JP2018087154A - Storage device and organ transplantation method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a storage device and an organ transplantation method capable of storing properly an organ with a simple structure.SOLUTION: A storage device 1 comprises: a container 2 for storing a corpse X; a coolant 5 which is supplied to the container 2 for cooling the corpse X; and a temperature adjustment part 7 for adjusting the temperature of the coolant 5 according to the temperature of the corpse X. The temperature adjustment part 7 lowers the temperature of the coolant 5 as the temperature of the corpse X is higher, and stores the corpse X in a range of -3.0°C-0°C. The coolant 5 is sherbet-like ice containing a salt content.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a storage device and an organ transplantation method.

  As a storage device (recovery device) for organs separated from a living body, for example, a storage device described in Patent Document 1 is disclosed. The storage device of Patent Document 1 mainly includes an organ holding unit that holds an organ, a storage liquid perfusion unit that perfuses an organ held in the organ holding unit, and a temperature control of the organ storage unit. A temperature control unit that performs the introduction, an introduction unit that introduces the active ingredient into the preservation solution to be circulated through the preservation solution perfusion unit, and a function evaluation unit that evaluates the organ function by measuring the flow rate of the preservation solution to be perfused into the organ, And an adjustment unit that adjusts the temperature of the temperature management unit, the type and amount of the active ingredient agent, and the flow rate of the preservation solution based on the data obtained by the function evaluation.

JP 2013-075888 A

  However, the storage device of Patent Document 1 has a complicated configuration such as perfusion of a storage solution into an organ. In Patent Document 1, the organ is cooled and stored with a storage solution of about 4 ° C., and the organ is reheated by heating the storage solution to about 25 ° C. The organ is removed with a storage solution of about 4 ° C. There is a risk that organs cannot be stored properly even if they are stored cold.

  An object of the present invention is to provide a storage device and an organ transplantation method that can appropriately store an organ with a simple configuration.

  Such an object is achieved by the present inventions (1) to (8) below.

(1) a container for storing a corpse;
A coolant supplied to the container to cool the corpse;
And a temperature adjusting unit that adjusts the temperature of the coolant according to the temperature of the corpse.

  (2) The storage device according to (1), wherein the temperature adjustment unit lowers the temperature of the coolant as the temperature of the dead body increases.

  (3) The storage device according to (1) or (2), wherein the corpse is stored within a range of −3.0 ° C. or higher and 0 ° C. or lower.

  (4) The storage device according to any one of (1) to (3), wherein the coolant is a sherbet-like ice containing salt.

  (5) Said (1) thru | or (4) which has a mounting part which can move to the 1st position located inside the said container, and the 2nd position located outside the said container, and mounts the said corpse. The preservation | save apparatus in any one of.

  (6) The storage device according to any one of (1) to (5), further including a temperature detection unit that detects a temperature of the corpse.

  (7) The storage device according to (6), wherein the temperature detection unit is disposed inside the corpse.

  (8) An organ transplantation method, wherein an organ separated from a cadaver stored by the storage device according to any one of (1) to (7) is transplanted into a living body.

  ADVANTAGE OF THE INVENTION According to this invention, while a structure of a preservation | save apparatus becomes simple, an organ can be preserve | saved appropriately. Therefore, for example, it becomes possible to preserve | save for a long time in the state which can transplant an organ to a biological body. In addition, it is possible to reduce a decrease in organ function after living-body transplantation.

It is a lineblock diagram showing the preservation device concerning a 1st embodiment of the present invention. It is a figure for demonstrating the movement of the mounting part which the preservation | save apparatus shown in FIG. 1 has. It is a perspective view which shows the temperature detection part which the preservation | save apparatus shown in FIG. 1 has. It is a graph which shows an example (the relationship between the temperature of a coolant and the temperature of a corpse) of the cooling method of a corpse. It is a block diagram which shows the preservation | save apparatus which concerns on 2nd Embodiment of this invention.

  Hereinafter, a storage device and an organ transplantation method of the present invention will be described in detail with reference to the accompanying drawings.

<First Embodiment>
FIG. 1 is a configuration diagram illustrating a storage device according to a first embodiment of the present invention. FIG. 2 is a diagram for explaining the movement of the placement unit included in the storage device illustrated in FIG. 1. FIG. 3 is a perspective view illustrating a temperature detection unit included in the storage device illustrated in FIG. 1. FIG. 4 is a graph showing an example of a corpse cooling method (relationship between coolant temperature and cadaver temperature).

  A storage device 1 shown in FIG. 1 is a storage device for storing a cadaver X (donor) for organ transplantation, for example. The organ transplanted from cadaver X is not particularly limited, and examples thereof include heart, lung, stomach, small intestine, duodenum, large intestine, rectum, liver, kidney, and spleen. However, the purpose of the storage device 1 is not limited to this. For example, the storage device 1 may be a storage device for storing the corpse X that is used for research, experiments, practical training, and the like.

  The storage device 1 includes a container 2 that stores a corpse X, a placement unit 3 that mounts the corpse X, a coolant 5 that is supplied to the container 2 and cools the corpse X, and a temperature at which the temperature of the corpse X is detected. It has the detection part 6 and the temperature adjustment part 7 which adjusts the temperature of the coolant 5 according to the temperature of the dead body X detected by the temperature detection part 6. FIG.

  The container 2 has a storage space S that can be stored with the corpse X extended. In addition, the container 2 is provided with an introduction part 21 into which the coolant 5 is introduced and a discharge part 22 through which the coolant 5 is discharged. Although not shown, the container 2 may have a lid so that the storage space S can be sealed with the lid. Thereby, it becomes difficult to be influenced by the outside air temperature, and the temperature of the corpse X in the storage space S can be controlled more accurately. In addition, the coolant 5 is not easily spilled from the container 2, and the storage device 1 can be easily transported (transported). Each of the container 2 and the lid is preferably configured to have a high heat insulating property, for example, a heat insulating material is disposed inside.

  In such a container 2, a placement unit 3 (mounting table) is provided, and the placement unit 3 can be moved up and down with respect to the container 2. That is, the placement unit 3 moves to a first position located inside the container 2 as shown in FIG. 1 and a second position located outside (above) the container 2 as shown in FIG. Is possible. Thereby, for example, after placing the corpse X on the placement unit 3 in the state of the second position, the corpse X can be easily stored in the container 2 by moving the placement unit 3 to the first position. it can. On the other hand, when taking out an organ from the corpse X for transplantation, the corpse X can be easily taken out from the container 2 by moving the mounting portion 3 to the second position. The placement unit 3 can also be used as an operating table at the second position. That is, an organ can be taken out from the corpse X on the placement unit 3 without moving the corpse X placed on the placement unit 3 to another operating table. Thereby, an organ can be transplanted in a shorter time. Moreover, since it is not subjected to stress due to movement, an organ with a better condition can be taken out.

  Further, the mounting portion 3 is provided with a plurality of through holes 31. Thereby, resistance with the coolant 5 when moving the mounting part 3 decreases, and the mounting part 3 can be moved more smoothly.

  In addition, it does not specifically limit as a raising / lowering mechanism which raises / lowers the mounting part 3, For example, a hydraulic type raising / lowering apparatus may be sufficient and a mechanical type raising / lowering apparatus may be sufficient.

  The coolant 5 is supplied into the container 2, and the corpse X is cooled by the coolant 5. A sufficient amount of the coolant 5 is stored in the container 2, and the entire corpse X can be immersed in the coolant 5. Thereby, the dead body X can be cooled more uniformly and more rapidly.

  The coolant 5 is not particularly limited, but for example, sherbet-like ice containing salt (that is, a mixture of water (liquid phase) and ice (solid phase) (mixed phase)) is preferably used. Such a coolant 5 can be manufactured by cooling physiological saline, for example. According to such a coolant 5, temperature fluctuation hardly occurs and the temperature of the corpse X can be controlled with high accuracy. The coolant 5 (sherbet-like ice containing salt) can be adjusted within a range of, for example, −20 ° C. to 0 ° C. by changing the salt concentration by the temperature adjusting unit 7 described later. Yes.

  As shown in FIG. 3, the temperature detection unit 6 includes a rod-shaped main body 61 and a temperature sensor unit 62 provided at the tip of the main body 61. Such a temperature detection unit 6 is used by inserting the main body 61 into the corpse X (as if piercing). That is, the temperature detection unit 6 is disposed inside the corpse X. As a result, the temperature sensor 62 can detect the internal temperature of the corpse X. Therefore, the temperature of the organ can be detected with higher accuracy. In addition, from the viewpoint of accurately detecting the temperature of an organ used for transplantation, it is preferable to insert (pierce) the main body 61 into the corpse X so that the temperature sensor 62 is disposed in the vicinity of the organ.

  In this embodiment, the main body 61 is provided with a camera 63 and an illumination 64 in addition to the temperature sensor 62. The camera 63 is provided at the distal end portion of the main body portion 61 so that the front of the main body portion 61 can be imaged. The illumination 64 can illuminate the field of view of the camera 63 (in front of the main body 61). Thereby, for example, when the main body 61 is inserted into the corpse X, the inside of the cadaver X can be confirmed by the camera 63, and the main body 61 can be inserted without damaging the organ. In addition, the position of the temperature sensor unit 62 can be confirmed by the camera 63, and the temperature sensor unit 62 can be arranged at a more appropriate position (in the vicinity of the organ used for transplantation). In the present embodiment, one temperature detection unit 6 is used. For example, when there are a plurality of organs used for transplantation, a plurality of temperature detection units 6 are used so as to correspond to each organ. May be.

  The temperature detection unit 6 has been described above, but the configuration of the temperature detection unit 6 is not particularly limited as long as the temperature of the corpse X can be detected. For example, the shape of the main body 61 is not limited to a rod shape. Further, the camera 63 and the illumination 64 may be omitted. In the camera 63, for example, a lens and an optical fiber that propagates the light collected by the lens are arranged in the main body 61, and an imaging element that receives the light propagated through the optical fiber is located outside the main body 61. It may be.

  The temperature adjustment unit 7 adjusts the temperature of the coolant 5 in the container 2. The method for adjusting the temperature of the coolant 5 is not particularly limited, and examples thereof include a method for adjusting the salt concentration of the coolant 5. As the salinity concentration of the coolant 5 increases, the freezing point decreases, so that the coolant 5 having a lower temperature can be obtained. The temperature of the coolant 5 is not particularly limited, but can be adjusted within a range of -20 ° C to 0 ° C. Thereby, the corpse X in the container 2 can be cooled more quickly to an appropriate temperature, and after being cooled to an appropriate temperature, the state can be appropriately maintained. Therefore, the organ in the corpse X can be preserve | saved with a more fresh state.

  The configuration of the temperature adjusting unit 7 is not particularly limited as long as the temperature of the coolant 5 in the container 2 can be adjusted. In the present embodiment, the configuration is as follows.

  As shown in FIG. 1, the temperature adjustment unit 7 includes a temperature detection unit 73 that detects the temperature of the coolant 5 in the container 2, and the temperature of the coolant 5 detected by the temperature detection unit 73 and the temperature detection unit 6. Based on the detected temperature of the corpse X (organ), the salt concentration of the coolant 5 supplied from the container 2 via the discharge unit 22 is adjusted (including the maintenance of the salt concentration), and the new coolant 5 A salinity concentration adjusting unit 71 for obtaining the raw material 5A, and a cooling unit 72 for cooling the raw material 5A having the salt concentration adjusted by the salt concentration adjusting unit 71 to generate a new coolant 5. The generated new coolant 5 is supplied to the container 2 through the introduction part 21. That is, the temperature adjustment unit 7 is configured to adjust the temperature of the coolant 5 in the container 2 by adjusting the salt concentration while circulating the coolant 5.

  The cooling unit 72 includes an ice generator 721 that generates ice from the raw material 5 </ b> A, and a refrigerator 722 that circulates a refrigerant through the ice generator 721. The raw material 5A fed to the ice generator 721 is gradually cooled by heat exchange with the refrigerant supplied from the refrigerator 722, and a part thereof becomes fine ice (ice crystals) containing salt. As a result, a new coolant 5 is generated, and this new coolant 5 is discharged from the ice generator 721 and then injected into the container 2 via the introduction part 21. Thus, the coolant 5 in the container 2 is simply and efficiently supplied by supplying the new coolant 5 into the container 2 while removing the coolant 5 used for use from the container 2. The temperature of can be adjusted.

  Such a temperature adjustment unit 7 has a function of adjusting the temperature of the coolant 5 in the container 2 in accordance with the temperature of the corpse X (organ). Specifically, the temperature adjustment unit 7 decreases the temperature of the coolant 5 in the container 2 as the temperature of the corpse X (organ) detected by the temperature detection unit 6 is higher. As a result, the corpse X in a high temperature state (a state shortly after death: about 36 to 40 ° C.) can be rapidly cooled to near the storage temperature. Further, after the temperature of the corpse X reaches the vicinity of the storage temperature, it can be cooled relatively slowly to the storage temperature, so that the temperature of the corpse X is prevented from excessively decreasing with respect to the storage temperature. it can. Thereby, the decay of the organ by high temperature and the freezing death (frostbite) of the organ by low temperature can be suppressed effectively. Furthermore, since the corpse X (organ) can be cooled to the storage temperature in a shorter time, the organ in the cadaver X can be stored in a more fresh state.

  In addition, although it does not specifically limit as said storage temperature, For example, it is preferable that it is -3.0 degreeC-0 degreeC, and it is more preferable that it is -2.5 degreeC--1.5 degreeC. In other words, the cadaver X (organ) is preferably stored within a range of −3.0 ° C. to 0 ° C., and more preferably stored within a range of −2.5 ° C. to −1.5 ° C. Thereby, an organ can be preserve | saved while being fresher.

  Next, an example of temperature adjustment of the coolant 5 by the temperature adjustment unit 7 will be described. However, the temperature adjustment of the coolant 5 is not limited to the following example. As shown in FIG. 4, the temperature of the coolant 5 in the container 2 is maintained at about −20 ° C. until the temperature of the corpse X is lowered to about 10 ° C., and the corpse X is rapidly cooled. Thereafter, the corpse X is gradually cooled to 0 ° C. by gradually increasing the temperature of the coolant 5 to 0 ° C. And if the temperature of the dead body X will be about 0 degreeC, the temperature of the coolant 5 will be maintained at 0 degreeC. That is, the temperature adjusting unit 7 maintains the temperature of the coolant 5 substantially constant and rapidly cools the corpse X, and gradually increases the temperature of the coolant 5 from the quenching state to A slow cooling state in which the temperature of the corpse X is cooled to the storage temperature by cooling more slowly than in the rapid cooling state and a storage state in which the temperature of the coolant 5 is kept substantially constant and the corpse X is stored at the storage temperature are performed. Thereby, since the corpse X (organ) can be cooled to the preservation | save temperature in a shorter time, the organ in the cadaver X can be preserve | saved with a more fresh state. Moreover, it is possible to effectively suppress the decay of the organ due to high temperature and the freeze death (frostbite) of the organ due to low temperature.

  In addition, if the temperature adjustment part 7 can adjust the temperature of the coolant 5 according to the temperature of the corpse X, it will be limited to the above control (control which has a rapid cooling state, a slow cooling state, and a preservation | save state). For example, one of the rapid cooling state and the slow cooling state may be omitted.

  The storage device 1 has been described above. According to such a storage device 1, the corpse X (organ) can be appropriately stored only by adjusting the temperature of the coolant 5, that is, with a simple configuration (longer in a state that can be transplanted into a living body). Can be saved for a long time). Further, according to the organ transplantation method of transplanting an organ separated from a cadaver stored in such a storage device 1 into a living body (patient), a fresher organ can be transplanted. Can be suppressed.

Second Embodiment
FIG. 5 is a block diagram showing a storage device according to the second embodiment of the present invention.

  Hereinafter, the storage device according to the second embodiment will be described focusing on the differences from the first embodiment described above, and description of similar matters will be omitted. The storage device of the present embodiment is mainly the same as the storage device of the first embodiment described above except that the configuration of the coolant and the temperature adjustment unit is different. In addition, the same code | symbol is attached | subjected to the structure similar to 1st Embodiment mentioned above.

  As shown in FIG. 5, in the storage device 1 of the present embodiment, a known organ / tissue storage solution (liquid) such as ET Kyoto (ET-Kyoto) solution is used as the coolant 5. By using such a coolant 5, the corpse X can be cooled and stored with almost no damage to the organ. The coolant 5 is not particularly limited as long as it does not damage the organ, and various antifreeze liquids (for example, liquids having a freezing point of −20 ° C. or lower) can also be used.

  The temperature adjustment unit 7 is provided in the middle of the flow path 75, a temperature detection unit 73 that detects the temperature of the coolant 5 in the container 2, a flow path 75 that connects the discharge part 22 and the introduction part 21, A pump 76 for circulating the coolant 5 and a heating / cooling unit 77 that is provided in the middle of the flow path 75 and heats or cools the coolant 5 are included. In the temperature adjustment unit 7 having such a configuration, the heating / cooling unit 77 is based on the temperature of the coolant 5 detected by the temperature detection unit 73 and the temperature of the corpse X (organ) detected by the temperature detection unit 6. Then, the coolant 5 is heated or cooled, thereby adjusting the temperature of the coolant 5 in the container 2.

  According to the second embodiment as described above, the same effect as that of the first embodiment described above can be exhibited.

  The storage device and the organ transplantation method of the present invention have been described above, but the present invention is not limited to this.

DESCRIPTION OF SYMBOLS 1 Storage device 2 Container 21 Introduction part 22 Discharge part 3 Placement part 31 Through-hole 5 Coolant 5A Raw material 6 Temperature detection part 61 Main body part 62 Temperature sensor part 63 Camera 64 Illumination 7 Temperature adjustment part 71 Salinity concentration adjustment part 72 Cooling unit 721 Ice generator 722 Refrigerator 73 Temperature detection unit 75 Channel 76 Pump 77 Heating / cooling unit S Storage space X Dead body

Claims (8)

A container for storing the corpse,
A coolant supplied to the container to cool the corpse;
And a temperature adjusting unit that adjusts the temperature of the coolant according to the temperature of the corpse.   The storage device according to claim 1, wherein the temperature adjustment unit lowers the temperature of the coolant as the temperature of the corpse increases.   The storage device according to claim 1 or 2, wherein the corpse is stored within a range of -3.0 ° C to 0 ° C.   The storage device according to any one of claims 1 to 3, wherein the coolant is a sherbet-like ice containing salt.   5. The apparatus according to claim 1, further comprising: a placement portion that is movable to a first position located inside the container and a second position located outside the container, and places the dead body. The storage device described.   The storage device according to any one of claims 1 to 5, further comprising a temperature detection unit that detects a temperature of the corpse.   The storage device according to claim 6, wherein the temperature detection unit is disposed in the body of the corpse.   An organ transplantation method, wherein an organ separated from a cadaver stored by the storage device according to any one of claims 1 to 7 is transplanted into a living body.

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