wt) or less. Examples of the hydrophobic polymer include alkyl cellulose, hydroxyalkylalkyl cellulose, hydrophobized cellulose, and ester derivatives thereof, and salts thereof, depending on the type of specific substituents and the like that the polymer has.

(A2) Active ingredient In the ingredient (A), the polymer particles may contain an active ingredient inside. Even after the polymer particles have been washed several times with the solution, it has been confirmed that the active ingredient is contained in the polymer particles. The active ingredient contained in the polymer particles is not covalently bonded to the polymer and is free from the polymer. One type or two or more types (for example, 2, 3, 4) of active ingredients may be contained in the polymer particles. The active ingredient can be dispersed in a solution (aqueous solution or organic solvent) in the polymer particles. The particles of the present invention may also contain other components such as additives (eg, preservatives such as methylbaraben, antioxidants) in addition to the active ingredients.

  As an active ingredient, a low molecular weight compound is mentioned, for example.

  The term “low molecular weight compound” refers to a compound having a molecular weight of 1500 or less. The low molecular compound is a natural compound or a synthetic compound. The molecular weight of the low molecular weight compound may be 1200 or less, 1000 or less, 900 or less, 800 or less, 700 or less, 600 or less, 500 or less, 400 or less, or 300 or less. The molecular weight of the low molecular compound may also be 30 or more, 40 or more, or 50 or more. Examples of the low molecular weight compound include amino acids, oligopeptides, vitamins, nucleosides, nucleotides, oligonucleotides, monosaccharides, oligosaccharides, lipids, fatty acids, and metabolites thereof, and salts thereof (for example, metals as described above) Salts, acid addition salts, and salts with bases).

  The active ingredient may be a water-soluble ingredient or a hydrophobic ingredient. The water-soluble component as an active ingredient is a component that is more easily dissolved in an aqueous solution (preferably water) than the organic solvent used in the method for producing particles described later. The hydrophobic component as an active ingredient is a component that is more easily dissolved in an organic solvent than an aqueous solution (preferably water) used in the method for producing particles to be described later. Active ingredients include, for example, allantoin, arbutin, ceramide, kojic acid, ellagic acid, amino acids, amino acid derivatives, peptides, oligopeptides, vitamins, vitamin derivatives, nucleosides, nucleotides, oligonucleotides, monosaccharides, oligosaccharides, hormones, nerves Examples include transmitter substances, and metabolites thereof, and salts thereof.

  Preferably, the active ingredient is an external preparation. As an external preparation, a moisturizer, a whitening agent, and a hair restorer are mentioned, for example.

  Examples of the humectant include pyrrolidone carboxylic acid, polyaspartic acid, 3-acetyl-2-ethoxycarbonyl-2-methyl-1,3-thiazolidine-4-carboxylic acid, amino acids (eg, glutamic acid, aspartic acid, arginine, Lysine, histidine, ornithine, glycine, alanine, valine, leucine, isoleucine, serine, threonine, asparagine, glutamine, cysteine, cystine, methionine, phenylalanine, tyrosine, tryptophan, proline, hydroxyproline), glycylglycine, alanylglutamine, Dipeptide-2 (valyltryptophan), dipeptide-4 (cystenylglycine), dipeptide-8 (alanylhydroxyproline), dipeptide-9 (glutamyllysine), dipeptide-11 ( Sutenirurijin), dipeptide -17 (glycyl proline), dipeptide -19 (isoleucyl glutamic acid), and salts thereof.

  Examples of whitening agents include vitamin C, vitamin C derivatives (eg, vitamin C glycosides such as L-ascorbic acid 2-glycoside), cysteine, tranexamic acid, hydroquinone, arbutin, ceramide, kojic acid, ellagic acid, plants Extracts as well as their salts are mentioned.

The ratio of the weight of the active ingredient to the weight of the polymer particles (total weight of the polymer and active ingredients constituting the particles) varies depending on the type of polymer and electrolyte active ingredients constituting the polymer particles, and the conditions of the method for producing the particles. Therefore, it is not particularly limited, but is, for example, 0.01 to 80%. The ratio of the weight of the active ingredient to the weight of the particles of the present invention is preferably 0.05 to 40%, more preferably 0.1 to 15%, still more preferably 0.2 to 14%, particularly preferably 0. 5 to 12% or 1.0 to 10%. Alternatively, the concentration of the active ingredient in the particles of the present invention is, for example, 0.01 to 50% (wt), preferably 0.02 to 40% (wt), more preferably 0.05 to 30% (wt). Even more preferably, it may be 0.1 to 20% (wt).
The weight of the active ingredient can be measured by any method known in the art. Examples of such a method include a method using high performance liquid chromatography (HPLC) and a spectrophotometer (eg, UV-VIS spectrophotometer). The concentration of the active ingredient can also be evaluated from the concentration of the active ingredient in the aqueous solution containing the active ingredient or the aqueous solution containing both the active ingredient and the second polymer used in the production of the polymer particles.

  The particles of the present invention are also required for the production of particles in certain components (eg, prior art) such as surfactants (eg, sorbitan monooleate), residual organic solvents (eg, hydrocarbon compounds such as hexane). The component) may be substantially not included. Since the particles of the present invention do not essentially require the use of these components in the production method, contamination of these components can be avoided. In the particle of the present invention, the expression “substantially free” means that the particle of the present invention does not completely contain a predetermined component, or even if the particle of the present invention contains a predetermined component. It means that it is contained in an amount of 0% (wt) or less. Preferably, the expression “substantially free” means “completely free”. With respect to the expression “substantially free”, the particles of the present invention preferably contain no more than 2.0% (wt), more preferably no more than 1.5% (wt), even more, when they contain a given component. Preferably, it is 1.0% (wt) or less, particularly preferably 0.5% (wt) or less, 0.4% (wt) or less, 0.3% (wt) or less, 0.2% (wt) or It is contained in an amount of 0.1% (wt) or less. More specifically, the particles of the present invention are preferably substantially free of one of a surfactant and a residual organic solvent, and more preferably substantially free of both a surfactant and a residual organic solvent. .

  As will be described later, the particles of the present invention can also be produced by using acetone, alcohol (eg, methanol), or an acetone / alcohol mixture which may contain a large amount of acetone as a preferred organic solvent. Therefore, the particles of the present invention may be substantially free of organic solvents other than acetone, alcohol, or an acetone / alcohol mixture. According to the method for producing particles of the present invention, such particles can be produced, but such particles cannot usually be produced by the conventional method for producing particles.

(A3) Further characteristics of polymer particles The polymer particles may contain other components in addition to the polymer or a salt thereof and an active ingredient. Examples of other components include active ingredient stabilizers (eg, antioxidants), surfactants, and dispersants.

The polymer particles may have a volume distribution average particle diameter of 1 to 1000 nm. The volume distribution average particle diameter is preferably 5 nm or more, more preferably 10 nm or more, still more preferably 20 nm or more, or 50 nm or more. The volume distribution average particle diameter is also preferably 900 nm or less, more preferably 800 nm, 700 nm, 600 nm, 500 nm, or 400 nm or less.
The volume distribution average particle diameter can be measured by measuring the particle size distribution by a laser diffraction method. Preferably, the particle size distribution can be measured by a laser diffraction method using a laser diffraction particle size distribution meter (manufactured by Malvern Instruments Ltd., Zetasizer NanoS).

The polymer particles may also have a property that the contact angle of water on the particle film is 20 to 70 degrees. A contact angle of water on the particle membrane of 20 degrees or more is preferable because it has moderate hydrophilicity and improves the distribution of active ingredients to intercellular lipids in the stratum corneum. Moreover, it is preferable that the contact angle of water on the particle membrane is 70 degrees or less, since it has moderate hydrophobicity and the compatibility with intercellular lipids in the stratum corneum is improved. The contact angle is preferably 25 degrees or more, more preferably 30 degrees or more, even more preferably 35 degrees or more, and particularly preferably 40 degrees or more. The contact angle may also be preferably 65 degrees or less, more preferably 60 degrees or less, even more preferably 55 degrees or less, and particularly preferably 50 degrees or less. When calculating the ratio, the inner angle is measured as the contact angle.
The contact angle of water on the particle film can be measured as follows. First, a polymer particle film (particle film) is obtained. For example, a solution containing polymer particles is dropped on a polystyrene substrate and is naturally dried at an appropriate temperature (eg, room temperature (27 ° C., etc.)) to obtain a polymer particle film (particle film) that completely covers the polystyrene substrate. Next, 20 μL of water droplets are dropped on the particle film thus obtained, and then an image is taken from the side. The contact angle value is measured from the image.

The polymer particles may have a property that the ratio of the contact angle of water on the particle film to the contact angle of water on the polystyrene substrate is in the range of 0.2 to 0.9. If the said ratio is 0.2 or more, it can be said that it has moderate hydrophilicity with respect to the polystyrene substrate surface. In this case, it is considered difficult to separate in blending into a prescription containing water. Therefore, the ratio is preferably 0.2 or more. Moreover, if the said ratio is 0.9 or less, it can be said that it has moderate hydrophobicity. In this case, it is considered difficult to separate in blending into a formulation containing oil. Therefore, the ratio is preferably 0.9 or less. The ratio may be preferably 0.3 or more, more preferably 0.4 or more, and even more preferably 0.5 or more. The ratio may also be preferably 0.8 or less, more preferably 0.7 or less, and even more preferably 0.6 or less. When calculating the ratio, the inner angle is measured as the contact angle.
The contact angle of water on the particle film can be measured in the same manner as described above.
The contact angle of water on the polystyrene substrate can be measured as follows. After dropping a 20 μL water droplet on the polystyrene substrate, the value of the contact angle is measured by the same method as the measurement of the contact angle of water on the particle film.
Calculate the ratio of the water contact angle on the particle film to the water contact angle on the polystyrene substrate by dividing the value of the water contact angle on the particle film by the value of the water contact angle on the polystyrene substrate. be able to.

The polymer particles may also have a property that the absolute value of mobility by electrophoresis is 2 μmcm / Vs or more. If the absolute value is 0.22 μmcm / Vs or more, the particles do not have a complete gel surface, but the active ingredient can be retained inside the particles, which is preferable. Therefore, the polymer particles have a property that the surface is not gel-like and has a solid boundary. The absolute value of the mobility is preferably 2.5 μmcm / Vs or more, more preferably 3.0 μmcm / Vs or more, and even more preferably 3.5 μmcm / Vs or more. The absolute value of the mobility may also be preferably 6.0 μmcm / Vs or less. If the absolute value is 6.0 μmcm / Vs or less, the particles are not hard and do not have surface properties that do not pass through the medium (eg, surface properties of polystyrene particles), but when they come into contact with living tissue such as the skin surface. It is preferable because it has surface characteristics that allow the active ingredient to be released together with the medium at an appropriate timing. The absolute value is more preferably 5.5 μmcm / Vs or less, and even more preferably 5.0 μmcm / Vs or less.
Electrophoretic mobility of polymer particles can be measured by analyzing the mobility of polymer particles in a 1 mM NaCl aqueous solution using Zetasizer NanoS (Malvern Instruments Ltd.) (preferably). Measured mobility in 1 mM NaCl aqueous solution).

  The polymer particles may also be composite particles or non-composite particles. The term “composite particle” refers to a particle aggregate formed by combining (eg, adsorbing or adhering) two or more different kinds of particles. Such composite particles can be produced from two or more different kinds of particles by a predetermined method (eg, granulation method, particle composite method). On the other hand, non-composite particles are not such composite particles and are not formed by combining two or more different particles. The polymer particles can be suitably used in the form of either composite particles or non-composite particles, but one of the advantages is that they can be freely designed to have a sufficiently small size (eg, 500 nm or less) as nanoparticles, Further, since the desired characteristics can be sufficiently exhibited even in the form of non-composite particles, it can be preferably used in the form of non-composite particles.

  The polymer particles may also have a hard or soft surface. The polymer particles may also have a shape such as a true spherical shape, an elliptical shape, a golf ball shape, or a Janus particle shape, but preferably has a true spherical shape. These properties of the polymer particles can be confirmed by observing the appearance with a scanning electron microscope.

  The polymer particles also have a high liquid stability. For example, the polymer particles can maintain a particle state without agglomeration even after being stored in a refrigerator (eg, 4 ° C.) for 6 months or more, 12 months or more, or 18 months or more.

  The polymer particles can be pulverized. Examples of the powdering method include freeze drying, spray drying, fluidized bed granulation, stirring granulation, supercritical granulation, and natural drying. The polymer particles also have a property of being dispersible in a solvent (for example, a solvent described later, preferably an aqueous solution such as water) after powderization.

  The polymer particles can be provided in liquid or powdered form, but are preferably provided in powdered form.

(B) Powder The powder used in the present invention is not particularly limited, and may be any shape such as a spherical shape, a rod shape, a needle shape, a plate shape, and a scale shape. Preferably, the particle shape is spherical. The powder may also have any particle structure such as porous or nonporous. The powder may be surface-treated with an arbitrary substance (eg, fatty acid, amino acid, organosilicon compound). Examples of the surface treatment include a hydrophilic treatment and a hydrophobic treatment.

  The volume distribution average particle diameter of the powder may be, for example, 100 μm or less, preferably 50 μm or less. The volume distribution average particle diameter of the powder may be, for example, 0.05 μm or more, preferably 0.1 μm or more. More specifically, the volume distribution average particle diameter of the powder may be, for example, 0.05 to 100 μm, preferably 0.1 to 50 μm. The volume distribution average particle diameter can be measured by measuring the particle size distribution using the laser diffraction method, optical microscope, or electron microscope described above.

  Examples of the powder include inorganic powder and organic powder.

  Examples of the inorganic powder include metal (eg, gold, silver, aluminum), metal oxide (eg, zinc oxide, titanium oxide, cerium oxide, iron oxide, chromium oxide, cobalt oxide, aluminum oxide, magnesium oxide, oxidation) Zirconium, antimony oxide), metal hydroxide (eg, chromium hydroxide, hydroxyapatite), metal carbonate (eg, calcium carbonate, magnesium carbonate), metal sulfate (eg, barium sulfate), silicon compound (eg, carbonized) Silicon, anhydrous silicic acid, aluminum silicate, magnesium magnesium silicate, calcium silicate, barium silicate, magnesium silicate), nitride (eg, boron nitride), talc, mica, muscovite, phlogopite, safmicite, Biotite, synthetic mica, sericite (sericite), synthetic sericite, kaolin, bismuth oxychloride Fish scale foil, and the like. Such powder is used, for example, as a pigment (eg, white pigment, colored pigment, extender pigment, pearl pigment) or an ultraviolet scattering agent.

  Examples of the organic powder include nylon, polyester, polystyrene, cellulose, silicone elastomer, silicone rubber, benzoguanamine, styrene divinylbenzene pinhole polymer, polyethylene, polypropylene, polyurethane, silk, starch, N-acylated lysine (eg, N -Octanoyl lysine, N-lauroyl lysine, N-myristoyl lysine, N-stearoyl lysine), organic pigment (eg, red pigment such as red 201; blue pigment such as blue 404; orange pigment such as orange 203; Yellow pigments such as yellow 205; green pigments such as green 3; organic lake pigments such as zirconium lake, barium lake, and aluminum lake; natural pigments such as chlorophyll and β-carotene), etc. The body is mentioned.

  The powder may be a powder composed of a single substance or material, or a powder composed of a plurality of substances or materials (eg, an aggregate of a plurality of substances or materials described above). There may be. The powder may be a molded body or a non-molded body.

(C) Powder composition The blending amount of the polymer particles in the powder composition of the present invention is an arbitrary blending amount capable of achieving the dispersion of the powder by the polymer particles alone or by the combination of the polymer particles and another dispersant. It is. Examples of such other dispersants include water-soluble polyoxyalkylene glycol derivatives (eg, International Publication No. 2007/007521), and organosilicon compounds (Japanese Patent Laid-Open No. 8-104606, Japanese Patent Publication No. 1-54381). Gazette and JP-A-7-62263). In the powder composition of the present invention, when polymer particles are used in combination with another dispersant, the powder can be dispersed while reducing the blending amount of the other dispersant. When the polymer particles are used in combination with other coating materials, the blending amount of the polymer particles is not particularly limited as long as it is an amount that can contribute to the reduction of the blending amount of the other dispersant for dispersing the powder. For example, when the polymer particles are used in combination with another dispersant, the weight ratio of the polymer particles to the other dispersant in the powder composition of the present invention is not particularly limited, but 1 part by weight of the polymer particles On the other hand, the other dispersant is, for example, 4 parts by weight or less, preferably 2 parts by weight or less, more preferably 1 part by weight or less, still more preferably 0.75 parts by weight or less, particularly preferably 0.5 parts by weight or less. It may be.

  More specifically, the blending amount of the polymer particles based on the polymer particles alone or in combination with the polymer particles and other dispersants depends on the types and amounts of the polymer particles and powder, and the presence or absence of other dispersants. Although it varies, for example, 0.5% (wt) or more, preferably 1.0% (wt) or more, more preferably 2.0% (wt) or more, and even more preferably 3.0% (wt) or more. There may be. The blending amount may also be 50% (wt) or less, preferably 45% (wt) or less, more preferably 40% (wt) or less, and even more preferably 35% (wt) or less. More specifically, the blending amount is, for example, 0.5% to 50% (wt), preferably 1.0 to 45% (wt), more preferably 2.0 to 40% (wt), and even more preferably. May be 3.0-35% (wt). The powder composition of the present invention may contain one or more polymer particles.

  The blending amount of the powder in the powder composition of the present invention is, for example, 1.0% (wt) or more, preferably 5.0% (wt) or more, more preferably 10.0% (wt) or more, and even more. Preferably it may be 20.0% (wt) or more. The blending amount is also, for example, 99.5% (wt) or less, preferably 99.0% (wt) or less, more preferably 98.0% (wt) or less, and even more preferably 97.0% (wt) or less. It may be. More specifically, the blending amount is, for example, 1.0 to 99.5% (wt), preferably 5.0 to 99.0% (wt), more preferably 10.0 to 98.0% (wt). ), And more preferably 20.0-97.0% (wt). The powder composition of the present invention may contain one or more powders.

  The weight ratio of the polymer particles to the powder in the powder composition of the present invention is not particularly limited, but the powder is preferably, for example, 0.1 parts by weight or more with respect to 1 part by weight of the polymer particles. May be 0.5 parts by weight or more, more preferably 1 part by weight or more, even more preferably 2 parts by weight or more, and particularly preferably 5 parts by weight or more. Further, the powder is, for example, 2000 parts by weight or less, preferably 1000 parts by weight or less, more preferably 500 parts by weight or less, even more preferably 200 parts by weight or less, particularly preferably 100 parts by weight with respect to 1 part by weight of the polymer particles. Or less. More specifically, the anionic water-soluble polymer is, for example, 0.1 to 2000 parts by weight, preferably 0.5 to 1000 parts by weight, more preferably 1 to 1 part by weight of the polymer particles containing the active ingredient. It may be 500 parts by weight, still more preferably 2 to 200 parts by weight, particularly preferably 5 to 100 parts by weight.

  In the powder composition of the present invention, the powder may be coated with polymer particles (not coated with polymer particles with powder) or uncoated. Coating of the powder with the polymer particles can be achieved by mixing the composition containing the polymer particles and the powder with a stirring device.

  The powder composition of the present invention may contain only the same kind of polymer particles or different kinds of polymer particles as the polymer particles. The term “homogeneous polymer particles” refers to polymer particles having similar particle sizes and constituents. Polymer particles produced under the same conditions (e.g., conditions with similar component types and amounts, and processing modes) can be considered to be the same type of polymer particles. On the other hand, the term “heterogeneous polymer particles” refers to polymer particles having different particle sizes and / or components. Polymer particles produced under different conditions (eg, conditions where any of the component types and amounts and processing conditions are different) can be considered to be heterogeneous polymer particles. Even if the powder composition of the present invention contains only the same kind of polymer particles as the polymer particles, the desired properties can be sufficiently exerted. From the viewpoint of reducing the burden of preparing / obtaining the particles, Preferably, only the same kind of polymer particles may be included. Therefore, the gel composition of the present invention may not contain polymer particles having an average particle diameter exceeding 1 μm.

  The powder composition of the present invention may further contain one or more external preparations as described above. Preferably, the external preparation further contained in the powder composition of the present invention may be the same as or different from the external preparation that can be contained in the polymer particles contained in the powder composition of the present invention. It is preferable.

  The powder composition of the present invention may further contain components useful as a powder composition in addition to the above components. Examples of such components include the above-mentioned external preparations, refreshing agents or fragrances (eg, limonene, citral, menthol, rose oil, rose oil), polyhydric alcohols (eg, ethylene glycol, propylene glycol, glycerin, Saccharides (eg, glucose, maltose)), oils, antioxidants, chelating agents, preservatives, ultraviolet absorbers (eg, t-butylmethoxydibenzoylmethane, ethylhexyl methoxycinnamate, oxybenzone-3). Specific types and amounts of these components can be appropriately set.

  The powder composition of the present invention can be provided, for example, in the form of a powder. The powder composition of the present invention is also in a liquid or gel form dispersed in a solvent such as an aqueous solution (eg, water) or an organic solvent (eg, alcohol), or kneaded into an oil or resin and pasty or creamy. It can be used as a form or the like.

  The powder composition of the present invention can permeate an active ingredient contained in polymer particles into a living tissue (eg, skin tissue such as stratum corneum (keratin layer)). Therefore, the powder composition of the present invention is also useful, for example, as a product (for example, cosmetics, pharmaceuticals, quasi drugs) in which penetration of an active ingredient into a living tissue is desired, or as a raw material for production thereof. is there.

  The present invention also provides a cosmetic comprising the powder composition of the present invention.

  The cosmetic of the present invention can contain the powder composition of the present invention in any degree. The cosmetic of the present invention comprises the powder composition of the present invention, for example, 1% (wt) or more, preferably 2% (wt) or more, more preferably 5% (wt) or more, and even more preferably 10% ( wt) or more, particularly preferably 20% (wt) or more. The cosmetic of the present invention also contains the powder composition of the present invention, for example, 99% (wt) or less, preferably 98% (wt) or less, more preferably 95% (wt) or less, and still more preferably 90%. (Wt) or less, particularly preferably 85% (wt) or less. More specifically, the cosmetic composition of the present invention comprises, for example, 1 to 99% (wt), preferably 2 to 98% (wt), more preferably 5 to 95% (wt) of the powder composition of the present invention. ), More preferably 10 to 90% (wt), particularly preferably 20 to 85% (wt).

  The cosmetics of the present invention include powders usually used in cosmetics, solvents (eg, aqueous solutions such as water, organic solvents such as alcohols), surfactants, ultraviolet absorbers, preservatives, bactericides, preservatives, Antioxidants, hormones, vitamins, humectants, fragrances and the like can be appropriately blended.

  The cosmetic of the present invention can be used as a non-aqueous cosmetic or an aqueous cosmetic.

  The cosmetic of the present invention can be made into a preparation in any form applicable to, for example, skin according to a conventional method. The cosmetics of the present invention include, for example, foundations (eg, loose foundation, powder foundation, liquid foundation, cream foundation, emulsion foundation, stick foundation), pressed powder, white powder, lipstick, blusher, eye shadow, eyebrow, eyeliner, mascara. , Nail color, teak color, sunscreen, emulsion, lotion.

2. Preparation method of powder composition The powder composition of the present invention is prepared by (1) preparing polymer particles containing a cellulose derivative or a salt thereof, and (2) mixing the prepared polymer particles with powder. Can do.

(1) Preparation of polymer particles containing cellulose derivative or salt thereof Preparation of polymer particles containing cellulose derivative or salt thereof (hereinafter referred to as “polymer” for simplification as needed) And (ii) an aqueous solution is mixed to form a W / O dispersion as a mixed solution of the organic solvent and the aqueous solution to precipitate particles. When preparation of polymer particles containing an active ingredient is intended, the active ingredient may be contained in either an organic solvent or an aqueous solution, or both, but is preferably contained in an aqueous solution. .

  In (i), the polymer contained in the organic solvent is not particularly limited as long as it is a polymer that can be dissolved in the organic solvent, but the hydrophobic polymer as described above is preferable. The amount of the polymer in the organic solvent is not particularly limited as long as the polymer can be dissolved in the organic solvent. For example, 0.05 to 30% (wt), preferably 0.1 to 15% (wt) More preferably, it is 0.2 to 10% (wt), and still more preferably 0.3 to 7% (wt).

  In (ii), the active ingredient and the aqueous solution are the same as those described above. The amount of the active ingredient in the organic solvent or aqueous solution is not particularly limited as long as the active ingredient can be dissolved in the organic solvent or aqueous solution and the amount of the active ingredient intended for use of the polymer particles can be achieved. -50% (wt), preferably 0.02-40% (wt), more preferably 0.05-30% (wt), and even more preferably 0.1-20% (wt). As the active ingredient, any of the above-mentioned water-soluble ingredients and hydrophobic ingredients can be used.

  The organic solvent containing the polymer is an aqueous solution (preferably the active ingredient) so that a W / O (water-in-oil) type dispersion is formed when mixed with an aqueous solution (preferably an aqueous solution containing the active ingredient). That can be phase-separated by a polymer dissolved in an organic solvent. Examples of such organic solvents include ketone solvents (eg, acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl butyl ketone), ether solvents (eg, diethyl ether, tetrahydrofuran, diisopropyl ether, dioxane), alcohol solvents (eg, methanol). , Ethanol, propanol, butanol), aprotic polar solvent (eg, N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), N, N-dimethylacetamide ( DMA)), carboxylic acid solvents (eg, formic acid, acetic acid, propionic acid, butyric acid, lactic acid), ester solvents (eg, ethyl acetate, butyl acetate, butyl propionate, butyl butyrate), halogenated hydrocarbon solvents (eg, Chloroform, methylene chloride Carbon tetrachloride, dichloroethane, trichloroethane, chlorobenzene), non-aromatic hydrocarbon solvents (eg, pentane, hexane, heptane, octane, cyclohexane, cyclopentane), aromatic hydrocarbon solvents (eg, benzene, toluene, xylene) As well as a mixture thereof.

  Preferably, the organic solvent is an organic solvent that is miscible with an aqueous solution (preferably water) from the viewpoint of efficiently producing polymer particles. Examples of the organic solvent miscible with the aqueous solution include ketone solvents, ether solvents, alcohol solvents, aprotic polar solvents, carboxylic acid solvents, and ester solvents. From the viewpoint of using an organic solvent that is miscible with an aqueous solution but not azeotroped with water, a preferable organic solvent is acetone, alcohol (eg, methanol), or an acetone-alcohol mixture that may contain a large amount of acetone.

  The temperature at the time of mixing is not particularly limited as long as the organic solvent and the aqueous solution are in a liquid state, but is, for example, 5 to 50 ° C., preferably 15 to 40 ° C. The mixing time is not particularly limited as long as the polymer particles are formed, for example, 5 to 60 minutes, and preferably 15 to 30 minutes.

  In one embodiment, the above mixing to form a W / O dispersion is performed, for example, by gradually adding (I) (i) an organic solvent containing a polymer to (ii) an aqueous solution. be able to. The active ingredient may be contained in either the organic solvent or the aqueous solution, or may be contained in both of them, but is preferably contained in the aqueous solution. In this case, the state of the solution can be changed from the O / W type dispersion to the W / O type dispersion by increasing the amount of the organic solvent containing the polymer. In this case, it is confirmed that polymer particles are formed (see Reference Examples 1 to 19). By causing a change in the state of the solution from the O / W type dispersion to the W / O type dispersion, the amount of polymer particles generated can be increased.

  In another embodiment, the mixing to allow a W / O type dispersion to form is, for example, by gradually adding (II) (ii) an aqueous solution to (i) an organic solvent containing the polymer, It can be carried out. The active ingredient may be contained in either the organic solvent or the aqueous solution, or may be contained in both of them, but is preferably contained in the aqueous solution. In this case, the solution from the W / O type dispersion to the O / W type dispersion is controlled by suppressing the amount of the aqueous solution containing (ii) the active ingredient lower than the amount of the organic solvent containing (i) the polymer. Can be set so as not to change (in other words, the state of the W / O type dispersion is maintained). In this case, it has been confirmed that polymer particles are formed (see Reference Example 20).

  In a preferred embodiment, the preparation of the polymer particles containing the active ingredient comprises (i ′) an organic solvent containing the first polymer and (ii ′) an aqueous solution containing both the active ingredient and the second polymer. It includes mixing to form a W / O type dispersion as a mixed solution to precipitate polymer particles. In the method for producing polymer particles, by using the first polymer in the organic solvent and the second polymer in the aqueous solution in combination, the produced polymer particles can have both properties of a water-soluble gel and a hard surface. There is an advantage.

  In (i ′), the definition, examples and preferred examples of the first polymer, the organic solvent, and the amount of the first polymer in the organic solvent are the polymer, the organic solvent, and the polymer in the organic solvent described in (i). The amount is the same.

  In (ii ′), the definition, examples, and preferred examples of the active ingredient, the aqueous solution, and the amount of the active ingredient in the aqueous solution are the same as those described in (ii).

  In (ii ′), the second polymer contained in the aqueous solution is not particularly limited as long as it is a polymer that can be dissolved in the aqueous solution, but a hydrophilic polymer as described above is preferable. The amount of the polymer in the aqueous solution is not particularly limited as long as the polymer can be dissolved in the aqueous solution. For example, 0.001 to 15% (wt), preferably 0.003 to 10% (wt) Preferably, it is 0.005-7% (wt), and still more preferably 0.01-5% (wt).

  In a preferred specific embodiment, the mixing to allow the W / O type dispersion to form is, for example, (I ′) (i ′) an organic solvent comprising a first polymer, (ii ′) an active ingredient and This can be done by gradually adding to an aqueous solution containing both of the second polymers. In this case, the state of the solution can be changed from the O / W type dispersion to the W / O type dispersion by increasing the amount of the organic solvent containing the polymer. In this case, it is confirmed that polymer particles are formed (see Reference Examples 1 to 19). By causing a change in the state of the solution from the O / W type dispersion to the W / O type dispersion, the amount of polymer particles generated can be increased.

  In another embodiment, the mixing to allow the W / O type dispersion to form is, for example, (II ′) (ii ′) an aqueous solution containing both the active ingredient and the second polymer, (i ′) This can be done by gradually adding to the organic solvent containing the first polymer. In this case, the amount of the aqueous solution containing both (ii ′) the active ingredient and the second polymer is suppressed to be lower than the amount of the organic solvent containing (i ′) the first polymer. It can be set so that the state of the solution does not change from 0 to the O / W type dispersion (in other words, the state of the W / O type dispersion is maintained). In this case, it has been confirmed that polymer particles are formed (see Reference Example 20).

  The addition can be preferably performed dropwise. During the addition, the solution can be left under stirring conditions. The stirring conditions can be set as appropriate according to the amount of the solution. For example, when the final liquid volume is about 45 mL, the scale is 200 to 800 rpm (preferably 400 rpm), and when the final liquid volume is about 1 L, the speed is 80 to 230 rpm.

  The powder composition of the present invention can be prepared using the polymer particles thus obtained. The polymer particles are preferably pulverized before the preparation of the powder composition of the present invention. Examples of the powdering method include freeze drying, spray drying, fluidized bed granulation, stirring granulation, supercritical granulation, and natural drying.

(2) Mixing of prepared polymer particles and powder The powder composition of the present invention is prepared by mixing polymer particles containing a cellulose derivative or a salt thereof in a powder and an aqueous solution in an arbitrary manner. Can do. For example, the mixing can be performed using a stirring device (eg, vacuum kneading device, stirring mill). If necessary, other components can also be mixed.

  EXAMPLES Next, although an Example is shown and this invention is demonstrated further in detail, this invention is not limited to a following example.

<Production Example 1> Preparation of Glutamyllysine-Containing Polymer Particles First, the following three types of solutions were prepared.

(1) Polymer liquid 1
Polymer liquid 1 was prepared by dissolving 8 g of ethyl cellulose (manufactured by Dow Chemical Company, STD7FP. Weight average molecular weight: 55,025) in 600 mL of acetone.

(2) Polymer liquid 2
The polymer liquid 2 was prepared by dissolving 2 g of hydroxypropylcellulose (manufactured by Nippon Soda Co., Ltd., SL. Weight average molecular weight: 100,000) in 300 mL of water.

(3) Active ingredient containing liquid The active ingredient containing liquid was prepared by dissolving 2.0 g of glutamyl lysine (Ajinomoto Co., Inc.) in 30 mL of water.

  Subsequently, the active ingredient containing liquid was dripped at the polymer liquid 2 stirred at 40 degreeC and 250 rpm, and the uniform liquid was obtained. The polymer liquid 1 was gradually added dropwise to this uniform liquid. While under polymer liquid 1, the uniform liquid was stirred at 250 rpm. When the polymer liquid 1 was dropped, the liquid became cloudy, and the state of the suspension changed from the O / W type dispersion to the W / O type dispersion as the amount dropped. As a result, when the polymer liquid 1 was dropped, particles containing glutamyl lysine, hydroxypropyl cellulose, and ethyl cellulose spontaneously precipitated, and a suspension containing such particles (W / O type dispersion) was obtained. . The suspension was suctioned under reduced pressure to remove acetone to obtain a particle liquid dispersed in water.

(4) Drying method The obtained particle liquid was instantaneously frozen at −80 ° C. and then dried at a reduced pressure of 30 mT or less until water was sufficiently removed to obtain glutamyllysine-containing polymer particles.

<Manufacture example 2> Preparation of glutamyl lysine inclusion polymer particle The glutamyl lysine of manufacture example 1 is changed to tranexamic acid (manufactured by Maruzen Pharmaceutical Co., Ltd.), 2.0 g, and prepared in the same manner, thereby containing tranexamic acid. Polymer particles were obtained.

<Examples 1-5, Comparative Examples 1-5> Preparation and Evaluation of Powder Composition By mixing the components described in Tables 1 and 2 and stirring with a lab mixer (LM-110T, HANIL) for 2 minutes, A powder composition in which the powder was coated with polymer particles was obtained.

<Dispersibility>
1 g of each powder composition prepared as described above was accurately measured, and an oil agent (liquid paraffin) was gradually added and mixed with a spatula. The amount of oil that became a whole was defined as the oil absorption point, and the amount of oil that showed uniform fluidity by adding an oil was defined as the pour point. In general, the difference between the pour point and the oil absorption point is often used as an index of dispersibility, and the smaller the numerical value, the higher the dispersibility.

  The dispersibility index calculated by the above method was compared with that of the untreated powder, and the dispersibility was evaluated based on the following criteria.

A: Dispersibility improved by 20% or more.
B: Dispersibility improved by 15 to 19.9%.
C: Dispersibility improved by 10 to 14.9%.
D: Dispersibility decreased or improved only by 0 to 9.9%.

<Sensory evaluation test>
[Evaluation method]
A use test was conducted by 10 professional evaluation panels, and the uniformity, adhesion, and effect persistence at the time of application were evaluated in five levels according to the following criteria, and the average score was determined.

[Evaluation criteria]
5 points: very good 4 points: good 3 points: normal 2 points: slightly bad 1 point: bad

[Criteria]
A: Average point 4 points or more B: Average point 3 points or more to less than 4 points C: Average point 2 points or more to less than 3 points D: Average point 2 points or less

  From the above, it was shown that the powder composition of the present invention is excellent in powder dispersibility and usability.

Reference Example 1 Preparation of Particle 1 First, the following three types of solutions were prepared.
(1) Polymer liquid 1
The polymer liquid 1 was prepared by dissolving 0.4 g of ethyl cellulose (manufactured by Dow Chemical Company, STD7FP. Weight average molecular weight: 55,025) in 30 mL of acetone.
(2) Polymer liquid 2
The polymer liquid 2 was prepared by dissolving 0.1 g of hydroxypropylcellulose (manufactured by Nippon Soda Co., Ltd., SL. Weight average molecular weight: 100,000) in 15 mL of water.
(3) Water-soluble active ingredient-containing liquid The water-soluble active ingredient-containing liquid was prepared by dissolving 0.1 g of tranexamic acid (manufactured by Maruzen Pharmaceutical Co., Ltd.) in 1.5 mL of water.

  Next, the water-soluble active ingredient containing liquid was dripped at the polymer liquid 2 stirred at 40 degreeC and 400 rpm, and the uniform liquid was obtained. The polymer liquid 1 was gradually added dropwise to this uniform liquid. While under polymer liquid 1, the uniform liquid was stirred at 400 rpm. When the polymer liquid 1 was dropped, the liquid became cloudy, and the state of the suspension changed from the O / W type dispersion to the W / O type dispersion as the amount dropped. As a result, when the polymer liquid 1 was dropped, particles containing tranexamic acid, hydroxypropylcellulose, and ethylcellulose were immediately deposited, and a suspension containing such particles (W / O type dispersion) was obtained. . The suspension was suctioned under reduced pressure to remove acetone to obtain a particle liquid dispersed in water. Thereafter, the particle size distribution was evaluated with a laser diffraction particle size distribution meter (manufactured by Malvern Instruments Ltd., Zetasizer NanoS) (see Table 3 below).

  The obtained particles were photographed with a scanning electron microscope. A scanning electron micrograph is shown in FIG.

Reference Example 2 Preparation of Particle 2 Tranexamic acid was directly added to polymer liquid 2 without changing the amount of tranexamic acid of Reference Example 1 to 2.0 g and preparing a solution in which tranexamic acid was dissolved in the active ingredient-containing liquid. A particle solution was prepared in the same manner as in Reference Example 1 except that the polymer solution 1 and the polymer solution 2 were used, and the particle size distribution was measured (see Table 3 below).

Reference Example 3 Preparation of Particle 3 First, the following three types of solutions were prepared.
(1) Polymer liquid 1
Polymer liquid 1 was prepared by dissolving 8 g of ethyl cellulose (manufactured by Dow Chemical Company, STD7FP. Weight average molecular weight: 55,025) in 600 mL of acetone.
(2) Polymer liquid 2
The polymer liquid 2 was prepared by dissolving 2 g of hydroxypropylcellulose (manufactured by Nippon Soda Co., Ltd., SL. Weight average molecular weight: 100,000) in 300 mL of water.
(3) Water-soluble active ingredient-containing liquid The water-soluble active ingredient-containing liquid was prepared by dissolving 2 g of tranexamic acid (manufactured by Maruzen Pharmaceutical Co., Ltd.) in 30 mL of water.

  Next, a water-soluble active ingredient-containing liquid was added dropwise to the polymer liquid 2 stirred at 40 ° C. and 230 rpm to obtain a uniform liquid. The polymer liquid 1 was gradually added dropwise to this uniform liquid. While under polymer liquid 1, the uniform liquid was stirred at 400 rpm. When the polymer liquid 1 was dropped, the liquid became cloudy, and the state of the suspension changed from the O / W type dispersion to the W / O type dispersion as the amount dropped. As a result, when the polymer liquid 1 was dropped, particles containing tranexamic acid, hydroxypropylcellulose, and ethylcellulose were immediately deposited, and a suspension containing such particles (W / O type dispersion) was obtained. . The suspension was suctioned under reduced pressure to remove acetone to obtain a particle liquid dispersed in water. Thereafter, the particle size distribution was evaluated with a laser diffraction particle size distribution meter (manufactured by Malvern Instruments Ltd., Zetasizer NanoS) (see Table 3 below).

Reference Example 4 Preparation of Particle 4 Ethyl cellulose of Reference Example 1 was mixed with hypromellose acetate succinate (Shin-Etsu Chemical Co., Ltd., AS-MG, weight average molecular weight: 18,000), and acetone of polymer liquid 1 was methanol. A particle solution was prepared and the particle size distribution was measured in the same manner as in Reference Example 1 except that the particle size distribution was changed (see Table 3 below).

Reference Example 5 Preparation of Particle 5 Reference Example 1 except that the ethyl cellulose of Reference Example 1 was changed to hypromellose phthalate (Shin-Etsu Chemical Co., Ltd., HP-55, weight average molecular weight: 84,000). Similarly, a particle liquid was prepared and the particle size distribution was measured (see Table 3 below). The hypromellose phthalate ester (HP-55) used had a pH solubility of ≧ 5.5 and a display viscosity of 40 mPa · s [10% solution viscosity of methanol / dichloromethane solution (1: 1) at 20 ° C. (Japan) Pharmacopoeia))].

[Reference Example 6] Preparation of Particle 6 A particle solution was prepared in the same manner as in Reference Example 1 except that the ethyl cellulose of Reference Example 1 was changed to methacrylic acid copolymer S (E-100, S-100, weight average molecular weight: 125,000). Prepared and measured particle size distribution (see Table 3 below).

[Reference Comparative Example 1] Preparation of Comparative Particle 1 (3) Water-soluble active ingredient-containing liquid of Reference Example 1 (0.1 g of tranexamic acid dissolved in 1.5 mL of water) was changed to 1.5 mL of water. Except for the above, a particle solution was prepared in the same manner as in Reference Example 1, and the particle size distribution was measured (see Table 3 below).

(Summary of results of Reference Examples 1 to 6 and Reference Comparative Example 1)
Table 3 shows the results of the particle size distribution measured in Reference Examples 1 to 6 and Reference Comparative Example 1.

[Reference Example 7] Preparation of Particle 7 An experiment was conducted in the same manner as Reference Example 1 except that 0.1 g of tranexamic acid in Reference Example 1 was changed to 0.01 g of edible red No. 3 (Hodogaya Chemical Co., Ltd.). . As a result, formation of particles was confirmed.

[Reference Examples 8 to 11] Preparation of Particles 8 to 11 The tranexamic acid of Reference Example 3 was prepared using L-arginine (Ajinomoto Co., Inc.), L-histidine (Ajinomoto Co., Inc.), glutamyl lysine (Ajinomoto Co., Inc.), and D-alanine (Tokyo). The experiment was conducted in the same manner as in Reference Example 3 except that the substance was changed to any one selected from the group consisting of Kasei Kogyo). As a result, formation of particles was confirmed when any substance was used.

[Reference Examples 12 and 13] Preparation of Particles 12 and 13 The tranexamic acid of Reference Example 3 was changed to one of L-valine (Ajinomoto Co., Inc.) and sodium L-glutamate (Ajinomoto Co., Inc.), and acetone was changed to methanol. Except that, the experiment was performed in the same manner as in Reference Example 3. As a result, formation of particles was confirmed when any substance was used.

[Reference Example 14] Preparation of Particle 14 Same as Reference Example 3 except that 2 g of tranexamic acid of Reference Example 3 was changed to 4 g of 50% (wt) aqueous solution of pyrrolidone carboxylic acid (PCA) sodium salt (Ajinomoto, NL-50). The experiment was conducted. As a result, formation of particles was confirmed.

Reference Example 15 Examination of Hydroxypropyl Cellulose Grade An experiment was conducted in the same manner as in Reference Example 7 except that the hydroxypropyl cellulose (HPC) grade of Reference Example 7 was changed as shown in Table 4 below. As a result, formation of particles was confirmed (Table 4).

[Reference Example 16] Examination of ethyl cellulose grade An experiment was conducted in the same manner as in Reference Example 7 except that the grade of ethyl cellulose (EC) in Reference Example 7 was changed as shown in Table 5 below. As a result, formation of particles was confirmed (Table 5).

[Reference Example 17] Examination of grades of hypromellose acetate succinate Esters other than changing the grade of hypromellose acetate succinate of Reference Example 4 (Shin-Etsu Chemical Co., Ltd., AS-MG) as shown in Table 6 below. Were conducted in the same manner as in Reference Example 4. As a result, formation of particles was confirmed.

Reference Example 18 Examination of Grade of Methacrylic Acid Copolymer Methacrylic acid copolymer S (Evonik, S-100) of Reference Example 6 was changed to methacrylic acid copolymer L (Evonik, L100, weight average molecular weight: 125,000). The experiment was performed in the same manner as Reference Example 6 except that the change was made. As a result, formation of particles having an average particle diameter of 747 nm was confirmed in the methacrylic acid copolymer L (L100).

[Reference Example 19] Examination of preparation of particles using one kind of polymer (1) Use of organic solvent not containing hydrophobic polymer 0.1 g of tranexamic acid of Reference Example 1 was edible red No. 3 (Hodogaya Chemical Co., Ltd.) ) The experiment was performed in the same manner as in Reference Example 1 except that 0.01 g was used and no ethyl cellulose was used. As a result, formation of particles was not confirmed.
From the above, it was confirmed that particles were not formed when an organic solvent not containing a hydrophobic polymer (non-polymer liquid instead of polymer liquid 1) and an aqueous solution containing a hydrophilic polymer (polymer liquid 2) were used. It was.
(2) Use of aqueous solution not containing hydrophilic polymer Reference was made except that 0.1 g of tranexamic acid in Reference Example 1 was changed to 0.01 g of edible red No. 3 (Hodogaya Chemical Industries) and hydroxypropylcellulose was not used. The experiment was conducted in the same manner as in Example 1. As a result, formation of particles was confirmed (dynamic light scattering measurement result: average particle diameter 217 nm).
From the above, it is confirmed that particles are formed when an organic solvent containing a hydrophobic polymer (polymer liquid 1) and an aqueous solution not containing a hydrophilic polymer (non-polymer liquid instead of polymer liquid 2) are used. It was done.

[Reference Example 20] Preparation of particles without changing state from O / W type dispersion to W / O type dispersion 0.1 g of tranexamic acid of Reference Example 1 was used as food red No. 3 (Hodogaya Chemical Co., Ltd.). ) An experiment was conducted in the same manner as in Reference Example 1 except that 0.01 g was changed to dropping the mixed solution of the polymer solution 2 and the water-soluble active ingredient-containing solution into the polymer solution 1. In this experimental condition, since a small amount of aqueous solution is added to a large amount of organic solvent, the state change from the O / W type dispersion to the W / O type dispersion confirmed in Reference Example 1 is not accompanied. As a result, the formation of particles was confirmed without any change in the state.

[Reference Examples 21, 22, and 23] Preparation of Particles 15, 16, and 17 Instead of tranexamic acid in Reference Example 1, methyl 4-hydroxybenzoate (methylparaben, manufactured by Junsei Kagaku), minoxidil (manufactured by Tokyo Chemical Industry), or dihydroxy An experiment was conducted in the same manner as in Example 1 except that any active ingredient of Capsiate (manufactured by Ajinomoto Co., Inc.) was dissolved in the polymer liquid 1 without preparing an active ingredient-containing liquid. As a result, formation of particles was confirmed when any substance was used. In addition, it was confirmed that particles containing the active ingredient can be obtained by dissolving the active ingredient in an organic solvent (polymer liquid 1) instead of an aqueous solution.

[Reference Test Example 1] Skin model permeability evaluation 1
First, the particle solution prepared in Reference Example 3 was centrifuged at a centrifugal acceleration of 21500 × g for 15 minutes in a centrifuge (manufactured by Hitachi Koki Co., Ltd., CF-15RN), and then the same amount of water as the removed supernatant was added. Then, a washing operation for redispersion was performed to obtain a purified particle liquid. For a part of this purified particle liquid, the washing liquid and the particle are separated again by centrifugation, and the liquid obtained by extracting tranexamic acid from the particle part with a mobile phase of a high-speed chromatograph containing methanol is analyzed, and tranexamic acid in the particle is analyzed. The amount was determined in advance. As a result, the amount of tranexamic acid relative to the weight of the particles was 6% (wt).

  Next, 0.2 mg of tranexamic acid as the amount of tranexamic acid on the donor side of a jacketed stationary Franz cell (manufactured by PermeGear) with a three-dimensional cultured epidermis model (Epi Model 12 manufactured by Japan Tissue Engineering Co., Ltd.) The purified particle solution was placed so as to contain, and the concentration of tranexamic acid on the receiver side after 24 hours was measured with a high-speed chromatograph (manufactured by Nippon Waters Co., Ltd., H-CLASS), and the permeation amount was determined (see Table 7 below) reference).

[Reference Test Example 2] Skin model permeability evaluation 2
The skin model permeability was evaluated in the same manner as in Reference Test Example 1 except that the particle liquid used for centrifugal purification in Reference Test Example 1 was changed to the particle liquid prepared in Reference Example 4 (see Table 7 below).

[Reference Comparative Test Example 1] Skin model permeability evaluation 3
The skin model permeability was evaluated in the same manner as in Reference Test Example 1 except that the purified particle solution of Reference Test Example 1 was changed to a 4 mg / mL tranexamic acid aqueous solution (see Table 7 below).

[Reference Comparative Test Example 2] Skin model permeability evaluation 4
The epidermal model permeability was the same as in Reference Test Example 1 except that the particle solution used for centrifugal purification in Reference Test Example 1 was changed to the particle solution prepared in Reference Comparative Example 1 and 0.2 mg of tranexamic acid was added later. (See Table 7 below).

(Summary of results of Reference Test Examples 1 and 2 and Reference Comparative Test Examples 1 and 2)
Table 7 shows the results of the permeation amount after 24 hours in Reference Test Examples 1 and 2 and Reference Comparative Test Examples 1 and 2.

[Reference Test Example 3] Confirmation of Particle Properties From the appearance of the particle liquid obtained in Reference Example 3 being naturally dried and observed with a scanning electron microscope, the surface of the particles obtained in Reference Example 3 is hard, Moreover, it was confirmed that the said particle | grain is a spherical shape (FIG. 2).

  In addition, 50 μL of the particle liquid obtained in Reference Example 3 was dropped on a polystyrene substrate and naturally dried at room temperature (25 ° C.) for 24 hours, and 20 μL of the particle film formed on the polystyrene substrate was prepared. An image was taken from the side with a drop of water. When the contact angle was measured from the image using image processing software image J, the contact angle (inner angle) of water on the particle film was 43.9 degrees. On the other hand, when a 20 μL water droplet was dropped on the polystyrene substrate and the contact angle was measured in the same manner, the contact angle (inner angle) of water on the polystyrene substrate was 78.4 degrees. Since the contact angle of water on the particle film showed a smaller value than the contact angle of water on the polystyrene substrate, the surface of the particles obtained in Reference Example 3 may have hydrophilic properties. confirmed.

  Furthermore, the prepared particles prepared in Reference Example 3 were subjected to measurement of electrophoretic mobility in a 1 mM NaCl aqueous solution (Malvern Instruments Ltd., Zetasizer NanoS). As a result, the mobility by electrophoresis was −4.1 ± 0.12 μmcm / Vs. Since the absolute value from 0 μmcm / Vs was large, it was confirmed that the particles were not hydrophilic gel particles.

  From the above results, it is confirmed that the particles prepared in Reference Example 3 have both hard properties such as polystyrene particles and soft gel-like properties such as polyacrylamide and poly N, N isopropylacrylamide particles. It was done. It was also confirmed that once the particles formed were dispersed in oil, organic solvent or water, they were instantly dissolved and not broken.

[Reference Test Example 4] Evaluation of Preservability and Aggregation of Particles (1) Evaluation of Preservability under Non-Freezing Conditions The particle solutions prepared in Reference Examples 1 to 20 were refrigerated (4 ° C.) at 1.5. It maintained the particle state without agglomeration after years of storage. Therefore, it was confirmed that the particles of the present invention are excellent in storage stability.
(2) Evaluation of particle dispersibility after lyophilization The particle liquid prepared in Reference Example 3 was stirred and vacuumed to reduce water to 1/10 and lyophilized to obtain a powder. When this powder was dispersed again in water so that the solid content concentration became 3% (wt), it was confirmed that the original particle liquid was obtained.
(3) Evaluation of particle dispersibility after spray drying The particle liquid prepared in Reference Example 3 was stirred and vacuumed to reduce water to 1/10, and spray dried (Nippon Büch B-290) to obtain powder. Obtained. When this powder was dispersed again in water so that the solid content concentration became 3% (wt), it was confirmed that the original particle liquid was obtained.

[Reference Test Example 5] Skin model permeability evaluation 5
For the particles 15, 16, and 17 obtained as described above, skin model permeability was evaluated in the same manner as in Reference Test Examples 1 and 2 and Reference Comparative Test Examples 1 and 2. As a result, it was confirmed that these particles containing the active ingredient had higher permeability in the epidermis model than the simple solution of the active ingredient.

[Reference Comparative Examples 2 to 19] Preparation of Comparative Particles 2 to 19 0.4 g of ethyl cellulose of the polymer liquid 1 of Reference Example 7 was added to a polylactic acid glycolic acid block copolymer (PLGA5015, manufactured by Wako Pure Chemical Industries), cetanol (NAA- 44, made by NOF), white petrolatum (made by Ogi Pharmaceutical), castor wax (made by NOF), stearyl alcohol (NAA-45, made by NOF), stearic acid (NAA-180P-1, made by NOF), propylene Glycol caprylate (SEFSOL-218, manufactured by Nikko Chemicals), propylene glycol dicaprylate (SEFSOL-228, manufactured by Nikko Chemicals), lipophilic monooleate glycerin (MGO, manufactured by Nikko Chemicals), lipophilic monostearic acid Glycerin (MGS-AMV, manufactured by Nikko Chemicals), lipophilic monosteari Acid glycerin (MGS-BMV, manufactured by Nikko Chemicals), polyethylene glycol distearate (CDS-6000P, manufactured by Nikko Chemicals), sucrose fatty acid ester (L-595, manufactured by Mitsubishi Chemical Foods), sucrose fatty acid ester (S-570, Mitsubishi Chemical Foods), sucrose fatty acid ester (S-770, manufactured by Mitsubishi Chemical Foods), polyoxyl 40 stearate (NIKKOL MYS-40MV, manufactured by Nikko Chemicals), Seto Macrogol 1000 (NIKKOL BC-23, manufactured by Nikko Chemicals) , Polyoxyethylene (160) polyoxypropylene (30) glycol (Pronon # 188, manufactured by NOF), povidone (K-30, manufactured by BASF), copolyvidone (VA64, manufactured by BASF), saturated polyglycolized glyceride (Gelucire 50 / 1 3, manufactured by Gattefosse), PEG 20000 (manufactured by Wako Pure Chemical Industries), polyvinyl alcohol (JMP-10L, manufactured by Nihon Vinegar / Poval), polyvinyl alcohol (LL-810, manufactured by Nihon Vine / Poval), polyvinyl alcohol (LL-) 920, manufactured by Nihon Vinegar / Poval), 0.1 g of polyvinyl alcohol (LL-940, manufactured by Nihon Vinegar / Poval), 30 mL of acetone in 15 mL, and 0.1 g of hydroxypropylcellulose of polymer solution 2 in polyvinyl alcohol (EG -05, manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) Experiments were performed in the same manner as in Reference Example 7 except that 15 mL of water was changed to 30 mL and 0.13 g of polysorbate 80 was added (Tables 8 and 9). . As a result, formation of particles was confirmed when any substance was used. However, in the evaluation of permeability using a three-dimensional cultured epidermis model, it did not show permeability within 24 hours.

[Reference Comparative Examples 20 to 27] Preparation of Comparative Particles 20 to 27 An experiment was performed in the same manner as Reference Comparative Example 2 except that water was used instead of acetone in the polymer liquid 1 of Reference Comparative Example 2 ( Table 10). As a result, formation of particles was confirmed when any substance was used. However, in the evaluation of permeability using a three-dimensional cultured epidermis model, it did not show permeability within 24 hours.

[Reference Comparative Examples 28 and 29] Preparation of Comparative Particles 28 and 29 Instead of the polyvinyl alcohol of the polymer liquid 2 of Reference Comparative Example 2, povidone (K-90, manufactured by BASF), PEG6000 (manufactured by Wako Pure Chemical Industries, Ltd.) An experiment was performed in the same manner as in Reference Comparative Example 2 except that any of the components was used (Table 10). As a result, formation of particles was confirmed when any substance was used. However, in the evaluation of permeability using a three-dimensional cultured epidermis model, it did not show permeability within 24 hours.

  The powder composition of the present invention is useful as a cosmetic, for example.

Claims (14)

Powder composition comprising the following components (A) and (B):
(A) polymer particles containing a cellulose derivative or a salt thereof; and (B) a powder.   The powder composition according to claim 1, wherein the polymer particles have a volume distribution average particle diameter of 1 to 1000 nm.   The powder composition according to claim 1 or 2, wherein the polymer particles are non-composite particles.   The powder composition according to any one of claims 1 to 3, wherein the powder composition contains only the same kind of polymer particles as the polymer particles. The powder composition according to any one of claims 1 to 4, wherein the polymer particles have one or more properties selected from the group consisting of (i) to (iii) below:
(I) the contact angle of water on the particle film is 20 to 70 degrees;
(Ii) the ratio of the water contact angle on the particle film to the water contact angle on the polystyrene substrate is in the range of 0.2 to 0.9; and (iii) the absolute value of mobility by electrophoresis. Is 2 μmcm / Vs or more.   6. The cellulose derivative according to claim 1, wherein the cellulose derivative is hydroxyalkyl cellulose, hydroxy cellulose, carboxyalkyl cellulose, carboxy cellulose, alkyl cellulose, hydroxyalkyl alkyl cellulose, cationized cellulose, hydrophobic cellulose, or an ester derivative thereof. A powder composition according to claim 1.   The powder composition according to any one of claims 1 to 6, wherein the cellulose derivative is hydroxypropylcellulose, ethylcellulose, hypromellose, or an ester derivative thereof.   The ester derivative is an ester derivative selected from the group consisting of acetate ester, butyrate ester, succinate ester, glycolate ester, propionate ester, phthalate ester, and combinations of two or more of these esters. Or the powder composition of 7.   The powder composition according to any one of claims 1 to 8, wherein the polymer particles include a mixture of two or more kinds of polymers.   The powder composition according to any one of claims 1 to 9, wherein the polymer particles contain an active ingredient.   The powder composition according to claim 10, wherein the active ingredient is one or more ingredients selected from the group consisting of a humectant, a whitening agent and a hair restorer.   The powder composition according to any one of claims 1 to 11, wherein the powder is an inorganic powder.   The powder composition according to any one of claims 1 to 12, wherein the powder is coated with the polymer particles.   Cosmetics containing the powder composition as described in any one of Claims 1-13.