JP2018100237A - Composition for preventing or improving hypomotility - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide means for preventing or improving conveniently hypomotility.SOLUTION: A composition for preventing or improving hypomotility contains olive extract and/or oleuropein.SELECTED DRAWING: None

Description

  The present invention relates to a composition for preventing or improving motor function deterioration.

  In recent years, as the aging society progresses, lowering of the motor function of the elderly is especially regarded as a problem. Even a healthy elderly person is likely to become locomotive syndrome, sarcopenia, etc. if she spends it without taking any special measures. Locomotive syndrome is a state in which the risk of needing long-term care increases due to a decline or disorder of the musculoskeletal system (caused by aging or lifestyle habits). In addition, sarcopenia is a state in which muscles are significantly atrophy and fat mass is increased, and there is a high possibility that the state will require nursing care.

  Under such circumstances, there is a demand for means for easily preventing or improving the decline in motor function.

JP2015-192622A Japanese Patent Laid-Open No. 2006-164138

  An object of the present invention is to provide a means for easily preventing or improving a decrease in motor function.

  The present inventors have found that an extract of a specific plant can solve the above-mentioned problems, and have further improved the present invention to complete the present invention.

That is, the present invention includes, for example, the subject matters described in the following sections.
Item 1.
A composition for preventing or improving motor function deterioration, comprising an olive extract. (It is preferred that the olive extract contains oleuropein.)
Item 2.
A composition for preventing or improving motor function deterioration, comprising oleuropein.
Item 3.
Item 3. The composition for preventing or improving motor function deterioration according to Item 1 or 2, further comprising sulforaphane.
Item 4.
Item 4. The composition for preventing or improving motor function deterioration according to any one of Items 1 to 3, which is an oral composition.
Item 5.
Item 5. The composition for preventing or improving motor function deterioration according to any one of Items 1 to 4, which is used so as to be administered or ingested to a subject who has a decreased physical function or a subject who is predicted to have a decreased physical function.
Item 6.
Item 6. The composition for preventing or improving motor function deterioration according to any one of Items 1 to 5, which is a pharmaceutical composition or a food composition.
Term A.
A body tightening composition comprising olive extract and / or oleuropein.
Term B.
The composition for body tightening according to Item A, further comprising sulforaphane.
Term C.
The composition for body tightening according to any one of Items A or B, which is an oral composition.
Term D.
Administered to subjects whose physical function (motor function) has not deteriorated (compared to normal) (for example, people in their 50s or lower, or people in their 60s or higher whose physical function has not greatly decreased) The composition for body tightening according to any one of Items A to C, which is used so as to be ingested.
Term E.
The composition for body tightening according to any one of Items A to D, which is a pharmaceutical composition or a food composition.

  The composition for preventing or improving motor function lowering of the present invention can be preferably used for preventing or improving motor function lowering. In particular, the composition is useful for increasing muscle mass and skeletal muscle mass. For this reason, it is effective for diseases caused by muscular dysfunction, muscle loss due to aging or illness / injury due to lack of exercise, muscle atrophy, etc., and muscles that are not directly related to motor functions associated with aging ( For example, it can be expected to have a beauty effect by preventing / improving the decline in function and muscle mass of facial muscles, pectoral muscles, buttocks, etc. Among them, elderly or lack of exercise due to illness or injury may cause locomotive syndrome or sarcopenia, and is particularly effective in preventing or improving these.

Under test subjects under 60 years old for each test item of muscle mass, skeletal muscle mass, abdominal circumference, visceral fat area, body fat percentage, lean mass, basal metabolic rate, body weight, and BMI (body mass index) The results when the subjects were analyzed by dividing them into those over 60 years old are shown by the amount of change from the start of the test (starting 4 weeks and 8 weeks). In both graphs, in the two bar graphs described for each subject, the left shows the result of the start 4 weeks, and the right shows the result of the start 8 weeks. The test subject's skeletal muscle index (SMI) at the start of the test, at the start of the 4th week, and at the start of the 8th week is shown as a result of analyzing the test subject separately for those under 60 years old and those over 60 years old. The three bar graphs show the skeletal muscle index (SMI) at the start of the test, the 4th week from the start, and the 8th week from the start in order from the left.

  Hereinafter, the composition for preventing or improving athletic function according to the present invention will be described in more detail.

  In one embodiment according to the present invention, the composition for preventing or improving motor function decline comprises an olive extract. Among the olive extracts, an extract containing oleuropein is preferable. Moreover, this invention also includes the composition for a motor function fall prevention or improvement containing an oleuropein.

  Oleuropein is a kind of glycoside of a phenolic compound and is a compound represented by the following structural formula.

  Oleuropein may be obtained by synthesis or by extracting flowers, pericarps, fruits, leaves, bark, roots or seeds of plants belonging to the genus Oleaceae using water or a water-ethanol mixture. Examples of the plants belonging to the genus Oleaceae include olives (Oleaeuropaea Linne) and the same species (Oleawelwitschii, Oleapaniculata, etc.). Representative examples of olive varieties include, for example, Neva di Bronco, Manzanillo, Picual, Hogi Blanco, Albequina, Catamara, Colonnage, Pitchorine, Paragon, Wagga Verdal, Mission, Washington, West Australia Mission, South Australia Verdal, Azapa, Balnea , Cornicabra, Gordal, Frantoio, Retino, Cipressino, Lucca, Ascorana Terena, Correggiola, Moloioro, Black Italian, Colatina, Helena, Rossiola, One Seven Seven, El Greco, Hardys Mammoth and the like.

  Oleuropein is contained in the pericarp, fruits, leaves, bark, roots or seeds of olives (Oleaeuropaea Linne) and its congeners (Oleawelwitschii, Oleapaniculata, etc.) exemplified above, and leaves are especially abundant compared to other parts. It is known that Therefore, it is preferable to use a plant mainly composed of leaves in the extraction of oleuropein. Examples of the extraction solvent include water, ethanol, petroleum ether, hexane, butanol, propanol, methanol, polyethylene glycol, propylene glycol, butylene glycol, and a mixed solution of these solvents. Hot water and a water-ethanol mixed solution are preferable. . The mixing ratio of water-ethanol mixture (water: ethanol) is preferably about 100: 1 to about 1: 200, more preferably about 20: 1 to about 1:20, and most preferably about 1 in volume ratio. : 9 to 1: 1.

  About the extraction method for obtaining an olive extract, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent during extraction may be in the range of about -4 ° C to about 200 ° C, but is preferably about 30 ° C to about 150 ° C, more preferably about 40 ° C to about 80 ° C. In addition, when olive leaves are used for extraction, it is preferable to use fresh leaves having a relatively high oleuropein content, as disclosed in JP-A-2003-335893, specifically, the fresh leaves are subjected to normal pressure or reduced pressure. It is preferable to perform extraction after performing a treatment in which the content of oleuropein in olive leaves is increased by drying at a temperature of 65 ° C. or lower or at a temperature of 85 ° C. to 145 ° C. for a certain period of time.

  The olive extract obtained by solvent extraction is preferably subjected to concentration or purification treatment when the oleuropein content is low. For example, after the solvent of the crude extract thus extracted from olive leaves is distilled off, for example, styrene divinylbenzene polymerization resin (Diaion HP20: Mitsubishi Chemical), Amberlite XAD resin: Rohm and Haas, Duolite S resin: An extract containing a high concentration of oleuropein can be obtained by passing through a resin column such as Diamond Shamrock, concentrating under reduced pressure, and drying at high temperature. The olive extract used in the present invention includes a crude product obtained by such concentration and purification treatment. Furthermore, treatments such as purification, concentration, and drying can be performed as necessary to increase the content of oleuropein, and to reduce product quality deterioration (appearance, flavor, etc.) due to blending. Examples of such treatment include decomposition by adding acid (inorganic acid, organic acid, etc.) or alkali (sodium hydroxide, calcium hydroxide, ammonia, etc.), fermentation treatment, metabolic conversion treatment using microorganisms, ion exchange. Adsorption of components by resin, activated carbon, diatomaceous earth, fractionation using chromatography, filtration using filter paper, membrane filter, ultrafiltration membrane, pressurization or decompression, heating or cooling, spray drying, freeze drying , PH adjustment, deodorization, decolorization, removal of contaminants by filtration treatment after standing treatment at low temperature, etc., and an olive containing a higher concentration of oleuropein by arbitrarily selecting and combining these An extract can be obtained.

  The olive extract that has been subjected to a purification treatment that can be optimally used for the purpose of blending oleuropein in the present invention preferably has a content of oleuropein of 10% by mass or more, and 20% by mass or more in terms of solid content. Is more preferably 25% by mass or more, and most preferably 30% by mass or more. When an extract with a low content of oleuropein is used, it is difficult to obtain the desired effect because the prescribed blending amount cannot be secured, and it is necessary to blend a large amount of the extract. Is not preferable because it is difficult. Moreover, what is marketed can also be used for the oleuropein used for this invention. Commercially available raw materials include Olive leaf extract (Zabinsa Japan Co., Ltd., containing about 12.5% oleuropein), Naturalive (Deletil Nature, containing about 15% oleuropein), Olive PE (Guilin Layn Natural) Ingredient corp., Containing about 18-20% oleuropein), dried olive leaf extract (Frutarom Switzerland, containing about 20-26% oleuropein), Oleuropein (Natac, containing 20%, 22% or 40% oleuropein) ), Olive leaf extract (manufactured by Bioactive Japan, containing 26% oleuropein), olive leaf extract (manufactured by Tama Seikagaku, 35% oleuropein), and opiace (manufactured by Eisai Food Chemical Co., containing 35% oleuropein). However, it is not limited to these.

   When the composition for preventing or improving athletic function includes an olive extract, it is not particularly limited, but the content of the olive extract is preferably 0.1 to 100% by mass, more preferably 1 to 99% by mass.

  In another embodiment according to the present invention, the composition for preventing or improving motor function deterioration comprises oleuropein. In this case, the oleuropein may be derived from an olive extract or may be produced by other methods such as synthesis. That is, in this embodiment, the olive extract may or may not be included in the composition for preventing or improving motor function deterioration. In the embodiment, the content of oleuropein in the composition for preventing or improving motor function deterioration is not particularly limited, but is preferably 0.01 to 80% by mass, more preferably 10 to 80% by mass, for example, 20 -70 mass% is further more preferable, and 30-60 mass% is still more preferable. In particular, in the case of a solid composition, for example, 10 to 80% by mass is preferable, 20 to 70% by mass is more preferable, and 30 to 60% by mass is more preferable. For example, in the case of a liquid composition, 0.05-5 mass% is preferable and 0.1-2 mass% is more preferable.

  In addition, when oleuropein is contained in the composition for preventing or improving motor function deterioration according to the present invention, the amount of oleuropein consumed by the composition is 10 to 150 mg per day for adults in any embodiment. The amount is preferably 30 to 100 mg, more preferably 50 to 90 mg, and most preferably 60 to 80 mg.

  In addition, the composition for preventing or improving motor function deterioration according to the present invention can be taken once or divided into a plurality of times (preferably 2 to 3 times). The subject of application is preferably a human, but may be a non-human mammal other than a human. Even when the subject of application is a non-human mammal (eg, a pet or livestock, more specifically, a dog, cat, cow, pig, chicken, sheep, etc.), the administration or intake amount of the human should be set as appropriate. Can do. When targeting humans, there is no particular limitation, but physical function (motor function) has decreased due to subjects with decreased physical function (motor function) (physical function decline group), age, illness, disability, etc. A subject who is predicted to go is more preferable. In addition, any age group such as infants, adolescents, middle-aged people, and elderly people can be preferably used. Among them, middle-aged and elderly people are preferred as subjects, and humans in their 60s or more (more preferably 65 years or more) are particularly preferred. . It is preferably used so that these humans are ingested or administered. Further, the method for applying the composition for preventing or improving motor function deterioration according to the present invention to a living body is not particularly limited as long as the effect of the present invention is not impaired, but it may be applied orally (that is, an oral composition). preferable.

  The composition for preventing or improving motor function deterioration according to the present invention includes an olive extract and / or oleuropein, and may further include other components. The other components can be appropriately selected depending on the field in which the composition is used. For example, a pharmaceutically or food hygienically acceptable carrier can be used. Further, for example, saccharides, fats and oils, emulsifiers, fragrances, sweeteners, dietary fibers and the like can be included, but there is no particular limitation.

  In particular, it is preferable to further contain sulforaphane. Sulforaphane is a kind of isothiocyanate and is contained in broccoli among cruciferous vegetables, promoting the production of detoxification enzymes and antioxidant enzymes in the body, increasing the body's antioxidant power and detoxification power, and also has anticancer activity It is a considered compound.

  When the composition for preventing or improving motor function deterioration according to the present invention contains sulforaphane, it is not particularly limited, but the amount of sulforaphane intake by the composition is 0.01 to 10 mg, preferably 0.05 to 5 mg per adult day. More preferably, the amount is 0.1 to 1 mg. The sulforaphane may be an extract of cruciferous vegetables (broccoli is preferred, broccoli sprout is more preferred) or a chemically synthesized product. Commercial products can also be used. For example, a commercially available broccoli sprout extract can be used.

  The composition for preventing or improving motor function deterioration according to the present invention can be preferably used as, for example, a pharmaceutical composition or a food composition (including a beverage composition and a food additive composition).

  When used as a pharmaceutical composition, other components include pharmaceutically acceptable bases, carriers, and / or additives (eg, solvents, dispersants, emulsifiers, buffers, stabilizers, excipients, binders). , Disintegrants, lubricants, etc.). Further, the form of the composition for preventing or improving motor function deterioration is not particularly limited, and examples thereof include tablets, pills, powders, solutions, suspensions, emulsions, granules, capsules, creams, and poultices. . These forms of pharmaceutical preparations can be prepared in a conventional manner by combining the other ingredients and olive extract or oleuropein as necessary.

  When used as a food composition, examples of other components include bases, carriers, additives, and other components and materials that can be used as food. In addition, the form of the composition for preventing or improving motor function deterioration is not particularly limited. For example, processed foods, health foods (dietary supplements, nutritional functional foods, foods for the sick, foods for specified health use, functional indication products, etc. ), Supplements, food for the sick (hospital food, sick food, nursing food, etc.) and the like. These can be prepared by conventional methods. In particular, when preparing a food composition for preventing or improving motor function deterioration as a health food (dietary supplement, nutritional functional food, food for the sick, food for specified health use, functional indication product, etc.) or supplement, In order to facilitate continuous ingestion, it is preferably prepared in the form of granules, capsules, tablets (including chewables, etc.), beverages (beverage powder, drinks, smoothies, etc.), especially capsules, tablets The form of tablets, beverage powders, drinks, jelly and gummi is preferable from the viewpoint of ease of ingestion, but is not particularly limited thereto. When used as a food additive composition among food compositions, examples of the form include liquid, powder, flake, granule, and paste. More specifically, seasonings (soy sauce, sauce, ketchup, dressing, etc.), flakes (sprinkles), grilled meat sauce, spices, roux paste (carrere paste, etc.) and the like can be exemplified.

  The composition for preventing or improving motor function lowering of the present invention can be preferably used for preventing or improving motor function lowering. In particular, the composition is useful for increasing muscle mass and skeletal muscle mass. For this reason, it is effective for diseases caused by muscular dysfunction, or muscle loss due to aging or illness / injury due to lack of exercise, muscle atrophy, etc., but muscles that are not directly related to motor functions associated with aging (for example, It is also expected to have a beauty effect by preventing / improving the decline in function and muscle mass of facial muscles, pectoral muscles, buttocks, etc.). Among them, elderly or lack of exercise due to illness or injury may cause locomotive syndrome or sarcopenia, and is particularly effective in preventing or improving these.

  Furthermore, the composition for preventing or improving motor function deterioration according to the present invention not only increases muscle mass and skeletal muscle mass, but also reduces abdominal circumference, visceral fat area, body fat percentage, etc. The effect which increases etc. can also be show | played. In addition, the composition increases body weight and BMI (body mass index), particularly in subjects with decreased physical function (motor function) (physical function decreased group; for example, subjects in their 60s or higher). This is thought to be the result of increased muscle mass. In subjects (for example, subjects under 50s) whose physical function (motor function) has not decreased (compared to normal), an effect of reducing body weight and BMI can be expected. For this reason, the composition mentioned above can be used not only as a composition for preventing or improving athletic function but also as a composition for body tightening. In other words, it can be used to obtain a firm and healthy body or to make a healthy shape. The present invention preferably also includes the body tightening composition. Moreover, about the structure of the said composition for body tightening, it is the same as that of the composition for a motor function fall prevention or improvement mentioned above. However, when targeting humans, any age group such as infants, adolescents, middle-aged and elderly people can be preferably used, and although there are no particular restrictions, subjects whose physical functions (motor functions) have not deteriorated It is preferable to target a person (for example, a person in their 50s or less, or a person in their 60s or more whose physical function is not greatly reduced), and more preferably adolescents and middle-aged persons.

  In this specification, “including” includes “consisting essentially of” and “consisting of” (The term “comprising” includes “consisting essentially of” and “consisting of.”).

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples.

<Summary>
The effect of ingesting olive leaf extract-containing chocolate for 8 weeks was examined by comparison between before and after ingestion for subjects over the age of 35 (17 men and 11 women). In addition, the subject of the said examination was a person who satisfy | fills all the following conditions. Fasting blood glucose ≧ 100 mg / dL, 5.6 ≦ HbA1c <6.9%, neutral fat ≧ 100 mg / dL, BMI ≧ 25, visceral fat ≧ 85 cm ² .

<Olive leaf extract-containing chocolate>
Chocolate containing olive leaf extract and broccoli sprout extract processed powder was prepared by a conventional method. In addition, the raw material of the said chocolate is shown below.
Ingredients: maltitol (8.1 g), vegetable oil (4.5 g), cocoa (4.2 g), polydextrose (3.2 g), brown rice (0.4 g), olive leaf extract (150 mg), emulsifier (160 mg) ), Flavor (20.4 mg), sweetener (sclarol, thaumatin) (16.3 mg), broccoli sprout extract processed powder (8.2 mg)

<Test content>
As a replacement for snacks (after breakfast-before lunch, after lunch-before dinner, after dinner-before going to bed), the chocolate was ingested daily at 20.4 g per bag. The test period is 8 weeks, and each test item (muscle mass, skeletal muscle mass, abdominal circumference, visceral fat area, body fat percentage, fat free mass, basics at the start of the test, the 4th week of the start, and the 8th week of the start Metabolism, body weight, BMI (body mass index) and skeletal muscle index (SMI) were measured by the bioelectrical impedance method. The measurement was performed using InBody 730 (Inbody Japan Co., Ltd.). The skeletal muscle index (SMI) is a value obtained by dividing the limb skeletal muscle mass (kg) by the square of the height (m), and is a measure of the decrease in the skeletal muscle mass. The muscle mass here is a value obtained by subtracting the body fat mass and the skeletal muscle mass from the body weight, and this is the muscle mass (Lean presented by DEXA (dual-energy X-ray absorptiometry)) which is a bone density test method. The definition is the same as Soft Tissue Mass; The skeletal muscle in the skeletal muscle mass here means a muscle that can be voluntarily exercised and has a striated pattern of muscle tissue, and excludes muscle components such as visceral and cardiac muscles from the total muscle mass. Value. (Thus, all muscle masses of the limbs coincide with skeletal muscle mass.) The lean mass is a value obtained by subtracting the body fat mass from the body weight. BMI (Body Mass Index) is widely used as a physique index representing the degree of obesity.

  The olive extract as a raw material contained oleuropein, and the broccoli sprout extract processed powder contained sulforaphane. In 20.4 g of the chocolate, 52.5 mg of oleuropein and 0.17 mg of sulforaphane were contained.

  The results are shown in FIGS. FIG. 1 shows 60 years of age for each of the examination items of muscle mass, skeletal muscle mass, abdominal circumference, visceral fat area, body fat percentage, lean mass, basal metabolic rate, body weight, and BMI (body mass index). The results when the test subjects were divided into less than 60 and over 60 years old are shown as the amount of change from the start of the test (4th week and 8th week). Further, FIG. 2 shows skeletal muscle index (SMI) at the start of the test, the 4th week from the start, and the 8th week from the start. In addition, the bar graph of FIG.1 and FIG.2 shows the average value of each test subject.

Claims (7)

A composition for preventing or improving motor function deterioration, comprising an olive extract. A composition for preventing or improving motor function deterioration, comprising oleuropein. The composition for preventing or improving motor function deterioration according to claim 1 or 2, further comprising sulforaphane. The composition for preventing or improving motor function deterioration according to any one of claims 1 to 3, which is an oral composition. The composition for preventing or improving motor function deterioration according to any one of claims 1 to 4, which is used to be administered or ingested to a subject whose physical function is reduced or a subject whose physical function is predicted to be reduced. . The composition for preventing or improving motor function deterioration according to any one of claims 1 to 5, which is a pharmaceutical composition or a food composition. A body tightening composition comprising olive extract and / or oleuropein.